Wei Li

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen
    Wei Li
    Department of Medicine, Norris Cancer Center, Los Angeles, California 90033, USA
    Exp Cell Res 273:219-28. 2002
  2. pmc The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing
    Arum Han
    The Department of Dermatology and the USC Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Biol Open 1:1169-77. 2012
  3. pmc Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally
    Wei Li
    Department of Dermatology, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Int Rev Cell Mol Biol 303:203-35. 2013
  4. pmc Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
    Wei Li
    The Department of Dermatology, The University of Southern California, Los Angeles, CA, USA
    Biochim Biophys Acta 1823:730-41. 2012
  5. pmc Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing
    Wei Li
    Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    EMBO J 26:1221-33. 2007
  6. ncbi request reprint Signals that initiate, augment, and provide directionality for human keratinocyte motility
    Wei Li
    The Department of Medicine, Division of Dermatology and the Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 123:622-33. 2004
  7. ncbi request reprint PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration
    Jianhua Fan
    The Department of Dermatology and the Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 126:1233-43. 2006
  8. pmc A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing
    Balaji Bandyopadhyay
    Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Biol 172:1093-105. 2006
  9. doi request reprint Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration
    Shengxi Guan
    Department of Dermatology and USC Norris Comprehensive Cancer Center, Keck School of Medicine, The University of Southern California, Los Angeles, California 90033, USA
    J Invest Dermatol 129:1909-20. 2009
  10. pmc Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing
    Chieh Fang Cheng
    Department of Dermatology, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 6320, Los Angeles, CA 90033, USA
    Mol Cell Biol 28:3344-58. 2008

Research Grants

Collaborators

Detail Information

Publications87

  1. ncbi request reprint An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen
    Wei Li
    Department of Medicine, Norris Cancer Center, Los Angeles, California 90033, USA
    Exp Cell Res 273:219-28. 2002
    ..Furthermore, PKCdelta is activated in migrating human keratinocytes. These observations indicate for the first time that the PKCdelta pathway plays an important role in the control of human keratinocyte migration...
  2. pmc The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing
    Arum Han
    The Department of Dermatology and the USC Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Biol Open 1:1169-77. 2012
    ..Significance of this finding is not only limited to wound healing but also to other human disorders, such as heart attack and cancer, where the diseased cells have often managed to avoid the anti-motility effect of TGFβ...
  3. pmc Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally
    Wei Li
    Department of Dermatology, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Int Rev Cell Mol Biol 303:203-35. 2013
    ....
  4. pmc Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
    Wei Li
    The Department of Dermatology, The University of Southern California, Los Angeles, CA, USA
    Biochim Biophys Acta 1823:730-41. 2012
    ..This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90)...
  5. pmc Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing
    Wei Li
    Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    EMBO J 26:1221-33. 2007
    ..This study has demonstrated a novel mechanism of hypoxia>HIF-1>hsp90alpha secretion>skin cell migration>wound healing, and identified extracellular hsp90alpha as a potential therapeutic agent for skin wounds...
  6. ncbi request reprint Signals that initiate, augment, and provide directionality for human keratinocyte motility
    Wei Li
    The Department of Medicine, Division of Dermatology and the Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 123:622-33. 2004
    ..Co-expression of both constitutively activated p38 and ERK1/2, however, could partially mimic the pro-motility effects of collagen and GF. This study reveals for the first time the specific functions of ECM and GF in cell motility...
  7. ncbi request reprint PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration
    Jianhua Fan
    The Department of Dermatology and the Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 126:1233-43. 2006
    ..Instead, inhibition of PKCdelta blocks PDGF-BB-stimulated activation of signal transducer and activator of transcription 3 (Stat3). This study unveiled the specificity of PKCdelta in the control of DF migration...
  8. pmc A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing
    Balaji Bandyopadhyay
    Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Biol 172:1093-105. 2006
    ..Therefore, the naturally occurring plasma-->serum-->plasma transition during wound healing orchestrates the orderly migration of dermal and epidermal cells...
