Jun Li

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stroke 38:2992-9. 2007
  2. ncbi request reprint Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
    Jun Li
    Department of Neurology, University of Connecticut Health Centre, 263 Farmington Avenue, Farmington, CT 06030, USA
    Curr Med Chem 14:1807-13. 2007
  3. ncbi request reprint The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1055:180-5. 2005
  4. ncbi request reprint The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1076:209-15. 2006
  5. ncbi request reprint The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1029:84-92. 2004
  6. doi request reprint Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice
    Qing Yan
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Neurol Sci 312:102-7. 2012
  7. pmc NF-κB contributes to the detrimental effects of social isolation after experimental stroke
    Venugopal Reddy Venna
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Acta Neuropathol 124:425-38. 2012
  8. pmc Evaluation of dermal myelinated nerve fibers in diabetes mellitus
    Amanda C Peltier
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Peripher Nerv Syst 18:162-7. 2013
  9. pmc Age-related changes in AMP-activated protein kinase after stroke
    Fudong Liu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    Age (Dordr) 34:157-68. 2012
  10. doi request reprint Fig4 expression in the rodent nervous system and its potential role in preventing abnormal lysosomal accumulation
    Jiasong Guo
    Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
    J Neuropathol Exp Neurol 71:28-39. 2012

Collaborators

Detail Information

Publications89

  1. pmc Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stroke 38:2992-9. 2007
    ..In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approaches in an in vivo stroke model...
  2. ncbi request reprint Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
    Jun Li
    Department of Neurology, University of Connecticut Health Centre, 263 Farmington Avenue, Farmington, CT 06030, USA
    Curr Med Chem 14:1807-13. 2007
    ..The exact mechanisms of the neuroprotection afforded by the polyamine antagonists and their clinical applicability is worthy of further study...
  3. ncbi request reprint The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1055:180-5. 2005
    ..These results clearly demonstrate the pre-ischaemic neuroprotective effect of N1-dansyl-spermine in a transient focal cerebral ischaemia model...
  4. ncbi request reprint The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1076:209-15. 2006
    ..These results demonstrate that BU43b administered 30 min before ischaemia provided a good level of neuroprotection in the two models of cerebral ischaemia used and may have potential as a neuroprotective treatment for stroke...
  5. ncbi request reprint The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice
    Jun Li
    Department of Pharmacology, School of Pharmacy, Trinity College Dublin, Ireland
    Brain Res 1029:84-92. 2004
    ..Moreover, in contrast to MK-801, N(1)-dansyl-spermine could be a promising therapeutic candidate for stroke as it is well tolerated at neuroprotective doses in sham-operated animals...
  6. doi request reprint Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice
    Qing Yan
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Neurol Sci 312:102-7. 2012
    ..Taken together, our results demonstrate that haploinsufficiency of fig4 does not impose risks in rodents to develop neuronal degeneration in either naïve or traumatic conditions...
  7. pmc NF-κB contributes to the detrimental effects of social isolation after experimental stroke
    Venugopal Reddy Venna
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Acta Neuropathol 124:425-38. 2012
    ..This suggests that NF-κB mediates the detrimental effects of SI...
  8. pmc Evaluation of dermal myelinated nerve fibers in diabetes mellitus
    Amanda C Peltier
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Peripher Nerv Syst 18:162-7. 2013
    ..This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with DPN...
  9. pmc Age-related changes in AMP-activated protein kinase after stroke
    Fudong Liu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    Age (Dordr) 34:157-68. 2012
    ..This has important translational relevance for the development of neuroprotective agents in preclinical models and our understanding of the enhanced metabolic stress experienced by the aged brain...
  10. doi request reprint Fig4 expression in the rodent nervous system and its potential role in preventing abnormal lysosomal accumulation
    Jiasong Guo
    Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
    J Neuropathol Exp Neurol 71:28-39. 2012
    ..We speculate that adequate levels of Fig4 may be required to prevent neurons and glia from excessive lysosomal accumulation after injury and in neurodegeneration...
  11. pmc Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke
    Jun Li
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Neurosci Lett 482:62-5. 2010
    ..This work demonstrates that AMPK activation is deleterious in experimental stroke, and this effect is independent of sex...
