Leonidas G Koniaris

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Induction of MIC-1/growth differentiation factor-15 following bile duct injury
    Leonidas G Koniaris
    Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Gastrointest Surg 7:901-5. 2003
  2. ncbi request reprint Two third-year medical student-level laboratory shock exercises without large animals
    Leonidas G Koniaris
    Department of Surgery, University of Rochester, Rochester, NY, USA
    Surg Infect (Larchmt) 5:343-8. 2004
  3. ncbi request reprint Inadequate anaesthesia in lethal injection for execution
    Leonidas G Koniaris
    DeWitt Daughtry Family Department of Surgery, School of Business, University of Miami, Miami, FL, USA
    Lancet 365:1412-4. 2005
  4. ncbi request reprint Pancreaticoduodenectomy in the presence of superior mesenteric venous obstruction
    Leonidas G Koniaris
    Department of Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Gastrointest Surg 9:915-21. 2005
  5. ncbi request reprint Can lethal injection for execution really be "fixed"?
    Leonidas G Koniaris
    University of Miami, Miami, FL 33156, USA
    Lancet 369:352-3. 2007
  6. doi request reprint Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later
    Leonidas G Koniaris
    Department of Surgery and Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Acad Med 85:687-91. 2010
  7. doi request reprint A comprehensive evaluation of outcomes for inflammatory breast cancer
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, Alan Livingstone Chair in Surgical Oncology, University of Miami Miller School of Medicine, 3550 Sylvester Comprehensive Cancer Center, 1475 NW 12th Ave, Miami, FL 33136, USA
    Breast Cancer Res Treat 117:631-41. 2009
  8. doi request reprint Are many community hospitals undertreating breast cancer?: lessons from 24,834 patients
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ann Surg 248:154-62. 2008
  9. doi request reprint African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients
    Manuel A Molina
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    Cancer 113:2797-806. 2008
  10. doi request reprint Preoperative imaging for resectable periampullary cancer: clinicopathologic implications of reported radiographic findings
    Zhi Ven Fong
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Gastrointest Surg 17:1098-106. 2013

Research Grants

  1. The Role of GDF-15 in Organ Injury
    Leonidas Koniaris; Fiscal Year: 2005
  2. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Induction of MIC-1/growth differentiation factor-15 following bile duct injury
    Leonidas G Koniaris
    Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Gastrointest Surg 7:901-5. 2003
    ..Taken together with the previously demonstrated growth inhibitory effects of MIC-1/GDF-15 on normal and transformed cells, MIC-1/GDF-15 may play a role in regulation of bile duct proliferation and biliary tumor formation...
  2. ncbi request reprint Two third-year medical student-level laboratory shock exercises without large animals
    Leonidas G Koniaris
    Department of Surgery, University of Rochester, Rochester, NY, USA
    Surg Infect (Larchmt) 5:343-8. 2004
    ..Herein, we describe two alternative exercises that communicated basic science and clinical principles of shock effectively...
  3. ncbi request reprint Inadequate anaesthesia in lethal injection for execution
    Leonidas G Koniaris
    DeWitt Daughtry Family Department of Surgery, School of Business, University of Miami, Miami, FL, USA
    Lancet 365:1412-4. 2005
    ..Methods of lethal injection anaesthesia are flawed and some inmates might experience awareness and suffering during execution...
  4. ncbi request reprint Pancreaticoduodenectomy in the presence of superior mesenteric venous obstruction
    Leonidas G Koniaris
    Department of Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Gastrointest Surg 9:915-21. 2005
    ..Further studies and more long-term follow-up at high-volume centers are required, however, to better determine the indications and potential benefit of such an undertaking...
  5. ncbi request reprint Can lethal injection for execution really be "fixed"?
    Leonidas G Koniaris
    University of Miami, Miami, FL 33156, USA
    Lancet 369:352-3. 2007
  6. doi request reprint Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later
    Leonidas G Koniaris
    Department of Surgery and Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Acad Med 85:687-91. 2010
    ..Furthermore, these results suggest that shortening the medical portion of combined MD-PhD programs might also be considered...
