Kenneth S Kosik

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint MicroRNAs and cellular phenotypy
    Kenneth S Kosik
    Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell 143:21-6. 2010
  2. pmc Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions
    Cecilia Conaco
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    BMC Genomics 13:209. 2012
  3. doi request reprint MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states
    Pierre Neveu
    Neuroscience Research Institute, University of California at Santa Barbara, 93106, USA
    Cell Stem Cell 7:671-81. 2010
  4. pmc Statistical analysis of dendritic spine distributions in rat hippocampal cultures
    Aruna Jammalamadaka
    Department of Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, CA, USA
    BMC Bioinformatics 14:287. 2013
  5. pmc Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns
    Mary L Arcila
    Neuroscience Research Institute and Department Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Neuron 81:1255-62. 2014
  6. pmc Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models
    Xuemei Zhang
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA
    J Biol Chem 288:22042-56. 2013
  7. pmc NMDA mediated contextual conditioning changes miRNA expression
    Min Jeong Kye
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 6:e24682. 2011
  8. pmc Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology
    Theresa M Yuraszeck
    Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
    PLoS Comput Biol 6:e1000997. 2010
  9. pmc Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease
    Matthew A Lalli
    Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, USA
    Alzheimers Dement 10:S277-S283.e10. 2014
  10. pmc Deep annotation of mouse iso-miR and iso-moR variation
    Hongjun Zhou
    Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Nucleic Acids Res 40:5864-75. 2012