  12. pmc miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
    Chad Siegel
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 108:11662-7. 2011
    ..Embelin treatment significantly exacerbated stroke-induced injury in females but had no effect in males, demonstrating that XIAP is an important mediator of sex-specific responses after stroke...
  13. doi request reprint Distinct pathogenic processes between Fig4-deficient motor and sensory neurons
    Istvan Katona
    Department of Neurology, Wayne State University, Detroit, MI, USA
    Eur J Neurosci 33:1401-10. 2011
    ..These two distinct pathological changes may contribute to neuronal degeneration...
  14. pmc Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice
    L Christine Turtzo
    Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA
    Neurobiol Dis 54:421-31. 2013
    ..This response is sex-specific, and is in part independent of physiological serum levels of estrogen...
  15. pmc Functional recovery in aging mice after experimental stroke
    Bharti Manwani
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Brain Behav Immun 25:1689-700. 2011
    ..Reactive gliosis, formation of glial scar, and an enhanced innate immune response was seen in the aging brain and may contribute to the delayed behavioral recovery seen in the aging animals...
  16. pmc Sex differences in caspase activation after stroke
    Fudong Liu
    Department of Neurology and Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA
    Stroke 40:1842-8. 2009
    ..The aim of this study is to examine whether sex differences exist in caspase activation in adult mice after stroke and to determine if interference with stroke-induced caspase activation preferentially protects females...
  17. pmc Shortened internodal length of dermal myelinated nerve fibres in Charcot-Marie-Tooth disease type 1A
    Mario A Saporta
    Department of Neurology, Wayne State University, Detroit 48201, USA
    Brain 132:3263-73. 2009
    ..Intra-axonal accumulation of mitochondria provides new insights into the pathogenesis of axonal degeneration in Charcot-Marie-Tooth disease type 1A...
  18. pmc Neuropathy in a human without the PMP22 gene
    Mario Andre Saporta
    Department of Neurology, Wayne State University, Detroit, Michigan, USA
    Arch Neurol 68:814-21. 2011
    ..However, the biological functions of the PMP22 protein in humans have largely been unexplored owing to the absence of patients with PMP22-null mutations...
  19. pmc Sex differences in minocycline-induced neuroprotection after experimental stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Cereb Blood Flow Metab 29:670-4. 2009
    ..Clinical trials must consider possible sex differences in the response to neuroprotective agents, if we hope to translate promising therapies to stroke patients of both sexes...
  20. pmc Estrogen enhances neurogenesis and behavioral recovery after stroke
    Jun Li
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Cereb Blood Flow Metab 31:413-25. 2011
    ..Improved behavioral deficits were seen in E2-treated mice, suggesting that E2-induced increases in poststroke neurogenesis contribute to poststroke recovery...
  21. pmc Effects of metformin in experimental stroke
    Jun Li
    Department of Neurology, Farmington, CT 06030, USA
    Stroke 41:2645-52. 2010
    ..Metformin is a known AMPK activator but reduces stroke incidence in clinical populations. We investigated the effect of acute and chronic metformin treatment on infarct volume and AMPK activation in experimental stroke...
  22. pmc Sex differences in the response to poly(ADP-ribose) polymerase-1 deletion and caspase inhibition after stroke
    Fudong Liu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    Stroke 42:1090-6. 2011
    ..The effect of caspase inhibition in PARP-1 knockout mice was evaluated to determine if the detrimental effects of PARP deletion in females were secondary to increased caspase activation...
  23. pmc Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia
    Louise D McCullough
    Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA
    Stroke 44:2559-66. 2013
    ..Compelling evidence has suggested that CaMKK and its downstream kinase CaMK IV are critical in neuronal survival when cells are under ischemic stress. We examined the functional role of CaMKK/CaMK IV signaling in stroke...
  24. pmc Protection from cerebral ischemia by inhibition of TGFβ-activated kinase
    Benjamin J White
    University of Connecticut School of Medicine, Farmington, CT, USA
    Exp Neurol 237:238-45. 2012
    ..We studied the functional role of TAK1 and its mechanistic link with AMPK after stroke...
