Mark E Linskey
Affiliation: University of California
- Propofol lipemia mimicking chyle leak during neck dissectionDavid E Vokes
Department of Otolaryngology Head and Neck Surgery, University of California Irvine Medical Center, 101 The City Drive South, Building 56, Suite 500, Orange, California 92868, USA
Head Neck 28:1147-9. 2006..Propofol is an intravenous agent used in anesthesia. Lipemia is an uncommon adverse effect of propofol infusion...
- The emergence of clinical practice parameter guidelines in neuro-oncology: promise of utility tempered with cautionMark E Linskey
Department of Neurological Surgery, University of CA, Irvine, UC Irvine Medical Center, 101 The City Drive South, Bldg 56, Suite 400, ZOT 5397, Orange, CA 92868, USA
J Neurooncol 89:359-62. 2008
- Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?Mark E Linskey
Department of Neurological Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
J Neurosurg 109:129-36. 2008..Serous otitis media, ossicular or temporal bone osteonecrosis, and chondromalacia are not likely to be relevant factors or considerations for hearing preservation after SRS...
- A prospective cohort study of microvascular decompression and Gamma Knife surgery in patients with trigeminal neuralgiaMark E Linskey
Department of Neurological Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
J Neurosurg 109:160-72. 2008..The aim of this study was to analyze 1 surgeon's 4-year experience with microvascular decompression ([MVD], 36 patients) and Gamma Knife surgery ([GKS], 44 patients) in 80 consecutive patients with trigeminal neuralgia (TN)...
- Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: a single-surgeon 4-year integrated experience with both modalitiesMark E Linskey
Department of Neurological Surgery and Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Neurosurg 102:59-70. 2005..The authors sought to assess the respective roles of microsurgery and gamma knife surgery (GKS) in the treatment of patients with meningiomas...
- The changing role of stereotaxis in surgical neuro-oncologyMark E Linskey
Department of Neurological Surgery, University of California, Irvine, UCI Medical Centre, Orange, CA 92868 3298, USA
J Neurooncol 69:35-54. 2004..Evaluate evolution and time course of stereotactic neurosurgery within surgical neuro-oncology...
- EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartmentYuanjie Hu
Department of Biological Chemistry, University of California Irvine, 5171 California Ave, Suite 150, Irvine, CA 92697, USA
Mol Cancer 10:123. 2011..There are conflicting reports regarding the function of EFEMP1 in different cancer types. In this study, we sought to evaluate the role of EFEMP1 in malignant glioma biology...
- Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21st century cancer therapeuticsYi Hong Zhou
Neurosurgery, Brain Tumor Research Laboratory, University of California Irvine, Irvine, CA, USA
Oncoscience 3:208-219. 2016..Therefore, ETSP may form the basis for further important research to develop a novel cancer therapy to treat many types of cancer by its tumor suppressor effect in the extracellular matrix compartment...
- Cell context-dependent dual effects of EFEMP1 stabilizes subpopulation equilibrium in responding to changes of in vivo growth environmentYuanjie Hu
Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA
Oncotarget 6:30762-72. 2015..This finding implies that EFEMP1 may restrain cancer plasticity in coping with ever-changing tumor microenvironments and/or therapeutic-intervention stresses. ..
- Dosimetric comparison of helical tomotherapy and Gamma Knife stereotactic radiosurgery for single brain metastasisJosé A Peñagarícano
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Radiat Oncol 1:26. 2006..Based on dosimetric comparisons, this study aims to find dosimetric equivalency between single fraction HT and Gamma Knife stereotactic radiosurgery (GKSRS) for the treatment of single brain metastasis...
- Radiation tolerance of normal temporal bone structures: implications for gamma knife stereotactic radiosurgeryMark E Linskey
Department of Neurosurgery, University of Arkansas, Little Rock, AR, USA
Int J Radiat Oncol Biol Phys 57:196-200. 2003..We reviewed the limited reported data regarding radiation tolerance of external, middle, and inner ear structures, and perspectives for therapy with gamma knife stereotactic radiosurgery are addressed...
- Radiation exposure of normal temporal bone structures during stereotactically guided gamma knife surgery for vestibular schwannomasMark E Linskey
Department of Neurosurgery, University of Arkansas, Little Rock, Arkansas, USA
J Neurosurg 98:800-6. 2003..The authors quantified the dose of radiation received by these structures after GKS for VS to assess the likelihood that these doses contributed to postradiosurgery complications...
