A K Lalwani

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
  2. ncbi request reprint In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
    Laryngoscope 112:1325-34. 2002
  3. ncbi request reprint Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  4. ncbi request reprint Auditory phenotype of DFNA17
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:107-12. 2002
  5. ncbi request reprint Sensorineural and conductive hearing loss associated with lateral semicircular canal malformation
    J Johnson
    Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
    Laryngoscope 110:1673-9. 2000
  6. pmc Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9
    A K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Hum Genet 67:1121-8. 2000
  7. ncbi request reprint Point mutation in the MITF gene causing Waardenburg syndrome type II in a three-generation Indian family
    A K Lalwani
    Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143 0526, USA
    Am J Med Genet 80:406-9. 1998
  8. ncbi request reprint Further characterization of the DFNA1 audiovestibular phenotype
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco 94143 0526, USA
    Arch Otolaryngol Head Neck Surg 124:699-702. 1998
  9. ncbi request reprint Green fluorescent protein as a reporter for gene transfer studies in the cochlea
    A K Lalwani
    Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94117, USA
    Hear Res 114:139-47. 1997
  10. ncbi request reprint Lectin binding characteristics of squamous cell carcinomas of the head and neck
    A K Lalwani
    Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, USA
    Acta Otolaryngol 116:125-31. 1996

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
    ..Finally, safety issues regarding dissemination of gene transfer vectors beyond the target cochlea will need to be adequately addressed...
  2. ncbi request reprint In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
    Laryngoscope 112:1325-34. 2002
    ..Administration of adeno-associated virus containing the gene for brain-derived neurotrophic factor will promote spiral ganglion neuron survival after the destruction of hair cells...
  3. ncbi request reprint Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  4. ncbi request reprint Auditory phenotype of DFNA17
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:107-12. 2002
  5. ncbi request reprint Sensorineural and conductive hearing loss associated with lateral semicircular canal malformation
    J Johnson
    Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
    Laryngoscope 110:1673-9. 2000
    ..The auditory phenotype associated with LSCC malformation is not well delineated. The objective of this study is to define the nature of the hearing loss associated with LSCC malformation...
  6. pmc Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9
    A K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Hum Genet 67:1121-8. 2000
    ..Both the precise role of MYH9 in the cochlea and the mechanism by which the R705H mutation leads to the DFNA17 phenotype (progressive hearing impairment and cochleosaccular degeneration) remain to be elucidated...
  7. ncbi request reprint Point mutation in the MITF gene causing Waardenburg syndrome type II in a three-generation Indian family
    A K Lalwani
    Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143 0526, USA
    Am J Med Genet 80:406-9. 1998
    ..This family, with the first documented case of two unrelated WS2 families harboring identical mutations, provides additional evidence for the importance of genetic background on the clinical phenotype...
  8. ncbi request reprint Further characterization of the DFNA1 audiovestibular phenotype
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco 94143 0526, USA
    Arch Otolaryngol Head Neck Surg 124:699-702. 1998
    ..Autosomal dominant, nonsyndromic, hereditary hearing impairment in a large Costa Rican kindred is caused by a mutation in the human homolog of the Drosophila diaphanous gene...
  9. ncbi request reprint Green fluorescent protein as a reporter for gene transfer studies in the cochlea
    A K Lalwani
    Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94117, USA
    Hear Res 114:139-47. 1997
    ..GFP's small gene size, stability, ease of detection, and potential for diverse biological applications will be invaluable for a variety of future gene transfer and expression studies in the cochlea...
  10. ncbi request reprint Lectin binding characteristics of squamous cell carcinomas of the head and neck
    A K Lalwani
    Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, USA
    Acta Otolaryngol 116:125-31. 1996
    ..Lectin binding profile may be useful in differentiating benign from malignant histopathology...
  11. ncbi request reprint A five-generation family with late-onset progressive hereditary hearing impairment due to cochleosaccular degeneration
    A K Lalwani
    Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, USA
    Audiol Neurootol 2:139-54. 1997
    ..The genetic study of this family will be helpful in identifying the genes which, when mutated, result in Scheibe degeneration...