  7. doi request reprint A comprehensive evaluation of outcomes for inflammatory breast cancer
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, Alan Livingstone Chair in Surgical Oncology, University of Miami Miller School of Medicine, 3550 Sylvester Comprehensive Cancer Center, 1475 NW 12th Ave, Miami, FL 33136, USA
    Breast Cancer Res Treat 117:631-41. 2009
    ..We sought to determine the effects of race, socioeconomic status and treatment on outcomes for women with IBC. Study design The Florida cancer registry, inpatient and ambulatory data were queried for patients diagnosed from 1998 to 2002...
  8. doi request reprint Are many community hospitals undertreating breast cancer?: lessons from 24,834 patients
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ann Surg 248:154-62. 2008
    ..To compare treatment patterns and long-term outcomes between teaching and community hospitals treating patients with infiltrating ductal carcinoma (IDC)...
  9. doi request reprint African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients
    Manuel A Molina
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    Cancer 113:2797-806. 2008
    ..To identify points of intervention and improve survival, the authors sought to determine the impact of race, ethnicity, and socioeconomic status for patients with cancers of the head and neck (HN)...
  10. doi request reprint Preoperative imaging for resectable periampullary cancer: clinicopathologic implications of reported radiographic findings
    Zhi Ven Fong
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Gastrointest Surg 17:1098-106. 2013
    ..High-resolution, multiphase, computed tomography (CT) is a standard preoperative test prior to pancreatectomy, yet the clinical significance of routinely reported findings remains unknown...
  11. doi request reprint Does chemoradiotherapy improve outcomes for surgically resected adenocarcinoma of the stomach or esophagus?
    Naveenraj L Solomon
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Ann Surg Oncol 17:98-108. 2010
    ..To use a population-based registry to evaluate the effect of chemotherapy or radiation on survival for patients undergoing curative-intent surgery for adenocarcinoma of the esophagus or stomach...
  12. ncbi request reprint Surgical outcomes of gastrointestinal sarcoma including gastrointestinal stromal tumors: a population-based examination
    Eduardo A Perez
    Department of Surgery, Epidemiology and Oncology, Sylvester Comprehensive Cancer Center and University of Miami, 3550 Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    J Gastrointest Surg 11:114-25. 2007
    ..The surgical approaches and outcomes for gastrointestinal sarcoma are determined largely from single institutional series...
  13. ncbi request reprint Splenic vein thrombosis is associated with an increase in pancreas-specific complications and reduced survival in patients undergoing distal pancreatectomy for pancreatic exocrine cancer
    Nishi Dedania
    Department of Surgery, Thomas Jefferson University, JeffersonPancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    J Gastrointest Surg 17:1392-8. 2013
    ..This paper was presented as a poster at the 53rd annual meeting of the Society for Surgery of the Alimentary Tract and at the 46th annual meeting of the Pancreas Club, San Diego, CA, May 2012...
  14. ncbi request reprint Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 130:45-51. 2006
    ..Our results demonstrate that GDF-15 induction is an immediate early response to liver injury that can occur through TNF and p53 independent pathways...
  15. doi request reprint Pediatric solid tumors and second malignancies: characteristics and survival outcomes
    Vanitha Vasudevan
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 160:184-9. 2010
    ..To examine the incidence, characteristics, and outcomes for second malignancies following the diagnosis of a primary solid tumor in pediatric patients...
  16. ncbi request reprint Is resection equivalent to transplantation for early cirrhotic patients with hepatocellular carcinoma? A meta-analysis
    Atiq Rahman
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    J Gastrointest Surg 16:1897-909. 2012
    ..Whether liver resection or liver transplantation is optimal therapy for patients with hepatocellular carcinoma (HCC) remains undefined. A meta-analysis was conducted to answer this question...
  17. ncbi request reprint 7201 carcinoids: increasing incidence overall and disproportionate mortality in the elderly
    Eduardo A Perez
    The DeWitt Daughtry Family Department of Surgery, University of Miami School of Medicine, Coral Gables, FL, 33124, USA
    World J Surg 31:1022-30. 2007
    ..The aim of the study was to determine outcomes for respiratory and gastrointestinal carcinoid tumors utilizing a large cancer registry...
