Genomes and Genes
Affiliation: University of California
- Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editingFeng Li
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 108:3542-7. 2011....
- Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger proteinGuanghan Gao
Department of Cardiodiagnostics, 200 UCLA Medical Plaza, Suite 330, Los Angeles, CA 90095, USA
Protist 161:489-96. 2010..The specificity for REL1 is consistent with MP63 being a component of the REL1 subcomplex. These results suggest that in vivo the interaction of MP63 with REL1 may play a role in regulating the overall activity of RNA editing...
- Uridine insertion/deletion RNA editing in trypanosomatid mitochondria: In search of the editosomeDaren Osato
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
RNA 15:1338-44. 2009..We suggest that the L*b-complexes may provide a scaffold for dynamic interaction with other editing factors during the editing process to form the active holoenzyme or "editosome."..
- Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondriaFeng Li
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:12306-10. 2009..The REL1 ligase was localized on the model to the base of the apex by decoration with REL1-specific IgG. This structure should prove useful for a detailed analysis of the editing reaction...
- Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in DrosophilaRoghiyh Aliyari
Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA
Cell Host Microbe 4:387-97. 2008..Our findings, therefore, provide a model in which small RNA-directed viral immunity is induced during the initiation of viral progeny (+)RNA synthesis and suppressed by B2 inside the viral RNA replication complex...
- Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligaseGuanghan Gao
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 102:4712-7. 2005..The ability to perform functional complementation in vitro provides a powerful tool for molecular dissection of the editing reaction...
- SoMART: a web server for plant miRNA, tasiRNA and target gene analysisFeng Li
Department of Plant and Microbial Biology, Plant Gene Expression Center, University of California, Berkeley, USA
Plant J 70:891-901. 2012..We further tested and confirmed the efficiency and accuracy of the server by analyses of 21 validated miRNA targets and 115 miRNA precursors in Arabidopsis thaliana. SoMART is available at http://somart.ist.berkeley.edu...
- MicroRNA regulation of plant innate immune receptorsFeng Li
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 109:1790-5. 2012..Our results demonstrate a conserved role for miRNAs and secondary siRNAs in NB-LRR/LRR immune receptor gene regulation and pathogen resistance in Solanaceae...
- Identification of miniature inverted-repeat transposable elements (MITEs) and biogenesis of their siRNAs in the Solanaceae: new functional implications for MITEsHanhui Kuang
Plant Gene Expression Center, Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California 94720, USA
Genome Res 19:42-56. 2009..We provide evidence that DICER-LIKE4 (DCL4) may also play a role in MITE siRNA generation in the Solanaceae...
- Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAsJuan A Diaz-Pendon
Center for Plant Cell Biology, Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
Plant Cell 19:2053-63. 2007....
- Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolaeLarry Simpson
Department of Microbiology, Immunology and Molecular Genetics, Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California, United States of America
PLoS Negl Trop Dis 9:e0003841. 2015..These data should provide the foundation for a deeper understanding of this dynamic genetic system as well as the evolutionary variation of editing in different strains. ..
- Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB functionXiaofei Gao
Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
PLoS Pathog 5:e1000708. 2009..coli infection. We suggest that NleH may disrupt host innate immune responses by binding to a cofactor of host transcriptional complexes...
- Virus counterdefense: diverse strategies for evading the RNA-silencing immunityFeng Li
Graduate Program for Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA
Annu Rev Microbiol 60:503-31. 2006..We propose that VSR families are evolved independently as a viral adaptation to immunity. Unresolved issues on the role of RNA silencing in virus-host interactions are highlighted...