Kit Lam

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 48:531-40. 2008
  2. pmc MXD3 regulation of DAOY cell proliferation dictated by time course of activation
    Tin Ngo
    Department of Pharmacology, UC Davis School of Medicine, 451 Health Sciences Drive, 3503 GBSF, Davis, CA 95616, USA
    BMC Cell Biol 15:30. 2014
  3. pmc Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
    Wenwu Xiao
    Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Int J Nanomedicine 7:1587-97. 2012
  4. pmc Immobilized OBOC combinatorial bead array to facilitate multiplicative screening
    Wenwu Xiao
    Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California Davis, 2700 Stockton Boulevard, Sacramento, California, CA 95817, USA
    Comb Chem High Throughput Screen 16:441-8. 2013
  5. ncbi request reprint Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research
    Kit S Lam
    UC Davis Cancer Center, Division of Hematology Oncology, and Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento, California 95817, USA
    Acc Chem Res 36:370-7. 2003
  6. ncbi request reprint From combinatorial chemistry to chemical microarray
    Kit S Lam
    Division of Hematology and Oncology, UCD Cancer Center, 4501 X Street, Sacramento CA 95817, USA
    Curr Opin Chem Biol 6:353-8. 2002
  7. ncbi request reprint Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging
    Li Peng
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California, Davis, 4501 X Street, Sacramento, California 95817, USA
    Nat Chem Biol 2:381-9. 2006
  8. ncbi request reprint Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer
    Derick Lau
    Division of Hematology Oncology, Department of Internal Medicine, University of California, Davis, Cancer Center and Northern California VA Health System, 4501 X Street, Sacramento, CA 95817, USA
    Lung Cancer 52:291-7. 2006
  9. pmc Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin
    Richard D Carpenter
    Department of Chemistry, University of California Davis, Davis, California 95616, USA
    J Med Chem 52:14-9. 2009
  10. ncbi request reprint Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates
    Gerald L DeNardo
    Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, CA 95816, USA
    Clin Cancer Res 9:3865S-72S. 2003

Collaborators

Detail Information

Publications86

  1. pmc Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 48:531-40. 2008
    ....
  2. pmc MXD3 regulation of DAOY cell proliferation dictated by time course of activation
    Tin Ngo
    Department of Pharmacology, UC Davis School of Medicine, 451 Health Sciences Drive, 3503 GBSF, Davis, CA 95616, USA
    BMC Cell Biol 15:30. 2014
    ....
  3. pmc Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
    Wenwu Xiao
    Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Int J Nanomedicine 7:1587-97. 2012
    ..The research reported herein describes the detailed quantitative imaging and biodistribution profiling of nanomicelles loaded with a cargo of paclitaxel...
  4. pmc Immobilized OBOC combinatorial bead array to facilitate multiplicative screening
    Wenwu Xiao
    Department of Biochemistry and Molecular Medicine, UC Davis Cancer Center, University of California Davis, 2700 Stockton Boulevard, Sacramento, California, CA 95817, USA
    Comb Chem High Throughput Screen 16:441-8. 2013
    ..with increased efficiency, capacity, and specificity...
  5. ncbi request reprint Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research
    Kit S Lam
    UC Davis Cancer Center, Division of Hematology Oncology, and Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento, California 95817, USA
    Acc Chem Res 36:370-7. 2003
    ..These ligands will be tested for their effects on cell signaling and used to construct chemical microarrays for further characterization of ligand-protein interactions...
  6. ncbi request reprint From combinatorial chemistry to chemical microarray
    Kit S Lam
    Division of Hematology and Oncology, UCD Cancer Center, 4501 X Street, Sacramento CA 95817, USA
    Curr Opin Chem Biol 6:353-8. 2002
    ..High-throughput protein expression systems, robust high-density protein, peptide and small-molecule microarray systems, and automatic mass spectrometers are critical tools for the field of functional proteomics...
  7. ncbi request reprint Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging
    Li Peng
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California, Davis, 4501 X Street, Sacramento, California 95817, USA
    Nat Chem Biol 2:381-9. 2006
    ..Thus, LLP2A provides an important tool for noninvasive monitoring of alpha4beta1 expression and activity during tumor progression, and it shows great potential as an imaging and therapeutic agent for alpha4beta1-positive tumors...