  18. pmc Should soft tissue sarcomas be treated at high-volume centers? An analysis of 4205 patients
    Juan C Gutierrez
    DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA
    Ann Surg 245:952-8. 2007
    ..To define the prognostic significance of surgical center case volume on outcome for soft tissue sarcoma (STS)...
  19. doi request reprint African-American and low-socioeconomic status patients have a worse prognosis for invasive ductal and lobular breast carcinoma: do screening criteria need to change?
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Am Coll Surg 208:853-68; discussion 869-70. 2009
    ..Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer...
  20. doi request reprint Rhabdomyosarcoma in children: a SEER population based study
    Eduardo A Perez
    Division of Pediatric Surgery and Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 170:e243-51. 2011
    ..To examine incidence and outcomes for pediatric rhabdomyosarcoma (RMS)...
  21. doi request reprint Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
    Xiaoling Jin
    Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Gut 59:186-96. 2010
    ..However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes...
  22. ncbi request reprint Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair
    Xiaoling Jin
    Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Hepatology 43:474-84. 2006
    ..In conclusion, elevated IL-6 in certain chronic liver diseases contributes to an increased likelihood of liver failure after injury...
  23. ncbi request reprint Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 141:105-14. 2007
    ..To more accurately elucidate population-based outcomes and prognostic factors associated with STS, a large cancer registry was examined...
  24. ncbi request reprint Optimizing diagnosis, staging, and management of gastrointestinal stromal tumors
    Juan C Gutierrez
    Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    J Am Coll Surg 205:479-91 (Quiz 524). 2007
  25. doi request reprint Disparities in survival among women with invasive cervical cancer: a problem of access to care
    Kathleen F Brookfield
    Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Cancer 115:166-78. 2009
    ..In this study, the authors sought to understand the effects of patient race, ethnicity, and socioeconomic status (SES) on outcomes for cervical cancer...
  26. doi request reprint Disappearance of racial disparities in gastrointestinal stromal tumor outcomes
    Michael C Cheung
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    J Am Coll Surg 209:7-16. 2009
    ..The purpose of this study was to determine the effects of race, socioeconomic status, and demographic and clinical variables on the outcomes of gastrointestinal stromal tumors (GISTs)...
  27. doi request reprint Primary lymphoma of bone in adult patients
    Muhammad U Jawad
    Department of Orthopedics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Cancer 116:871-9. 2010
    ..The database provides a standardized classification and documentation of outcomes and enables a meaningful evaluation of prognostic factors...
  28. doi request reprint Survival effects of adjuvant chemoradiotherapy after resection for pancreatic carcinoma
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, FL 33136, USA
    Arch Surg 145:49-56. 2010
    ..The survival benefit of adjuvant chemotherapy alone or chemoradiotherapy in patients with pancreatic cancer who have undergone surgical resection remains unclear...
  29. doi request reprint Do all patients with carcinoma of the esophagus benefit from treatment at teaching facilities?
    Michael C Cheung
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Oncol 102:18-26. 2010
    ..We sought to determine whether patients with esophageal carcinoma benefit from regionalization of care...
  30. doi request reprint Incidence and outcomes of extremity soft-tissue sarcomas in children
    Michael C Cheung
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 163:282-9. 2010
    ..We studied the outcomes of pediatric extremity tumors on a population scale...
  31. doi request reprint Influence of treatment modality in outcomes for different stages of resectable esophageal adenocarcinomas
    Bassan J Allan
    Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA
    Ann Surg Oncol 20:1660-7. 2013
    ..There is no consensus on the most effective modality for the treatment of resectable esophageal adenocarcinomas (EAC). We theorized that treatment modality may influence survival differently depending on the stage of disease...
  32. doi request reprint Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    J Cancer Res Clin Oncol 134:753-9. 2008
    ..The current study sought to determine the effect of GDF-15 ablation on the development of hepatocellular carcinoma (HCC) in vivo...
  33. doi request reprint Gender- and race-specific comparison of tobacco-associated cancer incidence trends in Florida with SEER regional cancer incidence data
    David J Lee
    Florida Cancer Data System, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA
    Cancer Causes Control 19:711-23. 2008
    ..This study compares Florida race- and gender-specific cancer trends with pooled data obtained from nine Surveillance, Epidemiology, and End Results (SEER-9) registries...
