J N Kline

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Immunotherapy of asthma using CpG oligodeoxynucleotides
    Joel N Kline
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, Graduate Program in Immunology, C33GH UIHC, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Immunol Res 39:279-86. 2007
  2. ncbi request reprint Central nervous system influences in asthma
    Joel N Kline
    Institute for Clinical and Translational Science, C305GH UIHC, 200 Hawkins Drive, Iowa City, IA, 52242, USA
    Adv Exp Med Biol 795:309-19. 2014
  3. pmc Safety assessment of inhaled xylitol in mice and healthy volunteers
    Lakshmi Durairaj
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Respir Res 5:13. 2004
  4. doi request reprint Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy
    Joel N Kline
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Drug News Perspect 21:434-9. 2008
  5. ncbi request reprint School proximity to concentrated animal feeding operations and prevalence of asthma in students
    Sigurdur T Sigurdarson
    Division of Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, Iowa City, IA, USA
    Chest 129:1486-91. 2006
  6. ncbi request reprint Working Group report 3: sensitivity to organic dusts--atopy and gene polymorphisms
    Joel N Kline
    Department of Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Ind Med 46:416-8. 2004
  7. pmc Eat dirt: CpG DNA and immunomodulation of asthma
    Joel N Kline
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Proc Am Thorac Soc 4:283-8. 2007
  8. ncbi request reprint Treatment of established asthma in a murine model using CpG oligodeoxynucleotides
    Joel N Kline
    Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 283:L170-9. 2002
  9. ncbi request reprint Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction
    J N Kline
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 89:1172-8. 2000
  10. ncbi request reprint DNA therapy for asthma
    Joel N Kline
    Department of Medicine, University of Iowa, 200 Newton Road, Iowa City, IA 52242, USA
    Curr Opin Allergy Clin Immunol 2:69-73. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Immunotherapy of asthma using CpG oligodeoxynucleotides
    Joel N Kline
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, Graduate Program in Immunology, C33GH UIHC, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Immunol Res 39:279-86. 2007
    ..These preclinical studies are now being translated into clinical trials exploring this new approach to immunotherapy for atopic disease...
  2. ncbi request reprint Central nervous system influences in asthma
    Joel N Kline
    Institute for Clinical and Translational Science, C305GH UIHC, 200 Hawkins Drive, Iowa City, IA, 52242, USA
    Adv Exp Med Biol 795:309-19. 2014
    ..However much we have recently learned, it is clear that further study of this topic is critical to fully explicate the role of the brain in asthma. ..
  3. pmc Safety assessment of inhaled xylitol in mice and healthy volunteers
    Lakshmi Durairaj
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Respir Res 5:13. 2004
    ..Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers...
  4. doi request reprint Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy
    Joel N Kline
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Drug News Perspect 21:434-9. 2008
    ....
  5. ncbi request reprint School proximity to concentrated animal feeding operations and prevalence of asthma in students
    Sigurdur T Sigurdarson
    Division of Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, Iowa City, IA, USA
    Chest 129:1486-91. 2006
    ..We compared the prevalence of asthma in two Iowa elementary schools, one adjacent to a CAFO, and the other distant from any large-scale farming operations...
  6. ncbi request reprint Working Group report 3: sensitivity to organic dusts--atopy and gene polymorphisms
    Joel N Kline
    Department of Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Ind Med 46:416-8. 2004
    ..Further studies are required to delineate more precisely the contribution (and the role in inflammatory cascade modulation) of these known polymorphisms, as well as to identify novel genetic factors...
  7. pmc Eat dirt: CpG DNA and immunomodulation of asthma
    Joel N Kline
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Proc Am Thorac Soc 4:283-8. 2007
    ..Ongoing clinical trials are examining the utility of CpG ODNs alone and as an adjuvant for immunotherapy in human populations with atopic disease...
  8. ncbi request reprint Treatment of established asthma in a murine model using CpG oligodeoxynucleotides
    Joel N Kline
    Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 283:L170-9. 2002
    ..Unlike previous studies, these data demonstrate that the combination of CpG ODN and allergen can effectively reverse established atopic eosinophilic airway disease, at least partially through redirecting a Th2 to a Th1 response...
