Patrick F Kiser

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties
    Pedro M M Mesquita
    Departments of Pediatrics and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    Retrovirology 10:113. 2013
  2. pmc A perspective on progress and gaps in HIV prevention science
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    AIDS Res Hum Retroviruses 28:1373-8. 2012
  3. ncbi request reprint State of the art in intravaginal ring technology for topical prophylaxis of HIV infection
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    AIDS Rev 14:62-77. 2012
  4. doi request reprint Design of tenofovir-UC781 combination microbicide vaginal gels
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112 5820, USA
    J Pharm Sci 101:1852-64. 2012
  5. pmc Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles
    Meredith R Clark
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 South 2030 East, Salt Lake City, UT 84112, United States
    Int J Pharm 413:10-18. 2011
  6. pmc A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Antimicrob Agents Chemother 56:6272-83. 2012
  7. doi request reprint Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir
    Justin T Clark
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, UT 84112, USA
    J Control Release 163:240-8. 2012
  8. pmc Osmotic pump tablets for delivery of antiretrovirals to the vaginal mucosa
    Rachna Rastogi
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, United States
    Antiviral Res 100:255-8. 2013
  9. doi request reprint Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir
    Todd J Johnson
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Eur J Pharm Sci 39:203-12. 2010
  10. pmc Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy
    Justin T Clark
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e88509. 2014

Research Grants

  1. Bioresponsive Microbicides for AIDS Prevention
    PATRICK KISER; Fiscal Year: 2005

Collaborators

  • David R Friend
  • Betsy C Herold
  • Robert W Buckheit Jr
  • Eric M Smith
  • Lisa C Rohan
  • Daniel H Appella
  • Chang Won Lee
  • Charlene S Dezzutti
  • Thomas J Hope
  • Anthony R Geonnotti
  • Bonnie E Lai
  • Todd J Johnson
  • Alamelu Mahalingam
  • Rachna Rastogi
  • Justin T Clark
  • Kavita M Gupta
  • Meredith R Clark
  • Judit Fabian
  • Ryan S Teller
  • Robert W Buckheit
  • Julie I Jay
  • Shweta R Ugaonkar
  • Pedro M M Mesquita
  • Joel S Nebeker
  • Theodore H Albright
  • Hyder A Aliyar
  • David F Katz
  • Karen W Buckheit
  • Priya Srinivasan
  • Anthony L Tuitupou
  • Karen M Watson
  • Manpreet Kaur
  • Festo Damian
  • Azadeh E Poursaid
  • Samuel Sung
  • Igal Szleifer
  • Justin Clark
  • David C Malaspina
  • Jonathan Su
  • Lexie B English
  • Robert J Bahde
  • Robert W Hitchcock
  • Namdev B Shelke
  • Andrew K Andreasen
  • Michael J Blair
  • James M Smith
  • Michael S Kay
  • Tammy Evans-Strickfaden
  • R Michael Hendry
  • Lorna Rabe
  • Amy Martin
  • Karen Watson-Buckheit
  • Gustavo F Doncel
  • Chou Pong Pau
  • Ron Otten
  • James Smith
  • Janet McNicholl
  • Satya Ponnapalli
  • Robert Buckheit
  • R Tyler McCabe
  • Neelima Chandra
  • Russell J Stewart
  • Prasoona Karra
  • Shetha Shukair
  • Mike D McRaven
  • Kristofer Langheinrich
  • Adam P Simmons
  • Jan Balzarini
  • David G Myszka
  • Jennifer J Peters
  • Kris Langheinrich
  • Festo R Damian
  • Patrick A Tresco
  • Serena M Pearce
  • Mark A Mitchnik
  • Scott R Barnes
  • Meredith C Roberts
  • Rachel A Tangaro
  • Derek H Owen