  25. pmc Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia
    Jun Li
    Department of Neurology and Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, United States
    Neurosci Lett 438:210-5. 2008
    ..Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors...
  26. pmc Effects of AMP-activated protein kinase in cerebral ischemia
    Jun Li
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Cereb Blood Flow Metab 30:480-92. 2010
    ..The interaction between AMPK and nitric oxide signaling is also discussed...
  27. pmc Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis
    Jun Li
    Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 76:1492-7. 2013
    ..Neither compound 1, compound 2, nor any of the other less active sesterterpenes suppressed breast tumor T47D or MDA-MB-231 cell viability...
  28. pmc PMP22 expression in dermal nerve myelin from patients with CMT1A
    Istvan Katona
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 132:1734-40. 2009
    ..The extra copy of PMP22 in CMT1A results in disruption of the tightly regulated expression of PMP22. Thus, variability of PMP22 levels, rather than absolute level of PMP22, may play an important role in the pathogenesis of CMT1A...
  29. pmc Evaluating dermal myelinated nerve fibers in skin biopsy
    M Iliza Myers
    Department of Neurology, A 0118 Medical Center North, 1161 21st Avenue South, Vanderbilt University, Nashville, Tennessee, 37232, USA
    Muscle Nerve 47:1-11. 2013
    ..The clinical relevance of a better understanding of the role of dermal myelinated nerve terminations in peripheral neuropathy will be addressed in light of recent publications in the growing field of skin biopsy...
  30. pmc Post-stroke hypothermia provides neuroprotection through inhibition of AMP-activated protein kinase
    Jun Li
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Neurotrauma 28:1281-8. 2011
    ..This suggests that AMPK represents a potentially important biological target for stroke treatment...
  31. doi request reprint Calcium/calmodulin-dependent protein kinase kinase β is neuroprotective in stroke in aged mice
    Lin Liu
    Department of Neurology, University of Texas Health Science Center, Houston, TX, 77030, USA
    Eur J Neurosci 44:2139-46. 2016
    ..We demonstrate that CaMKK β is neuroprotective in stroke in aged mice. Therefore, our data suggest that CaMKK β may be a potential target for reducing long-term disability after stroke. ..
  32. pmc Detection of copy number variation by SNP-allelotyping
    Brett Parker
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Neurogenet 29:4-7. 2015
    ..This finding suggests that this technique may serve as an alternative approach to identifying CNV in certain diseases, including CMT1A...
  33. pmc Loss of vascular early response gene reduces edema formation after experimental stroke
    Fudong Liu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, 06030, USA
    Exp Transl Stroke Med 4:12. 2012
    ..Verge deletion leads to decreased edema formation after ischemia; however acute stroke outcomes were unchanged...
  34. pmc Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration
    Xuebao Zhang
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 131:1990-2001. 2008
    ..This study represents the first documentation of the natural history of CMT4J. Physical obstruction of organelle trafficking by vacuoles is a potential novel cellular mechanism of neurodegeneration...
  35. ncbi request reprint Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family
    Jun Chen
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 411:333-42. 2008
    ..In summary, individual C1 domains of PKD isoforms differ in ligand-binding activity and selectivity, implying isoform-selective regulation of PKD by phorbol esters and DAG...
  36. pmc Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke
    Venugopal R Venna
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    Eur J Neurosci 39:2129-38. 2014
    ..The results from this study suggest that metformin mediates post-stroke recovery by enhancing angiogenesis, and these effects are mediated by AMPK signaling...
  37. pmc Glycolysis inhibitor screening identifies the bis-geranylacylphloroglucinol protonophore moronone from Moronobea coccinea
    Sandipan Datta
    Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 75:2216-22. 2012
    ..In the presence of rotenone, tumor cells may be hypersensitive to protonophores due to increased ATP utilization by the ATP synthase...
  38. doi request reprint Hypothesis of double polarization
    Jun Li
    Department of Neurology, John D Dingell VA Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurol Sci 275:33-6. 2008
    ..Thus, vulnerability of the nervous system may derive from additive impairments not only in axonal transport, but also in glial transport and neuronal-glial interactions...