  12. ncbi request reprint Cochlear gene delivery through an intact round window membrane in mouse
    J Jero
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Gene Ther 12:539-48. 2001
    ..Compared with the more invasive gene delivery methods, this technique represents a safer and a more clinically viable route of cochlear gene delivery in humans...
  13. ncbi request reprint A surgical approach appropriate for targeted cochlear gene therapy in the mouse
    J Jero
    Laboratory of Molecular Oncology, Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, 94143-0526, USA
    Hear Res 151:106-114. 2001
    ....
  14. ncbi request reprint A PAX3 polymorphism (T315K) in a family exhibiting Waardenburg Syndrome type 2
    C Wang
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA, USA
    Mol Cell Probes 12:55-7. 1998
    ..Here a neutral polymorphism is reported in the PAX3 gene (T315K) in a family with WS2...
  15. ncbi request reprint Mutation analysis of Connexin 31 (GJB3) in sporadic non-syndromic hearing impairment
    A N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Clin Genet 63:154-9. 2003
    ..Thus, dHPLC represents a highly efficient CX31 screening technique. This study suggests that while sequence alterations are common, pathogenic mutations of CX31 are infrequent in sporadic non-syndromic hearing impairment...
  16. ncbi request reprint The guinea pig cochlear AE2 anion exchanger: cDNA cloning and in situ localization within the cochlea
    A N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue, U490A, San Francisco, CA 94117, USA
    Biochim Biophys Acta 1414:1-15. 1998
    ..The results of these studies imply a physiologic role of AE2 in the cochlear homeostasis, but do not support its role as a potential 'motor protein' in mediating the in vitro-observed voltage-gated, ATP-independent OHC motility...
  17. ncbi request reprint Assessment of denaturing high-performance liquid chromatography (DHPLC) in screening for mutations in connexin 26 (GJB2)
    D Lin
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143 0526, USA
    Hum Mutat 18:42-51. 2001
    ..Further, our experience suggests that DHPLC screening alone followed by DNA sequencing only when DHPLC is abnormal may be adequate for identification of all sequence alterations in Cx26...
  18. ncbi request reprint Facial nerve monitoring in middle ear and mastoid surgery
    R S Noss
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94243 0112, U S A
    Laryngoscope 111:831-6. 2001
    ..Intraoperative electromyographic facial nerve monitoring, long accepted as the standard of care in surgery for acoustic neuroma and other cerebellopontine angle tumors, may be of aid in middle ear and mastoid surgery...
  19. ncbi request reprint Detection of fungi in the nasal mucosa using polymerase chain reaction
    M D Catten
    Laboratory of Molecular Otology, University of California-San Francisco, San Francisco, CA 94143-0342, USA
    Laryngoscope 111:399-403. 2001
    ..In addition, our study suggests that the presence of fungi alone is insufficient to implicate it as the pathogen in chronic sinusitis...
  20. ncbi request reprint Lethal fibrosarcoma complicating radiation therapy for benign glomus jugulare tumor
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco
    Am J Otol 14:398-402. 1993
    ....
  21. ncbi request reprint Mediastinal and thoracic complications of necrotizing fasciitis of the head and neck
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco 94143
    Head Neck 13:531-9. 1991
    ..Based on our experience, we recommend prompt aggressive surgical debridement in treating mediastinal complications resulting from head and neck infections...
  22. ncbi request reprint Conservative management of infections in cochlear implant recipients
    K C Yu
    Division of Otology, Neurotology, and Skull Base Surgery and Laboratory of Molecular Otology, Epstein Laboratories, and the Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA
    Otolaryngol Head Neck Surg 125:66-70. 2001
    ..Chronic implant infections may be explained by a primary immunodeficiency. With appropriate treatment leading to infection control, a conservative management strategy is advocated before consideration of device explantation...
  23. ncbi request reprint The use of Preyer's reflex in evaluation of hearing in mice
    J Jero
    Department of Otolaryngology--Head and Neck Surgery, University of California San Francisco, 94143-0526, USA
    Acta Otolaryngol 121:585-9. 2001
    ..For definitive hearing assessment, and for defining the hearing thresholds. objective electroacoustical methods such as ABR should be used...
