Pooja Khatri

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Intracranial hemorrhage associated with revascularization therapies
    Pooja Khatri
    University of Cincinnati, Department of Neurology, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 38:431-40. 2007
  2. doi request reprint Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients With Mild Stroke in the Third International Stroke Trial-3: Post Hoc Analysis
    Pooja Khatri
    From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH P K, J P B Genentech, Inc, South San Francisco, CA D T Division of Clinical Neurosciences G C, P S, and Division of Neuroimaging Sciences J M W, University of Edinburgh, Edinburgh, Scotland Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia R I L and Department of Public Health Sciences, Medical University of South Carolina, Charleston S D Y
    Stroke 46:2325-7. 2015
  3. pmc Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial
    Pooja Khatri
    University of Cincinnati, Cincinnati, OH, USA Electronic address
    Lancet Neurol 13:567-74. 2014
  4. pmc Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic stroke
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 43:560-2. 2012
  5. pmc The safety and efficacy of thrombolysis for strokes after cardiac catheterization
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    J Am Coll Cardiol 51:906-11. 2008
  6. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
  7. pmc Good clinical outcome after ischemic stroke with successful revascularization is time-dependent
    P Khatri
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    Neurology 73:1066-72. 2009
  8. pmc Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
    Stroke 41:2581-6. 2010
  9. ncbi request reprint Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Ohio, OH 45267 0525, USA
    Stroke 36:2400-3. 2005
  10. pmc Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk
    Pooja Khatri
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267 0525, USA
    Stroke 39:3283-7. 2008

Detail Information

Publications72

  1. ncbi request reprint Intracranial hemorrhage associated with revascularization therapies
    Pooja Khatri
    University of Cincinnati, Department of Neurology, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 38:431-40. 2007
    ..This review discusses the state of our current knowledge on hemorrhagic transformation (HT) and summarizes key factors to be considered when comparing risk associated with various approaches to revascularization...
  2. doi request reprint Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients With Mild Stroke in the Third International Stroke Trial-3: Post Hoc Analysis
    Pooja Khatri
    From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH P K, J P B Genentech, Inc, South San Francisco, CA D T Division of Clinical Neurosciences G C, P S, and Division of Neuroimaging Sciences J M W, University of Edinburgh, Edinburgh, Scotland Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia R I L and Department of Public Health Sciences, Medical University of South Carolina, Charleston S D Y
    Stroke 46:2325-7. 2015
    ..We sought to determine the efficacy of intravenous recombinant tissue-type plasminogen activator (IV r-tPA) in a subset of patients with mild deficit in the third International Stroke Trial (IST-3)...
  3. pmc Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial
    Pooja Khatri
    University of Cincinnati, Cincinnati, OH, USA Electronic address
    Lancet Neurol 13:567-74. 2014
    ..We sought to validate this association in a preplanned analysis of data from the IMS III trial...
  4. pmc Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic stroke
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 43:560-2. 2012
    ..We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening...
  5. pmc The safety and efficacy of thrombolysis for strokes after cardiac catheterization
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    J Am Coll Cardiol 51:906-11. 2008
    ..The purpose of this study was to systematically compare clinical outcomes of patients treated with thrombolysis with those without treatment in a multi-year, multicenter cohort of strokes after cardiac catheterization...
  6. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
    ..a.) approach to recanalization may be more effective than standard i.v. rt-PA (Activase) alone for moderate-to-large National Institutes of Health Stroke Scale (NIHSS>or=10) strokes, and with a similar safety profile...
  7. pmc Good clinical outcome after ischemic stroke with successful revascularization is time-dependent
    P Khatri
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    Neurology 73:1066-72. 2009
    ..An understanding of the relationship between timing of angiographic reperfusion and clinical outcome is needed to establish time parameters for intraarterial (IA) therapies...
  8. pmc Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
    Stroke 41:2581-6. 2010
    ..We sought to further characterize the patients with minor stroke who were included in the National Institute of Neurological Disorders and Stroke trials...