  39. ncbi request reprint System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury
    Birgit Fogal
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 27:10094-105. 2007
    ....
  40. pmc Conduction block in PMP22 deficiency
    Yunhong Bai
    Department of Neurology, Wayne State University, Detroit, Michigan, USA
    J Neurosci 30:600-8. 2010
    ..Together, these results demonstrate that a function of Pmp22 is to protect the nerve from mechanical injury...
  41. pmc Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice
    Xianbin Tian
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Drug Metab Dispos 36:61-4. 2008
    ..Mrp2 clearly plays a major role in FEX biliary excretion in mice. In conclusion, remarkable species differences exist in FEX hepatobiliary transport mechanisms...
  42. pmc Akt1 gene deletion and stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington CT, 06030, United States
    J Neurol Sci 269:105-12. 2008
    ..Our study demonstrates the limitations of genetic mouse models and suggests that the importance of Akt to ischemic outcome remains unclear...
  43. pmc The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods
    Shixia Wang
    China US Vaccine Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Vaccine 26:2100-10. 2008
    ..These findings provide important information for the further selection and optimization of DNA vaccine delivery methods for human applications...
  44. doi request reprint Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration
    Wen Zhu
    Department of Neurology, The 1st Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    J Neurochem 105:1970-8. 2008
    ..Our study indicates that compared with selegiline, rasagiline is more potent in protecting neurodegeneration induced by UPS impairment and may, therefore, exert disease-modifying effects in PD...
  45. doi request reprint An excitatory role for peripheral EP3 receptors in bladder afferent function
    Xin Su
    Department of Urology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Am J Physiol Renal Physiol 295:F585-94. 2008
    ..EP3 receptors are involved in the regulation of bladder micturition and bladder nociception at the peripheral level...
  46. pmc Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts
    Cynthia L Leaphart
    Division of Pediatric Surgery, Rm 4A 486 DeSoto Wing, Children s Hospital of Pittsburgh, and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 295:G559-69. 2008
    ..Taken together, these findings suggest an important role for lipid raft-Cx43 interactions in the regulation of enterocyte migration during exposure to IFN, such as NEC...
  47. ncbi request reprint Effect of total flavonoids of Chrysanthemum indicum on the apoptosis of synoviocytes in joint of adjuvant arthritis rats
    Xiao Yu Chen
    School of Pharmacy, Anhui Medical University, Hefei 230032, China
    Am J Chin Med 36:695-704. 2008
    ..These results suggest that TFC could induce synoviocytes apoptosis and suppress proliferation of synoviocytes in adjuvant-induced arthritis rats...
  48. ncbi request reprint Real-time 3-dimensional echocardiography for quantification of the difference in left ventricular versus right ventricular stroke volume in a chronic animal model study: Improved results using C-scans for quantifying aortic regurgitation
    Xiaokui Li
    Clinical Care Center for Congenital Heart Disease, Oregon Health and Science University, Portland, OR 97239, USA
    J Am Soc Echocardiogr 17:870-5. 2004
    ....
  49. pmc Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice
    Fawzia Bardag-Gorce
    Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
    Exp Mol Pathol 84:113-21. 2008
    ..The results indicate that SAMe prevented the epigenetic cellular memory involved in the MDB formation...
  50. pmc Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis
    Joan Oliva
    Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson Street Torrance, CA 90509, USA
    Exp Mol Pathol 84:102-12. 2008
    ..The refeeding of DDC increased the percent of FAT10 hepatocytes...
  51. doi request reprint Age-related differences in postinfarct left ventricular rupture and remodeling
    Yining Yang
    Cardiovascular Research Institute, Xinjiang Medical University, Xinjinag, China
    Am J Physiol Heart Circ Physiol 294:H1815-22. 2008
    ....
  52. ncbi request reprint Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge
    Marc Busch
    California National Primate Research Center, University California Davis, County Road 98, Hutchison Drive, Davis, CA 95616, USA
    Vaccine 23:4036-47. 2005
    ..These results suggest that the delay in systemic infection resulting from delivery of SHIV 89.6 as a plasmid decreased the effectiveness of this live attenuated vaccine...
