James D Lord
Affiliation: University of Washington
- Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cellsJames D Lord
Department of Medicine, University of Washington, Seattle, WA, USA
Dig Dis Sci 55:1396-405. 2010..However, we found no evidence of FOXP3(+) T cell depletion in any of the nine patients who developed colitis...
- Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host diseaseJames D Lord
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98101, USA
Biol Blood Marrow Transplant 17:486-96. 2011..There was no correlation of Treg frequency with the histologic or clinical severity of gastrointestinal GVHD. We conclude that Treg depletion is not a central feature in the pathogenesis of gastric GVHD in humans...
- A case of fatal idiopathic enteritis and multiple opportunistic infections associated with dendritic cell deficienciesJames D Lord
Translational Research Program Benaroya Research Institute, Seattle, WA 98101 2795, USA
J Gastrointestin Liver Dis 22:87-91. 2013..While the cause of her lack of DCs is unknown, this data suggests a key role for these cells in both regulating mucosal immunity and promoting effective cell-mediated immunity against pathogens in humans...
- Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2James D Lord
Translational Research Program, Benaroya Research Institute, Mailstop IN RC, 1201 Ninth Ave, Seattle, WA 98101 2795, USA
Dig Dis Sci 57:2846-55. 2012..FOXP3 inhibits IL-17A production, but a naturally occurring splice variant of FOXP3 lacking exon 2 (Δexon2) cannot...