PHILIP LANDFIELD

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
    Olivier Thibault
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Aging Cell 6:307-17. 2007
  2. pmc Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging
    Kuey Chu Chen
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Endocrinology 154:2807-20. 2013
  3. pmc Statistical implications of pooling RNA samples for microarray experiments
    Xuejun Peng
    Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
    BMC Bioinformatics 4:26. 2003
  4. pmc A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease
    Philip W Landfield
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Curr Alzheimer Res 4:205-12. 2007
  5. ncbi request reprint Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, 800 Rose Street, MS 310, University of Kentucky Medical Center, Lexington, 40536 0298, USA
    Cell Calcium 40:277-86. 2006
  6. ncbi request reprint Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Brain Res 1151:20-31. 2007
  7. pmc Estradiol reverses a calcium-related biomarker of brain aging in female rats
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 29:6058-67. 2009
  8. pmc Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
    Christopher M Norris
    Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 25:4649-58. 2005
  9. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
  10. pmc Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 30:6058-71. 2010

Research Grants

  1. MULTIUSER AFFYMETRIX GENE CHIP SYSTEM
    PHILIP LANDFIELD; Fiscal Year: 2001
  2. NOVEL METHODS FOR SINGLE NEURON GENE/FUNCTION STUDIES
    PHILIP LANDFIELD; Fiscal Year: 2001
  3. Calcium Regulation in Brain Aging & Alzheimer's Disease
    PHILIP LANDFIELD; Fiscal Year: 2008

Collaborators

Detail Information

Publications15

  1. pmc Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
    Olivier Thibault
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Aging Cell 6:307-17. 2007
    ..In turn, the increased transients result in dysregulation of multiple Ca2+-dependent processes and, through somewhat different pathways, in accelerated functional decline during aging and AD...
  2. pmc Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging
    Kuey Chu Chen
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Endocrinology 154:2807-20. 2013
    ..Therefore, we propose a new model in which aging-related GC resistance develops in some target pathways, whereas GC overstimulation develops in others, together generating much of the brain aging phenotype. ..
  3. pmc Statistical implications of pooling RNA samples for microarray experiments
    Xuejun Peng
    Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
    BMC Bioinformatics 4:26. 2003
    ..However, the statistical, technical and financial implications of pooling have not been explicitly investigated...
  4. pmc A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease
    Philip W Landfield
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Curr Alzheimer Res 4:205-12. 2007
    ..We also propose that changes in GC efficacy might be mediated in part by cell type specific shifts in the antagonistic balance between GC and insulin actions, which may be of relevance for Alzheimer's disease pathogenesis...
  5. ncbi request reprint Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, 800 Rose Street, MS 310, University of Kentucky Medical Center, Lexington, 40536 0298, USA
    Cell Calcium 40:277-86. 2006
    ..Thus, these results may have therapeutic implications and suggest that 1,25VitD, often taken to maintain bone health, may also retard some consequences of brain aging...
  6. ncbi request reprint Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Brain Res 1151:20-31. 2007
    ....
  7. pmc Estradiol reverses a calcium-related biomarker of brain aging in female rats
    Lawrence D Brewer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 29:6058-67. 2009
    ..2 LTCC subunit, but not the Ca(v)1.3 subunit, was decreased in aged E2-treated rats. Thus, the reported benefits of E2 on cognition and neuronal health may be attributed, at least in part, to its age-related decrease in LTCC current...
  8. pmc Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
    Christopher M Norris
    Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 25:4649-58. 2005
    ..Thus, the data identify calcineurin upregulation in astrocytes as a novel candidate for an intracellular trigger of astrogliosis, particularly in aging and AD brain...
  9. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
    ..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging...
  10. pmc Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 30:6058-71. 2010
    ..In turn, these MSI-associated neuroenergetic changes may promote inflammation, neuronal vulnerability, and risk of cognitive impairment/AD...
  11. pmc Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging
    Christopher M Norris
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:328-38. 2010
    ..Thus, these studies point to altered CN function as a novel and potentially key factor in aging-dependent neuronal Ca(2+) dysregulation...
  12. ncbi request reprint Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurosci 23:3807-19. 2003
    ....
  13. ncbi request reprint Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:3482-90. 2006
    ..Thus, this study provides the first evidence that altered CICR plays a role in driving the early and simultaneous emergence in hippocampus of multiple Ca2+-related biomarkers of aging...
  14. pmc Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, Spinal Cord and Brain Injury Research Center, and Sanders Brown Research Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:2173-8. 2004
    ..These findings suggest a new model of AD pathogenesis in which a genomically orchestrated up-regulation of tumor suppressor-mediated differentiation and involution processes induces the spread of pathology along myelinated axons...
  15. ncbi request reprint Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons
    Gregory V Clodfelter
    University of Kentucky Medical Center, Department of Molecular and Biomedical Pharmacology, MS 320, 800 Rose Street, Lexington, KY 40536, USA
    Eur J Pharmacol 447:189-200. 2002
    ....

Research Grants3

  1. MULTIUSER AFFYMETRIX GENE CHIP SYSTEM
    PHILIP LANDFIELD; Fiscal Year: 2001
    ..abstract_text> ..
  2. NOVEL METHODS FOR SINGLE NEURON GENE/FUNCTION STUDIES
    PHILIP LANDFIELD; Fiscal Year: 2001
    ..Thus, these studies should substantially enhance the accessibility and wider use of this valuable preparation. ..
  3. Calcium Regulation in Brain Aging & Alzheimer's Disease
    PHILIP LANDFIELD; Fiscal Year: 2008
    ..abstract_text> ..