- Recognizing schwannomatosis and distinguishing it from neurofibromatosis type 1 or 2Franklin D Westhout
Department of Neurological Surgery, School of Medicine, University of California Irvine, 101 The City Drive South, Orange, CA 92868, USA
J Spinal Disord Tech 20:329-32. 2007..Although the genetic loci are on chromosome 22, it lacks the classic bilateral vestibular schwannomas as seen in NF-2. We present the surgical treatment of 4 patients with schwannomatosis, including a brother and sister...
- Linking differential radiation responses to glioma heterogeneityChao Ke
Neurological Surgery, University of California, Irvine, CA, USA
Oncotarget 5:1657-65. 2014....
- Accelerated cerebral vasculopathy after radiation therapy to the brainJosé A Peñagarícano
Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, Arkansas 72205, USA
Neurol India 52:482-6. 2004..We will underscore the significance of this condition and suggest the overall management of patients receiving brain radiation at an early age...
- Detection of 1p19q deletion by real-time comparative quantitative PCRAbhishek Chaturbedi
Department of Neurological Surgery, University of California, Irvine, CA
Biomark Insights 7:9-17. 2012..We conclude that CQ-PCR is a potential means to gain 1p/19q deletion information, which prognostic and predictive values of CQ-PCR-derived 1p/19q status will be determined in a future study...
- Establishment of prognostic models for astrocytic and oligodendroglial brain tumors with standardized quantification of marker gene expression and clinical variablesYi Hong Zhou
Department of Neurological Surgery, The University of California, Irvine, CA 92697, USA
Biomark Insights 5:153-68. 2010..Gene expression data was a log-transformed ratio of marker and reference (ACTB) mRNA levels quantified using absolute real-time qRT-PCR...
- Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapyXing Gong
Department of Neurology, UC Irvine School of Medicine, Orange, CA, USA
Neurology 76:1126-34. 2011..As the role of NSCs in learning and memory is increasingly recognized, we need to identify drugs that reduce neurotoxicity but are still effective against glial tumors...
- Primary leptomeningeal plasmablastic lymphomaMarlon S Mathews
Department of Neurological Surgery, University of California, Irvine, USA
J Neurooncol 104:835-8. 2011..Even in cases where an infectious cause is suspected for the meningeal enhancement, neoplastic involvement should be considered, and cytology and flow-cytometry should be routinely ordered on the CSF samples...
- The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guidelineMark E Linskey
Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
J Neurooncol 96:45-68. 2010....
- Epidemiology of central nervous system metastasesDaniela Alexandru
Department of Neurological Surgery, University of California, Irvine, CA, USA
Prog Neurol Surg 25:13-29. 2012..Understanding the epidemiology of brain metastases can lead to the development of new strategies for the early identification and successful treatment of these patients...
- Neuroendovascular optical coherence tomography imaging and histological analysisMarlon S Mathews
Department of Neurological Surgery, University of California Irvine, Irvine, California, USA
Neurosurgery 69:430-9. 2011....
- Obstructive hydrocephalus and progressive psychosis: rare presentations of neurosarcoidosisFranklin D Westhout
Department of Neurological Surgery, University of California Irvine School of Medicine, Orange, CA 92868, USA
Surg Neurol 69:288-92; discussion 292. 2008..Communicating hydrocephalus arises from meningeal arachnoid granulation involvement. Reported cases of obstructive hydrocephalus have all involved obstructing ventricular lesions...
- The effect of bevacizumab (Avastin) on neuroimaging of brain metastasesMarlon S Mathews
Department of Neurological Surgery, University of California Irvine, Orange, CA 92868, USA
Surg Neurol 70:649-52; discussion 653. 2008..Bevacizumab is a monoclonal antibody that binds to, and inactivates, VEGF and is believed to be antiangiogenic...
- Frame-based stereotaxy in a frameless era: current capabilities, relative role, and the positive- and negative predictive values of blood through the needleChristopher M Owen
Department of Neurological Surgery, University of California, Orange, CA 92868 3298, USA
J Neurooncol 93:139-49. 2009..In the modern era of frameless stereotaxis (FL), the role of frame-based (FB) stereotactic needle biopsy is evolving...
- PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor AYi Hong Zhou
Department of Neurological Surgery, University of California, Irvine, Irvine, CA 92697, USA
J Neurooncol 96:191-200. 2010..PAX6 suppression of VEGFA appears to be blocked in LN229. In conclusion, our data showed that PAX6 can initiate in glioma cells a new signaling pathway independent of PI3K/Akt-HIF1A signaling to suppress VEGFA expression...
- Modeling prognosis for patients with malignant astrocytic gliomas: quantifying the expression of multiple genetic markers and clinical variablesYi Hong Zhou
Department of Neurobiology and Developmental Sciences, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Neuro Oncol 7:485-94. 2005..This finding suggests that the expression of IGFBP2 is associated with pathways activated specifically in GBMs that result in enhancing invasiveness and angiogenesis...
- Central causes of foot drop: rare and underappreciated differential diagnosesFranklin D Westhout
Department of Neurological Surgery, School of Medicine, University of California at Irvine, Orange, California 92868, USA
J Spinal Cord Med 30:62-6. 2007..Peripheral causes of foot drop are well recognized. However, causes stemming from the central nervous system represent rare, important, and underappreciated differential etiologies...
- Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illuminationDavid Abookasis
University of California Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:024033. 2009..This potentially provides a powerful approach for quantitative monitoring and imaging of neurophysiology and metabolism with high spatiotemporal resolution...
- Constitutional t(16;22)(p13.3;q11.2 approximately 12) in a primitive neuroectodermal tumor of the pineal regionJeffrey R Sawyer
Department of Pathology, Cytogenetics Laboratory, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
Cancer Genet Cytogenet 142:73-6. 2003..The finding of a 22q11.2 approximately 12 breakpoint in this patient suggests this constitutional translocation may somehow have predisposed the patient to the development of the tumor...
- Evidence-based medicine for neurosurgeons: introduction and methodologyMark E Linskey
Department of Neurological Surgery, University of California, Irvine and UCI Medical Center, Orange, CA, USA
Prog Neurol Surg 19:1-53. 2006..Commonly perceived objections, as well as substantive problems and limitations of EBM assumptions, tools, and approaches both for individual clinical practice and health policy design and implementation are explored in detail...
- William P. van Wagenen and the first corpus callosotomies for epilepsyMarlon S Mathews
Department of Neurological Surgery, University of California, Irvine, Orange, CA 92868, USA
J Neurosurg 108:608-13. 2008..Sperry in 1981. These contributions firmly establish William P. van Wagenen as one of the founding pioneers in the surgical treatment of patients with epilepsy...
- Neurosurgery quality: pay-for-performance, guidelines, and outcome measuresMark E Linskey
Department of Neurological Surgery, University of California, Irvine, California, USA
Clin Neurosurg 54:157-79. 2007
- Stereotactic radiosurgery for patients with cancer of the head and neckEdward Gardner
Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, 4301 West Markham Street, 543, Little Rock, AR 72205, USA
Curr Oncol Rep 5:164-9. 2003..Finally, questions to be addressed by future studies for clarification of the role of this technology are outlined...
- Stereotactic radiosurgery--an organized neurosurgery-sanctioned definitionGene H Barnett
Taussig Cancer Center, Brain Tumor Institute, Cleveland, Ohio 44195, USA
J Neurosurg 106:1-5. 2007
- Less common indications for stereotactic radiosurgery or fractionated radiotherapy for patients with benign brain tumorsJonathan P S Knisely
Department of Therapeutic Radiology, Yale University School of Medicine, Hunter Radiation Therapy Center, PO Box 208040, New Haven, CT 06520 8040, USA
Neurosurg Clin N Am 17:149-67, vii. 2006..Patients need to be apprised of all therapeutic options and to make their decisions with all information required to evaluate the risks and benefits. For benign brain tumors, these decisions may have consequences that last for decades...
- History of the AANS/CNS joint section on tumors and preface to the 20th anniversary Journal of Neuro-Oncology Special IssueFred G Barker
Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Neurooncol 69:1-18. 2004..These data suggest that the Section's goals of educating all surgeons in neurosurgical oncology are being successfully met. A bibliography of secondary sources on the history of brain tumor surgery is appended...