Thomas B Kornberg

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint A Path to Pattern
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, California, USA Electronic address
    Curr Top Dev Biol 116:551-67. 2016
  2. pmc The contrasting roles of primary cilia and cytonemes in Hh signaling
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, United States Electronic address
    Dev Biol 394:1-5. 2014
  3. pmc Barcoding Hedgehog for intracellular transport
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Sci Signal 4:pe44. 2011
  4. pmc Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein
    Sougata Roy
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 343:1244624. 2014
  5. pmc Specificity of Drosophila cytonemes for distinct signaling pathways
    Sougata Roy
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 332:354-8. 2011
  6. pmc Communicating by touch--neurons are not alone
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA Electronic address
    Trends Cell Biol 24:370-6. 2014
  7. pmc A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing
    David J Casso
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2711, USA
    Genetics 187:485-99. 2011
  8. pmc Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling
    Brian Biehs
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2711, USA
    Development 137:3887-98. 2010
  9. pmc Drosophila signal peptide peptidase is an essential protease for larval development
    David J Casso
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Genetics 170:139-48. 2005
  10. ncbi request reprint Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Development 132:3753-65. 2005

Collaborators

  • Makoto Sato
  • Katerina Kechris
  • Susan E Lott
  • Hao Li
  • Gerold Schubiger
  • Michael B Eisen
  • Li Lin
  • Sougata Roy
  • David J Casso
  • Brian Biehs
  • Songmei Liu
  • Arjun Guha
  • Hai Huang
  • Dan Yu
  • Ansgar Klebes
  • Frank Hsiung
  • Yuh Nung Jan
  • Xiaokun Shu
  • Zehra Ali-Murthy
  • Shiho Kawamura
  • Felipe Andrès Ramirez-Weber
  • Xingwu Lu
  • Elizabeth S Howe
  • Matthew P Klassen
  • Orion D Weiner
  • Anna Reade
  • Michael W Davidson
  • Shao Qing Zhang
  • Zehra Murthy
  • Kalpana Makhijani
  • Yuanquan Song
  • John R Allen
  • Michelle A Baird
  • William Clay Gustafson
  • Céline Lafaye
  • Antoine Royant
  • William A Weiss
  • Marjolaine Noirclerc-Savoye
  • Woo Ping Ge
  • Lily Yeh Jan
  • Chun Han
  • Desiree A Thayer
  • Kieran Hervold
  • Anne Sustar
  • Bruno Martoglio
  • Soichi Tanda
  • D David Iwaki
  • Francisco Cifuentes

