J R Lindner

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Molecular imaging with contrast ultrasound and targeted microbubbles
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    J Nucl Cardiol 11:215-21. 2004
  2. doi request reprint Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis
    Carolyn Z Behm
    Division of Cardiovascular Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 117:2902-11. 2008
  3. ncbi request reprint Microbubbles in medical imaging: current applications and future directions
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA
    Nat Rev Drug Discov 3:527-32. 2004
  4. ncbi request reprint Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:396-403. 2002
  5. ncbi request reprint Assessment of myocardial viability with myocardial contrast echocardiography
    Jonathan R Lindner
    Cardiovascular Division at the University of Virginia Medical Center, Charlottesville 22908, USA
    Echocardiography 19:417-25. 2002
  6. ncbi request reprint Evolving applications for contrast ultrasound
    Jonathan R Lindner
    Cardiac Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Am J Cardiol 90:72J-80J. 2002
  7. ncbi request reprint Detection of inflamed plaques with contrast ultrasound
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Cardiol 90:32L-35L. 2002
  8. ncbi request reprint Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin
    J R Lindner
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 104:2107-12. 2001
  9. ncbi request reprint Contrast echocardiography: clinical utility for the evaluation of left ventricular systolic function
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Am Heart Hosp J 2:16-20. 2004
  10. ncbi request reprint Delivery of drugs with ultrasound
    J R Lindner
    Box 158, Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Echocardiography 18:329-37. 2001

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Molecular imaging with contrast ultrasound and targeted microbubbles
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    J Nucl Cardiol 11:215-21. 2004
    ....
  2. doi request reprint Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis
    Carolyn Z Behm
    Division of Cardiovascular Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 117:2902-11. 2008
    ..We hypothesized that inflammatory cell recruitment and endothelial cell activation during vasculogenesis and ischemia-mediated arteriogenesis could be temporally assessed by noninvasive molecular imaging...
  3. ncbi request reprint Microbubbles in medical imaging: current applications and future directions
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA
    Nat Rev Drug Discov 3:527-32. 2004
  4. ncbi request reprint Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:396-403. 2002
    ..Microbubble entrapment within the pulmonary microcirculation after venous injection should be negligible and transient. These findings are important for establishing the safety of this agent...
  5. ncbi request reprint Assessment of myocardial viability with myocardial contrast echocardiography
    Jonathan R Lindner
    Cardiovascular Division at the University of Virginia Medical Center, Charlottesville 22908, USA
    Echocardiography 19:417-25. 2002
    ..The utility of this technique for determining treatment strategies has not been established but is forthcoming...
  6. ncbi request reprint Evolving applications for contrast ultrasound
    Jonathan R Lindner
    Cardiac Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Am J Cardiol 90:72J-80J. 2002
    ..Preliminary experience using microbubbles as vectors for gene delivery is also reviewed...
  7. ncbi request reprint Detection of inflamed plaques with contrast ultrasound
    Jonathan R Lindner
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Cardiol 90:32L-35L. 2002
    ....
  8. ncbi request reprint Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin
    J R Lindner
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 104:2107-12. 2001
    ..We hypothesized that tissue retention of microbubbles targeted to the endothelial cell adhesion molecule P-selectin would provide a means to assess inflammation with ultrasound imaging...
  9. ncbi request reprint Contrast echocardiography: clinical utility for the evaluation of left ventricular systolic function
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Am Heart Hosp J 2:16-20. 2004
    ..Accordingly, patient selection for contrast echocardiography should be based not only on adequacy of the baseline images, but also on the clinical question being asked...
  10. ncbi request reprint Delivery of drugs with ultrasound
    J R Lindner
    Box 158, Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Echocardiography 18:329-37. 2001
    ..In the case of thrombi, ultrasound-mediated microbubble destruction also may facilitate the process of clot lysis. This review also will consider current limitations and technological advances required for the development of this field...
  11. ncbi request reprint Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes
    J R Lindner
    Cardiovascular Division, Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA
    Circulation 102:2745-50. 2000
    ..We hypothesized that incorporation of phosphatidylserine (PS) into the microbubble shell may enhance these interactions by amplifying complement activation and thereby allow ultrasound imaging of inflammation...
  12. ncbi request reprint Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles
    J R Lindner
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 102:531-8. 2000
    ..We hypothesized that these microbubbles are phagocytosed by neutrophils and monocytes and remain acoustically active, permitting their detection in inflamed tissue...
  13. ncbi request reprint Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity
    S J Rim
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
    Circulation 104:2704-9. 2001
    ..We, therefore, hypothesized that abnormal coronary blood flow (CBF) reserve observed during hyperlipidemia is secondary to increased blood viscosity and not abnormal coronary vasomotion...
  14. ncbi request reprint Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin
    M A Vincent
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Am J Physiol Endocrinol Metab 285:E123-9. 2003
    ..05). We conclude that insulin specifically recruits flow to the microvasculture in skeletal muscle via a nitric oxide-dependent pathway and that this may be important to insulin's overall action to regulate glucose disposal...
  15. ncbi request reprint Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes
    J R Lindner
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Circulation 101:668-75. 2000
    ..Albumin microbubbles that are used for contrast echocardiography persist within the myocardial microcirculation after ischemia/reperfusion (I-R). The mechanism responsible for this phenomenon is unknown...
  16. ncbi request reprint Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow
    A L Klibanov
    University of Virginia, Charlottesville, VA 22908 0158, USA
    Contrast Media Mol Imaging 1:259-66. 2006
    ..In the inflamed femoral artery setting, PSLe(x)-mediated microbubble targeting was superior to antibody-mediated targeting...
  17. ncbi request reprint Noninvasive prediction of ultimate infarct size at the time of acute coronary occlusion based on the extent and magnitude of collateral-derived myocardial blood flow
    M P Coggins
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Circulation 104:2471-7. 2001
    ..Thus, it could help individualize risk and management in acute myocardial infarction...
  18. ncbi request reprint Delayed onset of inflammation in protease-activated receptor-2-deficient mice
    J R Lindner
    Cardiovascular Division and Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 165:6504-10. 2000
    ..These results indicate that activation of PAR2 produces microvascular inflammation by rapid induction of P-selectin-mediated leukocyte rolling. In the absence of PAR2, the onset of inflammation is delayed...
  19. ncbi request reprint Assessment of inflammation with contrast ultrasound
    J R Lindner
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Prog Cardiovasc Dis 44:111-20. 2001
    ..This review also considers ultrasound imaging methods that may be used to detect microbubbles retained within inflamed tissue...
  20. pmc Changes in myocardial blood volume over a wide range of coronary driving pressures: role of capillaries beyond the autoregulatory range
    D E Le
    The Cardiovascular Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Heart 90:1199-205. 2004
    ....
  21. ncbi request reprint Quantification of cerebral perfusion with "Real-Time" contrast-enhanced ultrasound
    S J Rim
    Cardiovascular Imaging Center, Cardiovascular Division, Department of Internal Medicine, Division of Neurosurgical Anesthesia, University of Virginia, Charlottesville, USA
    Circulation 104:2582-7. 2001
    ..Thus, CEU has the potential for bedside measurement and monitoring of cerebral perfusion in real time in patients with craniotomies or burr holes...
  22. ncbi request reprint Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow
    M A Vincent
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Diabetes 51:42-8. 2002
    ..We conclude that insulin increases tissue perfusion by recruiting microvascular beds, and at physiological concentrations this precedes increases in total muscle blood flow by 60-90 min...
  23. ncbi request reprint Automated quantification of the spatial extent of perfusion defects and viability on myocardial contrast echocardiography
    Antonio Micari
    Cardiovascular Division, University of Virginia, Charlottesville, USA
    J Am Soc Echocardiogr 19:379-85. 2006
    ..This technique may be useful for rapid and objective analysis of the extent of ischemia and viability, and for clinical experimentation where accurate and sequential analysis of perfusion defect size is imperative...
  24. ncbi request reprint Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease
    Christopher Bachmann
    Division of Gastroenterology and Hepatology Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Gastroenterology 130:8-16. 2006
    ..The aim of the present study was to develop a noninvasive imaging modality to detect and evaluate ileitis in SAMP1/YitFc (SAMP) mice...
  25. ncbi request reprint Contrast ultrasound assessment of angiogenesis by perfusion and molecular imaging
    Peter Heppner
    University of Virginia School of Medicine, Box 800158, Cardiovascular Division, Charlottesville, VA 22908, USA
    Expert Rev Mol Diagn 5:447-55. 2005
    ..For perfusion imaging, translation to the clinical setting is already taking place, whereas molecular imaging faces many more hurdles in terms of safety and testing efficacy...
