Alisa E Koch

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Suppression of endothelial cell activity by inhibition of TNFα
    Qiang Shu
    Department of Internal Medicine, Qilu Hospital of Shandong University, 1107 Jinan Culture Road, Jinan City, China
    Arthritis Res Ther 14:R88. 2012
  2. pmc Vascular involvement in rheumatic diseases: 'vascular rheumatology'
    Zoltan Szekanecz
    University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology, 22 Moricz Street, Debrecen, H 4032, Hungary
    Arthritis Res Ther 10:224. 2008
  3. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
  4. pmc Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Res Ther 9:R112. 2007
  5. pmc Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Drive, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 12:R118. 2010
  6. ncbi request reprint In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis
    Christian S Haas
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Rheum 56:2535-48. 2007
  7. pmc CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway
    Jeffrey H Ruth
    University of Michigan Medical School, Ann Arbor 48109 0680, USA
    Arthritis Rheum 54:765-78. 2006
  8. pmc Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
  9. doi request reprint H-2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and phosphatidylinositol 3-kinase pathways
    M Asif Amin
    Department of Internal Medicine Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 58:689-95. 2008
  10. doi request reprint Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Ann Rheum Dis 69:2204-12. 2010

Collaborators

Detail Information

Publications54

  1. pmc Suppression of endothelial cell activity by inhibition of TNFα
    Qiang Shu
    Department of Internal Medicine, Qilu Hospital of Shandong University, 1107 Jinan Culture Road, Jinan City, China
    Arthritis Res Ther 14:R88. 2012
    ..TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function and angiogenesis...
  2. pmc Vascular involvement in rheumatic diseases: 'vascular rheumatology'
    Zoltan Szekanecz
    University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology, 22 Moricz Street, Debrecen, H 4032, Hungary
    Arthritis Res Ther 10:224. 2008
    ..Vasoprotective agents may help to prevent premature atherosclerosis and cardiovascular disease...
  3. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
    ..This study demonstrates that IL-13 overexpression during ICA diminished both chondrocyte death and MMP-mediated VDIPEN expression, even though joint inflammation was enhanced...
  4. pmc Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Res Ther 9:R112. 2007
    ..Activation of the FAK family signaling cascade on RA and OA lining cells may be responsible for cell adhesion and migration into the diseased STs. Therapies targeting this novel signaling pathway may be beneficial in RA...
  5. pmc Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Drive, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 12:R118. 2010
    ..The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties...
  6. ncbi request reprint In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis
    Christian S Haas
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Rheum 56:2535-48. 2007
    ..The purpose of this study was to use a gene therapy approach to investigate the role of IL-13 in angiogenesis in vivo, using a rat adjuvant-induced arthritis model of RA...
  7. pmc CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway
    Jeffrey H Ruth
    University of Michigan Medical School, Ann Arbor 48109 0680, USA
    Arthritis Rheum 54:765-78. 2006
    ..We undertook this study to examine the participation of CXCL16, a novel chemokine, in recruitment of MNCs to RA ST in vivo and to determine the signal transduction pathways mediating this process...
  8. pmc Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
    ..Consistent with these results, MIF induced phosphorylation of JNK, PKCdelta, and c-jun. These results indicate a potential novel role for MIF in tissue destruction in RA...
  9. doi request reprint H-2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and phosphatidylinositol 3-kinase pathways
    M Asif Amin
    Department of Internal Medicine Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 58:689-95. 2008
    ..We hypothesized that soluble Le(y)/H plays an important role in monocyte recruitment in RA...
  10. doi request reprint Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Ann Rheum Dis 69:2204-12. 2010
    ..Interleukin 18 (IL-18) is a novel mediator of angiogenesis in rheumatoid arthritis (RA)...
  11. ncbi request reprint Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
    Mohammad A Amin
    Department of Internal Medicine, Division of Rheumatology, University of Michigan Medical School, University of Michigan Health System, Ann Arbor, MI, USA
    Arthritis Rheum 56:1787-97. 2007
    ....
