Genomes and Genes
Affiliation: University of Southern California
- An important role for protein kinase C-delta in human keratinocyte migration on dermal collagenWei Li
Department of Medicine, Norris Cancer Center, Los Angeles, California 90033, USA
Exp Cell Res 273:219-28. 2002..Furthermore, PKCdelta is activated in migrating human keratinocytes. These observations indicate for the first time that the PKCdelta pathway plays an important role in the control of human keratinocyte migration...
- The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healingArum Han
The Department of Dermatology and the USC Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Biol Open 1:1169-77. 2012..Significance of this finding is not only limited to wound healing but also to other human disorders, such as heart attack and cancer, where the diseased cells have often managed to avoid the anti-motility effect of TGFβ...
- Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionallyWei Li
Department of Dermatology, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Int Rev Cell Mol Biol 303:203-35. 2013....
- Secreted heat shock protein-90 (Hsp90) in wound healing and cancerWei Li
The Department of Dermatology, The University of Southern California, Los Angeles, CA, USA
Biochim Biophys Acta 1823:730-41. 2012..This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90)...
- Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healingWei Li
Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
EMBO J 26:1221-33. 2007..This study has demonstrated a novel mechanism of hypoxia>HIF-1>hsp90alpha secretion>skin cell migration>wound healing, and identified extracellular hsp90alpha as a potential therapeutic agent for skin wounds...
- Signals that initiate, augment, and provide directionality for human keratinocyte motilityWei Li
The Department of Medicine, Division of Dermatology and the Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
J Invest Dermatol 123:622-33. 2004..Co-expression of both constitutively activated p38 and ERK1/2, however, could partially mimic the pro-motility effects of collagen and GF. This study reveals for the first time the specific functions of ECM and GF in cell motility...
- PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migrationJianhua Fan
The Department of Dermatology and the Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California, USA
J Invest Dermatol 126:1233-43. 2006..Instead, inhibition of PKCdelta blocks PDGF-BB-stimulated activation of signal transducer and activator of transcription 3 (Stat3). This study unveiled the specificity of PKCdelta in the control of DF migration...
- A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healingBalaji Bandyopadhyay
Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Cell Biol 172:1093-105. 2006..Therefore, the naturally occurring plasma-->serum-->plasma transition during wound healing orchestrates the orderly migration of dermal and epidermal cells...
- Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migrationShengxi Guan
Department of Dermatology and USC Norris Comprehensive Cancer Center, Keck School of Medicine, The University of Southern California, Los Angeles, California 90033, USA
J Invest Dermatol 129:1909-20. 2009..Thus, this study has elucidated the independent roles and mechanisms of action of Nckalpha and Nckbeta in DF migration, which is critical for wound healing...
- Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healingChieh Fang Cheng
Department of Dermatology, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 6320, Los Angeles, CA 90033, USA
Mol Cell Biol 28:3344-58. 2008..This finding provides a long-sought answer to the question of how dermal cells migrate into the wound environment to build new connective tissues and blood vessels. Thus, secreted hsp90alpha is potentially a new agent for wound healing...
- Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migrationDavid T Woodley
Department of Dermatology and the USC Norris Comprehensive Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Cell Sci 122:1495-8. 2009..We propose that the hypoxia-HSP90alpha-LRP1 autocrine loop provides previously unrecognized therapeutic targets for human disorders such as chronic wounds and cancer invasion...
- Profiling motility signal-specific genes in primary human keratinocytesChieh Fang Cheng
Department of Dermatology and the USC Norris Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
J Invest Dermatol 128:1981-90. 2008..Three genes, all encoding secreted molecules, were investigated in HK migration. These cell motility-specific gene profiles may prove useful to skin wound healing...
- TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expressionBalaji Bandyopadhyay
The Department of Dermatology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Cell Sci 124:19-24. 2011..This study provides an explanation for why TGFβ selectively activates ERK1/2 in certain cell types and direct evidence for TβRI-independent TβRII signaling to a R-Smad-independent pathway...
- Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migrationYong Li
Department of Dermatology and the USC Norris Comprehensive Cancer Center, USC Laboratory for Investigative Dermatology, University of Southern California Keck School of Medicine, Los Angeles, USA
J Invest Dermatol 126:2096-105. 2006..Since insulin levels are identical between plasma and serum, we propose that TGFalpha is the physiologic HK pro-motility factor in HS...
- Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healingDavid T Woodley
Department of Dermatology, The Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Mol Ther 15:628-35. 2007..This is also the first evidence that IV injected, molecularly engineered skin fibroblasts can deliver C7 to skin wounds. This strategy could be useful for treating DEB patients...
- Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cellsFeng Chi
Saban Research Institute of Childrens Hospital Los Angeles, Department of Pediatrics, University of Southern California, Los Angeles, CA 90027, USA
Biochem J 427:79-90. 2010..coli K1 invasion...
- Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1Ling Zhou
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
BMC Immunol 10:15. 2009..In this study we investigated mechanism of cytokine induced MMP-9 with particular emphasis on the role of p21-activated-kinase-1 (PAK1) and the down stream signaling...
- Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesisDavid T Woodley
Department of Dermatology, The Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
J Biol Chem 283:17838-45. 2008..We conclude that known recessive DEB C7 mutations perturb critical functions of the C7 molecule and likely contribute to the clinical phenotypes of DEB patients...
- Migration of human keratinocytes in plasma and serum and wound re-epithelialisationGinard Henry
Division of Plastic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Lancet 361:574-6. 2003..We also showed that induced keratinocyte polarisation, activation of p38MAPK, and production of matrix metalloprotease 9 are possible mechanisms for promotion of re-epithelialisation of skin wounds by human serum...
- Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BBWei Li
The Division of Dermatology and the University of Southern California Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Mol Biol Cell 15:294-309. 2004..The experiments demonstrate 1) the genes' individual roles and specificities, 2) their combined effects and sufficiency, and 3) the mechanisms of their intermolecular connections in HDF migration driven by collagen and PDGF-BB...
- Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic EnvironmentHangming Dong
Department of Dermatology and the Norris Comprehensive Cancer Centre, University of Southern California Keck Medical Centre, Los Angeles, CA 90033, USA
Sci Rep 6:20605. 2016..Finally, direct inhibition of the secreted Hsp90α with monoclonal antibody, 1G6-D7, enhanced tumour cell death under hypoxia. Therefore, secreted Hsp90α is a novel survival factor for certain tumours under hypoxia. ..
- A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumorsDivya Sahu
Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Mol Biol Cell 23:602-13. 2012..Because normal cells do not secrete Hsp90α in the absence of stress, drugs that target F-5 should be more effective and less toxic in treatment of HIF-1α-positive tumors in humans...
- Wound-healing perspectivesWei Li
University of Southern California Dermatology, Norris Cancer Center, Keck School of Medicine, Los Angeles, 90033, USA
Dermatol Clin 23:181-92. 2005..The article then discusses selected clinical advances that are based less on evidence-based observation and more on what works in practice and promotes wound healing...
- A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in miceChieh Fang Cheng
Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
J Clin Invest 121:4348-61. 2011..The discovery of F-5 challenges the long-standing paradigm of wound healing factors and reveals a potentially more effective and safer agent for healing acute and diabetic wounds...
- Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigsAyesha Bhatia
Department of Dermatology, USC Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, California, USA
Mol Ther Methods Clin Dev 3:16041. 2016..This study addresses a topical agent that is capable of preventing burn wound progression and accelerating burn wound healing. ..
- Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healingPriyamvada Jayaprakash
Department of Dermatology and the Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, CA 90033, USA
J Cell Sci 128:1475-80. 2015..In addition to skin injury, we suggest that this repair mechanism applies broadly to other non-cutaneous injured tissues. ..
