Affiliation: University of California
- Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenanceJue Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, United States
J Immunol Methods 352:71-80. 2010..55, r<0.001), indicating possible common mechanisms for telomerase activity regulation in these two cell subtypes. These data will facilitate the understanding of leukocyte aging and its relationship to human health...
- Telomeres and lifestyle factors: roles in cellular agingJue Lin
University of California, San Francisco, CA 94158, USA
Mutat Res 730:85-9. 2012..Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions...
- Cell aging in relation to stress arousal and cardiovascular disease risk factorsElissa S Epel
UCSF Department of Psychiatry, San Francisco, CA, USA
Psychoneuroendocrinology 31:277-87. 2006..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
- Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere lengthAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, CA, USA
Brain Behav Immun 26:573-9. 2012..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging...
- Dynamics of telomerase activity in response to acute psychological stressElissa S Epel
Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
Brain Behav Immun 24:531-9. 2010....
- Dietary restraint and telomere length in pre- and postmenopausal womenAmy Kiefer
UCSF Department of Psychiatry, University of California, San Francisco, California, USA
Psychosom Med 70:845-9. 2008....
- Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul studyRamin Farzaneh-Far
Division of Cardiology, San Francisco General Hospital, San Francisco, California, USA
PLoS ONE 5:e8612. 2010..We sought to investigate the longitudinal trajectory of telomere length, and to identify the independent predictors of telomere shortening, in persons with coronary artery disease...
- Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorderAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, California Northern California Institute for Research and Education, San Francisco, California, USA
Biol Psychiatry 70:465-71. 2011..We also examined childhood trauma, a risk factor for both PTSD and short LTL, as a potential contributor to short LTL in PTSD...
- Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot studyJENNIFER DAUBENMIER
Osher Center for Integrative Medicine, Department of Medicine, University of California, San Francisco, CA, USA
Psychoneuroendocrinology 37:917-28. 2012....
- Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary reportChristina M Hough
Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, CA, USA
Mol Neuropsychiatry 2:88-96. 2016..Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples...
- Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and womenAric A Prather
Department of Psychiatry, University of California, San Francisco, United States Electronic address
Brain Behav Immun 47:155-62. 2015..These findings provide preliminary evidence that poorer global sleep quality is related to telomere length in several immune cell types, which may serve as a pathway linking sleep and disease risk in obese individuals. ..
- Maternal estriol concentrations in early gestation predict infant telomere lengthSonja Entringer
Departments of Pediatrics S E, C B, P D W, Obstetrics and Gynecology P D W, Epidemiology P D W, and Psychiatry and Human Behavior P D W, University of California, Irvine California 92697 Department of Obstetrics, Gynecology, and Reproductive Sciences H N S, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 Departments of Psychiatry E S E, and Biochemistry and Biophysics E H B, University of California, San Francisco, San Francisco, California 94143 and Institute for Medical Psychology S E, C B, Charite University Medicine, 10117 Berlin, Germany
J Clin Endocrinol Metab 100:267-73. 2015..The initial setting of telomere length (TL) in early life has important implications for telomere maintenance and related disorders throughout the life span. However, little is known about the predictors of this initial setting...
- Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere lengthSonja Entringer
Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
Am J Obstet Gynecol 208:134.e1-7. 2013..The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length...
- Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive declineJue Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94118, USA
Brain Res 1379:224-31. 2011..The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity...
- Systematic and Cell Type-Specific Telomere Length Changes in Subsets of LymphocytesJue Lin
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
J Immunol Res 2016:5371050. 2016..These results suggest systematically coordinated, yet cell type-specific responses to factors and pathways contribute to telomere length regulation. ..
- Association between kidney function and telomere length: the heart and soul studyNisha Bansal
Department of Medicine, University of California, San Francisco, USA
Am J Nephrol 36:405-11. 2012..Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening...