  53. ncbi request reprint Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury
    Jun Li
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite University Medicine Berlin, Germany
    FASEB J 19:617-9. 2005
    ..Our data indicate that cerebral AT2 receptors exert neuroprotective actions in response to ischemia-induced neuronal injury, possibly by supporting neuronal survival and neurite outgrowth in peri-ischemic brain areas...
  54. ncbi request reprint Pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes in mice
    Yong Jin
    Institute of Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, China
    Acta Pharmacol Sin 26:250-6. 2005
    ..To study the pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes (5-Fu-GCL) in mice...
  55. ncbi request reprint Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models
    Keun Su Kim
    Department of Neurosurgery, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Spine (Phila Pa 1976) 30:33-7. 2005
    ..A biochemical and radiologic comparison of 4 disc injury models to produce disc degeneration in the rabbit was carried out in 2 experiments...
  56. ncbi request reprint RNA interference of VCP/p97 increases Mallory body formation
    Li Nan
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90505, USA
    Exp Mol Pathol 78:1-9. 2005
    ..These results indicate that VCP plays an important role in inducing MB formation, probably through its molecular chaperone function in the ubiquitin-proteasome system (UPS)...
  57. ncbi request reprint ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo
    Sangwook Tim Yoon
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, GA, USA
    Spine (Phila Pa 1976) 29:2603-11. 2004
    ....
  58. ncbi request reprint Liver hypoxia and lack of recovery after reperfusion at high blood alcohol levels in the intragastric feeding model of alcohol liver disease
    Jun Li
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Exp Mol Pathol 77:184-92. 2004
    ..These results support the hypothesis that hypoxia occurs at the peaks of the BAL cycle and recovery from ischemia is impaired at the peaks...
  59. ncbi request reprint Are angiotensin receptor blockers neuroprotective?
    Christa Thone-Reineke
    Center for Cardiovascular Research CCR Institut für Pharmakologie und Toxikologie, Campus Charité Mitte Charité Universitätsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Curr Hypertens Rep 6:257-66. 2004
    ..In doing so, we also attempt to shed some light on the mechanisms by which AT1 receptor blockers, which leave the AT2 receptor unopposed, might exert protective actions in brain ischemia...
  60. ncbi request reprint The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation
    Fawzia Bardag-Gorce
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Exp Mol Pathol 76:9-16. 2004
    ..At the same time, the cells became dissociated from each other, however. The results simulated MB formation. MBs differ from cytokeratin aggresomes both morphologically and in ultrastructure...
  61. ncbi request reprint A novel recombinant antigen for immunodiagnosis of human cystic echinococcosis
    Jun Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia
    J Infect Dis 188:1951-60. 2003
    ..6%. The combined levels of sensitivity and specificity achieved with the rEpC1-GST fusion protein for diagnosis of CE are unprecedented, taking into account the large panel of serum samples that were tested...
  62. ncbi request reprint Immunoglobulin profiles in a murine intermediate host model of resistance for Echinococcus granulosus infection
    Wenbao Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland 4029, Australia
    Parasite Immunol 25:161-8. 2003
    ..i. The results suggest that protection against secondary infection was not principally antibody-mediated during the initial phases of infection, when cellular immune responses may play a pivotal role in the protective mechanism...
  63. ncbi request reprint Promoter usage and estrogen regulation of prolactin receptor gene in the brain of the female rat
    Xiujun Pi
    Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas 66160 7401, USA
    Neuroendocrinology 77:187-97. 2003
    ..Estrogen differentially regulates expression of the PRL-R mRNA in the different brain regions by increasing the utilization of PRL-R gene promoters 1A and 1C in the female rat...
  64. ncbi request reprint The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery
    Dongxin Wang
    Department of Anesthesiology, First Hospital, Peking University, No 8 Xishiku Street, Beijing 100034, China
    Anesth Analg 95:1134-41, table of contents. 2002
    ..6% versus 40.0%; P = 0.028). We conclude that intraoperative administration of lidocaine decreased the occurrence of cognitive dysfunction in the early postoperative period...
  65. ncbi request reprint Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction
    Jun Li
    Department of Internal Medicine II, University Hospital Benjamin Franklin, Free University Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Cardiovasc Res 56:235-47. 2002
    ..The possible relevance of MMPs in association with the inflammatory induction was investigated in a murine coxsackievirus B3 myocarditis model...