- Identification of the critical therapeutic entity in secreted Hsp90α that promotes wound healing in newly re-standardized healthy and diabetic pig modelsKathryn O'Brien
The Department of Dermatology and the Norris USC Comprehensive Cancer Center, The Keck School of Medicine, The University of Southern California, Los Angeles, California, 90033, United States of America
PLoS ONE 9:e113956. 2014..This is the first report that shows standardized pig models for acute and diabetic wound healing studies and proves its usefulness with both an approved drug and a new therapeutic agent. ..
- Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1αCaryn S Gonsalves
Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, California
Am J Hematol 89:273-81. 2014..These studies provide novel therapeutic targets for regulation of cell volume in RBC precursors, and thus, amelioration of dehydration in RBCs in sickle cell disease...
- Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and ClosureAyesha Bhatia
Department of Dermatology and USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California
Adv Wound Care (New Rochelle) 5:176-184. 2016..We propose that keratinocytes at the wound edge secrete Hsp90α that leads the reepithelialization process to close the wound...
- Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin levelShengxi Guan
Department of Dermatology and USC Norris Cancer Center, University of Southern California Keck School of Medicine, 1303 North Mission Road, Los Angeles, CA 90033, USA
Mol Cell Biol 27:6001-11. 2007..Thus, Nckbeta maintains paxillin stability during neuritogenesis...
- Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cellsShenghong Zhang
Division of Gastroenterology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080, People s Republic of China VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, CA, 94304, USA
Int J Cancer 134:1583-94. 2014..These data demonstrate that the malignant phenotypes seen in cancer can be corrected by a nuclear remodeling mechanism, thus highlighting a novel non-chemotherapeutic, non-radiotherapeutic approach for the treatment of cancer. ..
- Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosaDavid T Woodley
Department of Medicine, Division of Dermatology, University of Southern California, CRL 204, 1303 Mission Road, Los Angeles, California 90033, USA
Nat Med 10:693-5. 2004..The injected collagen localized to the basement membrane zone of both types of tissues, was organized into human anchoring fibril structures and reversed the features of DEB disease in the DEB skin equivalent...
- Increased survivin expression confers chemoresistance to tumor-associated endothelial cellsJenilyn J Virrey
Departments of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Ave, HMR 315A, Los Angeles, CA 90033, USA
Am J Pathol 173:575-85. 2008..Our studies demonstrate that targeting survivin may be an effective approach to chemosensitization and anti-vascular therapy for brain tumors...
- Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer CellsDongwon Choi
Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California
Cancer Res 76:582-93. 2016....
- Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotineYu Hua Chen
Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
Cell Microbiol 4:503-14. 2002..coli-mediated cellular responses. Thus, this study provides experimental evidence for the first time that the major component of tobacco, nicotine, enhances meningitic E. coli invasion of HBMEC through modulation of cytoskeleton...
- Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axisJason Boyang Wu
Uro Oncology Research Program, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Biomaterials 35:8175-85. 2014....
- Experimental verification of the identity of variant-specific surface proteins in Giardia lamblia trophozoitesWei Li
Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA
MBio 4:e00321-13. 2013..By these criteria, 73 genes are identified in the Giardia WB strain genome database as the putative repertoire of VSPs...
- Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα)Yang Li
Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 288:25007-24. 2013..Therefore, this study has established a previously unrecognized link between a growth signal and mitochondrial metabolism. ..
- IgE-mediated allergen gene vaccine platform targeting human antigen-presenting cells through the high-affinity IgE receptorAnne Behnecke
Hart and Louise Lyon Immunology Laboratory, Section of Clinical Immunology Allergy, Division of Pulmonary, Critical Care and Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Allergy Clin Immunol 124:108-13. 2009..Allergen gene vaccination represents a promising alternative, but difficulties in gene targeting and expression in antigen-presenting cells represent a major limitation for efficient gene vaccination...
- Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signalingWei Li
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
PLoS ONE 3:e1487. 2008..These findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment...
- Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2Jose Sangerman
Department of Pediatrics, Yale University, New Haven, CT, USA
Blood 108:3590-9. 2006..The data presented herein demonstrate that gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling...
- Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanismVijayalakshmi Thamilselvan
Department of Surgery, Wayne State University, Detroit, Michigan 48202, USA
In Vitro Cell Dev Biol Anim 38:246-53. 2002..ERK activation by S-1-P is not required for its mitogenic effect...