  9. ncbi request reprint Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Ohio, OH 45267 0525, USA
    Stroke 36:2400-3. 2005
    ..We sought to determine their relationship in the Interventional Management of Stroke (IMS) Phase I trial of combined intravenous (IV) and intraarterial (IA) recombinant tissue plasminogen activator...
  10. pmc Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk
    Pooja Khatri
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267 0525, USA
    Stroke 39:3283-7. 2008
    ..We tested the hypothesis that MCIs are a risk factor for intracranial hemorrhage (ICH) in the Interventional Management of Stroke (IMS) I and II trials of combined intravenous/IA recombinant tissue plasminogen activator therapy...
  11. pmc Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network
    Joshua Z Willey
    Department of Neurology, Columbia University, New York, New York, USA
    J Stroke Cerebrovasc Dis 22:318-22. 2013
    ..Current guidelines do not define the lower severity threshold for thrombolysis. In this study, we describe the variability of treatment of mild stroke patients across a network of academic stroke centers...
  12. pmc Age at stroke: temporal trends in stroke incidence in a large, biracial population
    Brett M Kissela
    University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Neurology 79:1781-7. 2012
    ..We hypothesized that stroke incidence in younger adults (age 20-54) increased over time, most notably between 1999 and 2005...
  13. pmc Trends in substance abuse preceding stroke among young adults: a population-based study
    Felipe de Los Ríos
    University of Cincinnati College of Medicine, Department of Neurology, and Cincinnati Children s Hospital, 260 Stetson St, Suite 2300, Cincinnati, OH 45267, USA
    Stroke 43:3179-83. 2012
    ..Approximately 5% of strokes occur in adults aged 18 to 44 years. Substance abuse is a prevalent risk factor for stroke in young adults. We sought to identify trends in substance abuse detection among stroke patients...
  14. pmc Eligibility for Intravenous Recombinant Tissue-Type Plasminogen Activator Within a Population: The Effect of the European Cooperative Acute Stroke Study (ECASS) III Trial
    Felipe de Los Ríos la Rosa
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA
    Stroke 43:1591-5. 2012
    ..5 hours from symptom onset. The impact of the expanded time window on treatment rates has not been comprehensively evaluated in a population-based study...
  15. pmc Efficiency of enrollment in a successful phase II acute stroke clinical trial
    Opeolu Adeoye
    Department of Emergency Medicine and Neurosurgery, University of Cincinnati Neuroscience Institute, Cincinnati, Ohio 45267 0525, USA
    J Stroke Cerebrovasc Dis 21:667-72. 2012
    ..We hypothesized that missed opportunities for enrollment of eligible patients occurred frequently, despite the success of the trial...
  16. pmc Patients living in impoverished areas have more severe ischemic strokes
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Stroke 43:2055-9. 2012
    ..However, predictors of initial stroke severity have not been well-described within a population. We hypothesized that poorer patients would have a higher initial stroke severity on presentation to medical attention...
  17. pmc Carotid artery stenosis as a cause of stroke
    Matthew L Flaherty
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267 0525, USA
    Neuroepidemiology 40:36-41. 2013
    ..We determined the types of large-vessel atherosclerosis responsible for ischemic strokes in a population-based stroke study...
  18. pmc Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population
    Jane C Khoury
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnett Av, MLC 5041, Cincinnati, OH 45229, USA
    Stroke 44:1500-4. 2013
    ..With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same population (≈1.3 million) 5 and 10 years later...
  19. pmc Endovascular therapy after intravenous t-PA versus t-PA alone for stroke
    Joseph P Broderick
    Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    N Engl J Med 368:893-903. 2013
    ....
  20. pmc Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study
    Dawn O Kleindorfer
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45242, USA
    Stroke 41:1326-31. 2010
    ..The objective of this study was to examine temporal trends in stroke incidence and case-fatality within a large biracial population over time by comparing stroke incidence rates from 1993 to 1994, 1999, and 2005...
  21. pmc The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial
    Arthur M Pancioli
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
    Stroke 39:3268-76. 2008
    ....