  9. doi request reprint Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration
    Shengxi Guan
    Department of Dermatology and USC Norris Comprehensive Cancer Center, Keck School of Medicine, The University of Southern California, Los Angeles, California 90033, USA
    J Invest Dermatol 129:1909-20. 2009
    ..Thus, this study has elucidated the independent roles and mechanisms of action of Nckalpha and Nckbeta in DF migration, which is critical for wound healing...
  10. pmc Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing
    Chieh Fang Cheng
    Department of Dermatology, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 6320, Los Angeles, CA 90033, USA
    Mol Cell Biol 28:3344-58. 2008
    ..This finding provides a long-sought answer to the question of how dermal cells migrate into the wound environment to build new connective tissues and blood vessels. Thus, secreted hsp90alpha is potentially a new agent for wound healing...
  11. pmc Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration
    David T Woodley
    Department of Dermatology and the USC Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Sci 122:1495-8. 2009
    ..We propose that the hypoxia-HSP90alpha-LRP1 autocrine loop provides previously unrecognized therapeutic targets for human disorders such as chronic wounds and cancer invasion...
  12. doi request reprint Profiling motility signal-specific genes in primary human keratinocytes
    Chieh Fang Cheng
    Department of Dermatology and the USC Norris Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    J Invest Dermatol 128:1981-90. 2008
    ..Three genes, all encoding secreted molecules, were investigated in HK migration. These cell motility-specific gene profiles may prove useful to skin wound healing...
  13. pmc TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression
    Balaji Bandyopadhyay
    The Department of Dermatology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Cell Sci 124:19-24. 2011
    ..This study provides an explanation for why TGFβ selectively activates ERK1/2 in certain cell types and direct evidence for TβRI-independent TβRII signaling to a R-Smad-independent pathway...
  14. ncbi request reprint Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration
    Yong Li
    Department of Dermatology and the USC Norris Comprehensive Cancer Center, USC Laboratory for Investigative Dermatology, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Invest Dermatol 126:2096-105. 2006
    ..Since insulin levels are identical between plasma and serum, we propose that TGFalpha is the physiologic HK pro-motility factor in HS...
  15. ncbi request reprint Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing
    David T Woodley
    Department of Dermatology, The Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Ther 15:628-35. 2007
    ..This is also the first evidence that IV injected, molecularly engineered skin fibroblasts can deliver C7 to skin wounds. This strategy could be useful for treating DEB patients...
  16. doi request reprint Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells
    Feng Chi
    Saban Research Institute of Childrens Hospital Los Angeles, Department of Pediatrics, University of Southern California, Los Angeles, CA 90027, USA
    Biochem J 427:79-90. 2010
    ..coli K1 invasion...
  17. pmc Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1
    Ling Zhou
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Immunol 10:15. 2009
    ..In this study we investigated mechanism of cytokine induced MMP-9 with particular emphasis on the role of p21-activated-kinase-1 (PAK1) and the down stream signaling...
  18. pmc Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis
    David T Woodley
    Department of Dermatology, The Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 283:17838-45. 2008
    ..We conclude that known recessive DEB C7 mutations perturb critical functions of the C7 molecule and likely contribute to the clinical phenotypes of DEB patients...
  19. ncbi request reprint Migration of human keratinocytes in plasma and serum and wound re-epithelialisation
    Ginard Henry
    Division of Plastic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lancet 361:574-6. 2003
    ..We also showed that induced keratinocyte polarisation, activation of p38MAPK, and production of matrix metalloprotease 9 are possible mechanisms for promotion of re-epithelialisation of skin wounds by human serum...
  20. pmc Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB
    Wei Li
    The Division of Dermatology and the University of Southern California Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Mol Biol Cell 15:294-309. 2004
    ..The experiments demonstrate 1) the genes' individual roles and specificities, 2) their combined effects and sufficiency, and 3) the mechanisms of their intermolecular connections in HDF migration driven by collagen and PDGF-BB...
