Satyan Lakshminrusimha

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, New York, USA
    J Appl Physiol (1985) 111:1441-7. 2011
  2. pmc Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, NY Electronic address
    Semin Perinatol 40:160-73. 2016
  3. pmc The pulmonary circulation in neonatal respiratory failure
    Satyan Lakshminrusimha
    Division of Neonatology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    Clin Perinatol 39:655-83. 2012
  4. pmc Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York, Buffalo, New York 14214, USA
    Pediatr Res 66:539-44. 2009
  5. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
  6. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol (1985) 101:135-9. 2006
  7. ncbi request reprint Adjacent bronchus attenuates pulmonary arterial contractility
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Center for Developmental Biology of the Lung, USA
    Am J Physiol Lung Cell Mol Physiol 291:L473-8. 2006
  8. doi request reprint Use of CT angiography in the diagnosis of total anomalous venous return
    S Lakshminrusimha
    Division of Neonatology, State University of New York at Buffalo, Buffalo, NY, USA
    J Perinatol 29:458-61. 2009
  9. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
  10. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007

Collaborators

Detail Information

Publications50

  1. pmc Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, New York, USA
    J Appl Physiol (1985) 111:1441-7. 2011
    ..Furthermore, 100% O(2) also induces oxidative stress and increases PA contractility. These findings support the new neonatal resuscitation guidelines recommending 21% O(2) for initial resuscitation of asphyxiated neonates...
  2. pmc Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, NY Electronic address
    Semin Perinatol 40:160-73. 2016
    ..Large multicenter randomized controlled trials with long-term follow-up are required to evaluate alternate pharmacologic strategies in PPHN. ..
  3. pmc The pulmonary circulation in neonatal respiratory failure
    Satyan Lakshminrusimha
    Division of Neonatology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    Clin Perinatol 39:655-83. 2012
    ..Various management strategies to correct respiratory failure are also discussed...
  4. pmc Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York, Buffalo, New York 14214, USA
    Pediatr Res 66:539-44. 2009
    ..Hypoxia increases PVR but hyperoxia does not confer significant additional pulmonary vasodilation in lambs with PPHN...
  5. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
    ..PA contractility to NE and KCl is increased following both brief (30 min) and prolonged (24 h) exposure to 100% oxygen during mechanical ventilation. In contrast, normoxic resuscitation and ventilation do not increase PA contractility...
  6. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol (1985) 101:135-9. 2006
    ..We speculate that BrDRF may have an important role in postnatal changes in pulmonary arterial reactivity...
  7. ncbi request reprint Adjacent bronchus attenuates pulmonary arterial contractility
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Center for Developmental Biology of the Lung, USA
    Am J Physiol Lung Cell Mol Physiol 291:L473-8. 2006
    ..NO gas relaxed PA when administered on the endothelial side only. We speculate that BrDRF is a diffusible factor that crosses the adventitia and stimulates production of NO within the PA...
  8. doi request reprint Use of CT angiography in the diagnosis of total anomalous venous return
    S Lakshminrusimha
    Division of Neonatology, State University of New York at Buffalo, Buffalo, NY, USA
    J Perinatol 29:458-61. 2009
    ..We suggest that CT with contrast is a noninvasive modality to obtain anatomic details of pulmonary venous drainage in TAPVR when echocardiography is inconclusive...
  9. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
    ....
  10. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007
    ..The redox environment, influenced by the balance between production and scavenging of ROS, may have important consequences on pulmonary vascular reactivity in the setting of increased Q(p)...
  11. pmc Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 62:313-8. 2007
    ..We conclude that, while ventilation with 100% O2 at birth results in a greater initial decrease in PVR, subsequent pulmonary vasodilation to NO/acetylcholine is impaired...
  12. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
    ..Forskolin is a direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP and is inhibited by milrinone...
  13. doi request reprint Exposure to supplemental oxygen downregulates antioxidant enzymes and increases pulmonary arterial contractility in premature lambs
    Anupama Patel
    Center for Developmental Biology of the Lung, Department of Pediatrics, University at Buffalo, Buffalo, NY 14222 2006, USA
    Neonatology 96:182-92. 2009
    ..The optimal oxygen concentration for the resuscitation of premature infants remains controversial...