  66. ncbi request reprint A new model of hepatitis B virus reinfection: liver transplantation in the woodchuck1
    Uta Dahmen
    Department of General and Transplantation Surgery, University Hospital Essen, Germany
    Transplantation 74:373-80. 2002
    ..This was the reason to establish the technique of liver transplantation in the woodchuck, which is a widely used animal model for HBV infection...
  67. ncbi request reprint [The role of beta irradiation on neointimal formation and apoptosis in vein grafts model]
    Xiaoou Lang
    Department of General Surgery, First Clinical College, Chinese Medical University, Shenyang 110001, China
    Zhonghua Wai Ke Za Zhi 40:133-5. 2002
    ..To evaluate the effect of beta irradiation on intimal proliferation and apoptosis in vein grafts...
  68. ncbi request reprint Modified sleeve anastomosis for reconstruction of the hepatic artery in rat liver transplantation
    Jun Li
    Department of General and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Microsurgery 22:62-8. 2002
    ..This technical modification simplified the procedure of reconstructing the hepatic artery and could contribute to a wider use of the arterialized liver transplantation model in rats...
  69. ncbi request reprint [The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model]
    Hong Bin Lu
    Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China
    Zhonghua Yan Ke Za Zhi 41:533-9. 2005
    ..To observe the expression of heat shock protein 27 (HSP27) in retinal ganglion cells in experimental rat glaucoma model and to study the relationship between HSP27 expression and hypertension using serum autoantibodies...
  70. ncbi request reprint Microarray analysis of gene expression in the liver during the urinary ethanol cycle in rats fed ethanol intragastrically at a constant rate
    Barbara A French
    Department of Pathology, Harbor UCLA Medical Center and LABioMed Research Institute, 1000 W Carson St, Torrance, CA 90509, USA
    Exp Mol Pathol 79:87-94. 2005
    ..For instance, the importance of blood alcohol levels at the time that the assays were performed, profoundly changed the gene expression, protein level, and protein phosphorylation level profiles...
  71. ncbi request reprint Change of TH1/TH2 cytokine equilibrium in rats with severe sepsis and therapeutic effect of recombinant interleukin-12 and Shenmai injection
    Yong Hao Yu
    General Hospital of Tianjin Medical University, Tianjin
    Chin J Integr Med 11:136-41. 2005
    ....
  72. doi request reprint Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms
    Rong Li
    School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, China
    J Pharm Pharmacol 60:221-8. 2008
    ..Hesperidin may therefore have therapeutic value for the clinical treatment of RA. Further research is required to clarify the detailed mechanisms of the protective effects of hesperidin on AA...
  73. ncbi request reprint Co-transplantation of neural stem cells and NT-3-overexpressing Schwann cells in transected spinal cord
    Xuebao Zhang
    Department of Histology and Embryology, Institute of Spinal Cord Injury, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    J Neurotrauma 24:1863-77. 2007
    ..However, this pre-differentiation of NSCs in vitro only mildly improved neuronal differentiation of NSCs in vivo...
  74. ncbi request reprint Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death
    Judy T T Zhu
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China
    J Agric Food Chem 55:2438-45. 2007
    ..Identification of these flavonoids could be very useful in finding potential drugs, or food supplements, for treating Alzheimer's disease...
  75. ncbi request reprint Cloning and expression pattern of dog SDF-1 and the implications of altered expression of SDF-1 in ischemic myocardium
    Ying Jie Wei
    Key Laboratory of Cardiovascular Regenerative Medicine, Ministry of Health, and Department of Cardiovascular Surgery, Cardiovascular Institute and Fu Wai Hospital, PUMC and CAMS, 167 Beilishilu, Beijing 100037, China
    Cytokine 40:52-9. 2007
    ..Our results provide insights into expression pattern and pathophysiologic significance of dog SDF-1 in normal and heart-damaged dogs...