  21. pmc Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment
    Hangming Dong
    Department of Dermatology and the Norris Comprehensive Cancer Centre, University of Southern California Keck Medical Centre, Los Angeles, CA 90033, USA
    Sci Rep 6:20605. 2016
    ..Finally, direct inhibition of the secreted Hsp90α with monoclonal antibody, 1G6-D7, enhanced tumour cell death under hypoxia. Therefore, secreted Hsp90α is a novel survival factor for certain tumours under hypoxia. ..
  22. pmc A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors
    Divya Sahu
    Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Biol Cell 23:602-13. 2012
    ..Because normal cells do not secrete Hsp90α in the absence of stress, drugs that target F-5 should be more effective and less toxic in treatment of HIF-1α-positive tumors in humans...
  23. ncbi request reprint Wound-healing perspectives
    Wei Li
    University of Southern California Dermatology, Norris Cancer Center, Keck School of Medicine, Los Angeles, 90033, USA
    Dermatol Clin 23:181-92. 2005
    ..The article then discusses selected clinical advances that are based less on evidence-based observation and more on what works in practice and promotes wound healing...
  24. pmc A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice
    Chieh Fang Cheng
    Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Clin Invest 121:4348-61. 2011
    ..The discovery of F-5 challenges the long-standing paradigm of wound healing factors and reveals a potentially more effective and safer agent for healing acute and diabetic wounds...
  25. pmc Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs
    Ayesha Bhatia
    Department of Dermatology, USC Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, California, USA
    Mol Ther Methods Clin Dev 3:16041. 2016
    ..This study addresses a topical agent that is capable of preventing burn wound progression and accelerating burn wound healing. ..
  26. pmc Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing
    Priyamvada Jayaprakash
    Department of Dermatology and the Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, CA 90033, USA
    J Cell Sci 128:1475-80. 2015
    ..In addition to skin injury, we suggest that this repair mechanism applies broadly to other non-cutaneous injured tissues. ..
  27. pmc Identification of the critical therapeutic entity in secreted Hsp90α that promotes wound healing in newly re-standardized healthy and diabetic pig models
    Kathryn O'Brien
    The Department of Dermatology and the Norris USC Comprehensive Cancer Center, The Keck School of Medicine, The University of Southern California, Los Angeles, California, 90033, United States of America
    PLoS ONE 9:e113956. 2014
    ..This is the first report that shows standardized pig models for acute and diabetic wound healing studies and proves its usefulness with both an approved drug and a new therapeutic agent. ..
  28. pmc Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α
    Caryn S Gonsalves
    Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, California
    Am J Hematol 89:273-81. 2014
    ..These studies provide novel therapeutic targets for regulation of cell volume in RBC precursors, and thus, amelioration of dehydration in RBCs in sickle cell disease...
  29. pmc Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure
    Ayesha Bhatia
    Department of Dermatology and USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California
    Adv Wound Care (New Rochelle) 5:176-184. 2016
    ..We propose that keratinocytes at the wound edge secrete Hsp90α that leads the reepithelialization process to close the wound...
  30. pmc Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level
    Shengxi Guan
    Department of Dermatology and USC Norris Cancer Center, University of Southern California Keck School of Medicine, 1303 North Mission Road, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:6001-11. 2007
    ..Thus, Nckbeta maintains paxillin stability during neuritogenesis...
  31. doi request reprint Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cells
    Shenghong Zhang
    Division of Gastroenterology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080, People s Republic of China VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, CA, 94304, USA
    Int J Cancer 134:1583-94. 2014
    ..These data demonstrate that the malignant phenotypes seen in cancer can be corrected by a nuclear remodeling mechanism, thus highlighting a novel non-chemotherapeutic, non-radiotherapeutic approach for the treatment of cancer. ..
