Haishan Li

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Mol Immunol 10:42-9. 2013
  2. pmc Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Clin Immunol 128:349-57. 2008
  3. pmc Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Retrovirology 10:60. 2013
  4. pmc Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cells
    Elizabeth M Urban
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Immunol 10:50. 2009
  5. pmc Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St Rm N546, Baltimore, MD 21201, USA
    Cancer Immunol Immunother 60:361-70. 2011
  6. pmc Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e7726. 2009
  7. pmc HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 118:5824-31. 2011
  8. pmc Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells
    Sarah Boudová
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 205:1448-55. 2012
  9. pmc TNF-alpha is a positive regulatory factor for human Vgamma2 Vdelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:7131-7. 2008
  10. pmc Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
    Immunology 132:96-103. 2011

Collaborators

Detail Information

Publications12

  1. pmc Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Mol Immunol 10:42-9. 2013
    ..This field is moving toward immune therapies based on targeting Vδ2 cells and we now have clear goals and expectations to guide interventional clinical trials...
  2. pmc Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Clin Immunol 128:349-57. 2008
    ..2Vdelta2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV...
  3. pmc Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Retrovirology 10:60. 2013
    ..The outcomes of Env binding are analyzed in terms of signal transduction and the effects on cell activation or cell death pathways...
  4. pmc Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cells
    Elizabeth M Urban
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Immunol 10:50. 2009
    ..Our goal was to show whether CD56 expression was regulated stochastically, similar to conventional activation antigens, or whether CD56 defined a lineage of cells committed to the cytotoxic phenotype...
  5. pmc Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St Rm N546, Baltimore, MD 21201, USA
    Cancer Immunol Immunother 60:361-70. 2011
    ..Rapamycin treatment during antigen-stimulation of Vγ2Vδ2 T cells may be a strategy for overcoming current obstacles in tumor immunotherapy...
  6. pmc Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e7726. 2009
    ..Their effects on gammadelta T cells, which are involved in animal model and human and animal autoimmune diseases, are unknown...
  7. pmc HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 118:5824-31. 2011
    ..Cell death was increased by antigen stimulation after exposure to envelope glycoprotein. Direct signaling by envelope glycoprotein killed CD4-negative γδ T cells and reproduced a defect observed in all patients with HIV disease...
  8. pmc Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells
    Sarah Boudová
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 205:1448-55. 2012
    ..By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia...
  9. pmc TNF-alpha is a positive regulatory factor for human Vgamma2 Vdelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:7131-7. 2008
    ..Our studies demonstrate that TNF-alpha plays a critical role in regulating human Vgamma2 Vdelta2 T cell immune responses...
  10. pmc Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
    Immunology 132:96-103. 2011
    ..The TCR has a specific role in Vγ2Vδ2 T-cell killing of tumour cells, which is distinct from its role in triggering cellular proliferation in response to phosphoantigens...
  11. pmc CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Eur J Immunol 45:298-308. 2015
    ..CD25 expression on Tfh cells and local production of IL-2 in tonsil or lymph node may support B helper T-cell function during later stages of B-cell maturation and the development of immune memory. ..
  12. pmc Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells
    Haishan Li
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    J Infect Dis 195:37-45. 2007
    ..Increased VV replication or expression in the absence of gammadelta T cell responses might contribute to its potency as a vaccine against poxvirus and recombinant antigens...