  24. ncbi request reprint Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    Laryngoscope 115:640-4. 2005
    ..Mutation screening in this gene has been recommended before use of aminoglycosides as a preventative strategy to reduce the risk of ototoxicity...
  25. ncbi request reprint Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA 94143, USA
    Otol Neurotol 24:205-9. 2003
    ..Recently, mutations in MYH9, a nonmuscle myosin heavy chain, have been found in several forms of hereditary macrothrombocytopenia...
  26. ncbi request reprint Cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, USA
    Ear Hear 24:342-8. 2003
  27. ncbi request reprint Otolaryngological manifestations of cleidocranial dysplasia, concentrating on audiological findings
    Ann Marie B Visosky
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, USA
    Laryngoscope 113:1508-14. 2003
    ..The objective of the study was to evaluate the auditory function and head and neck manifestations of patients with cleidocranial dysplasia...
  28. ncbi request reprint GJB2 mutations in the Swiss hearing impaired
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, USA
    Ear Hear 24:440-7. 2003
    ....
  29. ncbi request reprint Two temporal bone computed tomography measurements increase recognition of malformations and predict sensorineural hearing loss
    Derk D Purcell
    Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
    Laryngoscope 116:1439-46. 2006
    ..The objectives of this prospective study were to assess the reproducibility of the measurements of the cochlea and lateral semicircular canal (LSCC) and to determine if abnormal measurements predict sensorineural hearing loss (SNHL)...
  30. ncbi request reprint Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
    ..Localization of Myh9 within the stereocilia raises the possibility that mutations of MYH9 may effect hearing loss though disruption of the stereocilia structure...
  31. ncbi request reprint Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4
    Anand N Mhatre
    Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 75:25-31. 2004
    ....
  32. ncbi request reprint Biological therapy for the inner ear
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, NY 10016, USA
    Expert Opin Biol Ther 4:1811-9. 2004
    ..Potential areas of interest in gene therapy and its preclinical application to deafness are reviewed, and experimental progress that has occurred in cellular therapy for the inner ear is examined...
  33. ncbi request reprint Establishment of normative cochlear and vestibular measurements to aid in the diagnosis of inner ear malformations
    Derk Purcell
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143, USA
    Otolaryngol Head Neck Surg 128:78-87. 2003
    ..We sought to establish normative measurements of the inner ear using computed tomography (CT) of the temporal bone to aid in the diagnosis of inner ear malformations...
  34. ncbi request reprint Further evidence for a third deafness gene within the DFNA2 locus
    Jayne A Goldstein
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143 0526, USA
    Am J Med Genet 108:304-9. 2002
    ..We have investigated both identified deafness genes in affected and unaffected family members and have not found any disease-causing mutations, suggesting that another hearing impairment gene resides at the DFNA2 locus...
  35. ncbi request reprint Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
    Hear Res 170:59-69. 2002
    ....
  36. ncbi request reprint Aquaporin 4 expression in the mammalian inner ear and its role in hearing
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
    Biochem Biophys Res Commun 297:987-96. 2002
    ..In the Aqp4 deficient mouse, cochlear dysfunction is suggested as the primary cause of hearing impairment in the absence of neural conduction abnormality...
  37. ncbi request reprint Auditory phenotype of DFNA1
    Pedro E Leon
    Center for Research and Molecular Biology, University of Costa Rica, San Jose, Costa Rica
    Adv Otorhinolaryngol 61:34-40. 2002
  38. ncbi request reprint The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease
    Joseph L Hegarty
    Department of Otolaryngology Head and Neck Surgery, University of California, 400 Parnassus Avenue, San Francisco, CA 94143 0342, U S A
    Laryngoscope 112:8-17. 2002
    ..However, its value in the evaluation and diagnosis of cochlear pathology associated with sensorineural hearing loss (SNHL) has been less clear...