  8. ncbi request reprint Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer
    Derick Lau
    Division of Hematology Oncology, Department of Internal Medicine, University of California, Davis, Cancer Center and Northern California VA Health System, 4501 X Street, Sacramento, CA 95817, USA
    Lung Cancer 52:291-7. 2006
    ..These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer...
  9. pmc Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin
    Richard D Carpenter
    Department of Chemistry, University of California Davis, Davis, California 95616, USA
    J Med Chem 52:14-9. 2009
    ..The results presented herein utilized heterocyclic and solid-phase chemistry, cell adhesion assay, and in vivo optical imaging using the cyanine dye Cy5.5 conjugate...
  10. ncbi request reprint Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates
    Gerald L DeNardo
    Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, CA 95816, USA
    Clin Cancer Res 9:3865S-72S. 2003
    ..To assess whether in vitro cathepsin-degradable peptide linkers between the chelated radiometal and the antibody decreased hepatic radiation dose, cumulated activity was used as a surrogate for radiation dose...
  11. doi request reprint Structure-activity relationship studies of targeting ligands against breast cancer cells
    Nianhuan Yao
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, California 95817, USA
    J Med Chem 52:6744-51. 2009
    ..5-fold increase of the binding affinity. Fluorescent microscopy and in vivo and ex vivo imaging studies demonstrated that 29 is an efficient in vivo targeting agent against alpha3 integrin of MDA-MB-231 breast tumor xenograft implant...
  12. pmc Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method
    Nianhuan Yao
    Department of Internal Medicine, Division of Hematology and Oncology, UC Davis Cancer Center, University of California, Davis, Sacramento, California 95817, USA
    J Med Chem 52:126-33. 2009
    ..Moreover, the targeting efficiency and specificity of 2 to the breast adenocarcinoma tumors in mouse xenografts were further confirmed by in vivo and ex vivo near-infrared fluorescence optical imaging...
  13. doi request reprint On-demand cleavable linkers for radioimmunotherapy
    Pappanaicken R Kumaresan
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of Calfornia Davis, Sacramento, CA, USA
    Methods Mol Biol 539:191-211. 2009
    ..The focus of this chapter is on the methods that have been used to identify and characterize ODC linkers and protease-specific substrates...
  14. doi request reprint In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin
    Li Peng
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, Sacramento, CA 95817, USA
    Mol Cancer Ther 7:432-7. 2008
    ..This study showed that the combinatorial chemical library-derived peptidomimetic LLP2A can be easily developed into an optical imaging probe for noninvasively monitoring of activated alpha4beta1 integrin in vivo...
  15. pmc LAS0811: from combinatorial chemistry to activation of antioxidant response element
    Ming Zhu
    Division of Hematology Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    J Biomed Biotechnol 2009:420194. 2009
    ..Taken together, LAS0811 is a novel activator of the ARE and its associated detoxifying genes and, thus, a potential agent for cancer chemoprevention...
  16. pmc Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format
    Xiangdong Zhu
    Department of Physics, University of California, CA 95616, USA
    Appl Opt 46:1890-5. 2007
    ..x 3 in. (2.54 cm x 7.62 cm) microscope slide...
  17. ncbi request reprint Structure-activity relationship studies of a series of peptidomimetic ligands for alpha(4) beta(1) integrin on Jurkat T-leukemia cells
    Ruiwu Liu
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Biopolymers 84:595-604. 2006
    ..Extensive SAR studies provide important information for further ligand optimization, which has served as a foundation for studies that ultimately led to identification of a potent ligand with an IC(50) of 2 pM...
  18. ncbi request reprint Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries
    Olulanu H Aina
    Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Mol Cancer Ther 4:806-13. 2005
    ..Blocking study with a panel of anti-integrin antibodies strongly suggests alpha3 integrin present on these ovarian adenocarcinoma cells is the target receptor for this peptide...
  19. pmc Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin
    Wenwu Xiao
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Eur J Nucl Med Mol Imaging 36:94-103. 2009
    ..6 months. New treatment approaches to this cancer are needed. Our purpose is to develop new cell surface-binding ligands for glioblastoma cells and use them as targeted imaging and therapeutic agents for this deadly disease...