Collaborators

Detail Information

Publications27

  1. doi request reprint MicroRNAs and cellular phenotypy
    Kenneth S Kosik
    Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell 143:21-6. 2010
    ..Given the ease with which new microRNAs evolve, they may serve as ideal facilitators for the emergence of new cell types...
  2. pmc Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions
    Cecilia Conaco
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    BMC Genomics 13:209. 2012
    ....
  3. doi request reprint MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states
    Pierre Neveu
    Neuroscience Research Institute, University of California at Santa Barbara, 93106, USA
    Cell Stem Cell 7:671-81. 2010
    ..Thus, our results suggest a subdivision of pluripotent stem cell states that is independent of their origin but related to p53 network status...
  4. pmc Statistical analysis of dendritic spine distributions in rat hippocampal cultures
    Aruna Jammalamadaka
    Department of Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, CA, USA
    BMC Bioinformatics 14:287. 2013
    ..Finally, an important variant of Ripley's K-function applicable to linear networks was used to study the spatial distribution of spines along dendrites...
  5. pmc Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns
    Mary L Arcila
    Neuroscience Research Institute and Department Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Neuron 81:1255-62. 2014
    ....
  6. pmc Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models
    Xuemei Zhang
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA
    J Biol Chem 288:22042-56. 2013
    ..Treatment also induced the recovery of memory in a fear conditioning assay. Given the contribution of both CDK5/p25 and GSK3β to Tau phosphorylation, effective treatment of tauopathies may require dual kinase targeting. ..
  7. pmc NMDA mediated contextual conditioning changes miRNA expression
    Min Jeong Kye
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 6:e24682. 2011
    ..These findings point to a role for miRNAs in learning and memory that includes mTOR-dependent modulation of protein synthesis...
  8. pmc Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology
    Theresa M Yuraszeck
    Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
    PLoS Comput Biol 6:e1000997. 2010
    ....
  9. pmc Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease
    Matthew A Lalli
    Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, USA
    Alzheimers Dement 10:S277-S283.e10. 2014
    ..A mutation in presenilin 1 (E280A) causes early-onset Alzheimer's disease. Understanding the origin of this mutation will inform medical genetics...
  10. pmc Deep annotation of mouse iso-miR and iso-moR variation
    Hongjun Zhou
    Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Nucleic Acids Res 40:5864-75. 2012
    ..Sequence variation of the two strands at their cleavage sites suggested higher fidelity of Drosha than Dicer. These studies demonstrated multiple patterns of miRNA processing and considerable versatility in miRNA target selection...
  11. pmc Functionalization of a protosynaptic gene expression network
    Cecilia Conaco
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 109:10612-8. 2012
    ..This work shows that the application of network techniques to emerging genomic and expression data can provide insights into the evolution of complex cellular machines such as the synapse...
  12. pmc Detection of a microRNA signal in an in vivo expression set of mRNAs
    Tsunglin Liu
    Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California, United States of America Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California, United States of America
    PLoS ONE 2:e804. 2007
    ..We asked whether endogenous fluctuations in a set of mRNA and miRNA profiles contain correlated changes that are statistically distinguishable from the many other fluctuations in the data set...
  13. doi request reprint MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    Na Xu
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, The University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell 137:647-58. 2009
    ..This work reveals a direct link between the core reprogramming factors and miR-145 and uncovers a double-negative feedback loop involving OCT4, SOX2, KLF4, and miR-145...
  14. doi request reprint A delta-catenin signaling pathway leading to dendritic protrusions
    Kawther Abu-Elneel
    Neuroscience Research Institute, and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 283:32781-91. 2008
    ....
  15. doi request reprint Heterogeneous dysregulation of microRNAs across the autism spectrum
    Kawther Abu-Elneel
    Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Neurogenetics 9:153-61. 2008
    ..This study finds that altered miRNA expression levels are observed in postmortem cerebellar cortex from autism patients, a finding which suggests that dysregulation of miRNAs may contribute to autism spectrum phenotype...
  16. doi request reprint A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation
    Sourav Banerjee
    Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Neuron 64:871-84. 2009
    ..We established this protein synthesis to be MOV10 and proteasome dependent. These results suggest a unifying picture of a local translational regulatory mechanism during synaptic plasticity...
  17. pmc Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs
    Caroline Corbel
    Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA
    Neural Dev 10:20. 2015
    ..Regulation of GluN2A and GluN2B expressions are incompletely understood. Here, we showed the influence of miRNAs in this process...
  18. pmc Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers
    Matthew A Lalli
    Neuroscience Research Institute, University of California at Santa Barbara, CA, USA
    Hum Mutat 33:1630-4. 2012
    ..Future work and replication studies on these variants may provide mechanistic insights into the etiopathology of Alzheimer disease...
  19. pmc Identification of piRNAs in the central nervous system
    Eun Joo Lee
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    RNA 17:1090-9. 2011
    ..Antisense suppression of this piRNA suggested a role in spine morphogenesis. Possible targets include genes, which control spine shape by a distinctive mechanism in comparison to microRNAs...
  20. pmc The Amphimedon queenslandica genome and the evolution of animal complexity
    Mansi Srivastava
    Center for Integrative Genomics and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 466:720-6. 2010
    ..Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity...
  21. doi request reprint MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    Thales Papagiannakopoulos
    Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Cancer Res 68:8164-72. 2008
    ..These findings establish miR-21 as an important oncogene that targets a network of p53, TGF-beta, and mitochondrial apoptosis tumor suppressor genes in glioblastoma cells...
  22. pmc The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule
    Daniel C Carrettiero
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Neurosci 29:2151-61. 2009
    ..Thus, we propose that ubiquitinated Tau inclusions arise due to shunting of Tau degradation toward a less efficient ubiquitin-dependent pathway...
  23. pmc Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells
    Jiwon Jang
    Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, California, USA
    Stem Cells 32:2616-25. 2014
    ..Taken together, our findings suggest a new potential link between environmental stress and stemness with Nrf2 and the proteasome coordinately positioned as key mediators...
  24. pmc Particle display: a quantitative screening method for generating high-affinity aptamers
    Jinpeng Wang
    Department of Mechanical Engineering, Materials and Institute for Collaborative Biotechnologies, University of California, Santa Barbara, CA 93106 USA
    Angew Chem Int Ed Engl 53:4796-801. 2014
    ..We believe particle display offers an extraordinarily efficient mechanism for generating high-quality aptamers in a rapid and economic manner, towards accelerated exploration of the human proteome. ..
  25. pmc Mechanisms of age-related cognitive change and targets for intervention: epigenetics
    Kenneth S Kosik
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, USA
    J Gerontol A Biol Sci Med Sci 67:741-6. 2012
    ..This session established useful mileposts for gaging progress in this rapidly advancing area of research...
  26. doi request reprint MicroRNAs tell an evo-devo story
    Kenneth S Kosik
    Neuroscience Research Institute and the Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Nat Rev Neurosci 10:754-9. 2009
    ..The structure of microRNAs, their physical proximity to other genes and their network effects on targets make this class of transcripts tractable genetic material for evolutionary change...
  27. doi request reprint MicroRNA-124: micromanager of neurogenesis
    Thales Papagiannakopoulos
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Cell Stem Cell 4:375-6. 2009
    ..In a recent issue of Nature Neuroscience, Cheng et al. (2009) demonstrate that miR-124, the most abundant of the microRNAs in the adult brain, positively modulates the transitory progression of adult subventricular zone (SVZ) neurogenesis...