Robert F Lera

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
  2. pmc Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin Hematology Oncology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Mol Cancer Ther 15:48-59. 2016
  3. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:13026-31. 2013
  4. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
  5. pmc Decoding Polo-like kinase 1 signaling along the kinetochore-centromere axis
    Robert F Lera
    Department of Medicine, Hematology Oncology Division, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Chem Biol 12:411-8. 2016

Collaborators

  • Mark E Burkard
  • Beth A Weaver
  • Ryan A Denu
  • Alka Choudhary
  • Jennifer J Laffin
  • Sandeep Saha
  • Josephine M Harter
  • Kari B Wisinski
  • Hyunjung Kim
  • Lauren M Zasadil
  • Brittany Zachek
  • Craig Kanugh
  • Amber Lasek
  • Melissa L Martowicz
  • Kim Oxendine

Detail Information

Publications5

  1. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
    ..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
  2. pmc Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin Hematology Oncology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Mol Cancer Ther 15:48-59. 2016
    ..We conclude that polyploid breast cancers represent a high-risk subgroup and that DPBQ provides a functional core to develop polyploid-selective therapy. Mol Cancer Ther; 15(1); 48-59. ©2015 AACR. ..
  3. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:13026-31. 2013
    ..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity...
  4. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
    ..These results demonstrate that different thresholds of Plk1 activity can elicit distinct phenotypes, illustrating a general method for separating pleiotropic functions of a protein kinase even when these are executed close in time...
  5. pmc Decoding Polo-like kinase 1 signaling along the kinetochore-centromere axis
    Robert F Lera
    Department of Medicine, Hematology Oncology Division, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Chem Biol 12:411-8. 2016
    ..Although complex, this multiplicity of locales provides an opportunity to decouple functional and phosphoproteomic signatures for a comprehensive understanding of Plk1's kinetochore functions. ..