  20. doi request reprint Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy
    Arutselvan Natarajan
    Division of Hematology and Oncology, Internal Medicine, University of California Davis, 1508 Alhambra Blvd, Room 3100, Sacramento, CA 95816, USA
    Bioorg Med Chem Lett 18:4802-5. 2008
    ..The percent release of radiochelate from RIC was 50% at 24h and 85% over 7 2h in vitro. This novel ODC-linked RIC could be a potential molecule for RIT...
  21. doi request reprint Rainbow beads: a color coding method to facilitate high-throughput screening and optimization of one-bead one-compound combinatorial libraries
    Juntao Luo
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, California 95817, USA
    J Comb Chem 10:599-604. 2008
    ..One major advantage of this straightforward and yet powerful method is that only an ordinary inverted microscope is needed for the analysis, instead of sophisticated (and expensive) fluorescent microscopes or flow cytometers...
  22. ncbi request reprint Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization
    Patrick S C Leung
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Immunol 179:2651-7. 2007
    ....
  23. doi request reprint Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates
    Pappanaicken R Kumaresan
    UC Davis Medical Center, Sacramento, CA 95817, USA
    Bioconjug Chem 19:1313-8. 2008
    ..This orthogonal method is compatible with peptides containing a thiol, amino, or carboxyl groups in the conjugation moiety...
  24. pmc Screening of a one bead-one compound combinatorial library for beta-actin identifies molecules active toward Ramos B-lymphoma cells
    Suzanne Miyamoto
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Anal Biochem 374:112-20. 2008
    ....
  25. doi request reprint Discovery of high-affinity peptide ligands for vancomycin
    Nianhuan Yao
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California, Davis, Sacramento, CA 95817, USA
    Biopolymers 90:421-32. 2008
    ..03 microM, roughly a 50-fold improvement in affinity compared to Kaa (K(D) = 50 microM)...
  26. pmc An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice
    Nicholas J Kenyon
    Pulmonary and Critical Care Medicine, Genome and Biomedical Sciences Facility, Davis, CA 95616, United States
    Eur J Pharmacol 603:138-46. 2009
    ..Specifically engineered, PEGylated (PEG) formulations of this antagonist further reduce the airway inflammatory response to ovalbumin, presumably by improving the circulating half-life of the drug...
  27. doi request reprint 111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies
    Sally J DeNardo
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis School of Medicine, Sacramento, California, USA
    J Nucl Med 50:625-34. 2009
    ..6.2]hexadecane ((64)Cu-LLP2A-CB-TE2A)...
  28. ncbi request reprint Therapeutic cancer targeting peptides
    Olulanu H Aina
    Univeristy of California Davis Cancer Center, Division of Hematology Oncology, and Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento 95817, USA
    Biopolymers 66:184-99. 2002
    ..Results from preclinical studies with some peptides are encouraging in their targeting potential...
  29. ncbi request reprint Combinatorial peptide library methods for immunobiology research
    Ruiwu Liu
    UC Davis Cancer Center, Division of Hematology Oncology, and Department of Internal Medicine, University of California Davis, Sacramento, CA, USA
    Exp Hematol 31:11-30. 2003
    ..Combinatorial peptide libraries offer a high-throughput approach to study limitless biological targets. Peptides discovered from such studies may be therapeutically and diagnostically useful agents...
  30. ncbi request reprint Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice
    Sally J DeNardo
    Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California 95816, USA
    Clin Cancer Res 9:3854S-64S. 2003
    ....
  31. pmc Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor
    Pei Ching Chang
    Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    J Virol 85:3283-93. 2011
    ..The consequences of K-bZIP targeting JMJD2A during viral replication will be discussed. To our knowledge, this is the first description of a viral product shown to be a potent inhibitor of a host cellular histone demethylase...
  32. pmc Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries
    Jared B Townsend
    Department of Biochemistry and Molecular Medicine, Division of Hematology and Oncology, University of California Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 12:700-12. 2010
    ..This novel ultrahigh-throughput OBOC releasable method can potentially be adapted to many existing 96- or 384-well solution-phase cell-based or biochemical assays...
  33. pmc A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer
    Kai Xiao
    Division of Hematology and Oncology, Department of Internal Medicine, UCD Cancer Center, University of California, Davis, Sacramento, CA 95817, USA
    Biomaterials 30:6006-16. 2009
    ....
