Jeffrey D Long

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc 8OHdG as a marker for Huntington disease progression
    Jeffrey D Long
    Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 46:625-34. 2012
  2. pmc Cognitive decline in prodromal Huntington Disease: implications for clinical trials
    Jane S Paulsen
    Department of Neurology, Carver College of Medicine, Univeristy of Iowa, Iowa City, Iowa, USA
    J Neurol Neurosurg Psychiatry 84:1233-9. 2013
  3. pmc Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington disease
    Kathryn V Papp
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Arch Clin Neuropsychol 28:156-68. 2013
  4. pmc Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease
    Ji In Kim
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 23:1584-7. 2015
  5. pmc Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
    Jane S Paulsen
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Department of Psychology, University of Iowa, Iowa City, IA, USA Electronic address
    Lancet Neurol 13:1193-201. 2014
  6. pmc Motor onset and diagnosis in Huntington disease using the diagnostic confidence level
    Dawei Liu
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA
    J Neurol 262:2691-8. 2015
  7. pmc Disruption of response inhibition circuits in prodromal Huntington disease
    Julia A Rao
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Cortex 58:72-85. 2014
  8. pmc WHODAS 2.0 in prodromal Huntington disease: measures of functioning in neuropsychiatric disease
    Nancy R Downing
    College of Nursing, University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 22:958-63. 2014
  9. pmc Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study
    Eric A Epping
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Psychiatr Res 47:1423-31. 2013
  10. pmc T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression
    Shafik N Wassef
    Department of Radiology, University of Iowa, Iowa City, Iowa, USA
    Mov Disord 30:1107-14. 2015

Collaborators

Detail Information

Publications14

  1. pmc 8OHdG as a marker for Huntington disease progression
    Jeffrey D Long
    Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 46:625-34. 2012
    ..The finding that 8OHdG concentrations increased as a function of proximity to projected disease diagnosis and duration indicates support for the continued assessment of 8OHdG as a robust clinical HD biomarker...
  2. pmc Cognitive decline in prodromal Huntington Disease: implications for clinical trials
    Jane S Paulsen
    Department of Neurology, Carver College of Medicine, Univeristy of Iowa, Iowa City, Iowa, USA
    J Neurol Neurosurg Psychiatry 84:1233-9. 2013
    ..Many longitudinal studies of cognitive decline in prodromal HD have not stratified samples based on disease progression, thereby obscuring differences between symptomatic and nonsymptomatic individuals...
  3. pmc Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington disease
    Kathryn V Papp
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Arch Clin Neuropsychol 28:156-68. 2013
    ....
  4. pmc Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease
    Ji In Kim
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 23:1584-7. 2015
    ..Results suggest the 12-item WHODAS 2.0 can detect baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials. ..
  5. pmc Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
    Jane S Paulsen
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Department of Psychology, University of Iowa, Iowa City, IA, USA Electronic address
    Lancet Neurol 13:1193-201. 2014
    ..We compared various measures for tracking progression and predicting conversion to manifest Huntington's disease...
  6. pmc Motor onset and diagnosis in Huntington disease using the diagnostic confidence level
    Dawei Liu
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA
    J Neurol 262:2691-8. 2015
    ..Results suggest that more accurate estimates of HD onset age can be obtained by incorporating the current status of diagnostic confidence level into predictive models...
  7. pmc Disruption of response inhibition circuits in prodromal Huntington disease
    Julia A Rao
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Cortex 58:72-85. 2014
    ..These results are the first to demonstrate that response inhibition in prHD is associated with altered functioning in brain networks that govern inhibition, attention, and motor control. ..
  8. pmc WHODAS 2.0 in prodromal Huntington disease: measures of functioning in neuropsychiatric disease
    Nancy R Downing
    College of Nursing, University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 22:958-63. 2014
    ..Results suggest the WHODAS can identify baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials. Companions may provide more accurate data as the disease progresses. ..
  9. pmc Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study
    Eric A Epping
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Psychiatr Res 47:1423-31. 2013
    ..The clinical presentation appears to be similar to other populations. Severity and progression are not related to the HD mutation. ..
  10. pmc T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression
    Shafik N Wassef
    Department of Radiology, University of Iowa, Iowa City, Iowa, USA
    Mov Disord 30:1107-14. 2015
    ..We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters...
  11. pmc Diffusion weighted imaging of prefrontal cortex in prodromal Huntington's disease
    Joy T Matsui
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa John A Burns School of Medicine, The University of Hawaii, Honolulu, Hawaii
    Hum Brain Mapp 35:1562-73. 2014
    ..The gradient of effects that tracked with CAP group suggests DWI may provide markers of disease progression in future longitudinal studies as increasing diffusivity abnormalities in the lateral PFC of prodromal HD individuals...
  12. pmc Indexing disease progression at study entry with individuals at-risk for Huntington disease
    Ying Zhang
    Department of Biostatistics, University of Iowa, Iowa City, USA
    Am J Med Genet B Neuropsychiatr Genet 156:751-63. 2011
    ..The classification is an improvement over the one currently in use as it is based on observed data rather than model-based estimated values. © 2011 Wiley-Liss, Inc...
  13. pmc Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD
    Jeffrey D Long
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
    Mov Disord 30:1664-72. 2015
    ..The goal of this study was to assess whether additional motor, imaging, cognitive, functional, psychiatric, and demographic variables measured at study entry increased the ability to predict the risk of motor diagnosis over 12 years...
  14. pmc Onset of Huntington's disease: can it be purely cognitive?
    Jane S Paulsen
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA Department of Psychology, The University of Iowa, Iowa City, IA, USA
    Mov Disord 29:1342-50. 2014
    ..These findings show that cognitive deterioration can be seen in persons with the Huntington's disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington's disease may precede motor...