James G Kublin
Affiliation: University of Maryland
- Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malariaJames G Kublin
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
J Infect Dis 185:380-8. 2002..If this model is validated in other populations, it will finally be possible to use molecular markers for surveillance of antifolate-resistant P. falciparum malaria in Africa...
- Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective studyChristopher V Plowe
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, MD 21044, USA
BMJ 328:545. 2004..To measure the efficacy of sulfadoxine-pyrimethamine treatment of falciparum malaria in Malawi from 1998 to 2002, after a change from chloroquine to sulfadoxine-pyrimethamine as first line treatment in that country in 1993...
- Delayed-type hypersensitivity in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoitesJames G Kublin
Department of Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
Vaccine 20:1853-61. 2002..We conclude that the presence of T cell functional activity reflected by a positive DTH skin test response to the MAP antigen serves as another marker for vaccine immunogenicity...
- Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in MalawiJames G Kublin
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Infect Dis 187:1870-5. 2003..The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable...
- Immediate-type hypersensitivity and other clinical reactions in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoitesRobert Edelman
Department of Medicine, University of Maryland School of Medicine, Room 480, 685 West Baltimore Street, Baltimore, MD 21201 USA
Vaccine 21:269-80. 2002..Five of five non-immunized persons were also ITH-ST negative. ITH-STs may help identify individuals sensitized to malaria peptides and at potential risk of developing systemic allergic reactions after re-vaccination...
- Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in MalawiElena Artimovich
Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore
J Infect Dis 212:694-701. 2015..Here we estimate the effect of reduced SP pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci...
- Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian childrenFraction K Dzinjalamala
University of Cape Town, Division of Clinical Pharmacology, K50 Old Main Building, Groote Schuur Hospital, Cape Town 7925, South Africa
Antimicrob Agents Chemother 49:3601-6. 2005..falciparum should be interpreted with caution and needs further validation...
- Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sitesSarah J Bates
Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
J Infect Dis 190:1783-92. 2004..Overall, these results suggest that dhfr alleles that confer high levels of resistance to antifolates are rare, even in eastern and southern Africa, where pyrimethamine has been intensively used...
- Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malariaFraction K Dzinjalamala
Division of Pharmacology, University of Cape Town, Cape Town, South Africa
Am J Trop Med Hyg 72:267-72. 2005....
- Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural MalawiPadmaja Patnaik
Department of Epidemiology, University of North Carolina at Chapel Hill, 27599, USA
J Infect Dis 192:984-91. 2005....
- Challenges in the prevention, diagnosis, and treatment of malaria in human immunodeficiency virus infected adults in sub-Saharan AfricaPaula E Brentlinger
Department of Health Services, School of Public Health and Community Medicine, Box 357660, University of Washington, Seattle, WA 98195, USA
Arch Intern Med 167:1827-36. 2007..The likelihood of HIV-malaria coinfection may affect clinical management of patients. The extent to which standard clinical guidelines address HIV-malaria coinfection is unclear...
- Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan AfricaLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 314:1603-6. 2006..Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa...
- HIV infection and malaria--understanding the interactionsJames G Kublin
J Infect Dis 193:1-3. 2006
- A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for managementRemco P H Peters
Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
Trop Med Int Health 9:928-34. 2004..To determine the contribution of a blood culture service to the diagnosis of fever in a resource-poor setting and to identify clinical predictors of specific bloodstream infections (BSI)...
- Prevalence and indicators of HIV and AIDS among adults admitted to medical and surgical wards in Blantyre, MalawiDavid K Lewis
Department of Medicine, University of Malawi College of Medicine, Private Bag 360, Chichiri, Blantyre 3, Malawi
Trans R Soc Trop Med Hyg 97:91-6. 2003..4). Severe bacterial infections, TB and AIDS caused 68% of deaths. HIV dominates adult medicine, is a major part of adult surgery, is the main cause of death in hospital and affects the economically active age group of the population...
- Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort studyJames G Kublin
Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
Lancet 365:233-40. 2005..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi...