Affiliation: University of California
- Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cellsTheresa K Kelly
The Semel Institute for Neuroscience and Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
PLoS ONE 4:e4213. 2009..Furthermore, there is a population of a LeX negative NSC that is present in neurospheres derived from the embryonic spinal cord but not the cortex...
- Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferationIchiro Nakano
Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
J Cell Biol 170:413-27. 2005..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain...
- Brain tumor stem cells as therapeutic targets in models of gliomaDan Richard Laks
Intellectual and Developmental Disability Research Center, UCLA Medical Center, Los Angeles, California, USA
Yonsei Med J 51:633-40. 2010..Here, we review research and discuss perspectives on models of glioma in order to delineate the current issues in defining brain tumor stem cells as therapeutic targets in models of glioma...
- Introduction to neural stem cellsHarley I Kornblum
Semel Institute and Departments of Psychiatry, Pharmacology and Pediatrics, David Geffen School of Medicine at UCLA, Los Angles, CA, USA
Stroke 38:810-6. 2007..This brief review provides an introduction to neural stem cells and briefly describes some advances in neural stem-cell biology and biotechnology...
- In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)H I Kornblum
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Nat Biotechnol 18:655-60. 2000....
- Social communication in children with epilepsyRochelle Caplan
J Child Psychol Psychiatry 43:245-53. 2002..1-16.9 years...
- Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesionKoppany Visnyei
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Exp Neurol 197:465-74. 2006..These data demonstrate that progenitor cell implantation results in enhanced metabolic function and sparing of neuron number, but that these functions do not necessarily result in the restoration of complex circuitry...
- [Cancer stem cells in pediatric brain tumors]Ichiro Nakano
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
No Shinkei Geka 32:827-34. 2004..In this review, we discuss the difference as well as the similarity between tumor and normal stem cells, and also the possible clinical implication of cancer stem cells...
- A multipronged approach to the identification and study of an important oncogene in GBMHarley I Kornblum
Intellectual and Developmental Disabilities Research Center and Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Cancer Cell 17:417-8. 2010..provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling...
- Evolution of diaschisis in a focal stroke modelS Thomas Carmichael
Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Stroke 35:758-63. 2004..The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined...
- Endogenous Wnt signaling maintains neural progenitor cell potencyEric M Wexler
Department of Psychiatry, The Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
Stem Cells 27:1130-41. 2009..In sum, this study establishes that autonomous Wnt signaling is a conserved feature of the neurogenic niche that preserves the delicate balance between NSC maintenance and differentiation...
- Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferationIchiro Nakano
Department of Neurological Surgery, UCLA, Los Angeles, CA 90095 1769, USA
Stem Cells 25:1975-84. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiationJonathan P Saxe
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Chem Biol 14:1019-30. 2007..This work highlights the tremendous potential of developing effective small-molecule drugs for use in regenerative medicine or transplantation therapy...
- Methods for analysis of brain tumor stem cell and neural stem cell self-renewalIchiro Nakano
Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Methods Mol Biol 568:37-56. 2009..Utilizing our studies with MELK as an example, this chapter describes methods to culture NSC and BT stem cells, and to analyze the pathways, which regulate self-renewal of those cells...
- Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cellsDwain K Irvin
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California, USA
J Neurosci Res 75:330-43. 2004..Taken together, these results support multiple and differing roles for the various ligands during and after central nervous system (CNS) development...
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cellsIchiro Nakano
Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurosci Res 86:48-60. 2008..These results demonstrate a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors...
- Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesisCaroline Gregorian
Department of Molecular and Medical Pharmacology, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 29:1874-86. 2009....
- Extrinsic and intrinsic factors governing cell fate in cortical progenitor culturesDwain K Irvin
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, Calif 90095, USA
Dev Neurosci 25:162-72. 2003..These data suggest that both extrinsic and intrinsic factors differentially regulate cell fate choices of progenitors during cortical development...
- Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networksStanislav L Karsten
Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Dev Biol 261:165-82. 2003..We propose a putative network of gene expression linking cell cycle control to cell fate pathways, providing a framework for further investigations of neural stem cell proliferation and differentiation...
- Roles of insulin and transferrin in neural progenitor survival and proliferationRebecca I Erickson
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 94025, USA
J Neurosci Res 86:1884-94. 2008..These data indicate that the neurogenic potential of NSC may be intimately linked to a continuous exposure to mitogens...