  26. ncbi request reprint Improvement in microvascular reflow and reduction of infarct size with adenosine in patients undergoing primary coronary stenting
    Antonio Micari
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
    Am J Cardiol 96:1410-5. 2005
    ..In conclusion, the adjunctive use of intravenous adenosine after PCS reduces the infarct size relative to the risk area. This beneficial effect occurs primarily in those undergoing early intervention...
  27. ncbi request reprint Extent of myocardial viability predicts response to biventricular pacing in ischemic cardiomyopathy
    James P Hummel
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Heart Rhythm 2:1211-7. 2005
    ..The clinical response to biventricular pacing is unpredictable, especially in patients with ischemic cardiomyopathy...
  28. ncbi request reprint Effect of microbubble exposure to ultrasound on quantitation of myocardial perfusion
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Echocardiography 22:503-9. 2005
    ....
  29. ncbi request reprint Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression
    Howard Leong-Poi
    Cardiovascular Imaging Center and Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 111:3248-54. 2005
    ..We hypothesized that molecular imaging with contrast-enhanced ultrasound (CEU) and microbubbles targeted to endothelial integrins could be used to noninvasively assess early angiogenic responses to ischemia and growth factor therapy...
  30. ncbi request reprint Cellular and molecular imaging with targeted contrast ultrasound
    Carolyn Z Behm
    Cardiovascular Division, University of Virginia, Charlottesville, USA
    Ultrasound Q 22:67-72. 2006
    ....
  31. ncbi request reprint Contrast ultrasonographic assessment of cerebral perfusion in patients undergoing decompressive craniectomy for traumatic brain injury
    Peter Heppner
    Cardiovascular Division, and Departments of Neurological Surgery and Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, USA
    J Neurosurg 104:738-45. 2006
    ....
  32. ncbi request reprint Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis
    Joshua J Rychak
    VisualSonics, Inc, Toronto, ON
    Mol Imaging 6:289-96. 2007
    ..These data demonstrate that contrast-enhanced microultrasound imaging is a useful method for assessing molecular expression of tumor angiogenesis in mice at high resolution...
  33. ncbi request reprint Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1
    Beat A Kaufmann
    Cardiovascular Division, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 116:276-84. 2007
    ..We hypothesized that molecular imaging of vascular cell adhesion molecule-1 (VCAM-1) expression with contrast-enhanced ultrasound (CEU) could be used for this purpose...
  34. ncbi request reprint Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle
    Howard Leong-Poi
    Division of Cardiology, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Circ Res 101:295-303. 2007
    ..The results of our study demonstrate the utility of ultrasonic destruction of plasmid-bearing microbubbles to induce therapeutic arteriogenesis in the setting of severe chronic ischemia...
  35. ncbi request reprint Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography
    Beat A Kaufmann
    Cardiovascular Division, UHN 62, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Eur Heart J 28:2011-7. 2007
    ..We hypothesized that molecular imaging of endothelial P-selectin expression with targeted myocardial contrast echocardiography (MCE) could identify recently ischaemic myocardium without infarction...
  36. ncbi request reprint High-resolution myocardial perfusion imaging in mice with high-frequency echocardiographic detection of a depot contrast agent
    Beat A Kaufmann
    Cardiovascular Divisions at Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Am Soc Echocardiogr 20:136-43. 2007
    ..This technique can be used for characterizing murine models of myocardial infarction and left ventricular remodeling...
  37. ncbi request reprint Molecular imaging with targeted contrast ultrasound
    Beat A Kaufmann
    Cardiovascular Division, UHN 62, Oregon Health and Sciences University, Portland, OR 97221, USA
    Curr Opin Biotechnol 18:11-6. 2007
    ..Thus, targeted contrast ultrasound in the future could aid in the diagnosis of such diverse diseases as atherosclerosis, transplant rejection and tumor-related angiogenesis...
  38. ncbi request reprint Contrast echocardiography
    Beat A Kaufmann
    Oregon Health and Sciences University, Portland, OR, USA
    Curr Probl Cardiol 32:51-96. 2007
    ..The overall aim of the review is to update the clinician on state-of-the-art MCE and how it can be applied in patients with cardiovascular disease...