  34. doi request reprint Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 161:209-16. 2010
    ..To study the outcomes of solid tumors of the colon and rectum in pediatric patients...
  35. doi request reprint Survival disparities among African American women with invasive bladder cancer in Florida
    Kathleen F Brookfield
    Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Cancer 115:4196-209. 2009
    ..The authors sought to understand the effect of patient sex, race, and socioeconomic status (SES) on outcomes for bladder cancer...
  36. doi request reprint Incidence and outcomes of malignant pediatric lung neoplasms
    Holly L Neville
    Division of Pediatric Surgery and Division Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 156:224-30. 2009
    ..We sought to define current incidence trends and outcomes for children with lung and bronchus tumors...
  37. doi request reprint The roles of neoadjuvant radiotherapy and lymphadenectomy in the treatment of esophageal adenocarcinoma
    Naveenraj Solomon
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Ann Surg Oncol 17:791-803. 2010
    ..Using a population-based registry, we evaluated the impact of neoadjuvant radiotherapy and lymphadenectomy on survival of patients undergoing curative-intent surgery for esophageal adenocarcinoma (EAC)...
  38. doi request reprint Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma?
    Michael C Cheung
    DeWitt Daughtry Family Department of Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    Cancer 116:723-33. 2010
    ..The objective of this study was to define the effects of socioeconomic status (SES) and other demographic variables on outcomes for patients with pancreatic adenocarcinoma...
  39. doi request reprint Do racial or socioeconomic disparities exist in lung cancer treatment?
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Cancer 116:2437-47. 2010
    ..Determine the effects of race, socioeconomic status, and treatment on outcomes for patients diagnosed with lung cancer...
  40. doi request reprint Effects of poverty and race on outcomes in acute myeloid leukemia
    Margaret M Byrne
    Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Clin Oncol 34:297-304. 2011
    ..To determine how patient race, ethnicity, and degree of poverty affect treatment and survival for acute myeloid leukemia (AML)...
  41. doi request reprint Improved survival with lymph node sampling in Wilms tumor
    Ying Zhuge
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 167:e199-203. 2011
    ..We sought to determine the impact of number of lymph nodes examined on survival for Wilms tumor (WT)...
  42. doi request reprint Has the survival rate for surgically resected gastric gastrointestinal stromal tumors improved in the tyrosine kinase inhibitor era?
    Felipe E Pedroso
    Department of Surgery, Jefferson Medical College, Philadelphia, PA, USA
    Ann Surg Oncol 19:1748-58. 2012
    ....
  43. ncbi request reprint Liver regeneration
    Leonidas G Koniaris
    Department of Surgery, University of Rochester School of Medicine, Rochester, NY, USA
    J Am Coll Surg 197:634-59. 2003
  44. ncbi request reprint Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
    ..These data suggest that chronic IL-6 treatment selectively impairs hepatic insulin signaling in vivo, further supporting a role for IL-6 in hepatic insulin resistance of obesity...
  45. ncbi request reprint Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection
    Xiaoling Jin
    Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Hepatology 46:802-12. 2007
    ....
  46. doi request reprint Cancer care in the pediatric surgical patient: a paradigm to abolish volume-outcome disparities in surgery
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Surgery 145:76-85. 2009
    ..The objective of this study was to define the prognostic significance of hospital surgical volume on outcomes for pediatric neuroblastoma and Wilms tumor...
  47. doi request reprint Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients
    Eduardo A Perez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, FL 33136, USA
    J Pediatr Surg 44:197-203. 2009
    ..The purpose of the study was to examine current incidence trends and outcomes for children with pancreatic malignancies...
  48. doi request reprint Does Children's Oncology Group hospital membership improve survival for patients with neuroblastoma or Wilms tumor?
    Juan C Gutierrez
    Division of Pediatric Surgery and Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    Pediatr Blood Cancer 55:621-8. 2010
    ..To determine prognostic significance of hospital surgical volume and Children's Oncology Group (COG) membership on neuroblastoma (NBL) and Wilms tumor (WT) survival...
  49. doi request reprint Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?
    Robert A Grossman
    Sylvester Comprehensive Cancer Center, Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Oncol 104:604-12. 2011
    ..Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC...
  50. pmc Obesity and weight loss at presentation of lung cancer are associated with opposite effects on survival
    Relin Yang
    DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 170:e75-83. 2011
    ..In cancer, weight loss and obesity are associated with reduced survival. However, the effect of obesity or weight loss at presentation on lung cancer survival has not been well studied...
  51. doi request reprint Impact of teaching facility status and high-volume centers on outcomes for lung cancer resection: an examination of 13,469 surgical patients
    Michael C Cheung
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Surg Oncol 16:3-13. 2009
    ..Studies suggest that institutional case volume and teaching status significantly affect patient survival. We sought to compare outcomes of surgical resection for lung cancer at teaching facilities (TF) and at high-volume centers (HVC)...
  52. doi request reprint Preoperative docetaxel/cisplatin/5-fluorouracil chemotherapy in patients with locally advanced gastro-esophageal adenocarcinoma
    Ulas Darda Bayraktar
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Ave St, Miami, FL 3300, USA
    Med Oncol 29:1707-10. 2012
    ..0 months, median OS and PFS were 26.1 months (95% CI: 22.7-29.5) and 18.8 months (95% CI: 9.9-27.7), respectively. The DCF regimen is active in patients with gastric and GEJ adenocarcinoma in the preoperative setting...
  53. doi request reprint Does neoadjuvant chemotherapy improve outcomes for patients with gastric cancer?
    Subhasis Misra
    Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 178:623-31. 2012
    ..The role of neoadjuvant and adjuvant therapy for gastric cancer remains undefined. We compared the outcomes for patients treated with surgery alone or with the addition of adjuvant or neaodjuvant treatment...
  54. doi request reprint Primary gastrointestinal tract lymphoma in the pediatric patient: review of 265 patients from the SEER registry
    Noor Kassira
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Pediatr Surg 46:1956-64. 2011
    ..The objective of this study is to determine outcomes of pediatric patients with primary gastrointestinal tract lymphoma (PGTL) and the impact of surgery or radiation on survival...
  55. ncbi request reprint Massive liver growth in mice induced by systemic interleukin 6 administration
    Teresa A Zimmers
    Department of Surgery, University of Rochester School of Medicine, Rochester, NY, USA
    Hepatology 38:326-34. 2003
    ....
  56. ncbi request reprint Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury
    Teresa A Zimmers
    DeWitt Daughtry Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami 33136, USA
    Shock 23:543-8. 2005
    ..These data demonstrate that GDF-15/MIC-1 is an early mediator of the injury response in kidney and lung that might regulate inflammation, cell survival, proliferation, and apoptosis in a variety of injured tissues and disease processes...
  57. ncbi request reprint Hepatectomy enables prolonged survival in select patients with isolated noncolorectal liver metastasis
    Steven A Earle
    DeWitt Daughtry Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Am Coll Surg 203:436-46. 2006
    ..This study was done to determine the benefit of undergoing liver resection for noncolorectal metastasis...
  58. ncbi request reprint Retroperitoneal and truncal sarcomas: prognosis depends upon type not location
    Eduardo A Perez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, USA
    Ann Surg Oncol 14:1114-22. 2007
    ..Prognostication of truncal and retroperitoneal soft tissue sarcomas has traditionally been predicated on tumor location and grade...
  59. doi request reprint Malignant breast cancer in children: a review of 75 patients
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 147:182-8. 2008
    ..To determine incidence trends and outcomes for pediatric patients with malignant breast disease...
  60. doi request reprint Pediatric non-Wilms renal tumors: subtypes, survival, and prognostic indicators
    Ying Zhuge
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 163:257-63. 2010
    ..To determine the outcomes and predictors of survival for pediatric non-Wilms renal tumors (NWRT)...
  61. pmc Is surgical resection superior to transplantation in the treatment of hepatocellular carcinoma?
