Demetrius M Kokkinakis
Affiliation: University of Pittsburgh
- Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosineDemetrius M Kokkinakis
Department of Pathology and the Cancer Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 9:3801-7. 2003..These results suggest that pancreatic tumors, which are resistant to DNA alkylating agents, may be sensitized to such agents when pretreated with MGMT inactivators...
- O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomasS Clifford Schold
University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Neuro Oncol 6:28-32. 2004..We conclude that a BG dose of 120 mg/m(2) given 6 h before an alkylating drug would be effective in suppressing AGT and possibly potentiating the cytotoxic effects of the drug...
- Methionine-stress: a pleiotropic approach in enhancing the efficacy of chemotherapyDemetrius M Kokkinakis
Department of Pathology and the Cancer Institute, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
Cancer Lett 233:195-207. 2006....
- Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinomaDemetrius M Kokkinakis
Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
Mol Cancer Ther 4:1338-48. 2005....
- Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley ratsDemetrius M Kokkinakis
The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, USA
J Neuropathol Exp Neurol 63:1182-99. 2004..These data demonstrate that the events leading to malignancy in the rat brain in response to MNU treatment are to a great extent similar to those described for secondary glial malignancies in humans...
- Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stressDemetrius M Kokkinakis
Department of Pathology, University of Pittsburgh, Pennsylvania, USA
Mol Cancer Res 4:575-89. 2006..Although MDS targets several common genes in tumors, mutational variability among melanomas may decide which metabolic and signal transduction pathways will be activated or shutdown...
- Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenograftsDemetrius M Kokkinakis
Department of Pathology and the Cancer Institute, University of Pittsburgh, Pennsylvania 15261, USA
Chem Res Toxicol 15:1472-9. 2002..Further studies are needed to identify the source of MET in glial tumors under METdr and to develop more effective regimens to deplete tumor MET, which might result in a complete and sustained regression of high-grade gliomas...
- Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stressDemetrius M Kokkinakis
The University of Pittsburgh Cancer Institute and the Department of Pathology, Hillman Cancer Institute, Pittsburgh, Pennsylvania, USA
Cancer Res 64:7513-25. 2004..It is clear that methionine stress-induced cytotoxicity is not restricted by the p53 mutational status...
- Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivoSanjay K Srivastava
Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Carcinogenesis 24:1665-70. 2003..In conclusion, the results of the present study indicate that AITC administration inhibits growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity...
- Multifaceted resistance of gliomas to temozolomideDora B Bocangel
Department of Pathology, The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
Clin Cancer Res 8:2725-34. 2002....
- Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinomaGang Zeng
Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neoplasia 8:279-89. 2006..Thus, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors...
- Potential use of MDA-7 as a biological adjuvant for radiation therapyMohammed Momin Shareef
Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
Cancer Biol Ther 3:752-4. 2004