  14. pmc Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep
    Bernadette Chen
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Res 66:682-7. 2009
    ..The vasodilatory effects of milrinone were most pronounced in vessels from lambs with the highest PDE3 activity, i.e., 1dSB and 100% O2 + iNO lambs. Thus, milrinone may be most beneficial when used in conjunction with iNO...
  15. pmc Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Antioxid Redox Signal 17:460-70. 2012
    ..PDE5 degrades cyclic GMP (cGMP) and inhibits nitric oxide (NO)-mediated cGMP-dependent vasorelaxation. We sought to determine the mechanism by which hyperoxia initiates reactive oxygen species (ROS) production and regulates PDE5...
  16. doi request reprint Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension
    Vasanth H Kumar
    Division of Neonatology, Department of Pediatrics, University at Buffalo, The Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222 2006, USA
    J Appl Physiol (1985) 109:677-84. 2010
    ..Milrinone enhances the vasodilatory effects of PGI2 on the pulmonary vasculature but caution must be exercised regarding systemic hypotension...
  17. ncbi request reprint Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation
    Nasir Rashid
    Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 60:624-9. 2006
    ..We conclude that intravenous milrinone potentiates the pulmonary vasodilator effects of PGI(2) at lower doses...
  18. pmc Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, NY, USA
    Shock 39:278-85. 2013
    ..Collectively, these data suggest that consumption of NO due to excess superoxide resulting in peroxynitrite formation leads to diminished vascular reactivity following LC...
  19. pmc Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circ Res 102:226-33. 2008
    ..These data suggest that PDE5 expression and activity play a critical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments for PPHN, such as oxygen and inhaled NO...
  20. pmc Neonatal resuscitation adhering to oxygen saturation guidelines in asphyxiated lambs with meconium aspiration
    Munmun Rawat
    Department of Pediatrics, University at Buffalo, Buffalo, New York
    Pediatr Res 79:583-8. 2016
    ..The Neonatal Resuscitation Program (NRP) recommends upper and lower limits of preductal saturations (SpO2) extrapolated from studies in infants resuscitated in room air. These limits have not been validated in asphyxia and lung disease...
  21. pmc Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn
    Stephen Wedgwood
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Antioxid Redox Signal 18:1765-76. 2013
    ....
  22. doi request reprint Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release
    Christopher A D'Angelis
    Department of Pathology and Anatomical Sciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    Pediatr Res 63:239-44. 2008
    ..We speculate that increased activity of the ANP/NPR-A pathway in late gestation may prime the surfactant system, preparing the lung for air breathing...
  23. pmc Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension
    Stephen Wedgwood
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, 310 E Superior St, Chicago, IL 60611, USA
    Antioxid Redox Signal 15:1497-506. 2011
    ..The associated decrease in extracellular superoxide augments vasodilation, suggesting that H(2)O(2) scavengers may represent an effective therapy in the clinical management of PPHN...
  24. pmc Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs
    Praveen Kumar Chandrasekharan
    Division of Neonatology, Department of Pediatrics, University at Buffalo, Buffalo, N Y, USA
    Neonatology 109:265-73. 2016
    ..Considering that cerebral blood flow (CBF) correlates directly with PaCO2, continuous capnography monitoring of end-tidal CO2 (ETCO2) may limit fluctuations in PaCO2 and, therefore, CBF during resuscitation of asphyxiated infants...
  25. pmc Packed red cell transfusions alter mesenteric arterial reactivity and nitric oxide pathway in preterm lambs
    Jayasree Nair
    Department of Pediatrics, Division of Neonatology, State University of New York at Buffalo, Buffalo, New York
    Pediatr Res 74:652-7. 2013
    ..However, the mechanism of disruption of the balance between mesenteric vasoconstriction and relaxation following transfusion is not known...
  26. doi request reprint Neonatal hyperoxia increases airway reactivity and inflammation in adult mice
    Vasantha H S Kumar
    Department of Pediatrics, University at Buffalo, The State University of New York, New York
    Pediatr Pulmonol 51:1131-1141. 2016
    ..This study explores inflammatory and airway responses following neonatal hyperoxia in adult mice...
  27. doi request reprint Adverse neonatal outcomes associated with early-term birth
    Shaon Sengupta
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    JAMA Pediatr 167:1053-9. 2013
    ..However, recent evidence from studies based on mode of delivery has pointed toward increased morbidity associated with early-term cesarean section births (37-38 weeks) compared with term neonates (39-41 weeks)...