    Leonidas G Koniaris
    Department of Surgery, University of Miami Miller School of Medicine, FL, USA
    Ann Surg 254:527-37; discussion 537-8. 2011
    ..To compare outcomes for patients with hepatocellular carcinoma (HCC) treated with either liver resection or transplantation...
  62. pmc Will patients benefit from regionalization of gynecologic cancer care?
    Kathleen F Brookfield
    Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 4:e4049. 2009
    ..We sought to determine the effect of volume and teaching status on patient outcomes for five gynecologic malignancies: endometrial, cervical, ovarian and vulvar carcinoma and uterine sarcoma...
  63. doi request reprint A comprehensive analysis of parotid and salivary gland cancer: worse outcomes for male gender
    Michael C Cheung
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 171:151-8. 2011
    ..To determine the effects of patient demographics, socioeconomic status (SES) and clinical variables on outcomes for patients with salivary and parotid gland tumors...
  64. doi request reprint The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: an analysis of the Survival, Epidemiology, and End Results database
    Ali M Saeed
    Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Cancer 118:4495-501. 2012
    ..Therefore, the authors carried out a large-scale, population-based analysis using the Surveillance, Epidemiology, and End Results (SEER) data base to determine the impact of Hispanic ethnicity the survival of patients with NSCLC...
  65. ncbi request reprint Inflammatory myofibroblastic tumors
    Stephen J Kovach
    Department of Surgery and Pathology, University of Rochester School of Medicine, Rochester, New York, USA
    J Surg Oncol 94:385-91. 2006
    ..Historically, the literature regarding IMT has been confined to small one organ case series, with few reviews encompassing multiple anatomic sites, and little data regarding adjuvant treatment...
  66. ncbi request reprint Markedly improving survival of neuroblastoma: a 30-year analysis of 1,646 patients
    Juan C Gutierrez
    Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Pediatr Surg Int 23:637-46. 2007
    ..Early diagnosis and surgical therapy continue to provide the best chance for cure. More effective therapies for patients presenting over 1 year of age or those with advanced disease are still needed...
  67. ncbi request reprint Defining the role of surgery for primary gastrointestinal tract melanoma
    Michael C Cheung
    Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Gastrointest Surg 12:731-8. 2008
    ..The objective of the study was to determine the outcomes for primary gastrointestinal melanomas (PGIM)...
  68. doi request reprint Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database
    Angela Ylenia Giuffrida
    Department of Orthopaedics, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Bone Joint Surg Am 91:1063-72. 2009
    ....
  69. doi request reprint Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973-2005
    Muhammad U Jawad
    Department of Orthopedics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Cancer 115:3526-36. 2009
    ....
  70. doi request reprint Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients
    Anthony R Hogan
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Surg Res 156:167-72. 2009
    ..To examine outcomes and predictors of survival for pediatric patients with thyroid carcinoma...
  71. ncbi request reprint Is adjuvant 5-FU-based chemoradiotherapy for resectable pancreatic adenocarcinoma beneficial? A meta-analysis of an unanswered question
    Amit Khanna
    Department of Surgery, University of Rochester School of Medicine, Rochester, New York, USA
    J Gastrointest Surg 10:689-97. 2006
    ..The benefit of 5-FU-based adjuvant therapy, however, has declined in recent years, and its significance remains unproven in the context of current diagnostic and surgical practice...
  72. ncbi request reprint Surgery for rectal cancer performed at teaching hospitals improves survival and preserves continence
    Juan C Gutierrez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, 3550 Sylvester Comprehensive Cancer Center 310T, 1475 NW 12th Ave, Miami, FL 33136, USA
    J Gastrointest Surg 11:1441-8; discussion 1448-50. 2007
    ..Patients with high-grade tumors or advanced disease should be provided the opportunity to be treated at a teaching hospital...
  73. pmc 507 Warren-Zeppa distal splenorenal shunts: a 34-year experience
    Alan S Livingstone
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Surg 243:884-92; discussion 892-4. 2006
    ..To define the long-term characteristics, prognostic factors, and outcomes of patients undergoing selective splenorenal shunting procedures for portal hypertension-induced recurrent upper gastrointestinal bleeding...