  12. pmc Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
    ..MIF and MIF-dependent signaling pathways may be a potential target for treating diseases characterized by up-regulation of cell adhesion molecules...
  13. doi request reprint A novel role for inducible Fut2 in angiogenesis
    Pei Suen Tsou
    Department of Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Angiogenesis 16:195-205. 2013
    ..Angiogenesis plays an important role in wound healing and tumor growth. Fucosyltransferases synthesize fucosylated glycans and may play a major role in vascular biology...
  14. ncbi request reprint Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis
    Christian S Haas
    University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2402-14. 2006
    ..Interleukin-4 (IL-4) can modulate neovascularization. In this study, we used a gene therapy approach to investigate the role of IL-4 in angiogenesis in rat adjuvant-induced arthritis (AIA), a model for rheumatoid arthritis...
  15. pmc Accelerated development of arthritis in mice lacking endothelial selectins
    Jeffrey H Ruth
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 7:R959-70. 2005
    ....
  16. ncbi request reprint The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium
    Matthew D Silverman
    University of Michigan Health System, Internal Medicine Department, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 56:1817-26. 2007
    ..This study was undertaken to investigate the hypothesis that EPCs selectively home to inflamed joint tissue and may perpetuate synovial neovascularization...
  17. pmc Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis
    Hubert Marotte
    Department of Internal Medicine, University of Michigan Medical School, Department of Veterans Affairs, Ann Arbor, MI, USA
    Rheumatology (Oxford) 49:467-79. 2010
    ..Evaluation of the efficacy of green tea extract (GTE) in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA)...
  18. pmc Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production
    Salahuddin Ahmed
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Natl Acad Sci U S A 105:14692-7. 2008
    ..The results of these studies provide previously undescribed evidence of IL-6 synthesis and transsignaling inhibition by EGCG with a unique mechanism of sgp130 up-regulation, and thus hold promise as a potential therapeutic agent for RA...
  19. pmc Junctional adhesion molecule-C is a soluble mediator of angiogenesis
    Bradley J Rabquer
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 185:1777-85. 2010
    ..Moreover, sJAM-C-mediated HMVEC chemotaxis was dependent on Src, p38, and PI3K. Our results show that JAM-C exists in soluble form and suggest that modulation of sJAM-C may provide a novel route for controlling pathological angiogenesis...
  20. ncbi request reprint Chemokine receptor expression in rat adjuvant-induced arthritis
    Christian S Haas
    University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 52:3718-30. 2005
    ..In this study, we used rat adjuvant-induced arthritis (AIA), a model for RA, to define the temporospatial expression of chemokine receptors...
  21. ncbi request reprint Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    M Asif Amin
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 93:321-9. 2003
    ..Our findings support a role for MIF as an angiogenic factor and provide a rationale for the use of MIF as a therapeutic inducer of neovascularization in the development of collateral circulation in coronary artery disease...
  22. pmc Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosis
    Salahuddin Ahmed
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 60:1282-93. 2009
    ..This study was undertaken to evaluate the efficacy of epigallocatechin-3-gallate (EGCG) in down-regulating Mcl-1 expression and its mechanism of RA synovial fibroblast sensitization to TNFalpha-induced apoptosis...
  23. pmc Blocking ERK-1/2 reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein A
    Hubert Marotte
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 62:722-31. 2010
    ..To examine the mechanism of regulation of interleukin-18 (IL-18) bioactivity by IL-18 binding protein (IL-18BP) induction...
  24. pmc Expression and function of CXCL16 in a novel model of gout
    Jeffrey H Ruth
    University of Michigan Medical School, Division of Rheumatology, 109 Zina Pitcher Place, 4023 BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 62:2536-44. 2010
    ....
  25. pmc Amelioration of rat adjuvant-induced arthritis by Met-RANTES
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 52:1907-19. 2005
    ..The aim of this study was to investigate whether Met-RANTES could ameliorate adjuvant-induced arthritis (AIA) in the rat...