  28. pmc Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells
    Monica R Shah
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Int J Mol Sci 14:4334-48. 2013
    ..A better understanding of the interplay between these two distinct pathways could provide key insights into future avenues to treat infants with pulmonary hypertension...
  29. pmc Fetal and postnatal ovine mesenteric vascular reactivity
    Jayasree Nair
    Department of Pediatrics, University at Buffalo, Buffalo, New York
    Pediatr Res 79:575-82. 2016
    ..We hypothesized that MA vasoreactivity changes with gestation and vasodilator pathways predominate in the postnatal period...
  30. doi request reprint Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia
    Rita M Ryan
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, NY, USA
    Clin Rev Allergy Immunol 34:174-90. 2008
    ....
  31. ncbi request reprint Early Use of Inhaled Nitric Oxide in Preterm Infants: Is there a Rationale for Selective Approach?
    Praveen Chandrasekharan
    Division of Neonatology, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, New York
    Am J Perinatol . 2016
    ..b>Conclusion Preterm infants with HRF exposed to antenatal steroids and pPROM had improved oxygenation with iNO and survival without severe IVH/PVL. Precisely targeting this subset may be beneficial in future trials of iNO...
  32. pmc Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, Buffalo, New York
    Pediatr Res 77:347-55. 2015
    ..Current neonatal resuscitation guidelines recommend tracheal suctioning of nonvigorous neonates born through meconium-stained amniotic fluid...
  33. pmc Hydrocortisone normalizes phosphodiesterase-5 activity in pulmonary artery smooth muscle cells from lambs with persistent pulmonary hypertension of the newborn
    Marta Perez
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Pulm Circ 4:71-81. 2014
    ..These data suggest that hyperoxia activates NFκB, which in turn induces PDE5 activity in PPHN FPASMC, whereas treatment with hydrocortisone attenuates these changes by blocking reactive oxygen species-induced NFκB activity. ..
  34. doi request reprint Randomized controlled trial of vinyl bags versus thermal mattress to prevent hypothermia in extremely low-gestational-age infants
    Bobby Mathew
    Department of Pediatrics, Women and Children s Hospital of Buffalo, University of Buffalo, Buffalo, New York 14222, USA
    Am J Perinatol 30:317-22. 2013
    ..To compare the efficacy of vinyl bags and thermal warming mattresses in preventing hypothermia during delivery room resuscitation and stabilization of extremely low-gestational-age neonates (ELGANs)...
  35. pmc Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs
    Robert C Dukarm
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    J Appl Physiol (1985) 99:2331-6. 2005
    ..In contrast, the effects on E4021 on net lung liquid production appear to be independent of nitric oxide synthase, suggesting that these two critical perinatal events might be modulated independently...
  36. ncbi request reprint Growth factors in lung development
    Vasanth H Kumar
    Department of Pediatrics Neonatology, State University of New York, The Women and Children s Hospital of Buffalo, Buffalo, New York, USA
    Adv Clin Chem 40:261-316. 2005
    ....
  37. pmc Resuscitator's perceptions and time for corrective ventilation steps during neonatal resuscitation
    Vinay Sharma
    Division of Neonatology, Department of Pediatrics, The Women and Children s Hospital of Buffalo, University of Buffalo, 219 Bryant Street, Buffalo, NY, United States
    Resuscitation 91:63-6. 2015
    ..The perception of neonatal providers, time taken to perform these maneuvers or the effectiveness of these additional steps has not been evaluated...
  38. doi request reprint Association between caffeine citrate exposure and necrotizing enterocolitis in preterm infants
    Stacie J Lampkin
    Department of Pharmacy Practice, School of Pharmacy, D Youville College, 320 Porter Avenue, Buffalo, NY 14201, USA
    Am J Health Syst Pharm 70:603-8. 2013
    ..The results of a case-control study of the potential role of caffeine citrate therapy in the development of necrotizing enterocolitis (NEC) are presented...
  39. pmc Epidemiology and Clinical Research Design, Part 1: Study Types
    Veena Manja
    Department of Internal Medicine, University at Buffalo, Buffalo, NY Department of Clinical Epidemiology and Biostatistics, McMasters University, Hamilton, Ontario, Canada
    Neoreviews 15:e558-e569. 2014
    ..Various study types pertaining to neonatal-perinatal medicine are reviewed in this article...