  32. ncbi request reprint Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa
    David T Woodley
    Department of Medicine, Division of Dermatology, University of Southern California, CRL 204, 1303 Mission Road, Los Angeles, California 90033, USA
    Nat Med 10:693-5. 2004
    ..The injected collagen localized to the basement membrane zone of both types of tissues, was organized into human anchoring fibril structures and reversed the features of DEB disease in the DEB skin equivalent...
  33. pmc Increased survivin expression confers chemoresistance to tumor-associated endothelial cells
    Jenilyn J Virrey
    Departments of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Ave, HMR 315A, Los Angeles, CA 90033, USA
    Am J Pathol 173:575-85. 2008
    ..Our studies demonstrate that targeting survivin may be an effective approach to chemosensitization and anti-vascular therapy for brain tumors...
  34. pmc Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
    Dongwon Choi
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California
    Cancer Res 76:582-93. 2016
    ....
  35. ncbi request reprint Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine
    Yu Hua Chen
    Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
    Cell Microbiol 4:503-14. 2002
    ..coli-mediated cellular responses. Thus, this study provides experimental evidence for the first time that the major component of tobacco, nicotine, enhances meningitic E. coli invasion of HBMEC through modulation of cytoskeleton...
  36. pmc Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis
    Jason Boyang Wu
    Uro Oncology Research Program, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Biomaterials 35:8175-85. 2014
    ....
  37. pmc Experimental verification of the identity of variant-specific surface proteins in Giardia lamblia trophozoites
    Wei Li
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA
    MBio 4:e00321-13. 2013
    ..By these criteria, 73 genes are identified in the Giardia WB strain genome database as the putative repertoire of VSPs...
  38. pmc Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα)
    Yang Li
    Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 288:25007-24. 2013
    ..Therefore, this study has established a previously unrecognized link between a growth signal and mitochondrial metabolism. ..
  39. pmc IgE-mediated allergen gene vaccine platform targeting human antigen-presenting cells through the high-affinity IgE receptor
    Anne Behnecke
    Hart and Louise Lyon Immunology Laboratory, Section of Clinical Immunology Allergy, Division of Pulmonary, Critical Care and Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 124:108-13. 2009
    ..Allergen gene vaccination represents a promising alternative, but difficulties in gene targeting and expression in antigen-presenting cells represent a major limitation for efficient gene vaccination...
  40. pmc Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling
    Wei Li
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS ONE 3:e1487. 2008
    ..These findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment...
  41. pmc Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2
    Jose Sangerman
    Department of Pediatrics, Yale University, New Haven, CT, USA
    Blood 108:3590-9. 2006
    ..The data presented herein demonstrate that gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling...
  42. ncbi request reprint Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism
    Vijayalakshmi Thamilselvan
    Department of Surgery, Wayne State University, Detroit, Michigan 48202, USA
    In Vitro Cell Dev Biol Anim 38:246-53. 2002
    ..ERK activation by S-1-P is not required for its mitogenic effect...
  43. ncbi request reprint Quiescent subpopulations of human CD34-positive hematopoietic stem cells are preferred targets for stable recombinant adeno-associated virus type 2 transduction
    Helicia Paz
    Division of Virology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Hum Gene Ther 18:614-26. 2007
    ..These results represent the first demonstration of rAAV-mediated gene transfer to primitive, quiescent human CD34(+)CD38(-) stem cells and reveal that nondividing CD34(+)CD38(-) HSCs are the optimal CD34(+) targets for rAAV transduction...
  44. pmc Air exposure induced squamous metaplasia of human limbal epithelium
    Wei Li
    TissueTech, Inc, and the Ocular Surface Center, 7000 SW 9th Avenue, Miami, FL 33173, USA
    Invest Ophthalmol Vis Sci 49:154-62. 2008
    ..Squamous metaplasia is a pathologic process that frequently occurs in nonkeratinized stratified ocular surface epithelia. The mechanism for this occurrence is largely unknown except for vitamin A deficiency...
  45. ncbi request reprint Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
    Mao Ye
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China
    Cancer Lett 258:199-207. 2007
    ..These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent...
