GORDON KLEIN

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Aluminum: new recognition of an old problem
    Gordon L Klein
    Children s Hospital Room 3 270, University of Texas Medical Branch, 301 University Boulevard, Galveston TX 77555 0352, USA
    Curr Opin Pharmacol 5:637-40. 2005
  2. pmc Burn-induced bone loss: importance, mechanisms, and management
    Gordon L Klein
    Shriners Burns Hospital and The University of Texas Medical Branch, Department of Pediatrics, Galveston, TX, USA
    J Burns Wounds 5:e5. 2006
  3. ncbi request reprint The role of bone densitometry in the diagnosis and management of the severely burned patient with bone loss
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555 0352, USA
    J Clin Densitom 2:11-5. 1999
  4. pmc Standard multivitamin supplementation does not improve vitamin D insufficiency after burns
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch, Children s Hospital Room 3 270, 301 University Boulevard, Galveston, TX, 77555 0352, USA
    J Bone Miner Metab 27:502-6. 2009
  5. ncbi request reprint The interaction between burn injury and vitamin D metabolism and consequences for the patient
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston TX 77555 0352, USA
    Curr Clin Pharmacol 3:204-10. 2008
  6. ncbi request reprint The state of pediatric bone: summary of the ASBMR pediatric bone initiative
    Gordon L Klein
    University of Texas Medical Branch, Galveston, USA
    J Bone Miner Res 20:2075-81. 2005
  7. ncbi request reprint Effects of therapy with recombinant human growth hormone on insulin-like growth factor system components and serum levels of biochemical markers of bone formation in children after severe burn injury
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch, Galveston 77555 0352, USA
    J Clin Endocrinol Metab 83:21-4. 1998
  8. ncbi request reprint The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study
    Gordon L Klein
    Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas, TX 77555 0352, USA
    Osteoporos Int 16:631-5. 2005
  9. ncbi request reprint Magnesium deficit in major burns: role in hypoparathyroidism and end-organ parathyroid hormone resistance
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch, Galveston, USA
    Magnes Res 11:103-9. 1998
  10. ncbi request reprint Evidence supporting a role of glucocorticoids in short-term bone loss in burned children
    Gordon L Klein
    Department of Pediatrics, Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0352, USA
    Osteoporos Int 15:468-74. 2004