  26. ncbi request reprint The role of COX-2 in angiogenesis and rheumatoid arthritis
    James M Woods
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Exp Mol Pathol 74:282-90. 2003
    ..Our studies suggest that COX-2-induced angiogenic activity is an active mechanism within diseased synovium and may provide an additional rationale for the use of COX-2 inhibitors in RA...
  27. ncbi request reprint Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Arthritis Rheum 48:3568-83. 2003
    ..Furthermore, we investigated the signaling pathways associated with CC receptors as well as the cell type distribution of the receptors...
  28. ncbi request reprint Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis
    Jeffrey H Ruth
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Lab Invest 83:579-88. 2003
    ..These results further indicate that expression of CCR6, the receptor for MIP-3alpha, can be correlated with RA development...
  29. ncbi request reprint A novel function for a glucose analog of blood group H antigen as a mediator of leukocyte-endothelial adhesion via intracellular adhesion molecule 1
    Kui Zhu
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Biol Chem 278:21869-77. 2003
    ..Potential treatment strategies through the inhibition of JAK-dependent pathways to target H-2g signals may provide a useful approach in inflammation-driven diseases like rheumatoid arthritis...
  30. pmc Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 13:R18. 2011
    ..In addition, CXCL16 promotes angiogenesis by binding its unique receptor CXCR6. In this study, we determined the expression of these chemokines and receptors in SSc skin and serum...
  31. pmc Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts
    Pei Suen Tsou
    University of Michigan Medical School, Ann Arbor, MI, USA
    Arthritis Rheum 64:1978-89. 2012
    ..This study also sought to investigate the effect of a thiol antioxidant, N-acetylcysteine (NAC), in SSc...
  32. pmc Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair
    Douglas Arenberg
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 182:1030-7. 2010
    ..We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth...
  33. ncbi request reprint IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts
    Harris Perlman
    Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 170:838-45. 2003
    ..These data suggest that alterations in p21 expression may activate AP-1 leading to enhanced proinflammatory cytokine and MMP production and development of autoimmune disease...
  34. ncbi request reprint Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts
    Salahuddin Ahmed
    University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 54:2393-401. 2006
    ....
  35. ncbi request reprint ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Cytometry A 71:317-26. 2007
    ..Therefore, in the same joint, there may exist positive and negative influences on the inflammatory response, and perhaps, the negative signals dominate as joint inflammation resolves...
  36. ncbi request reprint Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis
    Pawan Kumar
    Veterans Administration, Lakeside Division, Chicago Health Care System, Chicago, IL, USA
    Blood 101:3960-8. 2003
    ..Taken together, our data clearly show that sE-selectin-induced angiogenesis is predominantly mediated through the Src-PI3K pathway...
  37. pmc Junctional adhesion molecule C mediates leukocyte adhesion to rheumatoid arthritis synovium
    Bradley J Rabquer
    University of Michigan Medical School, Department of Medicine, Ann Arbor, MI 48109, USA
    Arthritis Rheum 58:3020-9. 2008
    ..This study was undertaken to investigate the role of junctional adhesion molecule C (JAM-C) in mediating leukocyte recruitment and retention in the RA joint...
  38. pmc The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, AnnArbor, MI, USA
    Rheumatology (Oxford) 48:734-40. 2009
    ..The aim of this study was to examine adhesive interactions in SSc skin...
  39. ncbi request reprint Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
    ..To identify disease-specific gene expression profiles in patients with rheumatoid arthritis (RA), using complementary DNA (cDNA) microarray analyses on lymphoblastoid B cell lines (LCLs) derived from RA-discordant monozygotic (MZ) twins...
  40. ncbi request reprint Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis
    Kui Zhu
    Department of Medicine, Northwestern University of Feinberg School of Medicine, Chicago, IL, USA
    Blood 105:2343-9. 2005
    ..The critical role of Le(y)/H involvement in angiogenesis and its signaling pathways may provide new targets for therapy of diseases characterized by pathologic neovascularization...