- Quiescent subpopulations of human CD34-positive hematopoietic stem cells are preferred targets for stable recombinant adeno-associated virus type 2 transductionHelicia Paz
Division of Virology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
Hum Gene Ther 18:614-26. 2007..These results represent the first demonstration of rAAV-mediated gene transfer to primitive, quiescent human CD34(+)CD38(-) stem cells and reveal that nondividing CD34(+)CD38(-) HSCs are the optimal CD34(+) targets for rAAV transduction...
- Air exposure induced squamous metaplasia of human limbal epitheliumWei Li
TissueTech, Inc, and the Ocular Surface Center, 7000 SW 9th Avenue, Miami, FL 33173, USA
Invest Ophthalmol Vis Sci 49:154-62. 2008..Squamous metaplasia is a pathologic process that frequently occurs in nonkeratinized stratified ocular surface epithelia. The mechanism for this occurrence is largely unknown except for vitamin A deficiency...
- Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathwayMao Ye
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China
Cancer Lett 258:199-207. 2007..These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent...
- Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinaseQuanhai Chen
Department of Surgery, Yale University School of Medicine and Connecticut VA Health Care System, 333 Cedar Street, New Haven, CT 06520 8062, USA
J Vasc Surg 37:660-8. 2003..We assessed stretch-induced nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase activation and the redox sensitivity of cyclic strain-stimulated activation of the mitogen-activated protein kinase (MAPK) family...
- Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteinsJianhu Zhang
Departments of Surgery, Wayne State University, USA
FASEB J 17:926-8. 2003..Tissue or plasma fibronectin may regulate the intestinal epithelial response to strain via integrins containing alpha5 or alpha(v)...
- Signaling-transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membraneHua He
TissueTech, Inc and Ocular Surface Center, Miami, Florida 33173, USA
Invest Ophthalmol Vis Sci 47:151-7. 2006..Such expansion requires NGF-TrkA-mediated signaling, and this study was conducted to delineate the downstream signaling pathways...
- Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cellsWei Li
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
J Cell Physiol 195:202-9. 2003..05). The results suggest that strain-induced SMC alignment is dependent on activation of p38, but not S6 kinase. Strain induced SMC proliferation is S6 kinase, but not p38 activation, dependent...
- Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cellsJianhu Zhang
Department of Surgery, John D Dingell Veterans Administration Hospital Chief VAMC, Surgical Service 112, 4646 John R Street, Detroit, MI 48201 1932, USA
Biochem Biophys Res Commun 306:746-9. 2003..Since tissue and plasma fibronectin levels vary in acute or chronic inflammatory or infectious conditions, these results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation...
- Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiationYao Yao
Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:12759-64. 2003..These data indicate that ERK2 plays an essential role in mesoderm differentiation during embryonic development...
- Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formationGurjit Sidhu
Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Biol Chem 280:11379-86. 2005....
- Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathwayWei Li
Dept of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
Am J Physiol Heart Circ Physiol 288:H1591-7. 2005..Cyclic strain also activated 4E-BP1, which could be inhibited by PI3K inhibitors. These data suggest that the PI3K-dependent S6K-mTOR-4E-BP1 signal pathway may be critically involved in strain-induced bovine aortic EC proliferation...
- FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expressionWei Li
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Mol Cell Biol 24:10718-32. 2004..Because FAST is released from mitochondria in cells undergoing Fas- or UV-induced apoptosis, we propose that FAST serves as a sensor of mitochondrial stress that modulates a TIA-1-regulated posttranscriptional stress response program...
- Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replicationSahibzada T Rasool
Medical Virology Laboratory, The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, PR China
Immunol Lett 117:161-7. 2008..Our present work shows that raised IL-32 levels in HIV infection may in turn hamper HIV replication; one of the protective mechanisms of nature...
- Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clusteringRustem I Litvinov
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Biochemistry 45:4957-64. 2006....
