Genomes and Genes
Leonid E Lerner
Affiliation: University of Pennsylvania
- Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with CrxLeonid E Lerner
Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Biol Chem 280:20642-50. 2005..The other Sp family members may be involved in photoreceptor-specific transcription directly or through their competition with Sp4. These data suggest the potential importance of Sp4 in retinal neurobiology and pathology...
- The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRXLeonid E Lerner
Jules Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Biol Chem 277:25877-83. 2002..We found that it binds purified TBP and TFIIB in gel mobility shift assays with cooperative enhancement of binding affinity...
- Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degenerationEric H Souied
Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
Exp Eye Res 87:168-75. 2008..Therefore, transscleral iontophoresis of plasmid DNA containing therapeutic genes may be an efficient, safe and non-invasive method for the treatment of retinal degenerations...
- Transcriptional and post-transcriptional regulation of the rod cGMP-phosphodiesterase beta-subunit gene. Recent advances and current conceptsLeonid E Lerner
Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Adv Exp Med Biol 572:217-29. 2006