  46. ncbi request reprint Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinase
    Quanhai Chen
    Department of Surgery, Yale University School of Medicine and Connecticut VA Health Care System, 333 Cedar Street, New Haven, CT 06520 8062, USA
    J Vasc Surg 37:660-8. 2003
    ..We assessed stretch-induced nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase activation and the redox sensitivity of cyclic strain-stimulated activation of the mitogen-activated protein kinase (MAPK) family...
  47. ncbi request reprint Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins
    Jianhu Zhang
    Departments of Surgery, Wayne State University, USA
    FASEB J 17:926-8. 2003
    ..Tissue or plasma fibronectin may regulate the intestinal epithelial response to strain via integrins containing alpha5 or alpha(v)...
  48. pmc Signaling-transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membrane
    Hua He
    TissueTech, Inc and Ocular Surface Center, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 47:151-7. 2006
    ..Such expansion requires NGF-TrkA-mediated signaling, and this study was conducted to delineate the downstream signaling pathways...
  49. ncbi request reprint Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells
    Wei Li
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cell Physiol 195:202-9. 2003
    ..05). The results suggest that strain-induced SMC alignment is dependent on activation of p38, but not S6 kinase. Strain induced SMC proliferation is S6 kinase, but not p38 activation, dependent...
  50. ncbi request reprint Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells
    Jianhu Zhang
    Department of Surgery, John D Dingell Veterans Administration Hospital Chief VAMC, Surgical Service 112, 4646 John R Street, Detroit, MI 48201 1932, USA
    Biochem Biophys Res Commun 306:746-9. 2003
    ..Since tissue and plasma fibronectin levels vary in acute or chronic inflammatory or infectious conditions, these results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation...
  51. pmc Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
    Yao Yao
    Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12759-64. 2003
    ..These data indicate that ERK2 plays an essential role in mesoderm differentiation during embryonic development...
  52. ncbi request reprint Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation
    Gurjit Sidhu
    Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 280:11379-86. 2005
    ....
  53. ncbi request reprint Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway
    Wei Li
    Dept of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Heart Circ Physiol 288:H1591-7. 2005
    ..Cyclic strain also activated 4E-BP1, which could be inhibited by PI3K inhibitors. These data suggest that the PI3K-dependent S6K-mTOR-4E-BP1 signal pathway may be critically involved in strain-induced bovine aortic EC proliferation...
  54. pmc FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression
    Wei Li
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Mol Cell Biol 24:10718-32. 2004
    ..Because FAST is released from mitochondria in cells undergoing Fas- or UV-induced apoptosis, we propose that FAST serves as a sensor of mitochondrial stress that modulates a TIA-1-regulated posttranscriptional stress response program...
  55. doi request reprint Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication
    Sahibzada T Rasool
    Medical Virology Laboratory, The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, PR China
    Immunol Lett 117:161-7. 2008
    ..Our present work shows that raised IL-32 levels in HIV infection may in turn hamper HIV replication; one of the protective mechanisms of nature...
  56. ncbi request reprint Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering
    Rustem I Litvinov
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 45:4957-64. 2006
    ....
  57. pmc Reversal of myofibroblasts by amniotic membrane stromal extract
    Wei Li
    TissueTech, Inc, Miami, Florida, USA
    J Cell Physiol 215:657-64. 2008
    ..Further investigation into the identity of these factors and the control mechanisms may unravel a new scar-reversing strategy...
  58. ncbi request reprint [PCR site-directed mutagenesis of long QT syndrome KCNQ1 gene in vitro]
    Wei Li
    Institute of Cardiology, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430 022, China
    Yi Chuan 26:589-93. 2004
    ..Under the fluorescence microscope, the green fluorescence was spread in the transfected HEK293 cell, meaning the pIRES(2)-EGFP-KCNQ1 containing the mutation site was expressed correctly...