  40. pmc Neonatal resuscitation: evolving strategies
    Payam Vali
    Department of Pediatrics Neonatology, University at Buffalo, Buffalo, NY, USA Division of Neonatology, Department of Pediatrics, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222, USA
    Matern Health Neonatol Perinatol 1:. 2015
    ..Finally, efforts to improve resuscitative efforts in developing countries through education of basic steps of neonatal resuscitation are likely to decrease birth asphyxia and neonatal mortality...
  41. pmc Epidemiology and Clinical Research Design, Part 2: Principles
    Veena Manja
    Department of Internal Medicine, University at Buffalo, Buffalo, NY Department of Clinical Epidemiology and Biostatistics, McMasters University, Hamilton, Ontario, Canada
    Neoreviews 16:e94-e108. 2015
    ..This article reviews bias and confounding, causation, incidence and prevalence, decision analysis, cost-effectiveness, sensitivity analysis, and measurement...
  42. pmc Oral Dextrose Gel Reduces the Need for Intravenous Dextrose Therapy in Neonatal Hypoglycemia
    Munmun Rawat
    Division of Neonatology, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, N Y, USA
    Biomed Hub 1:. 2016
    ..Newborn infants with risk factors may require intravenous (IV) dextrose for asymptomatic hypoglycemia. Administration of IV dextrose and transfer to the neonatal intensive care unit (NICU) may interfere with parent-infant bonding...
  43. pmc Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review
    Veena Manja
    Division of Cardiology, Department of Internal Medicine, Veterans Affairs Medical Center, Buffalo, New York
    Pediatrics 139:. 2017
    ..The optimal oxygen saturation target for extremely preterm infants remains unclear...
  44. doi request reprint Oxygen saturation targeting by pulse oximetry in the extremely low gestational age neonate: a quixotic quest
    James J Cummings
    aDepartment of Pediatrics, The Children s Hospital at Albany Medical Center, Albany bDepartment of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, New York, New York, USA
    Curr Opin Pediatr . 2017
    ..We examine the results of those trials, collectively referred to as the Neonatal Oxygenation Prospective Meta-analysis or NeOProM. We also discuss the uncertainties that remain and the clinical challenges that lie ahead...
  45. pmc Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis
    Veena Manja
    Division of Cardiology, Department of Medicine, Veterans Affairs Medical Center, Buffalo, New York2Department of Internal Medicine, University at Buffalo, The State University of New York, Buffalo3Department of Clinical Epidemiology and Biostatistics, MCM
    JAMA Pediatr 169:332-40. 2015
    ..The optimal oxygen saturation (SpO2) target for extremely preterm infants is unknown...
  46. pmc Update on PPHN: mechanisms and treatment
    Jayasree Nair
    Center for Developmental Biology of the Lung, State University of New York, Buffalo, NY
    Semin Perinatol 38:78-91. 2014
    ..However, the risk of potential neurodevelopmental impairment warrants close follow-up after discharge for infants with PPHN. ..
  47. ncbi request reprint Pleural effusion with parenteral nutrition solution: an unusual complication of an "appropriately" placed umbilical venous catheter
    Maria Janina U Pabalan
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Perinatol 24:581-5. 2007
    ..We report for the first time a case of right-sided pleural effusion with parenteral nutrition solution following a UVC that appeared to be positioned appropriately in the inferior vena cava...
  48. ncbi request reprint Vinyl bags prevent hypothermia at birth in preterm infants
    Bobby Mathew
    Division of Neonatology, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, USA
    Indian J Pediatr 74:249-53. 2007
    ..To compare the effect of standard care vs. the use of vinyl bags (Vi-Drape (R) isolation bag) on admission temperature in extremely premature infants < or = 28 weeks gestational age at birth...
  49. pmc eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    Eugenia Mata-Greenwood
    Dept of Pediatrics, Northwestern Univ, Ward 12 191, 303 E Chicago Ave, Chicago, IL 60611 008, USA
    Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006
    ..We speculate this may be related to cellular production and/or maintenance of BH4 levels...
  50. pmc Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn
    Stephen Wedgwood
    Dept of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L660-6. 2005
    ..Overall our data suggest a role for H(2)O(2) in the abnormal vasodilation associated with the pulmonary arteries of PPHN lambs...