David C Knight

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Investigating the neural mechanisms of aware and unaware fear memory with FMRI
    David C Knight
    Department of Psychology, University of Alabama at Birmingham, USA
    J Vis Exp . 2011
  2. pmc Learning-related diminution of unconditioned SCR and fMRI signal responses
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroimage 49:843-8. 2010
  3. pmc Neural substrates of explicit and implicit fear memory
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroimage 45:208-14. 2009
  4. doi request reprint Conditioned diminution of the unconditioned skin conductance response
    David C Knight
    Department of Psychology, Civitan International Research Center, University of Alabama at Birhingham, 1530 3rd Avenue South, Birmingham, AL 35294 0021, USA
    Behav Neurosci 125:626-31. 2011
  5. ncbi request reprint The role of the human amygdala in the production of conditioned fear responses
    David C Knight
    Unit on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 1D80, Bethesda, MD 20892, USA
    Neuroimage 26:1193-200. 2005
  6. doi request reprint Human trace fear conditioning: right-lateralized cortical activity supports trace-interval processes
    Abhishek T Haritha
    Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cogn Affect Behav Neurosci 13:225-37. 2013
  7. ncbi request reprint Neural substrates mediating human delay and trace fear conditioning
    David C Knight
    Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    J Neurosci 24:218-28. 2004
  8. ncbi request reprint Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning
    Joseph E Dunsmoor
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA
    Behav Neurosci 121:635-42. 2007
  9. ncbi request reprint The role of awareness in delay and trace fear conditioning in humans
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Cogn Affect Behav Neurosci 6:157-62. 2006
  10. pmc Expression of conditional fear with and without awareness
    David C Knight
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15280-3. 2003

Collaborators

  • Peter A Bandettini
  • Elliot A Stein
  • Dominic T Cheng
  • James H Banos
  • Kimberly H Wood
  • Muriah D Wheelock
  • Nathaniel G Harnett
  • Lawrence W Ver Hoef
  • Sylvie Mrug
  • Joseph E Dunsmoor
  • Douglas A Granger
  • Ashley K Grady
  • Adam M Goodman
  • Kenton H Bowen
  • Joshua R Shumen
  • Abhishek T Haritha
  • Zachariah M Reagh
  • Andrew T Hyde
  • Pooja A Wagle
  • Stacie K Totsch
  • Tyler R Orem
  • Jordan C Ladnier

