Chengyu Liang

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Semin Cancer Biol 18:423-36. 2008
  2. pmc UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs
    Sara Dolatshahi Pirooz
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    Proc Natl Acad Sci U S A 111:2716-21. 2014
  3. pmc PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
    Shanshan He
    1 Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA 2
    Nat Cell Biol 15:1206-19. 2013
  4. pmc Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
    Shanshan He
    Department of Molecular Microbiology and Immunology, Keck Medical School, University of Southern California, Los Angeles, California 90033, USA
    Nat Commun 6:7839. 2015
  5. pmc UVRAG: at the crossroad of autophagy and genomic stability
    Zhen Zhao
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA
    Autophagy 8:1392-3. 2012
  6. pmc Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
    Hee Jin Kim
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Sci 125:4740-50. 2012
  7. pmc A dual role for UVRAG in maintaining chromosomal stability independent of autophagy
    Zhen Zhao
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Dev Cell 22:1001-16. 2012
  8. pmc Viral interferon regulatory factors
    Hye Ra Lee
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Interferon Cytokine Res 29:621-7. 2009
  9. pmc Beyond autophagy: the role of UVRAG in membrane trafficking
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA
    Autophagy 4:817-20. 2008
  10. pmc FLIP-mediated autophagy regulation in cell death control
    Jong Soo Lee
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, California 90033, USA
    Nat Cell Biol 11:1355-62. 2009

Collaborators

Detail Information

Publications20

  1. doi request reprint Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Semin Cancer Biol 18:423-36. 2008
    ..This review summarizes current knowledge of host immune evasion strategies of KSHV and their contributions to KSHV-associated diseases...
  2. pmc UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs
    Sara Dolatshahi Pirooz
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    Proc Natl Acad Sci U S A 111:2716-21. 2014
    ..Thus, UVRAG governs downstream viral entry, highlighting an important pathway capable of potential antiviral therapeutics. ..
  3. pmc PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
    Shanshan He
    1 Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA 2
    Nat Cell Biol 15:1206-19. 2013
    ....
  4. pmc Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
    Shanshan He
    Department of Molecular Microbiology and Immunology, Keck Medical School, University of Southern California, Los Angeles, California 90033, USA
    Nat Commun 6:7839. 2015
    ..These results identify UVRAG as a new MSI target gene and provide a mechanism for UVRAG participation in CRC pathogenesis and treatment response. ..
  5. pmc UVRAG: at the crossroad of autophagy and genomic stability
    Zhen Zhao
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA
    Autophagy 8:1392-3. 2012
    ....
  6. pmc Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
    Hee Jin Kim
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Sci 125:4740-50. 2012
    ....
  7. pmc A dual role for UVRAG in maintaining chromosomal stability independent of autophagy
    Zhen Zhao
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Dev Cell 22:1001-16. 2012
    ....
  8. pmc Viral interferon regulatory factors
    Hye Ra Lee
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Interferon Cytokine Res 29:621-7. 2009
    ..Here, we summarize the novel evasion mechanisms by which KSHV, through its vIRFs, circumvents IFN-mediated innate immune responses and deregulates the cell growth control mechanism...
  9. pmc Beyond autophagy: the role of UVRAG in membrane trafficking
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA
    Autophagy 4:817-20. 2008
    ..As more non-autophagic functions of UVRAG are unveiled, our understanding of seemingly different cellular processes may move a step further...
  10. pmc FLIP-mediated autophagy regulation in cell death control
    Jong Soo Lee
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, California 90033, USA
    Nat Cell Biol 11:1355-62. 2009
    ..Furthermore, the FLIP-derived short peptides induce growth suppression and cell death with autophagy, representing biologically active molecules for potential anti-cancer therapies...
  11. pmc An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction
    Arlet Minassian
    Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Pathog 11:e1005060. 2015
    ....
  12. pmc Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation
    Chul Su Yang
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J Norris Cancer Research Tower, Los Angeles, California 90033, USA
    Cell Host Microbe 11:264-76. 2012
    ..Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection...
  13. pmc Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Nat Cell Biol 10:776-87. 2008
    ....
  14. pmc Novel functions of viral anti-apoptotic factors
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA
    Nat Rev Microbiol 13:7-12. 2015
    ..If viral anti-apoptotic proteins are to be properly exploited as targets for antiviral drugs, their diverse and complex roles should be considered. ..
  15. pmc Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
    Qiming Liang
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Virol 89:5308-17. 2015
    ..Our study indicates that vBcl-2 harbors at least three important and genetically separable functions to modulate both cellular signaling and the virus life cycle...
  16. pmc Anti-autophagic Bcl-2: Not just an innocent bystander
    Soohwan Oh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA
    Autophagy 7:231-2. 2011
    ..The outcome of such a 'double hit' of Bcl-2 may synergistically promote tumor growth and increase the chance of cancer development and drug resistance...
  17. pmc Autophagy genes as tumor suppressors
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Curr Opin Cell Biol 22:226-33. 2010
    ..A better understanding of the mechanistic link between cellular autophagy and tumor growth control may ultimately better human cancer treatments...
  18. pmc Autophagy evasion in herpesviral latency
    Soohwan Oh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA
    Autophagy 6:151-2. 2010
    ..This discovery expands upon known antiviral activities of the autophagy machinery and also suggests new approaches for treating some virally induced diseases...
  19. pmc Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction
    Michaela U Gack
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 105:16743-8. 2008
    ..This study not only elucidates the vital role of the intact tandem CARD for TRIM25-mediated RIG-I activation but also identifies the RIG-I SV as an off-switch regulator of its own signaling pathway...
  20. pmc Perturbation of autophagic pathway by hepatitis C virus
    Donna Sir
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA
    Autophagy 4:830-1. 2008
    ..Our studies thus delineate a molecular pathway by which HCV induces autophagosomes. The prolonged perturbation of the autophagic pathway by HCV likely plays an important role in HCV pathogenesis...