  34. ncbi request reprint Synthesis and screening of "one-bead one-compound" combinatorial peptide libraries
    Kit S Lam
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, California 95817, USA
    Methods Enzymol 369:298-322. 2003
  35. ncbi request reprint Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase
    Jinzi J Wu
    UC Davis Cancer Center, Department of Internal Medicine, Division of Hematology Oncology, University of California, Davis, Sacramento, CA 95817, USA
    Comb Chem High Throughput Screen 5:83-91. 2002
    ..Our data suggest that protein tyrosine kinases have evolved to recognize multiple substrate motifs...
  36. ncbi request reprint A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries
    Ruiwu Liu
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    J Am Chem Soc 124:7678-80. 2002
    ..Potent and novel ligands with clear motifs have been identified...
  37. ncbi request reprint Screening chemical microarrays: methods and applications
    Pappanaicken R Kumaresan
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Mol Biosyst 2:259-70. 2006
  38. ncbi request reprint Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinatorial libraries
    Ruiwu Liu
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, California 95817, USA
    Methods Enzymol 369:271-87. 2003
  39. ncbi request reprint A novel approach to chemical microarray using ketone-modified macromolecular scaffolds: application in micro cell-adhesion assay
    Qingchai Xu
    UC Davis Cancer Center, Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento, Suite 3016, Sacramento, CA 95817, U S A
    Mol Divers 8:301-10. 2004
    ..These peptide microarrays were subsequently evaluated and optimized for binding of Jurkat leukemic cancer cells...
  40. ncbi request reprint Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures
    Alan Lehman
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 8:562-70. 2006
    ..The method is fast, efficient, and uses off-the-shelf equipment...
  41. ncbi request reprint High-throughput one-bead-one-compound approach to peptide-encoded combinatorial libraries: MALDI-MS analysis of single TentaGel beads
    Andreas H Franz
    Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    J Comb Chem 5:125-37. 2003
    ..A strategy of on-probe sample preparation is developed to minimize handling of the beads...
  42. ncbi request reprint Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags
    Xiaobing Wang
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Medical Center, 4501 X Street, Sacramento, California 95817, USA
    J Am Chem Soc 126:5740-9. 2004
    ..The chemical structures of the compound on each positive bead were unambiguously identified...
  43. pmc A novel size-tunable nanocarrier system for targeted anticancer drug delivery
    Yuanpei Li
    Division of Hematology and Oncology, Department of Internal Medicine, UCD Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    J Control Release 144:314-23. 2010
    ..Furthermore, PTX-loaded nanocarriers demonstrated superior anti-tumor efficacy compared to Taxol at equivalent PTX dose in ovarian cancer xenograft model...
  44. pmc Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment
    Juntao Luo
    Division of Hematology and Oncology, University of California, Davis Cancer Center, Sacramento, California 95817, USA
    Bioconjug Chem 21:1216-24. 2010
    ..The toxicity and antitumor efficacy profiles of these paclitaxel-loaded micelles in xenograft models were found to be superior to those of Taxol and Abraxane...
  45. ncbi request reprint Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries
    Pappanaicken R Kumaresan
    Division of Hematology and Oncology, and Radiodiagnosis and Therapy, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, School of Medicine, Sacramento, California 95817
    Bioconjug Chem 18:175-82. 2007
    ..This lead linker, after further optimization to increase its response to TNKase, may be useful in the development of more effective radioimmunotherapeutic and radioimaging agents...
  46. ncbi request reprint From combinatorial chemistry to cancer-targeting peptides
    Olulanu H Aina
    U C Davis Cancer Center, Division of Hematology Oncology, Department of Internal Medicine, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Mol Pharm 4:631-51. 2007
    ....
  47. ncbi request reprint Peptide and small-molecule microarrays
    Jan Marik
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California, Davis, USA
    Methods Mol Biol 310:217-26. 2005
    ..The final ligand-scaffold conjugates are then spotted and adsorbed onto the solid surface. Three different assay methods to screen such chemical microarrays are described...
  48. ncbi request reprint Partial alloc-deprotection approach for ladder synthesis of "one-bead one-compound" combinatorial libraries
    Xiaobing Wang
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Medical Center, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 7:197-209. 2005
    ....
