Phillip G Kopf
Affiliation: University of New Mexico
- In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphologyAndrea C Aragon
College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Toxicol Sci 101:321-30. 2008..These results demonstrate that in utero and lactational TCDD exposures alter cardiac gene expression and cardiac and renal morphology in adulthood, which may increase the susceptibility to cardiovascular dysfunction...
- Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxidePhillip G Kopf
College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA
Cardiovasc Toxicol 8:181-93. 2008..Our model is the first to definitely demonstrate that sustained AhR activation by TCDD increases blood pressure and induces cardiac hypertrophy, which may be mediated, in part, by increased superoxide...
- Overview of developmental heart defects by dioxins, PCBs, and pesticidesPhillip G Kopf
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:276-85. 2009..However, recent animal research has confirmed human epidemiology studies that dioxin exposure in adulthood is associated with hypertension and cardiovascular disease...
- Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxinPhillip G Kopf
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
Toxicol Sci 117:537-46. 2010..These results demonstrate that CYP1A1 is required for TCDD-induced cardiovascular superoxide anion production, endothelial dysfunction, and hypertension...