Genomes and Genes
John D Kriesel
Affiliation: University of Utah
- Deep sequencing for the detection of virus-like sequences in the brains of patients with multiple sclerosis: detection of GBV-C in human brainJohn D Kriesel
Department of Internal Medicine, Division of Infectious Diseases, University of Utah, Salt Lake City, Utah, United States of America
PLoS ONE 7:e31886. 2012..This study shows the feasibility of deep sequencing for the detection of occult viral infections in the brains of deceased persons with MS. The first isolation of GBV-C from human brain is reported here...
- C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility geneJohn D Kriesel
Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84132, USA
J Infect Dis 204:1654-62. 2011..Herpes simplex virus type 1 (HSV-1) infects >70% of the United States population. We identified a 3-megabase region on human chromosome 21 containing 6 candidate genes associated with herpes simplex labialis (HSL, "cold sores")...
- Persistent pulmonary infection with an azole-resistant Coccidioides speciesJohn D Kriesel
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Med Mycol 46:607-10. 2008..Since this diagnosis, the patient has received weekly amphotericin B for more than four years and remains in remission with a stable serum Coccidioides complement fixation antibody titer...
- Multiple sclerosis attacks are associated with picornavirus infectionsJohn D Kriesel
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Mult Scler 10:145-8. 2004..By contrast, only two of 12 (17%) picornavirus-negative URIs were associated with an MS attack (P = 0.01). The possible role of picornaviruses in the pathogenesis of MS deserves further study...
- Identification of a herpes simplex labialis susceptibility region on human chromosome 21Maurine R Hobbs
Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Infect Dis 197:340-6. 2008..Reactivations of HSV-1 infection cause herpes simplex labialis (HSL; cold sores or fever blisters), which is the most common recurring viral infection in humans...
- The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitisJohn D Kriesel
University of Utah School of Medicine, Departments of Internal Medicine and Ophthalmology, Salt Lake City, Utah 84132, USA
DNA Cell Biol 21:475-81. 2002..These studies suggest that the inhibitory effects of NGF/trkA signaling are lost after TG explantation while STAT expression is maintained, allowing HSV-1 reactivation to proceed...
- Recurrent antiviral-resistant genital herpes in an immunocompetent patientJohn D Kriesel
Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
J Infect Dis 192:156-61. 2005..These findings support the conclusion that both drug-sensitive and drug-resistant HSV-2 strains established latency in this patient and that both strains are capable of frequent reactivation...
- STAT1 binds to the herpes simplex virus type 1 latency-associated transcript promoterJohn D Kriesel
Department of Opthalomology, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Neurovirol 10:12-20. 2004..Further studies are required to determine if STAT1 is required for LAT expression in vivo. This work supports the hypothesis that interferons act through STAT1 to regulate the expression of HSV-1 LAT...
- Invasive fungal sinusitis caused by Scytalidium dimidiatum in a lung transplant recipientJames J Dunn
ARUP Laboratories, Inc, Salt Lake City, Utah, USA
J Clin Microbiol 41:5817-9. 2003..Following 6 months of voriconazole treatment, the patient remained radiographically and clinically stable for a short time before dying of respiratory failure precipitated by graft rejection...
- Deep sequencing to identify the causes of viral encephalitisBenjamin K Chan
Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS ONE 9:e93993. 2014..These results were concordant with pathogen-specific PCR and partially concordant with prior neuropathological examinations, demonstrating that deep sequencing can accurately identify viral infections in frozen brain tissue. ..
- Treatment of herpes simplex labialisSpotswood L Spruance
Division of Infectious Diseases, University of Utah School of Medicine, Room 4B319, 30 North 1900 East, Salt Lake City, UT 84132 2405, USA
Herpes 9:64-9. 2002..Selected subgroups of patients are candidates for prophylactic treatment with perorally administered nucleoside antiviral agents. Prophylaxis with topical agents is not effective...