  22. pmc Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain
    Aigang Lu
    Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267 0532, USA
    Exp Neurol 216:407-12. 2009
    ..Whether pharmacological treatments prior to reperfusion attenuate post-ischemic HT requires further study...
  23. pmc Distribution of National Institutes of Health stroke scale in the Cincinnati/Northern Kentucky Stroke Study
    Mathew Reeves
    From the Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI M R Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital, OH J K and Neuroscience Institute K A, C M, M F, D W, P K, S F, B K, D K, Department of Neurology K A, C M, M F, D W, P K, S F, B K, D K, and Department of Emergency Medicine O A, University of Cincinnati, OH
    Stroke 44:3211-3. 2013
    ..We describe the distribution of NIHSS in ischemic stroke cases from the Cincinnati/Northern Kentucky Stroke Study...
  24. pmc Profiles of the National Institutes of Health Stroke Scale items as a predictor of patient outcome
    Heidi Sucharew
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Stroke 44:2182-7. 2013
    ..We examined whether grouping strokes by presence of individual NIHSS symptoms could provide prognostic information additional or alternative to the NIHSS total score...
  25. pmc How often are patients with ischemic stroke eligible for decompressive hemicraniectomy?
    Ralph Rahme
    Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45267, USA
    Stroke 43:550-2. 2012
    ....
  26. pmc Comparison of two depression measures for predicting stroke outcomes
    Lawson Wulsin
    University of Cincinnati, Department of Psychiatry, Cincinnati, OH 45267 0559, United States
    J Psychosom Res 72:175-9. 2012
    ..This study compared a measure of current symptoms of depression at the time of the stroke and a measure of lifetime history of depression for their ability to predict quality of life and functioning at 3 and 12 months after stroke...
  27. pmc Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial
    Kit N Simpson
    From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH J P B, D K, P K, J A S Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada M D H and Department of Healthcare Leadership and Management K N S, A N S, Department of General Internal Medicine P D M, Department of Public Health Sciences S D Y, L D F, R M, Y Y P, Department of Emergency Medicine E C J, Medical University of South Carolina, Charleston
    Stroke 45:1791-8. 2014
    ..This report describes the factors affecting the costs of the initial hospitalization for acute stroke subjects from the United States...
  28. pmc Potential eligibility for recombinant tissue plasminogen activator therapy in children: a population-based study
    Laura L Lehman
    Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Child Neurol 26:1121-5. 2011
    ..Thus, recruitment for clinical studies is likely to be challenging and requires a concerted multicenter effort...
  29. pmc Equipoise among recanalization strategies
    T A Tomsick
    Department of Neurology, UC Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH 45267 0525, USA
    Neurology 74:1069-76. 2010
    ..Where equipoise exists, randomizing subjects to either IV rt-PA therapy or IV therapy followed by IA intervention, while incorporating new interventions into the study design, is a rational and appropriate research approach...
  30. pmc Withdrawal of antithrombotic agents and its impact on ischemic stroke occurrence
    Joseph P Broderick
    University of Cincinnati, Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center MSB 0525, Cincinnati, OH 45242, USA
    Stroke 42:2509-14. 2011
    ..These medications are also stopped by patients for various reasons such as cost, side effects, or unwillingness to take medication...
  31. pmc The impact of Magnetic Resonance Imaging (MRI) on ischemic stroke detection and incidence: minimal impact within a population-based study
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, Cincinnati, OH, 45267 0525, USA
    BMC Neurol 15:175. 2015
    ..We sought to investigate the impact of MRI on stroke detection and stroke incidence, by describing agreement between a strictly clinical definition of stroke and a definition based on physician opinion, including MRI imaging findings...
