Andrew M Lee

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus
    Andrew M Lee
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 442:114-21. 2013
  2. pmc Persistent LCMV infection is controlled by blockade of type I interferon signaling
    John R Teijaro
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 340:207-11. 2013
  3. pmc Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
    Cherie T Ng
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 17:653-61. 2015
  4. pmc Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence
    Brian M Sullivan
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2969-74. 2011
  5. pmc Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis
    Landon R Whitby
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3771-4. 2009
  6. pmc Novel approaches in anti-arenaviral drug development
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 411:163-9. 2011
  7. pmc Extraneural manifestations of prion infection in GPI-anchorless transgenic mice
    Andrew M Lee
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 411:1-8. 2011
  8. pmc Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:18734-42. 2008
  9. pmc IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
  10. pmc Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest
    Daniel L Popkin
    The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:7928-32. 2011

Collaborators

Detail Information

Publications10

  1. pmc Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus
    Andrew M Lee
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 442:114-21. 2013
    ..Interestingly, adoptive transfer of rLCMV Cl13/LASV Gp immune memory cells into such persistently infected mice failed to purge virus but, in contrast, cleared virus from mice persistently infected with wt LCMV Cl13...
  2. pmc Persistent LCMV infection is controlled by blockade of type I interferon signaling
    John R Teijaro
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 340:207-11. 2013
    ..Our results suggest that therapies targeting IFN-I may help control persistent virus infections...
  3. pmc Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
    Cherie T Ng
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 17:653-61. 2015
    ..Thus, despite their use of the same receptor, IFNβ and IFNα have unique and distinguishable biologic functions, with IFNβ being mainly responsible for promoting viral persistence...
  4. pmc Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence
    Brian M Sullivan
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2969-74. 2011
    ..This work emphasizes the importance of subtle differences in viral strains that determine disease outcomes...
  5. pmc Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis
    Landon R Whitby
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3771-4. 2009
    ..A limited deletion scan of lassamycin-1 defined key structural features required of the prototypical inhibitors...
  6. pmc Novel approaches in anti-arenaviral drug development
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 411:163-9. 2011
    ....
  7. pmc Extraneural manifestations of prion infection in GPI-anchorless transgenic mice
    Andrew M Lee
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 411:1-8. 2011
    ..By high-resolution electron microscopy, we show PrP is located primarily in α cells and also β cells. Islets contain abundant insulin and there is no abnormality in glucose metabolism in infected GPI⁻/⁻ PrP tg mice...
  8. pmc Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:18734-42. 2008
    ....
  9. pmc IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  10. pmc Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest
    Daniel L Popkin
    The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:7928-32. 2011
    ..These findings demonstrate the utility of tripartite LCMV in vitro and in vivo to study genes in the context of a well-defined model system...