Alan Laties

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration
    David G Birch
    Retina Foundation of the Southwest, Dallas, Texas 75231, USA
    Am J Ophthalmol 133:665-72. 2002
  2. doi request reprint Cataractogenic potential of quetiapine versus risperidone in the long-term treatment of patients with schizophrenia or schizoaffective disorder: a randomized, open-label, ophthalmologist-masked, flexible-dose, non-inferiority trial
    Alan M Laties
    University of Pennsylvania, Philadelphia, PA, USA
    J Psychopharmacol 29:69-79. 2015
  3. ncbi request reprint Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction
    Alan Laties
    Scheie Eye Institute, University of Pennsylvania Medical School Department of Ophthalmology, Philadelphia, PA 19104, USA
    J Sex Med 3:12-27. 2006
  4. doi request reprint Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date
    Alan M Laties
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Drug Saf 32:1-18. 2009
  5. ncbi request reprint Viagra (sildenafil citrate) and ophthalmology
    Alan Laties
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Medical School, Myrin Circle, 51 N 39th Street, Philadelphia, PA 19104, USA
    Prog Retin Eye Res 21:485-506. 2002
  6. doi request reprint CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:407-13. 2008
  7. ncbi request reprint Regulation of rod phototransduction machinery by ciliary neurotrophic factor
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:13523-30. 2006
  8. ncbi request reprint Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter
    Ying Song
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 44:4069-75. 2003
  9. pmc Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo
    Huiling Hu
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Exp Eye Res 91:425-32. 2010
  10. pmc The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells
    Mei Zhang
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6085, USA
    Neurochem Int 56:35-41. 2010

Research Grants

  1. EXCITATORY AMINO ACIDS IN GLAUCOMA
    Alan Laties; Fiscal Year: 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration
    David G Birch
    Retina Foundation of the Southwest, Dallas, Texas 75231, USA
    Am J Ophthalmol 133:665-72. 2002
    ..To assess the effects of a single 100-mg dose of sildenafil citrate on visual function in men with early-stage age-related macular degeneration...
  2. doi request reprint Cataractogenic potential of quetiapine versus risperidone in the long-term treatment of patients with schizophrenia or schizoaffective disorder: a randomized, open-label, ophthalmologist-masked, flexible-dose, non-inferiority trial
    Alan M Laties
    University of Pennsylvania, Philadelphia, PA, USA
    J Psychopharmacol 29:69-79. 2015
    ....
  3. ncbi request reprint Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction
    Alan Laties
    Scheie Eye Institute, University of Pennsylvania Medical School Department of Ophthalmology, Philadelphia, PA 19104, USA
    J Sex Med 3:12-27. 2006
    ..No consistent pattern has emerged to suggest any long-term effect of sildenafil on the retina or other structures of the eye or on the ocular circulation...
  4. doi request reprint Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date
    Alan M Laties
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Drug Saf 32:1-18. 2009
    ....
  5. ncbi request reprint Viagra (sildenafil citrate) and ophthalmology
    Alan Laties
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Medical School, Myrin Circle, 51 N 39th Street, Philadelphia, PA 19104, USA
    Prog Retin Eye Res 21:485-506. 2002
    ..Based on this experience, intermittent, short-term, partial inhibition of PDE5 or PDE6 by sildenafil is unlikely to induce any long-term visual change...
  6. doi request reprint CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:407-13. 2008
  7. ncbi request reprint Regulation of rod phototransduction machinery by ciliary neurotrophic factor
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:13523-30. 2006
    ..Whether CNTF-induced changes in rods are through the same mechanism that mediates light-induced photoreceptor plasticity remains to be answered...
  8. ncbi request reprint Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter
    Ying Song
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 44:4069-75. 2003
    ..This work examines the effects of cardiotrophin (CT)-1 on photoreceptor survival in transgenic rats that carry the rhodopsin mutation S334ter...
  9. pmc Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo
    Huiling Hu
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Exp Eye Res 91:425-32. 2010
    ..This implies that the balance between extracellular ATP and its protective metabolite adenosine can influence ganglion cell survival in the living eye...
  10. pmc The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells
    Mei Zhang
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6085, USA
    Neurochem Int 56:35-41. 2010
    ..It remains to be determined if partial block of the calcium rise by A(3) agonists can modify downstream responses to NMDA receptor stimulation...
  11. pmc Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
    Lian Zhao
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Mol Vis 13:873-80. 2007
    ..The biogenesis of sub-RPE deposits remains elusive. This work explores the pathological processes of sub-RPE deposit formation...
  12. ncbi request reprint Identification of the A3 adenosine receptor in rat retinal ganglion cells
    Mei Zhang
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Mol Vis 12:937-48. 2006
    ..We combined laser capture microdisection (LCM) and immunopurification with traditional and real-time PCR to unequivocally demonstrate the presence of the A3 receptor message in rat retinal ganglion cells...
  13. ncbi request reprint Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation
    Xiulan Zhang
    Department of Ophthalmology, University of Pensylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
    J Neurochem 98:566-75. 2006
    ..Hydrolysis of ATP into adenosine and perhaps inosine shifts the balance of purinergic action from that of death to the preservation of life...
  14. ncbi request reprint Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells
    Xiulan Zhang
    Department of Ophthalmology, University of Pennsylvania, Philadephia, 19104, USA
    Invest Ophthalmol Vis Sci 46:2183-91. 2005
    ..Stimulation of these receptors in other cells can elevate Ca(2+) and sometimes lead to cell death. This study asked whether P2X(7) receptor stimulation alters the Ca(2+) levels and viability of retinal ganglion cells...
  15. ncbi request reprint A 4-year update on the safety of sildenafil citrate (Viagra)
    Harin Padma-Nathan
    The Male Clinic, Keck School of Medicine at the University of Southern California School of Medicine, Beverly Hills, California, USA
    Urology 60:67-90. 2002
    ..Lastly, we review the specific effects on the visual system based on findings from studies conducted during drug development and post marketing...
  16. ncbi request reprint Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    Weng Tao
    Neurotech USA, Lincoln, Rhode Island 02865, USA
    Invest Ophthalmol Vis Sci 43:3292-8. 2002
    ..The dose-range effect of the treatment was also investigated...

Research Grants1

  1. EXCITATORY AMINO ACIDS IN GLAUCOMA
    Alan Laties; Fiscal Year: 2004
    ..These experiments will help test the central hypothesis--for if one can block the effects of IOP elevation with glutamate antagonists, then elevated 10P may toxic glutamate levels ganglion cell loss. ..