  49. ncbi request reprint Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase
    Aimin Song
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, CA 95817, USA
    Bioorg Med Chem Lett 14:161-5. 2004
    ..Protocols for biotinylation and fluorescent labeling of peptides in solid phase were developed. The linkers also provide good ionization ability for single-bead mass spectrometry analysis of peptides...
  50. doi request reprint Improved Mobilization of Exogenous Mesenchymal Stem Cells to Bone for Fracture Healing and Sex Difference
    Wei Yao
    Department of Internal Medicine, Center for Musculoskeletal Health, University of California at Davis Medical Center, Sacramento, California, USA
    Stem Cells 34:2587-2600. 2016
    ..Increased mobilization of exogenous MSCs to fracture sites accelerated endochondral bone formation and enhanced bone tissue regeneration. Stem Cells 2016;34:2587-2600...
  51. ncbi request reprint Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells
    Masahito Mikawa
    University of California at Davis Cancer Center, 4501 X Street, Sacramento, CA 95817, USA
    Mol Cancer Ther 3:1329-34. 2004
    ..Using Chinese hamster ovary cells transfected with either wild-type or mutant integrin alpha(4), a critical binding site for these peptides was localized to the glycine residue at position 190 of integrin alpha(4)...
  52. pmc Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries
    Hyoung Gee Baek
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, Sacramento, California 95817, USA
    J Comb Chem 11:91-102. 2009
    ..We have prepared an encoded OBOC small molecule library on the novel shell-core beads and demonstrated that the beads can be readily decoded...
  53. ncbi request reprint Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combinatorial synthesis of coumarins
    Aimin Song
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 6:112-20. 2004
    ..Thirteen of these derivatives were obtained in high yields. Many of these model compounds fluoresce. Combinatorial libraries constructed with this novel scaffold may have interesting biological or physical properties...
  54. ncbi request reprint A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries
    Aimin Song
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA
    J Am Chem Soc 125:6180-8. 2003
    ..Streptavidin binding ligands with structural similarity (17) were identified. The decoding results were clear and unambiguous...
  55. doi request reprint Global transformation of OBOC combinatorial peptide libraries into OBOC polyamine and small molecule libraries
    Joseph C Kappel
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 10:333-42. 2008
    ..Using this novel approach, a random encoded dipeptide library was prepared and subsequently transformed into polyamine and poly- N-acetylamine sublibraries. Random beads isolated from these sublibraries were reliably decoded...
  56. ncbi request reprint Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries
    Nianhuan Yao
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Medical Center, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 9:668-76. 2007
    ..A series of flavonoid derivatives were obtained in high yields, which demonstrates that these highly functionalized scaffolds can be used in the synthesis of natural product-based combinatorial libraries for drug discovery...
  57. pmc Glycomic approach for potential biomarkers on prostate cancer: profiling of N-linked glycans in human sera and pRNS cell lines
    Maria Lorna A de Leoz
    Department of Chemistry, University of California Davis, Davis, CA, USA
    Dis Markers 25:243-58. 2008
    ..Significant changes in some high-mannose and fucosylated biantennary complex N-linked glycans were observed in the serum of prostate cancer patients...
  58. doi request reprint A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells
    Tae Hun Kim
    Department of Internal Medicine, Transplant Research Program, University of California Davis Medical Center, 4635 2nd Ave Research Building I, Room 1001, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 379:876-81. 2009
    ..The results indicate that LAS-0811 protects VL-17A cells against ethanol-induced oxidative stress and apoptosis at least in part via nrf2 activation...
  59. pmc Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 283:26107-15. 2008
    ..These results suggest that integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, and that integrin-sPLA2-IIA interaction is a novel therapeutic target...
  60. ncbi request reprint Solid-phase synthesis and spectral properties of 2-alkylthio-6H-pyrano[2,3-f]benzimidazole-6-ones: a combinatorial approach for 2-alkylthioimidazocoumarins
    Aimin Song
    Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA
    J Comb Chem 6:604-10. 2004
    ..The desired products were obtained in good yield with high purity after trifluoroacetic acid cleavage. The unique spectral properties of 2-alkylthioimidazocoumarins indicate that they may be useful in photodynamic therapy...