Detail Information

Publications24

  1. pmc Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties
    Pedro M M Mesquita
    Departments of Pediatrics and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    Retrovirology 10:113. 2013
    ..The antiviral activity of cervicovaginal lavage samples against a primary Clade C isolate was also measured and correlated with drug levels...
  2. pmc A perspective on progress and gaps in HIV prevention science
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    AIDS Res Hum Retroviruses 28:1373-8. 2012
    ..This drives some of the most pressing questions in the field...
  3. ncbi request reprint State of the art in intravaginal ring technology for topical prophylaxis of HIV infection
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    AIDS Rev 14:62-77. 2012
    ....
  4. doi request reprint Design of tenofovir-UC781 combination microbicide vaginal gels
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112 5820, USA
    J Pharm Sci 101:1852-64. 2012
    ..The approach described herein provides a rational schema to design and evaluate vaginal gels for use as microbicides...
  5. pmc Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles
    Meredith R Clark
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 South 2030 East, Salt Lake City, UT 84112, United States
    Int J Pharm 413:10-18. 2011
    ..The solid phase synthesis of the crosslinkers, preparation of the particles by inverse microemulsion polymerization, HSP-triggered release of pSS and inactivation of HIV-1 studies are described...
  6. pmc A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Antimicrob Agents Chemother 56:6272-83. 2012
    ..In summary, the controlled release of TFV from this reservoir IVR provided elevated sheep vaginal concentrations for 90 days to merit its further evaluation as an HIV prophylactic...
  7. doi request reprint Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir
    Justin T Clark
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, UT 84112, USA
    J Control Release 163:240-8. 2012
    ..Drug release and mechanical properties were approximated by analytical models, which may prove useful for the continuing development of IVRs for HIV prevention or other women's health indications...
  8. pmc Osmotic pump tablets for delivery of antiretrovirals to the vaginal mucosa
    Rachna Rastogi
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, United States
    Antiviral Res 100:255-8. 2013
    ..Overall, our results show successful implementation of the osmotic pump technology for vaginal antiretroviral delivery. ..
  9. doi request reprint Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir
    Todd J Johnson
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Eur J Pharm Sci 39:203-12. 2010
    ..Altogether, these results suggest that multisegment polyurethane IVRs are an attractive formulation for the sustained vaginal delivery of drugs with contrasting hydrophilicity such as dapivirine and tenofovir...
  10. pmc Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy
    Justin T Clark
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e88509. 2014
    ..In summary, this system represents a significant advance in vaginal drug delivery technology, and is the first in a new class of long-acting multipurpose prevention drug delivery systems. ..
  11. pmc Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Biomaterials 32:8343-55. 2011
    ....
  12. pmc Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    Antimicrob Agents Chemother 56:1291-9. 2012
    ....
  13. pmc Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, United States
    Mol Pharm 8:2465-75. 2011
    ....
  14. pmc Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors
    Julie I Jay
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, USA
    Mol Pharm 7:116-29. 2010
    ..These polymers exhibited minimal cytotoxicity after 24 h exposure to a human vaginal cell line...
  15. pmc An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission
    Shweta R Ugaonkar
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, 84112
    J Pharm Sci 104:3426-39. 2015
    ..Our findings support the need for further preclinical evaluation. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3426-3439, 2015. ..
  16. doi request reprint Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine
    Manpreet Kaur
    Department of Bioengineering, University of Utah, Salt Lake City, UT, 84112, USA
    Drug Deliv Transl Res 1:223-37. 2011
    ..These results are encouraging for further development of this degradable IVR for topical vaginal delivery of microbicides. ..
  17. doi request reprint Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions
    Festo Damian
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Int J Pharm 396:1-10. 2010
    ....
  18. doi request reprint Design of a semisolid vaginal microbicide gel by relating composition to properties and performance
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 5820, USA
    Pharm Res 27:2478-91. 2010
    ....
  19. pmc Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release
    Ryan S Teller
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, United States Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, United States
    J Control Release 224:176-83. 2016
    ..This device could provide an adaptable platform for the vaginal drug delivery of many molecules. ..
  20. doi request reprint Intravaginal flux controlled pump for sustained release of macromolecules
    Ryan S Teller
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, Utah, 84112, USA
    Pharm Res 31:2344-53. 2014
    ..To design a flux controlled pump (FCP) capable of 30-day, controlled release of macromolecules to the vaginal mucosa...
  21. doi request reprint Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1
    Kavita M Gupta
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    J Pharm Sci 97:4228-39. 2008
    ..These results qualify polyether urethanes for development of intravaginal rings for sustained delivery of microbicidal agents...
  22. pmc Engineering and characterization of simplified vaginal and seminal fluid simulants
    Rachna Rastogi
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Contraception 93:337-46. 2016
    ..We report the design and characterization of stable and simplified buffers that mimic the salient physical/chemical properties of the physiological fluids...
  23. ncbi request reprint Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles
    Kavita M Gupta
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 S 2030 E Salt Lake City, Utah 84112, USA
    J Pharm Sci 96:670-81. 2007
    ....
  24. pmc Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E, Salt Lake City, Utah 84112, USA
    Antimicrob Agents Chemother 55:1650-60. 2011
    ..In summary, these results are encouraging and warrant further evaluation of IQP-0528 gel formulations in in vivo models, as well as the development of alternative formulations for the delivery of IQP-0528 as a microbicide...

Research Grants1

  1. Bioresponsive Microbicides for AIDS Prevention
    PATRICK KISER; Fiscal Year: 2005
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