  39. ncbi request reprint Audiologic evidence for further genetic heterogeneity at DFNA2
    Ryan E Stern
    Laboratory of Molecular Otology, Epstein Laboratories and Division of Otology, Neurotology and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143 0526, USA
    Acta Otolaryngol 122:730-5. 2002
    ..Therefore, this family provides clinical evidence of genetic heterogeneity at the DFNA2 locus and can serve as a model for age-related hearing loss...
  40. ncbi request reprint Use of laboratory evaluation and radiologic imaging in the diagnostic evaluation of children with sensorineural hearing loss
    Derek D Mafong
    Division of Otology, Department of Otolaryngology Head and Neck Surgery, University of California, 400 Parnassus Avenue, San Francisco, CA 94143 0342, U S A
    Laryngoscope 112:1-7. 2002
    ..The aim of this study was to examine the yield of laboratory tests and radiologic imaging commonly used in the diagnostic evaluation of SNHL in children...
  41. ncbi request reprint Evaluation of childhood sensorineural hearing loss in the post-genome world
    Anil K Lalwani
    Arch Otolaryngol Head Neck Surg 128:88-9. 2002
  42. ncbi request reprint Implication of central asymmetry in speech processing on selecting the ear for cochlear implantation
    Luc G Morris
    Department of Otolaryngology and Cochlear Implant Center, New York University School of Medicine, New York, New York 10016, USA
    Otol Neurotol 28:25-30. 2007
    ..The purpose of this study is to determine if this central asymmetry in speech processing has implications for selecting the ear for cochlear implantation...
  43. ncbi request reprint Cochlear implantation in Children with CHARGE syndrome: therapeutic decisions and outcomes
    Biana G Lanson
    Department of Otolaryngology, NYU School of Medicine, New York, NY 10016, USA
    Laryngoscope 117:1260-6. 2007
    ..The aim of this study is to explore the viability of cochlear implantation in children with CHARGE syndrome and to assess the outcome...
  44. ncbi request reprint Endolymphatic sac tumors in von Hippel-Lindau disease
    Anil K Lalwani
    Department of Otolaryngology, New York University, 550 First Avenue, New York, NY 10016, USA
    Arch Otolaryngol Head Neck Surg 133:857. 2007
  45. ncbi request reprint Generation and characterization of mice with Myh9 deficiency
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
    Neuromolecular Med 9:205-15. 2007
    ..The results of these studies do not support the Myh9 haploinsufficiency as a pathogenic factor in the etiology of auditory dysfunction...
  46. ncbi request reprint Fluctuating corticosteroid-responsive auditory neuropathy/dyssynchrony is suggestive of central nervous system pathology
    Pavan S Mallur
    Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Otol Neurotol 28:1002-4. 2007
    ..To highlight diagnostic and management features of auditory neuropathy/auditory dyssynchrony (AN/DS) due to central demyelinating disorder...
  47. pmc Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, NY 10016
    Brain Res 1197:13-22. 2008
    ..Thus, mutant NMHC-IIa may cause hearing loss by affecting hair cell dysfunction through structural and or functional disruption of its stereocilia, plasma membrane, and/or mitochondria...
  48. doi request reprint Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle
    Pavan S Mallur
    Department of Otolaryngology, New York University School of Medicine, New York, NY 10016, United States
    Int J Pediatr Otorhinolaryngol 72:529-34. 2008
    ..This case highlights that suspicion of central nervous system pathology should be heightened in the presence of steroid responsive, fluctuating sensorineural hearing loss with normal outer hair cell function...
  49. doi request reprint MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Cell Motil Cytoskeleton 65:393-405. 2008
    ..However, the results also indicate that the NMHC-IIA mutants, R702C and R705H do not inactivate or suppress the endogenous wild type NMHC-IIA within the HeLa or HEK293 cell assay system...
  50. ncbi request reprint Sensorineural hearing loss, early greying, and essential tremor: a new hereditary syndrome?
    Collin S Karmody
    Department of Otorhinolaryngology Head and Neck Surgery, Tufts University School of Medicine, Boston, USA
    Otolaryngol Head Neck Surg 133:94-9. 2005
    ..To present a syndrome composed of sensorineural hearing loss, early greying of scalp hair, and adult-onset essential tremor...