  9. ncbi request reprint Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction
    J N Kline
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 89:1172-8. 2000
    ..These results suggest that, although subjects with BHR develop a more precipitous decline in FEV(1) after exposure to CDE, the inflammatory response to CDE is similar in subjects with and without BHR...
  10. ncbi request reprint DNA therapy for asthma
    Joel N Kline
    Department of Medicine, University of Iowa, 200 Newton Road, Iowa City, IA 52242, USA
    Curr Opin Allergy Clin Immunol 2:69-73. 2002
    ..No clinical experience has yet been reported for any of these areas of research in asthma, but clinical trials are ongoing utilizing CpG oligonucleotides...
  11. ncbi request reprint Effects of CpG DNA on Th1/Th2 balance in asthma
    J N Kline
    Division of Pulmonary Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Curr Top Microbiol Immunol 247:211-25. 2000
    ..These results suggest that CpG ODN may be an effective immunomodulatory agent in the treatment, and possibly prevention, of asthma...
  12. ncbi request reprint Variable airway responsiveness to inhaled lipopolysaccharide
    J N Kline
    Departments of Medicine, Pediatrics, and Preventive Medicine, University of Iowa College of Medicine, Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Am J Respir Crit Care Med 160:297-303. 1999
    ..These findings demonstrate that an LPS phenotype can be reproducibly elicited in humans, which creates an opportunity to identify genes involved in this response to inhaled LPS...
  13. ncbi request reprint Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    J N Kline
    Department of Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Immunol 160:2555-9. 1998
    ..Significantly, in a previously sensitized mouse, CpG ODN can prevent allergen-induced airway inflammation. These studies suggest that exposure to CpG DNA may protect against asthma...
  14. ncbi request reprint CpG oligodeoxynucleotides in asthma
    I Hussain
    Department of Medicine, University of Iowa, Iowa City 52242 USA
    Curr Opin Investig Drugs 2:914-8. 2001
    ..These agents have the potential to reverse Th2-type responses to allergens and thus restore balance to the immune system. Clinical trials are ongoing...
  15. pmc Early-life co-administration of cockroach allergen and endotoxin augments pulmonary and systemic responses
    K Kulhankova
    Environmental Health Sciences Research Center, University of Iowa, Iowa City, IA 52242 5000, USA
    Clin Exp Allergy 39:1069-79. 2009
    ..Because of this, it is important to examine the role of early-life concurrent inhalation exposures to cockroach allergen and endotoxin in the pathogenesis of allergic airways disease...
  16. ncbi request reprint Endotoxin responsiveness and subchronic grain dust-induced airway disease
    C L George
    Division of Pediatric Critical Care, Department of Pediatrics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 280:L203-13. 2001
    ....
  17. ncbi request reprint Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure
    Vipul V Jain
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1137-46. 2003
    ..These results suggest that CpG DNA may provide the basis for a novel form of immunotherapy of allergic asthma. Both antigen-specific and, to a lesser extent, antigen-nonspecific responses to mucosal administration of CpG DNA are seen...
  18. pmc Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice
    K Kitagaki
    Division of Pulmonary, Critical Care and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Clin Exp Immunol 143:249-59. 2006
    ..CpG-ODNs may be useful as a component of oral immunotherapy to promote tolerance in established asthma...
  19. pmc Immunomodulatory effects of CpG oligodeoxynucleotides on established th2 responses
    Kunihiko Kitagaki
    Department of Medicine, Roy J and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Diagn Lab Immunol 9:1260-9. 2002
    ..These properties of CpG ODNs might be a useful feature in the development of immunotherapy adjuvants against allergic diseases such as asthma...
  20. ncbi request reprint Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides
    Iftikhar Hussain
    Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Laryngoscope 112:1819-26. 2002
    ..CpG oligodeoxynucleotides (ODN) are known to induce TH-1 and to suppress TH-2 cytokines in a variety of settings, including murine models of asthma...
  21. doi request reprint Use of CpG oligonucleotides in treatment of asthma and allergic disease
    David E Fonseca
    Roy J and Lucille A Carver College of Medicine, University of Iowa, USA
    Adv Drug Deliv Rev 61:256-62. 2009
    ..Further study of CpG-ODNs for the treatment of asthma and other atopic disorders is warranted by existing data...