- Reversal of myofibroblasts by amniotic membrane stromal extractWei Li
TissueTech, Inc, Miami, Florida, USA
J Cell Physiol 215:657-64. 2008..Further investigation into the identity of these factors and the control mechanisms may unravel a new scar-reversing strategy...
- [PCR site-directed mutagenesis of long QT syndrome KCNQ1 gene in vitro]Wei Li
Institute of Cardiology, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430 022, China
Yi Chuan 26:589-93. 2004..Under the fluorescence microscope, the green fluorescence was spread in the transfected HEK293 cell, meaning the pIRES(2)-EGFP-KCNQ1 containing the mutation site was expressed correctly...
- Lysosomal destabilization in p53-induced apoptosisXi Ming Yuan
Pathology II, Linkoping University, Linköping 581 85, Sweden
Proc Natl Acad Sci U S A 99:6286-91. 2002..These findings on the induction of p53-induced lysosomal destabilization can also help to formulate new therapies for diseases with apoptotic disorders...
- Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survivalTakuya Takayama
Thomas E Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
Transplantation 74:112-9. 2002....
- Effects of early treatment with growth hormone on infarct size, survival, and cardiac gene expression after acute myocardial infarctionHongkui Jin
Department of Cardiovascular Research, Genentech, Inc, South San Francisco, CA 94080, USA
Growth Horm IGF Res 12:208-15. 2002..This study examined the effects of growth hormone (GH) on infarct size, survival, and cardiac gene expression in rats with acute myocardial infarction...
- Selection of peptide ligands binding to fibroblast growth factor receptor 1Hongkuan Fan
College of Life Science, Jilin University, Changchun, People s Republic of China
IUBMB Life 54:67-72. 2002..The synthetic peptide Ac-ValTyrMetSerProPhe-NH2 can inhibit mitogenic activity of aFGF and has the potential to become a therapeutic agent as an aFGF antagonist...
- The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationXuemin Wang
Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Mol Cell Biol 23:1546-57. 2003..However, in 4E-BP3, replacement of the alanine at the position corresponding to S112 by serine or glutamate did not confer the ability to be released from eIF4E in response to insulin...
- The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrixMauro Alini
Orthopaedic Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Canada
Spine (Phila Pa 1976) 28:446-54; discussion 453. 2003..The use of a cell-seeded biomatrix for tissue engineering of the intervertebral disc...
- Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1Daniel Kirchhofer
Department of Physiology, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 278:36341-9. 2003..Therefore, previously demonstrated roles of HAI-1 in various physiological and pathological processes likely involve both HAI-1B and HAI-1...
- TOUCHSTONEX: protein structure prediction with sparse NMR dataWei Li
Center of Excellence in Bioinformatics, University at Buffalo, Buffalo, New York 14203, USA
Proteins 53:290-306. 2003....
- The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolorWei Li
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
J Mol Biol 333:461-72. 2003..Redox stress induces disulphide bond formation amongst zinc-ligating residues, expelling the metal ion and stabilising a structure incapable of binding the sigma factor...
- Neural development of selective attention and response inhibitionJames R Booth
Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
Neuroimage 20:737-51. 2003..The extensive developmental differences on the response inhibition task are consistent with the prolonged maturation of the fronto-striatal network...
- Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic ratsWei Li
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 200031, China
Acta Pharmacol Sin 25:490-5. 2004..To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabetic renal complications...
- FAST is a BCL-X(L)-associated mitochondrial proteinWei Li
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Biochem Biophys Res Commun 318:95-102. 2004..Our results suggest that FAST-BCL-X(L) interactions are likely to regulate mitochondrial metabolism during Fas-induced apoptosis...
- Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbitsWei Li
Division of Pathology II, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
J Mol Cell Cardiol 37:969-78. 2004..Apoptosis reduction by alpha-tocopherol and astaxanthin may be a new anti-atherogenic property of these antioxidants...
- Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxiaWei Li
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 280:7941-8. 2005..These results identify new binding partners for connexin43 and demonstrate that interactions between connexin43 and protein kinases and phosphatases are dynamically altered as a consequence of connexin43 phosphorylation...