  51. ncbi request reprint Two families with nonsyndromic low-frequency hearing loss harbor novel mutations in Wolfram syndrome gene 1
    Nicolas Gürtler
    Hals Nasen Ohren Klinik, Kantonsspital Aarau, Aarau, Switzerland
    J Mol Med (Berl) 83:553-60. 2005
    ..We confirm that most mutations in WFS1 associated with isolated low-frequency hearing loss are clustered in the C-terminal protein domain coded by exon 8...
  52. ncbi request reprint Ocular findings in children with congenital sensorineural hearing loss
    Derek D Mafong
    Division of Otology, Neurotology, Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 128:1303-6. 2002
    ..To examine the yield of ophthalmologic examination in the diagnostic workup of unexplained sensorineural hearing loss (SNHL) in children...
  53. ncbi request reprint Isolated vestibular ossification after meningitis associated with sensorineural hearing loss
    Jay B Reeck
    Division of Otology, Neurotology and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA
    Otol Neurotol 24:576-81. 2003
    ..We review our recent experience with isolated vestibular ossification associated with profound sensorineural hearing loss and the implication for cochlear implantation in this population...
  54. ncbi request reprint Identification of previously "undetectable" abnormalities of the bony labyrinth with computed tomography measurement
    Derk D Purcell
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, USA
    Laryngoscope 113:1908-11. 2003
    ..However, subtle bony malformations may be missed because visual inspection alone is insensitive for detection...
  55. ncbi request reprint Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors
    Christina J Laane
    Laboratory of Molecular Otology, Epstein Laboratory, Department of Otolaryngology Head and Neck Surgery, University of California, 400 Parnassus Avenue, Rm A730, San Francisco 94143 0342, USA
    Head Neck 24:443-50. 2002
    ..The aim of this study was to determine whether Epstein-Barr virus (EBV) or cytomegalovirus (CMV) might play a role in the pathogenesis of pleomorphic adenomas and Warthin's tumors...
  56. ncbi request reprint Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
    ..Identification of Myh9 in the developing and mature inner ear suggests a role for this protein in the development and maintenance of auditory function...
  57. ncbi request reprint Cochlear implant outcomes in the elderly
    Veronique Chatelin
    Douglas Grant Cochlear Implant Center, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, California, USA
    Otol Neurotol 25:298-301. 2004
    ..This study aimed to review cochlear implantation with respect to surgical and auditory outcomes in subjects aged 70 years and older...
  58. ncbi request reprint GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcome
    Lawrence R Lustig
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC, Baltimore, MD 21287, USA
    Arch Otolaryngol Head Neck Surg 130:541-6. 2004
    ..To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation (CI) and their impact on rehabilitative outcome following implantation...
  59. ncbi request reprint Molecular pathogenesis of skull base tumors
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
    Otol Neurotol 25:636-43. 2004
    ..To review contemporary molecular biological literature related to skull base tumor biology and tumorigenesis...
  60. ncbi request reprint DFNA54, a third locus for low-frequency hearing loss
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Mol Med (Berl) 82:775-80. 2004
    ..Because of the differences in auditory phenotype and the absence of pathogenic mutation in the coding region of POU4F3 it is likely that there is a second gene in 5q31, designated DFNA54, associated with NSHHI...
  61. ncbi request reprint Etiology of syndromic and nonsyndromic sensorineural hearing loss
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue Room U490A, San Francisco, CA 94143 0526, USA
    Otolaryngol Clin North Am 35:891-908. 2002
    ..Ultimately, availability of gene therapy for the affected patients will bring to closure the circle of detection, identification, and correction of the disease...
  62. ncbi request reprint Speech perception benefits of sequential bilateral cochlear implantation in children and adults: a retrospective analysis
    Daniel M Zeitler
    New York University School of Medicine, New York, New York, USA
    Otol Neurotol 29:314-25. 2008
    ..To examine speech perception outcomes and determine the impact of length of deafness and time between implants on performance in the sequentially bilateral implanted population...