  61. ncbi request reprint Congo red and thioflavin-T analogs detect Abeta oligomers
    Izumi Maezawa
    M I N D Institute and Department of Pathology, University of California Davis, Sacramento, California 95817, USA
    J Neurochem 104:457-68. 2008
    ..We propose that by improving the binding affinity of current ligands, in vivo imaging of AbetaO is feasible by a 'signal subtraction' procedure. This approach may facilitate the identification of individuals with early AD...
  62. ncbi request reprint New approaches in identifying drugs to inactivate oncogene products
    Ruiwu Liu
    Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California at Davis, 4501 X Street, Sacramento, CA 95817, USA
    Semin Cancer Biol 14:13-21. 2004
    ..By applying these various drug discovery techniques, it is anticipated that more potent and specific anti-cancer agents will be discovered within the next decade...
  63. pmc Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP
    Yoshihiro Izumiya
    University of California Davis, Cancer Center, Research III Room 2400B, 4645 2nd Ave, Sacramento, CA 95817, USA
    J Virol 81:1072-82. 2007
    ..Our data thus identify a new role of vPK as a modulator of viral transcription...
  64. pmc Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity
    Hyun Seok Hong
    M I N D Institute and Department of Pathology, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Brain Res 1130:223-34. 2007
    ..Both assays are simple, suitable for rapid screening of a large number of medicinal libraries, and amenable for automation...
  65. ncbi request reprint Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay
    Scott R Nagy
    Department of Environmental Toxicology, University of California, Davis 95616, USA
    Biochemistry 41:861-8. 2002
    ..Overall, these results have not only allowed the identification of novel activators of the AhR but also demonstrate the utility of the recombinant H1G1.1c3 cell bioassay for high-throughput chemical screening...
  66. ncbi request reprint Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies
    Patrick S C Leung
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    J Immunol 170:5326-32. 2003
    ....
  67. ncbi request reprint Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design
    Seth Dixon
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    J Med Chem 49:7413-26. 2006
    ..The methods presented here constitute a paradigm for inhibitor discovery through active site targeting, enabled by rapid library synthesis, facile massively parallel screening, and straightforward hit identification...
  68. ncbi request reprint Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible
    Katsushi Amano
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 172:6444-52. 2004
    ..e., the primary tolerance-breaking autoantigen. Detailed analysis of this system may provide strategies on how to restore tolerance in patients with autoimmune disease...
  69. ncbi request reprint Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid
    Katsushi Amano
    Division of Rheumatology, Allergy and Clinical Immunology, Genomic and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    J Immunol 174:5874-83. 2005
    ..Not only does 2-octynoic acid have the potential to modify PDC-E2 in vivo but importantly it was/is widely used in the environment including perfumes, lipstick, and many common food flavorings...
  70. ncbi request reprint Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin
    Richard D Carpenter
    Department of Chemistry, University of California, Davis, Davis, CA 95616, USA
    J Med Chem 50:5863-7. 2007
    ..With exceptional solubility, this finding has the potential for improving PK to help diagnose and treat lymphomas...
  71. ncbi request reprint Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries
    Seth M Dixon
    Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA
    J Med Chem 49:2388-97. 2006
    ..They provide a pharmacophore for the future isolation of more potent ligands that may prove useful in probing and understanding the biological role of hSR...
  72. ncbi request reprint Near-infrared optical imaging of ovarian cancer xenografts with novel alpha 3-integrin binding peptide "OA02"
    Olulanu H Aina
    University of California, Davis
    Mol Imaging 4:439-47. 2005
    ..5. Some kidney and bladder signal were noted. Prior injection with anti-alpha3 monoclonal antibody blocked the binding of this peptide to the ES-2 tumors...
  73. ncbi request reprint Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
    Roman Rieger
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, GBSF 6510, 95616, USA
    J Autoimmun 27:7-16. 2006
    ..Our findings illustrate an unusual polyreactivity of anti-PDC-E2 and support the idea of epitope mimicry in the genesis of this autoantibody and perhaps of PBC itself...
  74. ncbi request reprint Conformational studies of resin-bound vancomycin and the complex of vancomycin and Ac2-L-Lys-D-Ala-D-Ala
    Nian Huan Yao
    Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P R China
    J Comb Chem 7:123-9. 2005
    ....