  59. pmc Lysosomal destabilization in p53-induced apoptosis
    Xi Ming Yuan
    Pathology II, Linkoping University, Linköping 581 85, Sweden
    Proc Natl Acad Sci U S A 99:6286-91. 2002
    ..These findings on the induction of p53-induced lysosomal destabilization can also help to formulate new therapies for diseases with apoptotic disorders...
  60. ncbi request reprint Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival
    Takuya Takayama
    Thomas E Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Transplantation 74:112-9. 2002
    ....
  61. ncbi request reprint Effects of early treatment with growth hormone on infarct size, survival, and cardiac gene expression after acute myocardial infarction
    Hongkui Jin
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, CA 94080, USA
    Growth Horm IGF Res 12:208-15. 2002
    ..This study examined the effects of growth hormone (GH) on infarct size, survival, and cardiac gene expression in rats with acute myocardial infarction...
  62. ncbi request reprint Selection of peptide ligands binding to fibroblast growth factor receptor 1
    Hongkuan Fan
    College of Life Science, Jilin University, Changchun, People s Republic of China
    IUBMB Life 54:67-72. 2002
    ..The synthetic peptide Ac-ValTyrMetSerProPhe-NH2 can inhibit mitogenic activity of aFGF and has the potential to become a therapeutic agent as an aFGF antagonist...
  63. pmc The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
    Xuemin Wang
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 23:1546-57. 2003
    ..However, in 4E-BP3, replacement of the alanine at the position corresponding to S112 by serine or glutamate did not confer the ability to be released from eIF4E in response to insulin...
  64. ncbi request reprint The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix
    Mauro Alini
    Orthopaedic Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Canada
    Spine (Phila Pa 1976) 28:446-54; discussion 453. 2003
    ..The use of a cell-seeded biomatrix for tissue engineering of the intervertebral disc...
  65. ncbi request reprint Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1
    Daniel Kirchhofer
    Department of Physiology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 278:36341-9. 2003
    ..Therefore, previously demonstrated roles of HAI-1 in various physiological and pathological processes likely involve both HAI-1B and HAI-1...
  66. ncbi request reprint TOUCHSTONEX: protein structure prediction with sparse NMR data
    Wei Li
    Center of Excellence in Bioinformatics, University at Buffalo, Buffalo, New York 14203, USA
    Proteins 53:290-306. 2003
    ....
  67. ncbi request reprint The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor
    Wei Li
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    J Mol Biol 333:461-72. 2003
    ..Redox stress induces disulphide bond formation amongst zinc-ligating residues, expelling the metal ion and stabilising a structure incapable of binding the sigma factor...
  68. ncbi request reprint Neural development of selective attention and response inhibition
    James R Booth
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    Neuroimage 20:737-51. 2003
    ..The extensive developmental differences on the response inhibition task are consistent with the prolonged maturation of the fronto-striatal network...
  69. ncbi request reprint Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats
    Wei Li
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Pharmacol Sin 25:490-5. 2004
    ..To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabetic renal complications...
  70. ncbi request reprint FAST is a BCL-X(L)-associated mitochondrial protein
    Wei Li
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Biochem Biophys Res Commun 318:95-102. 2004
    ..Our results suggest that FAST-BCL-X(L) interactions are likely to regulate mitochondrial metabolism during Fas-induced apoptosis...
  71. ncbi request reprint Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits
    Wei Li
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    J Mol Cell Cardiol 37:969-78. 2004
    ..Apoptosis reduction by alpha-tocopherol and astaxanthin may be a new anti-atherogenic property of these antioxidants...
  72. ncbi request reprint Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia
    Wei Li
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:7941-8. 2005
    ..These results identify new binding partners for connexin43 and demonstrate that interactions between connexin43 and protein kinases and phosphatases are dynamically altered as a consequence of connexin43 phosphorylation...
  73. pmc A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, United States of America
    PLoS ONE 2:e1153. 2007
    ..We previously reported that green tea brewed from the leaves of the plant Camellia sinensis is effective in inhibiting endotoxin-induced HMGB1 release...