  22. ncbi request reprint CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma
    Vipul V Jain
    Department of Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    J Allergy Clin Immunol 110:867-72. 2002
    ..Because remodeling is thought to be responsible for many of the long-term adverse effects on asthmatic patients, we evaluated whether CpG-ODNs might similarly prevent these changes using a murine model of recurrent allergen exposure...
  23. ncbi request reprint Intestinal helminths protect in a murine model of asthma
    Kunihiko Kitagaki
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:1628-35. 2006
    ..Helminthic colonization appears to protect against asthma and atopic disorders; the regulatory cytokine, IL-10, may be a critical player...
  24. ncbi request reprint TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    N C Arbour
    1 Department of Medicine, Department of Veterans Affairs Medical Center, The University of Iowa, Iowa City, Iowa, USA
    Nat Genet 25:187-91. 2000
    ....
  25. pmc Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma
    Melissa E Munroe
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:5586-97. 2010
    ....
  26. ncbi request reprint CpG DNA: immunomodulation and remodelling of the asthmatic airway
    Vipul V Jain
    C33GH, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Expert Opin Biol Ther 4:1533-40. 2004
    ..In this paper, the effects of CpG DNA on asthma inflammation and remodelling are reviewed...
  27. ncbi request reprint DNA immunomodulation of asthma
    Joel N Kline
    University of Iowa College of Medicine, Iowa City, Iowa, USA
    Clin Allergy Immunol 16:551-64. 2002
    ..Because most of the Th2 cytokines are on chromosome 5, the completion of the human genome project may open whole new venues of research aimed at controlling these cytokines at the chromosomal level...
  28. ncbi request reprint Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responses
    Caroline L S George
    Department of Pediatrics, University of Iowa, Iowa City, 52242, USA
    Am J Physiol Lung Cell Mol Physiol 291:L512-22. 2006
    ..In conclusion, exposure to a nonhygienic environment did not induce significant airway neutrophilia, yet altered the population of immunologically active cells in the lung and reduced subsequent allergic inflammation...
  29. ncbi request reprint The TGF-beta response to Leishmania chagasi in the absence of IL-12
    Mary E Wilson
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Eur J Immunol 32:3556-65. 2002
    ..chagasi has an inherent propensity to elicit a prominent TGF-beta response that either suppresses, or is suppressed by, a type 1 response. We propose this be termed a "type 3" immune response, which can antagonize a type 1 response...
  30. ncbi request reprint Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function
    Stephen E McGowan
    Department of Veterans Affairs Research Service, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1031-9. 2002
    ..Vitamin A (retinol) and its congeners (retinoids) may be required to regulate bronchial responsiveness in addition to maintaining a normal bronchial epithelium...
  31. ncbi request reprint Characterization of a hooded human exposure apparatus for inhalation of gases and aerosols
    PATRICK T O'SHAUGHNESSY
    Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA
    J Occup Environ Hyg 1:161-6. 2004
    ....
  32. ncbi request reprint Experimental human exposure to inhaled grain dust and ammonia: towards a model of concentrated animal feeding operations
    Sigurdur T Sigurdarson
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Am J Ind Med 46:345-8. 2004
    ..We hypothesized that experimental exposure to ammonia and dust would impair pulmonary function, and that these exposures would be synergistic...
  33. ncbi request reprint Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis
    J N Kline
    Department of Internal Medicine, Veteran s Affairs Medical Center, Iowa City
    Chest 104:47-53. 1993
    ..Current smoking was associated with lower IL-1 beta and IL-1ra release in ILD. The IL-1AI is a convenient method for comparison of IL-1 beta activity between patient populations...
  34. ncbi request reprint CpG DNA and immunotherapy of allergic airway diseases
    V V Jain
    Division of Pulmonary, Critical Care and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Clin Exp Allergy 33:1330-5. 2003
    ..These data suggest that CpG ODN may be a novel therapeutic tool for the treatment of atopic asthma...
  35. ncbi request reprint CpG oligodeoxynucleotides: a novel therapeutic approach for atopic disorders
    Iftikhar Hussain
    Roy J and Lucille A Carver College of Medicine, University of Iowa, C33GH UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Curr Drug Targets Inflamm Allergy 2:199-205. 2003
    ..These agents may represent a novel therapeutic approach toward restoring immune tolerance in atopic individuals...