  32. pmc Twelve-Month Clinical and Quality-of-Life Outcomes in the Interventional Management of Stroke III Trial
    Yuko Y Palesch
    From the Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati J P B, P K, J S, J C, T A T Department of Public Health Sciences Y Y P, S D Y, L D F, A s, K N S and Division of Emergency Medicine E C J, Medical University of South Carolina, Charleston Calgary Stroke Program, Seaman Family MR Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada A M D, M D H, M G, K J R Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh T G J Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia B Y Department of Neuroradiology, Dresden University Stroke Center, University Hospital, Dresden, Germany R v K Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d Hebron, Anorganische Chemie
    Stroke 46:1321-7. 2015
    ..Randomized trials have indicated a benefit for endovascular therapy in appropriately selected stroke patients at 3 months, but data regarding outcomes at 12 months are currently lacking...
  33. pmc The practice of carotid revascularization in a large metropolitan population
    Matthew L Flaherty
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267 0525, USA
    J Stroke Cerebrovasc Dis 22:143-8. 2013
    ..Point estimates for perioperative risk after CEA were improved from previous studies but remained above the recommended benchmarks. The number of CAS procedures was low, but the perioperative risk was significant...
  34. ncbi request reprint Hyperlipidemia is associated with lower risk of poststroke mortality independent of statin use: A population-based study
    Samrat Yeramaneni
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA Center for Clinical Effectiveness, Baylor Scott and White Health, Dallas, Texas, USA
    Int J Stroke . 2016
    ..Although statin therapy is associated with reduced stroke and mortality risk, some studies report that higher lipid levels are associated with improved outcomes following ischemic stroke...
  35. pmc Evolution of practice during the Interventional Management of Stroke III Trial and implications for ongoing trials
    Joseph P Broderick
    From the Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati J P B, P K, J S, J C, T A T Department of Public Health Sciences Y Y P, S D Y, L D F and the Division of Emergency Medicine E C J, Medical University of South Carolina, Charleston Calgary Stroke Program, Seaman Family MR Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada A M D, M D H, M G Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh T G J Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia B Y Department of Neuroradiology, Dresden University Stroke Center, University Hospital, Dresden, Germany R v K Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d Hebron, Barcelona C A M Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht, The Netherlands, and the St Antonius Hospital
    Stroke 45:3606-11. 2014
    ..We explored changes in the patient population and practice of endovascular therapy during the course of the Interventional Management of Stroke (IMS) III Trial...
  36. doi request reprint Microcatheter contrast injections during intra-arterial thrombolysis increase intracranial hemorrhage risk
    Rakesh Khatri
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Neurointerv Surg 2:115-9. 2010
    ..The reliability of these observations was tested in our local registry of IA cases...
  37. pmc How much would performing diffusion-weighted imaging for all transient ischemic attacks increase MRI utilization?
    Opeolu Adeoye
    Departments of Emergency Medicine and Neurosurgery, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
    Stroke 41:2218-22. 2010
    ..We determined how frequently MRI/DWI was performed for TIA and ascertained the proportion of clinically defined TIA patients who had ischemic lesions on DWI in our community in 2005...
  38. pmc Age, subjective stress, and depression after ischemic stroke
    Michael J McCarthy
    College of Allied Health Sciences, School of Social Work, University of Cincinnati, PO Box 210108, Cincinnati, OH, 45221, USA
    J Behav Med 39:55-64. 2016
    ..Those with financial, family, and health-related stress at the time of stroke, irrespective of age, also had significantly higher scores. ..
  39. doi request reprint Endovascular revascularization results in IMS III: intracranial ICA and M1 occlusions
    Thomas A Tomsick
    Department of Radiology, University of Cincinnati Academic Health Center, University Hospital 234 Goodman St, Cincinnati, Ohio, USA
    J Neurointerv Surg 7:795-802. 2015
    ..Interventional Management of Stroke III did not show that combining IV recombinant tissue plasminogen activator (rt-PA) with endovascular therapies (EVTs) is better than IV rt-PA alone...
  40. pmc The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study
    Patrick J Gillard
    Department of Global Health Outcomes Strategy and Research, Allergan, Inc, 2525 Dupont Drive, Irvine, California, 92612 1531, USA
    Health Qual Life Outcomes 13:159. 2015
    ..Spasticity often leads to symptomatic and functional problems that can cause disability for stroke survivors. We studied whether spasticity has a negative impact on health-related quality of life (HRQoL)...