Detail Information

Publications20

  1. ncbi request reprint Aluminum: new recognition of an old problem
    Gordon L Klein
    Children s Hospital Room 3 270, University of Texas Medical Branch, 301 University Boulevard, Galveston TX 77555 0352, USA
    Curr Opin Pharmacol 5:637-40. 2005
    ....
  2. pmc Burn-induced bone loss: importance, mechanisms, and management
    Gordon L Klein
    Shriners Burns Hospital and The University of Texas Medical Branch, Department of Pediatrics, Galveston, TX, USA
    J Burns Wounds 5:e5. 2006
    ..The purpose of this article is to familiarize the reader with the issue of bone loss that accompanies severe burn injury. Why is this important? How does it happen? How can we treat it?..
  3. ncbi request reprint The role of bone densitometry in the diagnosis and management of the severely burned patient with bone loss
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555 0352, USA
    J Clin Densitom 2:11-5. 1999
    ..The reduced bone density increases the risk for postburn fractures and for reduced peak bone mass, increasing the risk of these patients for adult-onset osteoporosis...
  4. pmc Standard multivitamin supplementation does not improve vitamin D insufficiency after burns
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch, Children s Hospital Room 3 270, 301 University Boulevard, Galveston, TX, 77555 0352, USA
    J Bone Miner Metab 27:502-6. 2009
    ..Supplementation of burned children with a standard multivitamin tablet stated to contain 400 IU of vitamin D(2) failed to correct the vitamin D insufficiency...
  5. ncbi request reprint The interaction between burn injury and vitamin D metabolism and consequences for the patient
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston TX 77555 0352, USA
    Curr Clin Pharmacol 3:204-10. 2008
    ..Thus vitamin D supplementation is the only means by which to ensure vitamin D sufficiency for burn victims. The proper requirement for vitamin D in acutely burned patients remains unknown...
  6. ncbi request reprint The state of pediatric bone: summary of the ASBMR pediatric bone initiative
    Gordon L Klein
    University of Texas Medical Branch, Galveston, USA
    J Bone Miner Res 20:2075-81. 2005
  7. ncbi request reprint Effects of therapy with recombinant human growth hormone on insulin-like growth factor system components and serum levels of biochemical markers of bone formation in children after severe burn injury
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch, Galveston 77555 0352, USA
    J Clin Endocrinol Metab 83:21-4. 1998
    ..The rHGH-independent rise in serum levels of the inhibitory binding protein IGFBP-4 suggests a mechanism by which improved bone formation is prevented despite successful elevation of IGF-1 and IGFBP-3 in the burned child...
  8. ncbi request reprint The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study
    Gordon L Klein
    Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas, TX 77555 0352, USA
    Osteoporos Int 16:631-5. 2005
    ..In summary, acute intravenous pamidronate administration following burns may help to preserve bone mass, perhaps by inhibiting the glucocorticoid-induced apoptosis of osteoblasts and osteocytes...
  9. ncbi request reprint Magnesium deficit in major burns: role in hypoparathyroidism and end-organ parathyroid hormone resistance
    G L Klein
    Department of Pediatrics, University of Texas Medical Branch, Galveston, USA
    Magnes Res 11:103-9. 1998
    ....
  10. ncbi request reprint Evidence supporting a role of glucocorticoids in short-term bone loss in burned children
    Gordon L Klein
    Department of Pediatrics, Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0352, USA
    Osteoporos Int 15:468-74. 2004
    ..05). The eightfold elevation of urinary free cortisol excretion, low osteoblast number, decreased resorptive surface, and reduced markers of osteoblast differentiation are all consistent with an acute glucocorticoid effect on bone...
  11. ncbi request reprint Synthesis of vitamin D in skin after burns
    Gordon L Klein
    Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555 0352, USA
    Lancet 363:291-2. 2004
    ..Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury...
  12. ncbi request reprint Hepatic osteodystrophy in chronic cholestasis: evidence for a multifactorial etiology
    Gordon L Klein
    Pediatric Gastroenterology Division, Children s Hospital, University of Texas Medical Branch, Galveston TX 77555 0352, USA
    Pediatr Transplant 6:136-40. 2002
    ....
  13. ncbi request reprint Vitamin D depletion following burn injury in children: a possible factor in post-burn osteopenia
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch at Galveston and Shriners Burns Hospital, 77555 0352, USA
    J Trauma 52:346-50. 2002
    ..Because they are advised to avoid sunlight to prevent burn scar hyperpigmentation, we hypothesized that they develop vitamin D depletion, which could contribute to post-burn osteopenia...
  14. ncbi request reprint Persistent hypoparathyroidism following magnesium repletion in burn-injured children
    G L Klein
    Pediatric Gastroenterology Division, Children s Hospital, University of Texas Medical Branch, Galveston 77555 0352, USA
    Pediatr Nephrol 14:301-4. 2000
    ..We conclude that Mg depletion is not the chief cause of hypoparathyroidism following thermal injury and we postulate that the persistent hypoparathyroidism is consistent with a reduced set-point for Ca suppression of PTH secretion...
  15. ncbi request reprint Effects of long-term oxandrolone administration in severely burned children
    Kevin D Murphy
    Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Surgery 136:219-24. 2004
    ..The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn patients...
  16. pmc Pamidronate preserves bone mass for at least 2 years following acute administration for pediatric burn injury
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 0352, USA
    Bone 41:297-302. 2007
    ....
  17. ncbi request reprint Effects of pharmacologic agents on bone in childhood: an editorial overview
    Gordon L Klein
    Pediatrics 119:S125-30. 2007
  18. ncbi request reprint Impaired zinc and copper status in children with burn injuries: need to reassess nutritional requirements
    V Saroja Voruganti
    Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
    Burns 31:711-6. 2005
    ..We demonstrate that burn injury in children results in low plasma levels of Zn and Cu that are inadequately compensated during hospitalization...
  19. ncbi request reprint Cardiovascular distribution of the calcium sensing receptor before and after burns
    Gordon L Klein
    Department of Pediatrics, University of Texas Medical Branch Galveston, Galveston, TX, United States
    Burns 34:370-5. 2008
    ..We suggest that CaR has a local, tissue-specific role, and functions in vascular calcium sensing for intravascular calcium deposition or regulation of other calcium channels after trauma or burn...
  20. ncbi request reprint Burns
    Gordon L Klein
    University of Texas Medical Branch and Shriners Burns Hospital, Galveston, USA
    Pediatr Rev 25:411-7. 2004