- Increased telomerase activity and comprehensive lifestyle changes: a pilot studyDean Ornish
Department of Medicine, University of California, San Francisco, CA, USA
Lancet Oncol 9:1048-57. 2008..We aimed to assess whether 3 months of intensive lifestyle changes increased telomerase activity in peripheral blood mononuclear cells (PBMC)...
- Telomere shortening in formerly abused and never abused womenJanice Humphreys
Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
Biol Res Nurs 14:115-23. 2012..Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging...
- The power of exercise: buffering the effect of chronic stress on telomere lengthEli Puterman
Department of Psychiatry, University of California San Francisco, San Francisco, California, USA
PLoS ONE 5:e10837. 2010..We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening...
- Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart diseaseRamin Farzaneh-Far
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
JAMA 303:250-7. 2010..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
- Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002Belinda L Needham
From the aDepartment of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, MI bDivision of General Medical Disciplines, Stanford University, Stanford, CA cDepartment of Psychiatry, dDivision of General Internal Medicine, and eDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA
Epidemiology 26:528-35. 2015..We also examined moderating effects of age, sex, race/ethnicity, and education...
- Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity?Julia Buss
University of California, San Francisco, School of Nursing, United States
Appetite 76:84-94. 2014..Furthermore, ghrelin is associated with metabolic and cardiovascular health, and may have anti-aging effects, but these effects may be attenuated in obesity. ..
- Chronic stress elevates telomerase activity in ratsAnnaliese K Beery
Robert Wood Johnson Health and Society Scholar at University of California at San Francisco, San Francisco, CA 04143, USA
Biol Lett 8:1063-6. 2012..This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence...
- Shorter leukocyte telomere length in midlife women with poor sleep qualityAric A Prather
Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
J Aging Res 2011:721390. 2011..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging...
- Stress exposure in intrauterine life is associated with shorter telomere length in young adulthoodSonja Entringer
Department of Pediatrics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 108:E513-8. 2011..This observation may help shed light on an important biological pathway underlying the developmental origins of adult health and disease risk...
- Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination SurveysCindy W Leung
Cindy W Leung is with the Center for Health and Community, School of Medicine, University of California, San Francisco Barbara A Laraia is with the School of Public Health, University of California, Berkeley Belinda Needham is with the Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor David H Rehkopf is with the Department of Medicine, Stanford University, Palo Alto, CA Nancy E Adler and Elissa S Epel are with the Center for Health and Community and the Department of Psychiatry, School of Medicine, University of California, San Francisco Jue Lin and Elizabeth H Blackburn are with the Department of Biochemistry and Biophysics, University of California, San Francisco
Am J Public Health 104:2425-31. 2014..We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and the risk of cardiometabolic disease...
- Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal changeJanet M Wojcicki
Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
Mol Genet Genomics 291:1379-89. 2016..While some of this shared variance is genetic, there are likely environmental factors that need to be further identified that impact rate of telomere length change. ..
- Human telomere biology: A contributory and interactive factor in aging, disease risks, and protectionElizabeth H Blackburn
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Science 350:1193-8. 2015..These and other recent findings highlight both causal and potentiating roles for telomere attrition in human diseases. ..
- Leukocyte telomere length: Effects of schizophrenia, age, and genderOwen M Wolkowitz
University of California San Francisco School of Medicine UCSF, San Francisco, CA, USA
J Psychiatr Res 85:42-48. 2016..One putative marker of biological aging is leukocyte telomere length (LTL), which typically shortens with age...
- Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) CohortKyle Lapham
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 2517
Genetics 200:1061-72. 2015..The GERA cohort represents the largest currently available such resource, linked to comprehensive electronic health and genotype data for analysis. ..
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular agingDaniel Lindqvist
Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden Department of Psychiatry, University of California San Francisco UCSF, School of Medicine, San Francisco, CA, USA
Neurosci Biobehav Rev 55:333-64. 2015..A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets. ..
- Accelerated telomere shortening in response to life stressElissa S Epel
Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:17312-5. 2004..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...