  41. pmc Synovial inflammation in patients with osteonecrosis of the femoral head
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Transl Sci 2:273-8. 2009
    ..Our results suggest the presence of a previously unrecognized population of ON patients without a diagnosed inflammatory co-morbidity and a highly inflammed synovium consisting primarily of a macrophage and CD4(+) T-cell infiltrate...
  42. ncbi request reprint The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production
    Michael V Volin
    Department of Medicine, Nortwestern University Medical School, Chicago, Illinois 60611, USA
    Exp Mol Pathol 73:84-92. 2002
    ..These data suggest that SASP may function to reduce inflammation in RA through the effects of its metabolite SP to reduce the secretion of the inflammatory chemokines IL-8, GROalpha, and MCP-1...
  43. ncbi request reprint Chemokines and their receptors in rheumatoid arthritis: future targets?
    Alisa E Koch
    University of Michigan Medical School, Ann Arbor 48109 0680, USA
    Arthritis Rheum 52:710-21. 2005
  44. pmc Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue
    Shiva Shahrara
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Arthritis Res 4:201-8. 2002
    ..In conclusion, the dominance of Ang-1 mRNA and protein expression over Ang-2 is in agreement with an active neovascularization in RA synovial tissue...
  45. doi request reprint CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008
    ..CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells...
  46. pmc 125I-labeled gold nanorods for targeted imaging of inflammation
    Xia Shao
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 5:8967-73. 2011
    ..Other than diagnosis, radiolabeled gold nanoparticles also hold promise for targeted therapy of a variety of disorders...
  47. ncbi request reprint Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression
    Jacques C M Morel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:34679-91. 2002
    ..Targeting VCAM-1 signaling mechanisms may represent therapeutic approaches to inflammatory and angiogenic diseases characterized by adhesion molecule up-regulation...
  48. pmc Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
    Alisa E Koch
    Veterans Hospital, and The University of Michigan Medical School, Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    Arthritis Res Ther 9:S3. 2007
    ....
  49. doi request reprint Blocking of interferon regulatory factor 1 reduces tumor necrosis factor α-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein a: role of the nuclear interferon regulatory factor 1
    Hubert Marotte
    University of Michigan Medical School, Ann Arbor, MI, USA
    Arthritis Rheum 63:3253-62. 2011
    ..To examine the role of interferon regulatory factor 1 (IRF-1) in tumor necrosis factor α (TNFα)-induced interleukin-18 binding protein a (IL-18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs)...
  50. pmc Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome
    Naresh V Desireddi
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 179:1857-61; discussion 1861-2. 2008
    ..In addition, chemokine levels were correlated with clinical pain as determined by the National Institutes of Health chronic prostatitis symptom index...
  51. ncbi request reprint Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression
    Harris Perlman
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Rheumatol 29:1593-600. 2002
    ..To characterize the adenoviral properties required to enhance intracellular transgene expression for gene therapy...
  52. doi request reprint Association of plasma interleukin-18 levels with emotion regulation and μ-opioid neurotransmitter function in major depression and healthy volunteers
    Alan R Prossin
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 2700, USA
    Biol Psychiatry 69:808-12. 2011
    ..We examined the relationship between μ-opioid receptor (OR)-mediated neurotransmission and a proinflammatory cytokine (interleukin [IL]-18)...
  53. doi request reprint Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Curr Rheumatol Rep 14:56-63. 2012
    ..In this review, we discuss these findings and examine the role that chemokine and growth factor receptors, proteases, adhesion molecules, and transcription factors play in the dysregulation of angiogenesis in SSc...
  54. ncbi request reprint Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis
    James M Woods
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Hum Gene Ther 13:381-93. 2002
    ..Thus, increasing IL-13 levels significantly ameliorates the course of rat AIA, suggesting that similar strategies for the treatment of human RA are worthy of further study...