  41. pmc Antihypertensives are administered selectively in emergency department patients with subarachnoid hemorrhage
    Virginia Culyer
    Department of Emergency Medicine, University of Cincinnati Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio Electronic address
    J Stroke Cerebrovasc Dis 22:1225-8. 2013
    ..In the absence of definitive evidence, current blood pressure management in local EDs appears reasonable. Further studies of blood pressure management in acute SAH are warranted...
  42. doi request reprint Parenchymal hematoma and total lesion volume in combined IV/IA revascularization stroke therapy
    Haiyang Tao
    Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Neurointerv Surg 4:256-60. 2012
    ....
  43. pmc Impact of acute ischemic stroke treatment in patients >80 years of age: the specialized program of translational research in acute stroke (SPOTRIAS) consortium experience
    Joshua Z Willey
    Department of Neurology, 710 West 168 Street, Box 30, New York, NY 10032, USA
    Stroke 43:2369-75. 2012
    ....
  44. pmc Ischemic stroke survivors' opinion regarding research utilizing exception from informed consent
    Dawn Kleindorfer
    University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Cerebrovasc Dis 32:321-6. 2011
    ..We obtained ischemic stroke survivors' opinions regarding hypothetical enrollment into a clinical trial at the time of their stroke without personal or proxy consent...
  45. pmc Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years
    Opeolu Adeoye
    UC Neuroscience Institute, Department of Emergency Medicine, 231 Albert Sabin Way, ML 0769, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
    Stroke 42:1952-5. 2011
    ..In 2004, 1.8% to 2.1% of AIS patients in the United States received rtPA. Given incentives from regulatory agencies and payors to increase rtPA use, we hypothesized that rtPA use in the United States would increase from 2005 to 2009...
  46. pmc Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke: propensity score-matched post hoc analysis
    Opeolu Adeoye
    From the University of Cincinnati Neuroscience Institute, OH O A, P K, P A S, A M P, J P B Departments of Emergency Medicine O A, P A S, A M P, Neurosurgery O A, Radiology T T, and Neurology P K, J P B, University of Cincinnati, OH Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, OH H S, J K and Division of Biostatistics, Medical University of South Carolina, Charleston, SC Y P
    Stroke 46:461-4. 2015
    ..Our aim was to compare outcomes in CLEAR-ER combination arm patients to propensity score-matched r-tPA only subjects in Albumin in Acute Stroke Part 2 and Interventional Management of Stroke III...
  47. doi request reprint External carotid artery embolus with internal carotid artery occlusion with acute ischemic stroke: predictor of cardioembolic etiology
    Thomas Tomsick
    Department of Radiology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neurointerv Surg 4:101-4. 2012
    ..It is hypothesized that finding embolus within the external carotid artery on angiography in stroke patients with internal carotid artery occlusion allows confident ascription to a proximal, usually cardiac, source...
  48. pmc Malignant MCA territory infarction in the pediatric population: subgroup analysis of the Greater Cincinnati/Northern Kentucky Stroke Study
    Ralph Rahme
    Department of Neurosurgery, University of Cincinnati, Cincinnati, OH, USA
    Childs Nerv Syst 29:99-103. 2013
    ..However, population-based rates have not been published. We performed subgroup analysis of a population-based study to determine the rate of malignant MCA infarctions in children...
  49. pmc Is intra-arterial thrombolysis beneficial for M2 occlusions? Subgroup analysis of the PROACT-II trial
    Ralph Rahme
    Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45219, USA
    Stroke 44:240-2. 2013
    ..The role of endovascular therapy for acute M2 trunk occlusions is debatable. Through a subgroup analysis of Prolyse in Acute Cerebral Thromboembolism-II, we compared outcomes of M2 occlusions in treatment and control arms...