- A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1Wei Li
Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, United States of America
PLoS ONE 2:e1153. 2007..We previously reported that green tea brewed from the leaves of the plant Camellia sinensis is effective in inhibiting endotoxin-induced HMGB1 release...
- A push-pull mechanism for regulating integrin functionWei Li
Department of Medicine, Hematology Oncology Division, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:1424-9. 2005....
- Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healingLung Kun Yeh
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 46:479-86. 2005..To purify and characterize the glycoprotein lumican, isolated from human amniotic membrane (AM), and to examine its efficacy in treating corneal epithelium debridement...
- Ribozymes against TGFbeta1 reverse character of activated hepatic stellate cells in vitro and inhibit liver fibrosis in ratsYu Hu Song
Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
J Gene Med 7:965-76. 2005..The purpose of this investigation was to evaluate the activity of ribozymes against TGFbeta1 in a cell-free system and activated hepatic stellate cells (HSCs), and antifibrotic effect in activated HSCs in vitro and in rats...
- Prokaryotic expression and biological activity analysis of human arresten geneZifang Song
Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 25:8-12. 2005....
- Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposureTetsuya Kawakita
TissueTech, Inc, Ocular Surface Center, 7000 SW 97 Ave, Suite 213, Miami, FL 33173, USA
Am J Pathol 167:381-93. 2005....
- Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasinBin Fan
Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 280:34513-20. 2005..The identification of HAI-1B as a potential physiological regulator of prostasin function, as described herein, may further the investigation of the role of prostasin in normal physiology and cancer...
- Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen speciesCheng Hui Hsiao
University of Texas at Dallas, Department of Molecular and Cell Biology, Richardson, TX 75083, USA
Exp Hematol 34:264-73. 2006..Therefore, we determined the role of the reactive oxygen species hydrogen peroxide (H(2)O(2)) in drug-mediated fetal hemoglobin (HbF) induction...
- Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphaseQing Liu
Laboratory for Nutrition and Vision Research, JMUSDA HNRCA at Tufts University, Boston, Massachusetts 02111, USA
Invest Ophthalmol Vis Sci 47:1302-9. 2006..Expecting to find similar effects in human lens epithelial cells (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC cycle...
- [Construction of RNA interference expression vectors of human neuropathy target esterase and its inhibition for expression of NTE in mammalian cells]Ping An Chang
Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:27-30. 2006..To construct the RNA interference expression vector for expression of human neuropathy target esterase (NTE) gene in mammalian cells...
- Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaTeresa Palomero
Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
Blood 108:986-92. 2006..Our results indicate that TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis...
- Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cellsJie Ouyang
Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, FL 33136, USA, and Department of Ophthalmology, Veterans General Hospital, Taichung, Taiwan
Invest Ophthalmol Vis Sci 47:2397-407. 2006..Pax6 continues to be expressed in the ocular surface epithelia of the postnatal eye. The goal of this study was to investigate a possible role for Pax6 in controlling dynamics of the ocular surface epithelia...
- Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinaseHang Ping Yao
Laboratory of Cheung Kong Scholars Program for Tumor Biology, Institute of Infectious Diseases at First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Cancer Biol Ther 5:1179-86. 2006..These mAbs will be useful in studying mechanisms underlying RON activation which lead to increased tumorigenic activities...
- The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membraneWei Li
Ocular Surface Center, and TissueTech, Inc, Miami, Florida 33173, USA
Invest Ophthalmol Vis Sci 48:605-13. 2007..However, the ultimate fate of limbal epithelial progenitor cells in the explant remains unclear...
- Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activityWei Li
Department of Biochemistry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Glycobiology 17:655-62. 2007..Thus, the structure of N-glycans of ACIII regulates its enzymatic activity and downstream signaling...
- Signal Transduction of Human Keratinocyte MigrationWei Li; Fiscal Year: 2010..We suggest that extracellular hsp90alpha can replace human serum or growth factors to jumpstart the re-epithelialization process. ..