Genomes and Genes
Rick A Kittles
Affiliation: University of Chicago
- 8q24 allelic imbalance and MYC gene copy number in primary prostate cancerH Chen
Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
Prostate Cancer Prostatic Dis 13:238-43. 2010..Our findings also suggest that these two somatic alterations may be due to the same preferential chromosomal duplication event during prostate tumorigenesis...
- An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panelsRami Nassir
Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
BMC Genet 10:39. 2009..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
- Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control studyNicole A Lavender
Department of Pharmacology and Toxicology, University of Louisville UofL, School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA
BMC Cancer 9:397. 2009..Thus, we evaluated the effects of polymorphic GSTs (M1, T1, and P1) alone and combined with cigarette smoking on PCA susceptibility...
- Smoking and prostate cancer in a multi-ethnic cohortAdam B Murphy
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Prostate 73:1518-28. 2013..Smoking is associated with high-grade PCa and incidence, but few studies have focused on AA men. This study aims to determine the effect of tobacco-use on odds of PCa and of high-grade PCa in a population of predominantly AA men...
- Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and CaucasiansSonia S Kupfer
Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, United States of America
PLoS ONE 6:e26123. 2011..In summary, using a systematic tagSNP approach, we have not found evidence for significant associations between VDR and CRC in AAs or Caucasians...
- Genetic heterogeneity in colorectal cancer associations between African and European americansSonia S Kupfer
Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Gastroenterology 139:1677-85, 1685.e1-8. 2010..None of these studies included African Americans, who have the highest incidence and mortality from CRC in the United States. For the 10 genomic regions, we performed an association study of Americans of African and European descent...
- Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African AmericansStanley Hooker
Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA
Prostate 70:270-5. 2010..Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs...
- Fine-mapping of IL16 gene and prostate cancer risk in African AmericansKen Batai
Institute of Human Genetics, College of Medicine, School of Public Health, University of Illinois at Chicago, Chicago, IL 60607 4067, USA
Cancer Epidemiol Biomarkers Prev 21:2059-68. 2012..Here we explore single-nucleotide polymorphism (SNP) variation in IL16 in AAs and test for association with prostate cancer...
- Predictors of serum vitamin D levels in African American and European American men in ChicagoAdam B Murphy
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Am J Mens Health 6:420-6. 2012..Supplementation is a high-impact, modifiable risk factor. Race and sunlight exposure should be taken into account for recommended daily allowances for vitamin D intake...
- Genetic variation in vitamin D-related genes and risk of colorectal cancer in African AmericansFabio Pibiri
Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, 900 S Ashland Ave MC 767, Chicago, IL, 60607, USA
Cancer Causes Control 25:561-70. 2014..Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk...
- Contribution of higher risk genes and European admixture to Crohn's disease in African AmericansMing Hsi Wang
Lyn P and Harvey M Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Inflamm Bowel Dis 18:2277-87. 2012..Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major established risk genes to AA CD...
- Effect of NQO1 and CYP4F2 genotypes on warfarin dose requirements in Hispanic-Americans and African-AmericansAdam Bress
Department of Pharmacy Practice, University of Illinois at Chicago, 833 S Wood St, Rm 164, Chicago, IL 60612 7230, USA
Pharmacogenomics 13:1925-35. 2012..The objective of this study was to determine the additional contribution of NQO1 and CYP4F2 genotypes to warfarin dose requirements across two racial groups after accounting for known clinical and genetic predictors...
- Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European AmericansSonia S Kupfer
Sections of Gastroenterology and Genetic Medicine, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
Carcinogenesis 30:1353-7. 2009..In summary, these results are evidence that 8q24 region 4 contains novel CRC-associated alleles in European and African Americans...
- 8q24 risk alleles in West African and Caribbean menAdam B Murphy
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Prostate 72:1366-73. 2012..Multiple genetic studies have confirmed associations of 8q24 variants with susceptibility to prostate cancer (CaP). However, the magnitude of risk conferred in men living in West Africa is unknown...
- National Cancer Institute Prostate Cancer Genetics WorkshopWilliam J Catalona
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Cancer Res 71:3442-6. 2011..The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics...
- IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-AmericansWenndy Hernandez
Cancer Biology Program, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
Carcinogenesis 28:2154-9. 2007..Our study adds clarity and further support to the previous findings, implicating serum IGFBP-3 levels and the IGFBP-3 -202 A/C SNP in prostate carcinogenesis...