  39. ncbi request reprint Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours
    Petra Haag
    Department of Urology, Innsbruck Medical University, A 6020 Innsbruck, Anichstrasse 35, Austria
    J Steroid Biochem Mol Biol 102:103-13. 2006
    ..Uptake of the ODN was also observed in tumors after treatment with ultrasound alone, with only minor differences compared to the combined use of microbubbles and ultrasound...
  40. ncbi request reprint Anatomy and flow in normal and ischemic microvasculature based on a novel temporal fractal dimension analysis algorithm using contrast enhanced ultrasound
    Dimitrios Charalampidis
    Department of Electrical Engineering, College of Engineering, University of New Orleans, LA 70148, USA
    IEEE Trans Med Imaging 25:1079-86. 2006
    ..This method is proposed as an experimental methodology to distinguish ischemic from nonischemic tissue. Moreover, an improved approach for extracting the FD unique to this application is introduced...
  41. ncbi request reprint Deformable gas-filled microbubbles targeted to P-selectin
    Joshua J Rychak
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908 0158, USA
    J Control Release 114:288-99. 2006
    ..Overall, the mechanical aspects of adhesion, such as particle shape, deformability and surface microstructure, are important in engineering efficient site-targeted particle-based agents for medical imaging and therapy...
  42. ncbi request reprint Myocardial perfusion imaging with contrast echocardiography
    Chad L Carr
    Cardiovascular Division UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Curr Cardiol Rep 10:233-9. 2008
    ..This article focuses on myocardial contrast-enhanced ultrasound perfusion techniques, emphasizing the unique information this modality provides compared with other noninvasive perfusion imaging techniques...
  43. ncbi request reprint Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve
    Thanjuvar Bragadeesh
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia
    J Am Coll Cardiol 45:780-5. 2005
    ..We sought to determine whether the severity of peripheral arterial disease (PAD) can be assessed by measuring blood flow reserve in limb skeletal muscle with contrast-enhanced ultrasound (CEU)...
  44. ncbi request reprint Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville 22908, USA
    Circulation 107:455-60. 2003
    ..We hypothesized that angiogenesis could be imaged with the use of contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins...
  45. ncbi request reprint Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi
    Patricia A Schumann
    ImaRx Therapeutics, Inc, Tucson, Arizona 85719, USA
    Invest Radiol 37:587-93. 2002
    ..The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in vivo efficacy...
  46. ncbi request reprint Influence of microbubble shell properties on ultrasound signal: Implications for low-power perfusion imaging
    Howard Leong-Poi
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA
    J Am Soc Echocardiogr 15:1269-76. 2002
    ..We conclude that the acoustic power for maximizing acoustic signal without destroying microbubbles during low mechanical index imaging varies according to shell characteristics...
  47. ncbi request reprint Contrast echocardiography
    Jonathan R Lindner
    Cardiovascular Division, University of Virginia Medical Center, Charlottesville, VA, USA
    Curr Probl Cardiol 27:454-519. 2002
  48. ncbi request reprint Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivo
    Laurent M Riou
    University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    Circulation 106:592-8. 2002
    ....
  49. ncbi request reprint Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve
    Eduardo Balcells
    Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 41:827-33. 2003
    ....
  50. ncbi request reprint Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3
    Dilantha B Ellegala
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, USA
    Circulation 108:336-41. 2003
    ..We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used to image angiogenesis...
  51. ncbi request reprint Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles
    Jonathan P Christiansen
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Ultrasound Med Biol 29:1759-67. 2003
    ....
  52. ncbi request reprint Relation between myocardial oxygen consumption and myocardial blood volume: a study using myocardial contrast echocardiography
    D Elizabeth Le
    Cardiovascular Imaging Center, Cardiovascular Division, School of Medicine, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    J Am Soc Echocardiogr 15:857-63. 2002
    ..Thus, capillary recruitment plays an important role in the physiologic regulation of CBF. Lack of increase in MBV during dobutamine stress may indicate the presence of coronary stenosis or microvascular disease...
  53. ncbi request reprint Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography
    Jonathan P Christiansen
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA
    Circulation 105:1764-7. 2002
    ..We hypothesized that myocardial contrast echocardiography (MCE) with leukocyte-targeted microbubbles could temporally and spatially characterize the severity of postischemic myocardial inflammation...
