Demetrius M Kokkinakis

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 9:3801-7. 2003
  2. pmc O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas
    S Clifford Schold
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Neuro Oncol 6:28-32. 2004
  3. ncbi request reprint Methionine-stress: a pleiotropic approach in enhancing the efficacy of chemotherapy
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Lett 233:195-207. 2006
  4. ncbi request reprint Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
    Mol Cancer Ther 4:1338-48. 2005
  5. ncbi request reprint Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, USA
    J Neuropathol Exp Neurol 63:1182-99. 2004
  6. ncbi request reprint Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Mol Cancer Res 4:575-89. 2006
  7. ncbi request reprint Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, University of Pittsburgh, Pennsylvania 15261, USA
    Chem Res Toxicol 15:1472-9. 2002
  8. ncbi request reprint Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute and the Department of Pathology, Hillman Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 64:7513-25. 2004
  9. ncbi request reprint Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
    Sanjay K Srivastava
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Carcinogenesis 24:1665-70. 2003
  10. ncbi request reprint Multifaceted resistance of gliomas to temozolomide
    Dora B Bocangel
    Department of Pathology, The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 8:2725-34. 2002

Detail Information

Publications12

  1. ncbi request reprint Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 9:3801-7. 2003
    ..These results suggest that pancreatic tumors, which are resistant to DNA alkylating agents, may be sensitized to such agents when pretreated with MGMT inactivators...
  2. pmc O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas
    S Clifford Schold
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Neuro Oncol 6:28-32. 2004
    ..We conclude that a BG dose of 120 mg/m(2) given 6 h before an alkylating drug would be effective in suppressing AGT and possibly potentiating the cytotoxic effects of the drug...
  3. ncbi request reprint Methionine-stress: a pleiotropic approach in enhancing the efficacy of chemotherapy
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Lett 233:195-207. 2006
    ....
  4. ncbi request reprint Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
    Mol Cancer Ther 4:1338-48. 2005
    ....
  5. ncbi request reprint Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, USA
    J Neuropathol Exp Neurol 63:1182-99. 2004
    ..These data demonstrate that the events leading to malignancy in the rat brain in response to MNU treatment are to a great extent similar to those described for secondary glial malignancies in humans...
  6. ncbi request reprint Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Mol Cancer Res 4:575-89. 2006
    ..Although MDS targets several common genes in tumors, mutational variability among melanomas may decide which metabolic and signal transduction pathways will be activated or shutdown...
  7. ncbi request reprint Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, University of Pittsburgh, Pennsylvania 15261, USA
    Chem Res Toxicol 15:1472-9. 2002
    ..Further studies are needed to identify the source of MET in glial tumors under METdr and to develop more effective regimens to deplete tumor MET, which might result in a complete and sustained regression of high-grade gliomas...
  8. ncbi request reprint Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute and the Department of Pathology, Hillman Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 64:7513-25. 2004
    ..It is clear that methionine stress-induced cytotoxicity is not restricted by the p53 mutational status...
  9. ncbi request reprint Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
    Sanjay K Srivastava
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Carcinogenesis 24:1665-70. 2003
    ..In conclusion, the results of the present study indicate that AITC administration inhibits growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity...
  10. ncbi request reprint Multifaceted resistance of gliomas to temozolomide
    Dora B Bocangel
    Department of Pathology, The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 8:2725-34. 2002
    ....
  11. pmc Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma
    Gang Zeng
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neoplasia 8:279-89. 2006
    ..Thus, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors...
  12. ncbi request reprint Potential use of MDA-7 as a biological adjuvant for radiation therapy
    Mohammed Momin Shareef
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Cancer Biol Ther 3:752-4. 2004