Detail Information

Publications27

  1. doi request reprint A Path to Pattern
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, California, USA Electronic address
    Curr Top Dev Biol 116:551-67. 2016
    ..In this essay, I offer my perspectives and my sense of some principles that have emerged. ..
  2. pmc The contrasting roles of primary cilia and cytonemes in Hh signaling
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, United States Electronic address
    Dev Biol 394:1-5. 2014
    ..Implicit in this model is the idea that initial binding and uptake of Hh is independent of and segregated from the processes of signal transduction and activation...
  3. pmc Barcoding Hedgehog for intracellular transport
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Sci Signal 4:pe44. 2011
    ..Another interpretation and model is that the C-terminal cholesterol acts to target Hedgehog to an intracellular trafficking pathway that prepares Hedgehog for release in an encapsulated form...
  4. pmc Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein
    Sougata Roy
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 343:1244624. 2014
    ....
  5. pmc Specificity of Drosophila cytonemes for distinct signaling pathways
    Sougata Roy
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 332:354-8. 2011
    ....
  6. pmc Communicating by touch--neurons are not alone
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA Electronic address
    Trends Cell Biol 24:370-6. 2014
    ..We review here contact-mediated signaling in neurons and discuss how this signaling mechanism is shared by other cell types...
  7. pmc A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing
    David J Casso
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2711, USA
    Genetics 187:485-99. 2011
    ..This work thus reveals a novel collaboration by the Hedgehog and Notch pathways that regulates proliferation in the 3-4 intervein region independently of Decapentaplegic...
  8. pmc Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling
    Brian Biehs
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2711, USA
    Development 137:3887-98. 2010
    ....
  9. pmc Drosophila signal peptide peptidase is an essential protease for larval development
    David J Casso
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Genetics 170:139-48. 2005
    ..Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae...
  10. ncbi request reprint Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Development 132:3753-65. 2005
    ..Our findings are likely to be relevant to the mechanisms that lead to disease when homologs of Wingless are expressed at abnormal levels and to the manifestation of pluripotency of stem cells...
  11. pmc The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    Xingwu Lu
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143, USA
    Genes Dev 20:2539-51. 2006
    ..These data show that degradation of Ptc is regulated at a step subsequent to endocytosis, although endocytosis is a likely prerequisite. We also show that the CTD of mouse Ptc regulates turnover...
  12. pmc Cytonemes as specialized signaling filopodia
    Thomas B Kornberg
    Cardiovascular Research Institute, University of California, San Francisco, CA 94156, USA
    Development 141:729-36. 2014
    ..This evidence suggests that cytoneme-mediated signaling is a dispersal mechanism that delivers signaling proteins directly at sites of cell-cell contact. ..
  13. pmc Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease
    David J Casso
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e33827. 2012
    ..This was unexpected given that genetic knockdown phenotypes in other organisms suggested significant roles for Spp-related proteases...
  14. pmc Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Biol 335:317-26. 2009
    ..These findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix...
  15. pmc Understanding morphogen gradients: a problem of dispersion and containment
    Thomas B Kornberg
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 17:264-71. 2007
    ..We argue that in the absence of constraining barriers, gradient-generating dispersion of morphogens cannot be achieved by passive diffusion and that other mechanisms for distribution must be considered...
  16. pmc Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover
    Shiho Kawamura
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    J Biol Chem 283:30964-9. 2008
    ..We show that one of the conserved sequence regions in the C-terminal domain of Ptch1 is responsible, at least in part, for rapid turnover. This sequence is absent in the stable Ptch2 protein...
  17. pmc Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium
    Hai Huang
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States
    elife 4:e06114. 2015
    ..Wg signaling negatively regulates Dl expression in the myoblasts. These results reveal an essential role for cytonemes in Wg and Notch signaling and for a signal relay system in the myoblasts. ..
  18. pmc An essential role for zygotic expression in the pre-cellular Drosophila embryo
    Zehra Ali-Murthy
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003428. 2013
    ....
  19. ncbi request reprint FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system
    Makoto Sato
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Cell 3:195-207. 2002
    ....
  20. ncbi request reprint Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Dev Biol 287:192-200. 2005
    ....
  21. pmc Organ renewal and cell divisions by differentiated cells in Drosophila
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:10832-6. 2008
    ..We report here that they reinitiate cell divisions during the third instar (L3) to increase the Tr2 population by approximately 10-fold with multipotent cells...
  22. doi request reprint Direct delivery mechanisms of morphogen dispersion
    Sougata Roy
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Sci Signal 4:pt8. 2011
    ..Results presented here show that these proteins transfer from producing to target cells at points of direct contact, even when the producing and target cells are not immediate neighbors...
  23. ncbi request reprint Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic
    Frank Hsiung
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Nature 437:560-3. 2005
    ..We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes. These observations are consistent with a role for cytonemes in signal transduction...
  24. pmc Paracrine signaling mediated at cell-cell contacts
    Sougata Roy
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Bioessays 37:25-33. 2015
    ..Also watch the Video Abstract. ..
  25. pmc A naturally monomeric infrared fluorescent protein for protein labeling in vivo
    Dan Yu
    1 Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA 2 Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
    Nat Methods 12:763-5. 2015
    ..We demonstrate that mIFP correctly labels proteins in live cells, Drosophila and zebrafish. It should be useful in molecular, cell and developmental biology. ..
  26. pmc Expression profiling of Drosophila imaginal discs
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Genome Biol 3:RESEARCH0038. 2002
    ..To identify genes that establish and express the different states of determination in discs and larval tissues, we used DNA microarrays to analyze mRNAs isolated from single imaginal discs...
  27. pmc An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging
    Dan Yu
    1 Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA 2 Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nat Commun 5:3626. 2014
    ..We also show that this strategy improves the sensitivity when imaging brain tumours in whole mice. Our work shows promise in the application of IFPs for protein labelling and in vivo imaging. ..