  50. pmc Emergency department adherence to American Heart Association guidelines for blood pressure management in acute ischemic stroke
    Erin McDonough Grise
    Departments of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267 0769, USA
    Stroke 43:557-9. 2012
    ..We hypothesized that patients with AIS often receive antihypertensives in the emergency department below the recommended threshold and that BP reduction is often >20%...
  51. doi request reprint US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati, Ohio 45267 0525, USA
    Stroke 40:3580-4. 2009
    ..We describe the US geographic distribution of hospitals using rt-PA for acute ischemic stroke...
  52. doi request reprint The rate of hemicraniectomy for acute ischemic stroke is increasing in the United States
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0525, USA
    J Stroke Cerebrovasc Dis 20:251-4. 2011
    ..Publication of the landmark study did not appear to significantly change this rate. Future studies should investigate the appropriateness of patient selection and missed opportunities for treatment...
  53. doi request reprint Do current animal models of intracerebral hemorrhage mirror the human pathology?
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Transl Stroke Res 2:17-25. 2011
    ..We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena. ..
  54. pmc Drug treatment of acute ischemic stroke
    Sameer Bansal
    Department of Neurology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Am J Cardiovasc Drugs 13:57-69. 2013
    ..Ongoing clinical trials may lead to further medical breakthroughs to limit the damage inflicted by this devastating disease...
  55. pmc Reperfusion activates metalloproteinases that contribute to neurovascular injury
    Aigang Lu
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532
    Exp Neurol 210:549-59. 2008
    ..Administering AHA 30 min before reperfusion decreased MMP-9 activation and neurovascular injury in ischemic cerebral cortex...
  56. doi request reprint Trends in surgical management and mortality of intracerebral hemorrhage in the United States before and after the STICH trial
    Opeolu Adeoye
    Department of Emergency Medicine, UC Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
    Neurocrit Care 13:82-6. 2010
    ..Using a national hospital database, we determined trends in surgery for ICH before and after publication of STICH. We also determined trends in ICH mortality during the study period...
  57. pmc Impact of General Anesthesia on Safety and Outcomes in the Endovascular Arm of Interventional Management of Stroke (IMS) III Trial
    Alex Abou-Chebl
    From Baptist Neuroscience Associates, Baptist Health, Louisville, KY A A C Department of Public Health Sciences, Medical University of South Carolina, Charleston S D Y Department of Neurology, Royal Melbourne Hospital, Parkville, Australia B Y Departments of Neurosurgery, Radiology, and Public Health Sciences, Penn State Hershey, PA K C Departments of Radiology and Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada M G Department of Neurology, University of Pittsburgh Medical Center, PA T J Department of Neurology P K, J S, J B and Department of Radiology T T, University of Cincinnati, OH Departments of Radiology and Neurological Surgery, Columbia University, New York, NY P M Department of Neurology, University of Mississippi, Jackson R S Department of Neurology, Martin Luther University Halle Wittenberg, Halle, Germany K E W and Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada M D H
    Stroke 46:2142-8. 2015
    ..General anesthesia (GA) for endovascular therapy (EVT) of acute ischemic stroke may be associated with worse outcomes...
  58. pmc Evaluation of interval times from onset to reperfusion in patients undergoing endovascular therapy in the Interventional Management of Stroke III trial
    Mayank Goyal
    Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada M G, M A A, B K M, A M D, M D H, M E Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia M A A Department of Public Health Sciences, Medical University of South Carolina, Charleston L F, S D Y Departments of Neurology and Radiology, University of Cincinnati, Cincinnati, OH T T, P K, J P B Department of Radiology, Medical College of Wisconsin, Milwaukee O O Z Division of Emergency Medicine, Medical University of South Carolina, Charleston E C J and Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA T G J
    Circulation 130:265-72. 2014
    ..Meaningful delays occurred in the Interventional Management of Stroke (IMS) III trial. Analysis of the work flow will identify factors contributing to the in-hospital delays...
  59. pmc Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials
    Jeffrey L Saver
    Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Stroke 40:2594-600. 2009
    ..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials...