  74. pmc A push-pull mechanism for regulating integrin function
    Wei Li
    Department of Medicine, Hematology Oncology Division, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:1424-9. 2005
    ....
  75. pmc Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing
    Lung Kun Yeh
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:479-86. 2005
    ..To purify and characterize the glycoprotein lumican, isolated from human amniotic membrane (AM), and to examine its efficacy in treating corneal epithelium debridement...
  76. ncbi request reprint Ribozymes against TGFbeta1 reverse character of activated hepatic stellate cells in vitro and inhibit liver fibrosis in rats
    Yu Hu Song
    Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    J Gene Med 7:965-76. 2005
    ..The purpose of this investigation was to evaluate the activity of ribozymes against TGFbeta1 in a cell-free system and activated hepatic stellate cells (HSCs), and antifibrotic effect in activated HSCs in vitro and in rats...
  77. ncbi request reprint Prokaryotic expression and biological activity analysis of human arresten gene
    Zifang Song
    Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 25:8-12. 2005
    ....
  78. pmc Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure
    Tetsuya Kawakita
    TissueTech, Inc, Ocular Surface Center, 7000 SW 97 Ave, Suite 213, Miami, FL 33173, USA
    Am J Pathol 167:381-93. 2005
    ....
  79. ncbi request reprint Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
    Bin Fan
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 280:34513-20. 2005
    ..The identification of HAI-1B as a potential physiological regulator of prostasin function, as described herein, may further the investigation of the role of prostasin in normal physiology and cancer...
  80. ncbi request reprint Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species
    Cheng Hui Hsiao
    University of Texas at Dallas, Department of Molecular and Cell Biology, Richardson, TX 75083, USA
    Exp Hematol 34:264-73. 2006
    ..Therefore, we determined the role of the reactive oxygen species hydrogen peroxide (H(2)O(2)) in drug-mediated fetal hemoglobin (HbF) induction...
  81. ncbi request reprint Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase
    Qing Liu
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 47:1302-9. 2006
    ..Expecting to find similar effects in human lens epithelial cells (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC cycle...
  82. ncbi request reprint [Construction of RNA interference expression vectors of human neuropathy target esterase and its inhibition for expression of NTE in mammalian cells]
    Ping An Chang
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:27-30. 2006
    ..To construct the RNA interference expression vector for expression of human neuropathy target esterase (NTE) gene in mammalian cells...
  83. pmc Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
    Teresa Palomero
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Blood 108:986-92. 2006
    ..Our results indicate that TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis...
  84. ncbi request reprint Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells
    Jie Ouyang
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, FL 33136, USA, and Department of Ophthalmology, Veterans General Hospital, Taichung, Taiwan
    Invest Ophthalmol Vis Sci 47:2397-407. 2006
    ..Pax6 continues to be expressed in the ocular surface epithelia of the postnatal eye. The goal of this study was to investigate a possible role for Pax6 in controlling dynamics of the ocular surface epithelia...
  85. ncbi request reprint Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase
    Hang Ping Yao
    Laboratory of Cheung Kong Scholars Program for Tumor Biology, Institute of Infectious Diseases at First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Cancer Biol Ther 5:1179-86. 2006
    ..These mAbs will be useful in studying mechanisms underlying RON activation which lead to increased tumorigenic activities...
  86. pmc The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membrane
    Wei Li
    Ocular Surface Center, and TissueTech, Inc, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 48:605-13. 2007
    ..However, the ultimate fate of limbal epithelial progenitor cells in the explant remains unclear...
  87. ncbi request reprint Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity
    Wei Li
    Department of Biochemistry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Glycobiology 17:655-62. 2007
    ..Thus, the structure of N-glycans of ACIII regulates its enzymatic activity and downstream signaling...

Research Grants1

  1. Signal Transduction of Human Keratinocyte Migration
    Wei Li; Fiscal Year: 2010
    ..We suggest that extracellular hsp90alpha can replace human serum or growth factors to jumpstart the re-epithelialization process. ..