Detail Information

Publications22

  1. pmc Investigating the neural mechanisms of aware and unaware fear memory with FMRI
    David C Knight
    Department of Psychology, University of Alabama at Birmingham, USA
    J Vis Exp . 2011
    ..Here we present a methodology to simultaneously monitor autonomic and behavioral responses during fMRI, and demonstrate the use of these methods to investigate aware and unaware memory processes during fear conditioning...
  2. pmc Learning-related diminution of unconditioned SCR and fMRI signal responses
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroimage 49:843-8. 2010
    ..In turn, prefrontal cortex activity appears to modulate the expression of unconditioned SCRs...
  3. pmc Neural substrates of explicit and implicit fear memory
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroimage 45:208-14. 2009
    ..These findings demonstrate the distinct roles of these brain regions in explicit and implicit fear memory processes...
  4. doi request reprint Conditioned diminution of the unconditioned skin conductance response
    David C Knight
    Department of Psychology, Civitan International Research Center, University of Alabama at Birhingham, 1530 3rd Avenue South, Birmingham, AL 35294 0021, USA
    Behav Neurosci 125:626-31. 2011
    ..Further, these findings suggest that although UCR amplitude is modified by conscious expectations of the UCS, conditioned diminution of the UCR can be expressed independent of learning-related changes in these expectations...
  5. ncbi request reprint The role of the human amygdala in the production of conditioned fear responses
    David C Knight
    Unit on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 1D80, Bethesda, MD 20892, USA
    Neuroimage 26:1193-200. 2005
    ..These results suggest the amygdala not only responds to fearful stimuli, but also generates learning-related changes in human autonomic fear expression...
  6. doi request reprint Human trace fear conditioning: right-lateralized cortical activity supports trace-interval processes
    Abhishek T Haritha
    Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cogn Affect Behav Neurosci 13:225-37. 2013
    ....
  7. ncbi request reprint Neural substrates mediating human delay and trace fear conditioning
    David C Knight
    Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53201, USA
    J Neurosci 24:218-28. 2004
    ..These data suggest that the hippocampus codes temporal information during trace conditioning, whereas brain regions supporting working memory processes maintain the CS-UCS representation during the trace interval...
  8. ncbi request reprint Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning
    Joseph E Dunsmoor
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA
    Behav Neurosci 121:635-42. 2007
    ..These findings may further clarify the role of these brain regions in Pavlovian fear conditioning...
  9. ncbi request reprint The role of awareness in delay and trace fear conditioning in humans
    David C Knight
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Cogn Affect Behav Neurosci 6:157-62. 2006
    ..In contrast, differential SCRs were demonstrated only for perceived trace CSs. These data suggest that awareness is necessary for conditional responding during trace, but not delay, fear conditioning...
  10. pmc Expression of conditional fear with and without awareness
    David C Knight
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15280-3. 2003
    ..These data indicate that conditional fear can be expressed when individuals are unaware of fear-eliciting stimuli and suggest that the degree of conditioning is independent of awareness during differential Pavlovian fear conditioning...
  11. pmc Neural mechanisms of human temporal fear conditioning
    Nathaniel G Harnett
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Neurobiol Learn Mem 136:97-104. 2016
    ..The current findings suggest these brain regions constitute a neural circuit that encodes the temporal information necessary for Pavlovian fear conditioning...
  12. pmc Prefrontal Cortex Activity Is Associated with Biobehavioral Components of the Stress Response
    Muriah D Wheelock
    Department of Psychology, University of Alabama at Birmingham, Birmingham AL, USA
    Front Hum Neurosci 10:583. 2016
    ..These findings underscore that PFC activity regulates behavioral and psychobiological components of the stress response...
  13. pmc The hippocampal response to psychosocial stress varies with salivary uric acid level
    Adam M Goodman
    Department of Psychology, University of Alabama at Birmingham, CIRC 235 H, 1720 2nd Avenue South, Birmingham, AL 35294 1170, United States
    Neuroscience 339:396-401. 2016
    ..Given that the hippocampus has been implicated in emotion regulation during psychosocial stress, the present findings offer a potential mechanism by which uric acid impacts mental health...
  14. pmc The amygdala mediates the emotional modulation of threat-elicited skin conductance response
    Kimberly H Wood
    Department of Psychology, University of Alabama at Birmingham
    Emotion 14:693-700. 2014
    ..g., arousal) of other stimuli in the environment. In turn, the amygdala appears to mediate important aspects of the peripheral emotional response to threat...
  15. pmc Controllability modulates the neural response to predictable but not unpredictable threat in humans
    Kimberly H Wood
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuroimage 119:371-81. 2015
    ..e., ventromedial PFC and hippocampus) involved in emotion regulation, and may have important implications for better understanding neural processes that mediate emotional resilience to stress. ..
  16. pmc Affective state and locus of control modulate the neural response to threat
    Nathaniel G Harnett
    Department of Psychology, University of Alabama at Birmingham, USA
    Neuroimage 121:217-26. 2015
    ....
  17. doi request reprint Negative, but not positive emotional images modulate the startle response independent of conscious awareness
    Zachariah M Reagh
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA
    Emotion 13:782-91. 2013
    ..However, the attenuation of the startle response by positive images appears to require perception of the emotional valence of an image...
  18. doi request reprint Neural mechanisms underlying the conditioned diminution of the unconditioned fear response
    Kimberly H Wood
    Department of Psychology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuroimage 60:787-99. 2012
    ..These findings are consistent with the view that the amygdala and PFC support learning-related processes that influence the emotional response evoked by a threat...
  19. pmc Neural correlates of unconditioned response diminution during Pavlovian conditioning
    Joseph E Dunsmoor
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroimage 40:811-7. 2008
    ..These findings demonstrate UCR diminution within the fMRI signal, and suggest that UCS expectancies modulate UCR magnitude...
  20. ncbi request reprint Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression
    Dominic T Cheng
    Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
    Behav Neurosci 117:3-10. 2003
    ..These data support the view that the amygdala is important for the expression of learned behavioral responses during Pavlovian fear conditioning...
  21. doi request reprint Effect of continuous and partial reinforcement on the acquisition and extinction of human conditioned fear
    Ashley K Grady
    Department of Psychology, University of Alabama at Birmingham
    Behav Neurosci 130:36-43. 2016
    ..In contrast, the CR extinguished quickly within the C-C group. These findings suggest that partial followed by continuous CS-UCS pairings elicit strong CRs and prolong the extinction process following human fear conditioning...