- BMPing off glioma stem cellsIchiro Nakano
Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
Cancer Cell 13:3-4. 2008..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
- Neurosphere formation is an independent predictor of clinical outcome in malignant gliomaDan R Laks
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Stem Cells 27:980-7. 2009..Furthermore, this study suggests that the ability to propagate brain tumor stem cells in vitro is associated with clinical outcome...
- A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimensJing Sun
Crump Institute for Molecular Imaging, University of California at Los Angeles, Los Angeles, California 90095, USA
Cancer Res 70:6128-38. 2010..Together with bioinformatic analysis, the MIC platform represents a robust, enabling in vitro molecular diagnostic technology for systems pathology analysis and personalized medicine...
- Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brainLijuan Fu
Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Comp Neurol 462:265-73. 2003..The current study suggests that HEGFR and HFGFR1 are likely to play different roles during human brain development, but that these roles will be similar to those observed in the rodent brain...
- PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entryMatthias Groszer
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:111-6. 2006..Therefore, loss of PTEN leads to cell physiological changes, which collectively are sufficient to increase the pool of self-renewing neural stem cells and promote their escape from the homeostatic mechanisms of proliferation control...
- Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populationsMathew C Easterday
Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Dev Biol 264:309-22. 2003..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...
- The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAPTetsuya Imura
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
J Neurosci 23:2824-32. 2003....
- Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytesTetsuya Imura
Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
Glia 53:277-93. 2006..The findings provide evidence that GFAP-expressing NSCs are phenotypically and functionally distinct from non-neurogenic astrocytes...
- The RAS effector RIN1 modulates the formation of aversive memoriesAjay Dhaka
Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
J Neurosci 23:748-57. 2003..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
- Brain tumor stem cellsIchiro Nakano
Departments of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, 90095, USA
Pediatr Res 59:54R-8R. 2006..In this review, we discuss the cellular and molecular relationships between brain tumor stem cells and normal neural stem cells, and also the possible clinical implications of brain tumor stem cells...
- Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006Jerry C Cheng
Division of Hematology Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories and Mattel Children s Hospital, Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
Stem Cells 25:1070-88. 2007
- Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamilySeema K Tiwari-Woodruff
Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Neurosci Res 77:166-73. 2004....
- Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formationEduard H Panosyan
Department of Pediatrics, University of California Los Angeles UCLA, Los Angeles, California 90095, USA
Pediatr Blood Cancer 55:644-51. 2010..Renewable neurosphere formation has clinical predictive value in adult malignant gliomas, yet its prognostic role for pediatric brain tumors is unknown...
- Metabolic correlates of lesion-specific plasticity: an in vivo imaging studyHalleh M Mir
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Brain Res 1002:28-34. 2004....
- Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biologyIrina J Fox
UCLA Interdepartmental Program in Molecular, Cellular, and Integrative Physiology, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Brain Res Dev Brain Res 153:121-5. 2004..The current findings indicate that while some GFAP-expressing cells in the GZ may be NSCs, most are not likely to function in a neurogenic capacity...
- Directed differentiation of human-induced pluripotent stem cells generates active motor neuronsSaravanan Karumbayaram
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Stem Cells 27:806-11. 2009..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases...
- Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALSSaravanan Karumbayaram
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Dis Model Mech 2:189-95. 2009..These genetically manipulated hESC-derived motor neurons can facilitate and advance the study of disease-specific cellular pathways, and serve as a model system to test new therapeutic approaches...
- Cancerous stem cells can arise from pediatric brain tumorsHouman D Hemmati
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 100:15178-83. 2003..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...
- Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNALaura L Bruce
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 0405, USA
Brain Res Bull 57:455-61. 2002..Most neurons in the rotundus and ovoidalis nuclei of chick may be homologous to unlabeled clusters of neurons intermingled with ErbB4-expressing cells of the mammalian posterior/intralaminar region...
- Identity and Function of CNS Progenitor Cell GenesHarley Kornblum; Fiscal Year: 2007..In another set of experiments, microarray analysis will be used to compare gene expression in PTEN-deficient and wild type neurosphere cultures to discover genes and gene networks regulating self-renewal. ..
- A Proteomic Analysis of Neural ProgenitorsHarley Kornblum; Fiscal Year: 2004..It is anticipated that these pilot studies will pave the way for new avenues in the study of neural progenitor cell biology. ..