Zhang Xu Liu

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Neutrophil depletion protects against murine acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 43:1220-30. 2006
  2. ncbi request reprint Role of innate immunity in acetaminophen-induced hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Expert Opin Drug Metab Toxicol 2:493-503. 2006
  3. ncbi request reprint Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 127:1760-74. 2004
  4. ncbi request reprint c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
    Basuki K Gunawan
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 131:165-78. 2006
  5. pmc Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity
    Zhang Xu Liu
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Virol 76:990-7. 2002
  6. ncbi request reprint Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption
    Masahiro Minagawa
    Department of Molecular Microbiology, Norris Comprehensive Cancer Center, University of Southern California Los Angeles, 1441 Eastlake Avenue, M S 73, Los Angeles, CA 90033 0800, USA
    Gastroenterology 126:1387-99. 2004
  7. pmc Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
    Sayaka Inokuchi
    Division of Gastroenterology, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0702, USA
    Alcohol Clin Exp Res 35:1509-18. 2011
  8. pmc Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB
    Jo Suda
    Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    J Immunol 197:3120-3129. 2016
  9. pmc Questions and controversies: the role of necroptosis in liver disease
    Lily Dara
    Research Center for Liver Disease, Keck School of Medicine, Department of Medicine, University of Southern California, Los Angeles, CA, USA Division of GI Liver, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Death Discov 2:16089. 2016
  10. pmc Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications
    Lily Dara
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Liver Int 36:158-65. 2016

Research Grants

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Neutrophil depletion protects against murine acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 43:1220-30. 2006
    ..In conclusion, accumulated neutrophils in the liver contribute to the progression and severity of APAP-induced liver injury...
  2. ncbi request reprint Role of innate immunity in acetaminophen-induced hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Expert Opin Drug Metab Toxicol 2:493-503. 2006
    ....
  3. ncbi request reprint Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 127:1760-74. 2004
    ..Among hepatic nonparenchymal inflammatory cells, we examined the role of the abundant natural killer (NK) cells and NK cells with T-cell receptors (NKT cells) in APAP-induced liver injury...
  4. ncbi request reprint c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
    Basuki K Gunawan
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 131:165-78. 2006
    ..In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases...
  5. pmc Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity
    Zhang Xu Liu
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Virol 76:990-7. 2002
    ..It is concluded that the HCV core protein of genotype 1b has no modulatory effects on induction of virus-specific immune responses and may therefore be a suitable component of an HCV vaccine...
  6. ncbi request reprint Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption
    Masahiro Minagawa
    Department of Molecular Microbiology, Norris Comprehensive Cancer Center, University of Southern California Los Angeles, 1441 Eastlake Avenue, M S 73, Los Angeles, CA 90033 0800, USA
    Gastroenterology 126:1387-99. 2004
    ..This report analyzes the role of natural killer T cells, Fas, and TNF-alpha in a model of chronic alcohol consumption...
  7. pmc Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
    Sayaka Inokuchi
    Division of Gastroenterology, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0702, USA
    Alcohol Clin Exp Res 35:1509-18. 2011
    ....
  8. pmc Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB
    Jo Suda
    Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    J Immunol 197:3120-3129. 2016
    ..Our findings reveal a critical kinase-independent platform role for RIPK1 in protecting against TNF/caspase-dependent apoptosis of hepatocytes in immune-mediated liver injury...
  9. pmc Questions and controversies: the role of necroptosis in liver disease
    Lily Dara
    Research Center for Liver Disease, Keck School of Medicine, Department of Medicine, University of Southern California, Los Angeles, CA, USA Division of GI Liver, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Death Discov 2:16089. 2016
    ..The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field...
  10. pmc Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications
    Lily Dara
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Liver Int 36:158-65. 2016
    ..In this review we explore the immuno-tolerant microenvironment of the liver and the mechanisms of clinical adaptation in IDILI with a focus on the role of immune-tolerance and cellular adaptive responses. ..
  11. pmc Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria
    Derick Han
    University of Southern California Research Center for Liver Diseases and Southern California Research Center for ALPD, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9121, USA
    Trends Pharmacol Sci 34:243-53. 2013
    ..In this review, we highlight the role of signal transduction pathways, which frequently involve mitochondria, in the development of DILI...
  12. ncbi request reprint IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver
    Katsumitsu Arai
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Cell Immunol 219:48-56. 2002
    ..1 and AsGM1; elimination of these cells leads to inhibition of IFNgamma and chemokine transcript induction. The conclusion is drawn that both NK cells and T cells provide the two signals for induction of IP-10 and Mig in the liver...
  13. ncbi request reprint Immune-mediated drug-induced liver disease
    Zhang Xu Liu
    Department of Microbiology Immunology, Keck School of Medicine, University of Southern California, Norris Cancer Center, Room 6318, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Clin Liver Dis 6:755-74. 2002
    ..Immune-mediated drug-induced liver disease nearly always disappears or becomes quiescent when the drug is removed. Methyldopa, minocycline, and nitrofurantoin can produce a chronic hepatitis resembling AIH if the drug is continued...
  14. doi request reprint How to protect against acetaminophen: don't ask for JUNK
    Neil Kaplowitz
    Gastroenterology 135:1047-51. 2008

Research Grants1

  1. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..