  54. ncbi request reprint Myocardial contrast echocardiography
    Wolfgang Lepper
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908 0158, USA
    Circulation 109:3132-5. 2004
  55. ncbi request reprint Simultaneous integrin alphavbeta3 and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty
    Tadamichi Sakuma
    Cardiovascular Division, Medical Center, University of Virginia, Charlottesville, 22908 0158, USA
    Cardiovasc Res 66:552-61. 2005
    ....
  56. ncbi request reprint Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo
    Michelle A Vincent
    Department of Internal Medicine, Box 801410, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Diabetes 53:1418-23. 2004
    ..05). We conclude that insulin rapidly recruits skeletal muscle capillaries in vivo by a nitric oxide-dependent action, and the increase in capillary recruitment may contribute to the subsequent glucose uptake...
  57. ncbi request reprint Myocardial and microcirculatory kinetics of BR14, a novel third-generation intravenous ultrasound contrast agent
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Coll Cardiol 39:530-7. 2002
    ..This study sought to investigate the myocardial and microvascular kinetics of BR14, a novel third-generation ultrasound contrast agent...
  58. ncbi request reprint Skin perfusion assessed by contrast ultrasound predicts tissue survival in a free flap model
    Jonathan P Christiansen
    Cardiac Imaging Center, The Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Ultrasound Med Biol 28:315-20. 2002
    ..We conclude that skin perfusion can be assessed with CEU. Perfusion 18 h following a secondary ischemic insult in a free flap accurately predicts subsequent tissue survival in this model...
  59. ncbi request reprint Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement
    Nicholas G Fisher
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908 0158, USA
    J Am Coll Cardiol 40:811-9. 2002
    ..The goal of the study was to determine whether microbubble charge influences the microvascular retention of microbubble contrast agents...
  60. ncbi request reprint Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound
    Dana Dawson
    Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 282:E714-20. 2002
    ..Exercise increases both V(RBC) and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake...
  61. ncbi request reprint Assessment of ischemia-induced microvascular remodeling using contrast-enhanced ultrasound vascular anatomic mapping
    Marco Pascotto
    Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA
    J Am Soc Echocardiogr 20:1100-8. 2007
    ..We conclude that CEU can separately assess collateral development, more distal arteriogenesis, and secondary changes in capillary perfusion that occur differentially with ischemia and growth factor therapy...
  62. ncbi request reprint Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging
    Miles Lankford
    Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA
    Invest Radiol 41:721-8. 2006
    ..The aim of this study was to determine whether microbubble attachment to cells influences their acoustic signal generation and stability...
  63. ncbi request reprint Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow
    Amol M Takalkar
    Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA 22908 1394, USA
    J Control Release 96:473-82. 2004
    ..Overall, accumulation and retention of targeted ultrasound contrast agents is possible under physiologic flow conditions and is strongly influenced by shear stress and surface density of the target receptor...
  64. ncbi request reprint Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
    Lucy H Clerk
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    Diabetes 55:1436-42. 2006
    ..482, P = 0.027) in response to insulin. In conclusion, obesity eliminated the insulin-stimulated muscle microvascular recruitment and increased brachial artery blood flow seen in lean individuals...
  65. ncbi request reprint Increased prevalence of regurgitant valvular heart disease in acromegaly
    Alberto M Pereira
    Department of Endocrinology and Metabolism, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 89:71-5. 2004
    ..This increased prevalence of occult valvular disease indicates that these patients require appropriate follow-up care and monitoring, especially patients with inadequate control of GH overproduction...
  66. ncbi request reprint The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake
    Lucy H Clerk
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Diabetes Metab Res Rev 20:3-12. 2004
    ..We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle...
  67. ncbi request reprint Visualizing coronary atherosclerosis in vivo: thinking big, imaging small
    Sanjiv Kaul
    J Am Coll Cardiol 43:461-3. 2004
  68. ncbi request reprint Placing faith in numbers: quantification of perfusion with myocardial contrast echocardiography
    Jonathan R Lindner
    J Am Coll Cardiol 43:1814-6. 2004
  69. ncbi request reprint Mixed meal and light exercise each recruit muscle capillaries in healthy humans
    Michelle A Vincent
    Division of Cardiovascular Medicine, Dept of Internal Medicine, Box 801410, Univ of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 290:E1191-7. 2006
    ....