Affiliation: University of California
- Role of miRNAs in neuronal differentiation from human embryonic stem cell-derived neural stem cellsJing Liu
University of California, Davis, 2921 Stockton Blvd, Room 1300, Sacramento, CA 95817, USA
Stem Cell Rev 8:1129-37. 2012..These studies shed light on strategies to optimize in vitro differentiation efficiencies to mature neurons for use in drug discovery studies and potential future clinical applications...
- RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expressionJing Liu
Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA, Department of Chemistry and Institute for Life Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK and Alnylam Pharmaceuticals, 300 Third St, Cambridge, MA 02142, USA
Nucleic Acids Res 41:8788-801. 2013..Several different abasic duplexes achieve potent and selective inhibition, providing a broad platform for subsequent development. These findings introduce abasic substitutions as a tool for tailoring RNA duplexes for gene silencing. ..
- Signaling defects in iPSC-derived fragile X premutation neuronsJing Liu
Stem Cell Program and Institute for Regenerative Cures, Health System, University of California, Davis, Health System, Sacramento CA, 95817, USA
Hum Mol Genet 21:3795-805. 2012..g. autism) and neurodegenerative (e.g. Parkinsonism, dementias) disorders...