  60. pmc Seizures are common in the acute setting of childhood stroke: a population-based study
    Madeline A Chadehumbe
    Division of Child Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Child Neurol 24:9-12. 2009
    ..As compared with adults, seizures within the acute setting of childhood stroke are common with an occurrence rate in our population of 58%...
  61. pmc Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke: Pooled Analysis of Interventional Management of Stroke III and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands
    Joseph P Broderick
    From the Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH J P B, P K, J S, J C, T A T Division of Emergency Medicine E C J, Department of Public Health Sciences Y Y P, L D F, and Department of Healthcare Management and Leadership K N S, Medical University of South Carolina, Charleston Calgary Stroke Program, Seaman Family MR Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada A M D, M D H, M G, K J R the Stroke Institute, University of Pittsburgh Medical Center, PA T G J Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia B Y Department of Neuroradiology, Dresden University Stroke Center, University Hospital, Dresden, Germany R v K Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d Hebron, Barcelona, Spain C A M Department of Neurology
    Stroke 46:3416-22. 2015
    ..We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, ≥20) after a prespecified analysis plan...
  62. pmc Final infarct volume discriminates outcome in mild strokes
    Achala S Vagal
    Department of Radiology, University of Cincinnati UC College of Medicine and Comprehensive Stroke Center at UC Neuroscience Institute, Cincinnati, OH, USA
    Neuroradiol J 28:404-8. 2015
    ..Knowledge of whether final infarct volume (FIV) predicts disability after mild stroke is limited. We sought to determine if FIV could differentiate good versus poor outcome after mild stroke...
  63. pmc Design of the economic evaluation for the Interventional Management of Stroke (III) trial
    Patrick D Mauldin
    Department of Pharmacy and Clinical Sciences, Medical University of South Carolina, Ralph H Johnson VA Medical Center, Charleston, SC 29425, USA
    Int J Stroke 3:138-44. 2008
    ..To assist in informing discussions on early adoption of potential treatments, economic analyses should accompany investigations that seek to improve outcomes for stroke patients...
  64. doi request reprint Time to angiographic reperfusion in acute ischemic stroke: decision analysis
    Achala S Vagal
    From the Department of Radiology A S V, T A T, Department of Neurology P K, J P B, and Department of Internal Medicine M H E, University of Cincinnati Medical Center, OH and Department of Public Health Sciences, Medical University of South Carolina, Charleston S D Y
    Stroke 45:3625-30. 2014
    ....
  65. ncbi request reprint Ischemic strokes after cardiac catheterization: opportune thrombolysis candidates?
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    Arch Neurol 63:817-21. 2006
    ..Whether thrombolysis is safe and efficacious remains to be determined, but the existing evidence seems favorable for individual circumstances...
  66. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...
  67. ncbi request reprint Association of apolipoprotein E4 and haplotypes of the apolipoprotein E gene with lobar intracerebral hemorrhage
    Daniel Woo
    University of Cincinnati, Cincinnati, OH, USA
    Stroke 36:1874-9. 2005
    ..We genotyped 12 single-nucleotide polymorphisms in the 5' upstream regulatory, exonic, and intronic regions of the apo E gene and performed genotype and haplotype association analyses...
  68. ncbi request reprint Mortality of stroke patients treated with thrombolysis: analysis of nationwide inpatient sample
    Matthew L Flaherty
    Neurology 68:710-1; author reply 711. 2007
  69. ncbi request reprint Risk of thrombolysis-associated intracerebral hemorrhage: the need to compare apples with apples
    Pooja Khatri
    Stroke 36:1109-10; author reply 1110. 2005
  70. ncbi request reprint Reasons for exclusion from thrombolytic therapy following acute ischemic stroke
    Dawn O Kleindorfer
    Neurology 65:1844; author reply 1844. 2005
  71. doi request reprint Advantages of a combined approach to recanalization therapy
    Christopher Nichols
    Stroke 39:e71; author reply e72. 2008
  72. ncbi request reprint Measuring treatment effect in acute stroke trials
    Pooja Khatri
    Stroke 37:2204. 2006