  74. ncbi request reprint Results of 23,810 cases of ductal carcinoma-in-situ
    William E Sumner
    Division of Surgical Oncology, Department of Surgery, Sylvester Comprehensive Cancer Center, Room 3550, University of Miami, Miami, Florida 33136, USA
    Ann Surg Oncol 14:1638-43. 2007
    ..The Florida Cancer Data System is the largest single source incident cancer registry in the United States. We analyzed this registry to determine the changing incidence and treatment patterns for DCIS...
  75. ncbi request reprint Florida bladder cancer trends 1981 to 2004: minimal progress in decreasing advanced disease
    Alan M Nieder
    Departments of Urology and Epidemiology and Preventive Health, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Urol 179:491-5; discussion 495. 2008
    ..Bladder cancer survival correlates highly with disease stage. We ascertained whether there have been any demographic changes in the stage at presentation and mortality of bladder cancer in Florida during the last 25 years...
  76. doi request reprint Peritoneal drainage versus laparotomy for necrotizing enterocolitis and intestinal perforation: a meta-analysis
    Juan E Sola
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 161:95-100. 2010
    ..To determine whether peritoneal drain (PD) or laparotomy (LAP) is the most effective intervention in premature neonates with necrotizing enterocolitis (NEC) or intestinal perforation (IP)...
  77. doi request reprint Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer
    Teresa A Zimmers
    Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    J Cancer Res Clin Oncol 136:571-6. 2010
    ..We sought to determine the effect of loss of Gdf15 on animal tumor models of hereditary colon cancer and in the NSAID-mediated prevention of heritable colorectal cancer...
  78. doi request reprint Survival disparities in newborns with congenital diaphragmatic hernia: a national perspective
    Juan E Sola
    Division of Pediatric Surgery, DeWitt Daughtry Family Department of Surgery University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Pediatr Surg 45:1336-42. 2010
    ..The aim of the study was to examine national outcomes for congenital diaphragmatic hernia (CDH)...
  79. ncbi request reprint Embolization as first-line therapy for diverticulosis-related massive lower gastrointestinal bleeding: evidence from a meta-analysis
    Amit Khanna
    Department of Surgery, University of Rochester School of Medicine, Rochester, New York, USA
    J Gastrointest Surg 9:343-52. 2005
    ..An inpatient observation period of 2 days is suggested following embolization for diverticular bleeding...
  80. ncbi request reprint Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors
    Eduardo A Perez
    Department of Surgery, Division of Surgical Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    J Am Coll Surg 202:623-9. 2006
    ....
  81. pmc Lethal injection for execution: chemical asphyxiation?
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Med 4:e156. 2007
    ..We sought to determine whether the current drug regimen results in death in the manner intended...
  82. ncbi request reprint How many lymph nodes properly stage a periampullary malignancy?
    Juan C Gutierrez
    Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Gastrointest Surg 12:77-85. 2008
    ..To optimize the prognostic accuracy and prevent stage migration errors in multicenter trials a minimum of 10 lymph nodes should be obtained and examined before the determination of node-negative disease...
  83. doi request reprint A population-based analysis of 1037 malignant ovarian tumors in the pediatric population
    Kathleen F Brookfield
    Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, USA
    J Surg Res 156:45-9. 2009
    ..Concerns of malignant potential have impacted the utilization of ovarian salvage for treatment of ovarian masses in children...
  84. ncbi request reprint Cryoablation of unresectable pancreatic cancer
    Stephen J Kovach
    Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Surgery 131:463-4. 2002
    ..The goal of this study was to evaluate the safety of an intraoperative ultrasound-guided cryosurgical procedure in a phase I study of unresectable pancreatic cancer...
  85. ncbi request reprint Intraoperative colonic lavage in a premature infant: a case report
    Steven J Ognibene
    Department of Surgery, University of Rochester, Rochester, NY, USA
    J Pediatr Surg 37:1645-7. 2002
    ..This case discusses a modified application of on-table colonic lavage in the management of an obstructing sigmoid stricture in a premature infant...
