Cathy C Laurie

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants
    Cathy C Laurie
    Biostatistics Department, University of Washington, Seattle, WA, USA Electronic address
    Cancer Genet 207:19-30. 2014
  2. pmc Detectable clonal mosaicism from birth to old age and its relationship to cancer
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Nat Genet 44:642-50. 2012
  3. pmc Genome-wide association scan of dental caries in the permanent dentition
    Xiaojing Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    BMC Oral Health 12:57. 2012
  4. pmc Imputation-based genomic coverage assessments of current human genotyping arrays
    Sarah C Nelson
    Department of Biostatistics, University of Washington, Seattle, Washington, 98195
    G3 (Bethesda) 3:1795-807. 2013
  5. pmc Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL)
    Jean Morrison
    Department of Biostatistics, University of Washington, Seattle, WA 98077, USA
    Hum Mol Genet 25:807-16. 2016
  6. pmc Meta-Analysis of Genome-Wide Association Studies with Correlated Individuals: Application to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
    Tamar Sofer
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    Genet Epidemiol 40:492-501. 2016
  7. pmc Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models
    Han Chen
    Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 98:653-66. 2016
  8. pmc Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos
    Matthew P Conomos
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 98:165-84. 2016
  9. pmc GWASTools: an R/Bioconductor package for quality control and analysis of genome-wide association studies
    Stephanie M Gogarten
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    Bioinformatics 28:3329-31. 2012
  10. pmc Local Ancestry Inference in a Large US-Based Hispanic/Latino Study: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
    Sharon R Browning
    Department of Biostatistics, University of Washington, Seattle, Washington 98195
    G3 (Bethesda) 6:1525-34. 2016

Collaborators

Detail Information

Publications16

  1. pmc Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants
    Cathy C Laurie
    Biostatistics Department, University of Washington, Seattle, WA, USA Electronic address
    Cancer Genet 207:19-30. 2014
    ..However, the patients from E2997 (and other studies of symptomatic CLL) have recurrent acquired anomalies that were not found in GENEVA participants, thus identifying genomic changes that may be unique to symptomatic stages of CLL. ..
  2. pmc Detectable clonal mosaicism from birth to old age and its relationship to cancer
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Nat Genet 44:642-50. 2012
    ....
  3. pmc Genome-wide association scan of dental caries in the permanent dentition
    Xiaojing Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    BMC Oral Health 12:57. 2012
    ..Therefore, we conducted the first genome-wide association study (GWAS) to identify genes affecting susceptibility to caries in adults...
  4. pmc Imputation-based genomic coverage assessments of current human genotyping arrays
    Sarah C Nelson
    Department of Biostatistics, University of Washington, Seattle, Washington, 98195
    G3 (Bethesda) 3:1795-807. 2013
    ..These imputation-based genomic coverage and power analyses are intended as a practical guide to researchers planning genetic studies. ..
  5. pmc Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL)
    Jean Morrison
    Department of Biostatistics, University of Washington, Seattle, WA 98077, USA
    Hum Mol Genet 25:807-16. 2016
    ....
  6. pmc Meta-Analysis of Genome-Wide Association Studies with Correlated Individuals: Application to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
    Tamar Sofer
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    Genet Epidemiol 40:492-501. 2016
    ..050 (pooled) to λGC=1.028 (MetaCor). Furthermore, even after removing close relatives to obtain nearly uncorrelated strata, a naïve stratified analysis resulted in λGC=1.058 compared to λGC=1.027 for MetaCor. ..
  7. pmc Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models
    Han Chen
    Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 98:653-66. 2016
    ..We show in simulation studies and real data analysis that GMMAT effectively controls for population structure and relatedness when analyzing binary traits in a wide variety of study designs. ..
  8. pmc Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos
    Matthew P Conomos
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 98:165-84. 2016
    ..We expect that the methods applied here will be useful in other studies with multiple ethnic groups, admixture, and relatedness. ..
  9. pmc GWASTools: an R/Bioconductor package for quality control and analysis of genome-wide association studies
    Stephanie M Gogarten
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    Bioinformatics 28:3329-31. 2012
    ..GWASTools provides a convenient interface for linking genotypes and intensity data with sample and single nucleotide polymorphism annotation...
  10. pmc Local Ancestry Inference in a Large US-Based Hispanic/Latino Study: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
    Sharon R Browning
    Department of Biostatistics, University of Washington, Seattle, Washington 98195
    G3 (Bethesda) 6:1525-34. 2016
    ..It also provides a basis for admixture mapping and ancestry-specific allele frequency estimation, which are useful in the identification of risk factors for disease. ..
  11. pmc Improved imputation accuracy in Hispanic/Latino populations with larger and more diverse reference panels: applications in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
    Sarah C Nelson
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 25:3245-3254. 2016
    ..Our findings can inform imputation design for other genome-wide association studies of participants with diverse ancestries, especially as larger and more diverse reference panels continue to become available...
  12. pmc Quality control and quality assurance in genotypic data for genome-wide association studies
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Genet Epidemiol 34:591-602. 2010
    ..The methods are illustrated with examples from the "Gene Environment Association Studies" (GENEVA) program. The results suggest several recommendations for QC/QA in the design and execution of GWAS...
  13. pmc A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL
    Tamar Sofer
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    Genet Epidemiol . 2017
    ..But when testing all SNPs with P-values <6.6×10-5 (89 regions), we generalized SNPs from 27 regions...
  14. pmc Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans
    Ursula M Schick
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Am J Hum Genet 98:229-42. 2016
    ..Our results underscore the value of diverse populations to extend insights into the allelic architecture of complex traits. ..
  15. doi Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States
    Lisa A Brown
    Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington
    J Am Soc Nephrol . 2017
    ..01; n=1568). Our findings provide evidence for the presence of Amerindian-specific variants influencing the variation of urine albumin excretion in Hispanics/Latinos...
  16. pmc Using family data as a verification standard to evaluate copy number variation calling strategies for genetic association studies
    Xiaojing Zheng
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genet Epidemiol 36:253-62. 2012
    ..But if we understand the error process, we can still use CNV calls appropriately in genetic association studies...