  76. ncbi request reprint Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on intestinal function in streptozotocin-induced diabetic rats
    Yoshihiko Hirotani
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University, Nishikiorikita, Tondabayashi City, Japan
    Yakugaku Zasshi 127:1509-13. 2007
    ..These results suggest that HJ may normalize or suppress the small intestinal disaccharidase activity and the epithelial cell proliferation mediated by GLP-2 in the animal model rats...
  77. ncbi request reprint Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis
    Rahul J Anand
    Division of Pediatric Surgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Pediatr Surg 42:927-32; discussion 933. 2007
    ..We hypothesized that TLR4 regulates bacterial clearance from the peritoneal cavity and sought to investigate whether macrophage phagocytosis was involved...
  78. pmc The beta2 adrenergic receptor regulates morphine tolerance and physical dependence
    De Yong Liang
    Veterans Affairs Palo Alto Health Care System, Stanford University, Department of Anesthesiology, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Behav Brain Res 181:118-26. 2007
    ..Therefore, beta2-AR antagonists show some promise as agents to enhance chronic opioid analgesic therapy...
  79. pmc Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells
    Qifei Rong
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People s Republic of China
    Virol J 4:36. 2007
    ....
  80. ncbi request reprint Preservation of the pHi during ischemia via PKC by intermittent hypoxia
    Jun Li
    Laboratory of Molecular Cardiology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine SJTUSM corrected Shanghai 200025, China
    Biochem Biophys Res Commun 356:329-33. 2007
    ..Our data suggest that the stable PKC activation might contribute to preservation of the pH(i), which may be beneficial to maintain cardiac function during I/R in IHA rats...
  81. ncbi request reprint A pharmacokinetic formalism explicitly integrating the patient drug compliance
    Jun Li
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec H3C3J7, Canada
    J Pharmacokinet Pharmacodyn 34:115-39. 2007
    ..This analytical approach allows to characterize drug concentration variations directly inherited from patient compliance...
  82. ncbi request reprint Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared
    Fawzia Bardag-Gorce
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Exp Mol Pathol 80:241-51. 2006
    ..These two enzymes have antioxidant effects. In summary, remarkably similar responses to high alcohol levels in the form of changes in gene expression pathways were found in the in vivo and in vitro models tested...
  83. ncbi request reprint Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats
    Steffen Sandmann
    Center for Cardiovascular Research CCR Institute of Pharmacology and Toxicology, Charite University Medicine Berlin, Germany
    Blood Press 15:116-28. 2006
    ....
  84. pmc Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models
    Qing He Nie
    Chinese PLA Centre of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    World J Gastroenterol 12:3044-9. 2006
    ..To evaluate serum TIMP-1 level and the correlation between TIMP-1 expression and liver fibrosis in immune-induced and CCL4-induced liver fibrosis models in rats...
  85. ncbi request reprint Rapid induction and activation of Tec tyrosine kinase in liver regeneration
    Si Ying Wang
    Department of Pathophysiology, Anhui Medical University, Hefei, China
    J Gastroenterol Hepatol 21:668-73. 2006
    ..The purpose of the present study was to further investigate the potential involvement of Tec tyrosine kinase in hepatocyte proliferation and liver regeneration...
  86. ncbi request reprint High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    Yuhong Zou
    Institute of Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Heifei, 230032 Anhui Province, China
    Life Sci 79:1100-7. 2006
    ..This model provides a valuable research tool and reproduces many of the clinical indices of human NASH...
  87. ncbi request reprint Evaluation of a bioartificial liver based on a nonwoven fabric bioreactor with porcine hepatocytes in pigs
    Lan Juan Li
    Key Laboratory of Infectious Diseases, Ministry of Public Health, Department of Infectious Diseases, The 1st Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    J Hepatol 44:317-24. 2006
    ..We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model...
  88. ncbi request reprint Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats
    Yan Huang
    School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China 230032
    Life Sci 78:2749-57. 2006
    ..These results suggest that TAL inhibits HO-1 expression and MDA production and up-regulates SOD expression in AM from CB rats, which might be one of molecular mechanisms of its anti-inflammatory effects in CB rats...
  89. ncbi request reprint Lymphocyte activation with localized pGL1-TNF-alpha gene therapy in a glioma model
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Oncology 62:66-77. 2002
    ....