  86. ncbi request reprint Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  87. ncbi request reprint Complications of laparoscopic urologic surgery
    Ralph Madeb
    Department of Urology, University of Rochester Medical Center, Rochester, New York 14642 8656, USA
    J Laparoendosc Adv Surg Tech A 14:287-301. 2004
    ..A discussion of urologic laparoscopy (UL) with particular attention to potential complications and limitations is presented. Awareness of these evolving technologies remains critical to all surgeons with an interest in laparoscopy...
  88. doi request reprint Scientific impact of women in academic surgery
    Nadine Housri
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Surg Res 148:13-6. 2008
    ..To evaluate the scientific impact of women in the surgical literature...
  89. doi request reprint Body surface area prediction in normal, hypermuscular, and obese mice
    Michael C Cheung
    Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 153:326-31. 2009
    ..We found older values of k overestimated BSA in certain mice; thus we determined empirically k for various strains of normal, obese, and hypermuscular mice...
  90. doi request reprint Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases
    Ying Zhuge
    Division of Pediatric Surgery and Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Surg Res 156:95-102. 2009
    ..The outcomes of pediatric intestinal foregut and small bowel solid tumors have never been studied on a population scale...
  91. doi request reprint Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia
    Margaret E Benny Klimek
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 391:1548-54. 2010
    ..More importantly, skeletal muscle preservation with ACVR2B-Fc establishes that targeting myostatin-family ligands using ACVR2B-Fc or related molecules is an important and potent therapeutic avenue in cancer cachexia...
  92. ncbi request reprint The quick, no-twist, no-kink portal confluence reconstruction
    Leonidas G Koniaris
    Department of Surgery, University of Rochester School of Medicine, Rochester, NY, USA
    J Am Coll Surg 196:490-4. 2003
  93. ncbi request reprint Diagnostic laparoscopy for periampullary and pancreatic cancer: what is the true benefit?
    Christopher J Barreiro
    The Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD 21287 4603, USA
    J Gastrointest Surg 6:75-81. 2002
    ..Of the 107 patients categorized as likely to be resectable, 89 were actually resected (83.2%). In contrast, only 10 of the 51 patients categorized as likely to be unresectable could be resected (19.6%)...
  94. ncbi request reprint DSRS versus TIPS for variceal bleeding: Lessons from late follow-up of 507 DSRS patients
    Leonidas G Koniaris
    Gastroenterology 131:978. 2006
  95. ncbi request reprint Racial disparities in the treatment of rectal cancer in Florida
    Juan C Gutierrez
    J Am Coll Surg 204:724. 2007
  96. ncbi request reprint Image of the month. Acute respiratory distress syndrome
    Shariq Sayeed
    Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arch Surg 137:491-2. 2002
  97. ncbi request reprint Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    ..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...
  98. ncbi request reprint Intrahepatic gas
    Peter L Abt
    University of Rochester School of Medicine, NY, USA
    J Am Coll Surg 195:129. 2002
  99. ncbi request reprint Detecting blunt pancreatic injuries
    Robert L Cirillo
    Department of Radiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gastrointest Surg 6:587-98. 2002
    ..Blunt pancreatic trauma can be managed successfully by means of both operative and selective approaches...
  100. ncbi request reprint Small bowel obstruction due to a paracolonic retroperitoneal hernia
    Richard J Hendrickson
    Department of Surgery, University of Rochester School of Medicine and Dentistry, New York, USA
    Am Surg 68:756-8. 2002
    ..A retroperitoneal hernia occurring from a lateral defect in the colonic retroperitoneal attachments is presented. We believe that this case represents a newly recognized variant of retroperitoneal hernias...
  101. ncbi request reprint Can ethanol therapies injure the bile ducts?
    Leonidas G Koniaris
    Departments of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Hepatogastroenterology 50:69-72. 2003
    ....

Research Grants2

  1. The Role of GDF-15 in Organ Injury
    Leonidas Koniaris; Fiscal Year: 2005
    ..The completion of this mentored research training will further the candidate?s goal of applying bench-derived scientific discovery to the treatment of surgical disease as an independent investigator. ..
  2. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005
    ..2) Determine the extent to which and mechanisms by which co-administrating HCF and Follistatin along with IL-6 facilitates the liver growth response and reduces IL-6 associated toxicity. ..