  75. ncbi request reprint An unnatural amino acid that induces beta-sheet folding and interaction in peptides
    James S Nowick
    Department of Chemistry, University of California Irvine, Irvine, California 92697 2025, USA
    J Am Chem Soc 124:4972-3. 2002
    ..This feature of Orn(i-PrCO-Hao) is important, because it allows the creation of beta-sheet structure with minimal perturbation of the peptide sequence...
  76. ncbi request reprint Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives
    Wei Chieh Cheng
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616 5295, USA
    J Org Chem 67:5673-7. 2002
    ..tert-Butyl spiroisoxazolinoprolinates were separable by column chromatography and amenable to scale-up leading to single diastereoisomers of N-Boc and N-Fmoc protected spiroisoxazolinoproline amino acids...
  77. ncbi request reprint A serum glycomics approach to breast cancer biomarkers
    Crystal Kirmiz
    Department of Chemistry, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 6:43-55. 2007
    ..quot;..
  78. ncbi request reprint Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives
    Nian Huan Yao
    Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China
    Bioorg Med Chem Lett 15:2325-9. 2005
    ..Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis...
  79. ncbi request reprint Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer
    Hyun Joo An
    Department of Chemistry, University of California Davis Cancer Center, California 95616, USA
    J Proteome Res 5:1626-35. 2006
    ..One major advantage of this approach is that glycans are examined directly from patient sera without the need to obtain cancer biopsy specimens or to purify glycosylated proteins from these specimens...
  80. ncbi request reprint Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy
    Seth Dixon
    Department of Chemistry, University of California, Davis, 95616 5295, USA
    Bioorg Med Chem Lett 15:2938-42. 2005
    ..Resynthesis results validate the selectivity of these ligands...
  81. ncbi request reprint Carbodiimide-based benzimidazole library method
    Richard D Carpenter
    Department of Chemistry, University of California, Davis, Davis, California 95616, USA
    J Comb Chem 8:907-14. 2006
    ..Using these mild conditions and environmentally safe reagents, we demonstrated that these pharmaceutically ornate heterocycles can also be constructed on solid support...
  82. doi request reprint Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation changes in individual proteins
    Bensheng Li
    Department of Chemistry, Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    J Proteome Res 7:3776-88. 2008
    ..This study shows that not only a single protein but several are aberrantly glycosylated, and those abnormal glycosylation changes can be detected and may ultimately serve as glycan biomarkers for ovarian cancer...
  83. ncbi request reprint A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis
    Seth M Dixon
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    J Comb Chem 9:143-57. 2007
    ..A 129,600 member one-bead-one-compound (OBOC) library based on the scaffold 7 was synthesized utilizing a dual amino acid encoding method and bifunctionalization of TentaGel resin...
  84. pmc The minimum element of a synthetic peptide required to block prostate tumor cell migration
    Thomas C Sroka
    The Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Biol Ther 5:1556-62. 2006
    ..These linear peptide sequences provide the starting point for development of novel compounds to target cancer cell adhesion and migration...
  85. ncbi request reprint Meeting report: high-throughput technologies for in vivo imaging agents
    Robert J Gillies
    University of Arizona, Tucson, AZ, USA
    Mol Imaging 4:98-103. 2005
    ....

Research Grants5

  1. PEPTIDE MICROARRAY FOR CANCER CELL SURFACE RECEPTORS
    Kit Lam; Fiscal Year: 2003
    ..Peptides that are unique to human tumors can then be used to determine the ligand binding profile of human cancer biopsy specimens. ..
  2. UC Davis AP4 Center
    Kit Lam; Fiscal Year: 2004
    ..Prepare an AP4 Center application for submission to NCI in 2005 ..
  3. Small molecule microarrays for intracellular proteins
    Kit Lam; Fiscal Year: 2005
    ..This technique, if successful, can readily be applied to other cancer types as well. ..
  4. Protein kinase specific PET imaging agent for cancer
    Kit Lam; Fiscal Year: 2005
    ..5. To radiolabel and perform in vivo PET imaging studies in nude mice with the top three substrates with best cellular uptake and retention. ..
  5. c-src inhibitors from novel encoded chemical libraries
    Kit Lam; Fiscal Year: 2007
    ..3. To evaluate the enzyme inhibitory activity and cellular effects of the identified p60c-src PTK ligands. ..