  36. pmc Exploration of the volumetric composition of human lung cancer nodules in correlated histopathology and computed tomography
    J C Sieren
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Lung Cancer 74:61-8. 2011
    ....
  37. ncbi request reprint Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2
    Hong Peng Jia
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L428-37. 2004
    ..The regulation of MD-2 expression in airway epithelia and pulmonary macrophages may serve as a means to modify endotoxin responsiveness in the airway...
  38. pmc Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia
    Alok S Shah
    Departments of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:3380-5. 2008
    ..These results emphasize the role of BBS proteins in both the structure and function of motile cilia. They also invite additional scrutiny of motile cilia dysfunction in patients with this disease...
  39. ncbi request reprint Perspectives in asthma: molecular use of microbial products in asthma prevention and treatment
    Doina M Racila
    Division of Pulmonary, Critical Care and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, IA 52242, USA
    J Allergy Clin Immunol 116:1202-5. 2005
    ..Clinical trials have been conducted for some of these biologic compounds, such as cytosine-guanine dinucleotide DNA and Mycobacterium vaccae, whereas others remain in preclinical testing...
  40. pmc Motile cilia of human airway epithelia are chemosensory
    Alok S Shah
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 325:1131-4. 2009
    ..Hence, like primary cilia, classical motile cilia also contain sensors to detect the external environment...
  41. ncbi request reprint DNA, the immune system, and atopic disease
    Iftikhar Hussain
    Department of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Investig Dermatol Symp Proc 9:23-8. 2004
    ..They have the potential to reverse TH2-type responses to allergens and thus restore balance to the immune system without the adverse effects of TH1 cytokines...
  42. ncbi request reprint Acute toxic pneumonitis complicating chronic obstructive pulmonary disease (COPD) in a farmer
    Sigurdur T Sigurdarson
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Ind Med 46:393-5. 2004
    ..Toxic pneumonitis or Organic Dust Toxic Syndrome (ODTS) is a common, usually self-limiting condition among agricultural workers, occurring after high level exposure to agricultural dust...
  43. ncbi request reprint Safety of incremental inhaled lipopolysaccharide challenge in humans
    John S Sundy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Endotoxin Res 12:113-9. 2006
    ..Inhaled airway challenge using lipopolysaccharide in humans has been performed for over 20 years to assess the airway response to endotoxin. However, there are no published data on the short-term safety of endotoxin inhalation protocols...
  44. pmc MMP9 modulates tight junction integrity and cell viability in human airway epithelia
    Paola D Vermeer
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Lung Cell Mol Physiol 296:L751-62. 2009
    ..Taken together, these data suggest that a component of airway remodeling associated with asthma may be directly regulated by MMP9...
  45. pmc Health effects of airborne exposures from concentrated animal feeding operations
    Dick Heederik
    University of Utrecht, Utrecht, The Netherlands
    Environ Health Perspect 115:298-302. 2007
    ....
  46. ncbi request reprint Placebo response in asthma: a robust and objective phenomenon
    Margaret E Kemeny
    University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 119:1375-81. 2007
    ..Nevertheless, mind-body links and placebo responsivity in asthma are widely believed to exist...
  47. ncbi request reprint Expression of cysteinyl leukotriene receptor-1 in skin
    Iftikhar Hussain
    J Am Acad Dermatol 51:1032-3. 2004

Research Grants12

  1. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2006
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  2. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..Question 2A: What mediators promote immune tolerance induced by early life exposure to microbial products? Question 2B: What cells are responsible for immune tolerance induced by early life exposure to microbial products? ..
  3. Helminth-Induced Immune Tolerance in Asthma
    Joel Kline; Fiscal Year: 2005
    ..Although completion of the second Aim is almost certainly beyond the scope of this two-year developmental research grant, these studies will be continued and extended through an R01 grant application. ..
  4. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2005
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  5. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2004
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  6. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2003
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  7. Precise Correspondence of 3D Pathology with Radiological Features in Lung Nodules
    Joel N Kline; Fiscal Year: 2010
    ..Further, other imaging modalities relevant to lung cancer, such as positron emission tomography and micro-endoscopy, will find the 3D information vital to their clinical development. ..