Abdelnaby Khalyfa

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction
    Siriporn Chatsuriyawong
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 900 E, 57th Street, KCBD, 4112, Chicago 60637, IL, USA
    J Transl Med 11:227. 2013
  2. pmc Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Transl Med 12:162. 2014
  3. pmc Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea
    Siriporn Chatsuriyawong
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 900 E, 57th Street, KCBD, 4112, Chicago, IL 60637, USA
    BMC Med Genomics 6:29. 2013
  4. pmc Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Bharat Bhushan
    Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL 60637, USA
    Sleep Med 12:666-71. 2011
  5. pmc Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Sleep 34:153-60. 2011
  6. pmc Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Pediatr Pulmonol 47:1001-11. 2012
  7. pmc Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 181:1114-20. 2010
  8. pmc DNA methylation in inflammatory genes among children with obstructive sleep apnea
    JinKwan Kim
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Illinois 60637, USA
    Am J Respir Crit Care Med 185:330-8. 2012
  9. pmc Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Lipids Health Dis 9:18. 2010
  10. doi request reprint Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea
    Abdelnaby Khalyfa
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:75-86. 2009

Collaborators

Detail Information

Publications27

  1. pmc Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction
    Siriporn Chatsuriyawong
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 900 E, 57th Street, KCBD, 4112, Chicago 60637, IL, USA
    J Transl Med 11:227. 2013
    ..We hypothesized that genetic variants in NO synthase and EDN isoforms and its receptors (EDNRA and EDNRB) may account for a proportion of the risk for ED in developing children...
  2. pmc Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Transl Med 12:162. 2014
    ....
  3. pmc Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea
    Siriporn Chatsuriyawong
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 900 E, 57th Street, KCBD, 4112, Chicago, IL 60637, USA
    BMC Med Genomics 6:29. 2013
    ..We aimed to identify single nucleotide polymorphisms (SNPs) in the NOS family (3 isoforms), and EDN family (3 isoforms) to identify potential associations of these SNPs in children with OSA...
  4. pmc Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Bharat Bhushan
    Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL 60637, USA
    Sleep Med 12:666-71. 2011
    ..Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA...
  5. pmc Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Sleep 34:153-60. 2011
    ..Since increasing evidence suggest that PS may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in PS children...
  6. pmc Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Pediatr Pulmonol 47:1001-11. 2012
    ..In adults with OSA, serum levels of macrophage migration inhibitory factor (MIF) are elevated. Therefore, we assessed plasma MIF levels and MIF allelic variant frequencies in children with and without OSA (NOSA)...
  7. pmc Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 181:1114-20. 2010
    ..Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is associated with potential morbidity and mortality...
  8. pmc DNA methylation in inflammatory genes among children with obstructive sleep apnea
    JinKwan Kim
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Illinois 60637, USA
    Am J Respir Crit Care Med 185:330-8. 2012
    ..Because not all children with OSA exhibit increased systemic inflammation, genetic and environmental factors may be affecting patterns of DNA methylation in genes subserving inflammatory functions...
  9. pmc Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Lipids Health Dis 9:18. 2010
    ..The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity...
  10. doi request reprint Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea
    Abdelnaby Khalyfa
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:75-86. 2009
    ..If left untreated, OSA may lead to significant cardiovascular and neurocognitive and behavioral morbidities. We hypothesized that pediatric OSA would lead to altered gene expression in circulating leukocytes...
  11. pmc Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathing
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Sleep 33:319-25. 2010
    ..Since, at any given level of apnea-hypopnea index, there is significant variability in EDS, we hypothesized that morning tumor necrosis factor (TNF)-alpha plasma levels may provide a biologic correlate of EDS...
  12. pmc Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea
    JinKwan Kim
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 S Maryland Ave, Chicago, IL 60637, USA
    Chest 138:91-9. 2010
    ..Leukocyte telomere length (LTL) reflects not only chronologic age but also the burden of disease. We hypothesized that LTL would be decreased in children with OSA...
  13. pmc Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene
    Leila Kheirandish-Gozal
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL 60637, USA
    Chest 143:971-7. 2013
    ....
  14. pmc Lipopolysaccharide-binding protein plasma levels in children: effects of obstructive sleep apnea and obesity
    Leila Kheirandish-Gozal
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, Illinois 60637
    J Clin Endocrinol Metab 99:656-63. 2014
    ..LPS-binding protein (LBP) serves as a surrogate marker of underlying low-grade endotoxemia by LPS from the gut. We hypothesized that systemic LBP levels would be higher in obese children and in those with OSA...
  15. doi request reprint Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: effect of tumor microenvironment
    Isaac Almendros
    Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL 60637, USA
    Cancer Lett 361:233-9. 2015
    ..IH-induced phenotypic alterations in AT macrophages surrounding the tumor and their increased infiltration within the tumor may contribute to the accelerated tumor progression associated with IH. ..
  16. pmc Cognitive function in prepubertal children with obstructive sleep apnea: a modifying role for NADPH oxidase p22 subunit gene polymorphisms?
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois, USA
    Antioxid Redox Signal 16:171-7. 2012
    ..Thus, polymorphisms within the NOX gene or its functional subunits may account for important components of the variance in cognitive function deficits associated with OSA in children...
  17. pmc Insulin sensitivity, serum lipids, and systemic inflammatory markers in school-aged obese and nonobese children
    JinKwan Kim
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Suite K 160, 5721, Maryland Avenue, MC 8000, Chicago, IL 60637, USA
    Int J Pediatr 2010:846098. 2010
    ....
  18. doi request reprint Circulating microRNAs as Potential Biomarkers of Endothelial Dysfunction in Obese Children
    Abdelnaby Khalyfa
    Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL
    Chest 149:786-800. 2016
    ....
  19. pmc Sex dimorphism in late gestational sleep fragmentation and metabolic dysfunction in offspring mice
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Biological Sciences Division, The University of Chicago, Chicago, IL
    Sleep 38:545-57. 2015
    ..Adult-onset metabolic disorders may begin during early development and exhibit substantial sex dimorphism. We hypothesized that metabolic dysfunction induced by gestational SF in male mice would not be apparent in female littermates...
  20. pmc Sleep fragmentation during late gestation induces metabolic perturbations and epigenetic changes in adiponectin gene expression in male adult offspring mice
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Biological Sciences Division, The University of Chicago, Chicago, IL
    Diabetes 63:3230-41. 2014
    ..Thus, altered gestational environments elicited by SF impose the emergence of adverse, long-lasting metabolic consequences in the next generation. ..
  21. pmc Early-life physical activity reverses metabolic and Foxo1 epigenetic misregulation induced by gestational sleep disturbance
    Vesco Mutskov
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, Illinois and
    Am J Physiol Regul Integr Comp Physiol 308:R419-30. 2015
    ..Thus, we have identified a restricted postnatal period during which lifestyle interventions may reverse the Foxo1 epigenetically mediated risk for metabolic dysfunction later in the life, as induced by gestational sleep disorders...
  22. pmc Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children
    David Gozal
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL
    Sleep 37:935-41. 2014
    ..We hypothesized that GPR 120 levels would be reduced in children with OSA, particularly among obese children...
  23. doi request reprint Nitric oxide production by monocytes in children with OSA and endothelial dysfunction
    Leila Kheirandish-Gozal
    Section of Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, IL 60637, U S A
    Clin Sci (Lond) 127:323-30. 2014
    ..Thus OSA in children is associated with increased numbers of pro-inflammatory monocytes and reduced NO production in circulating monocytes that are closely associated with endothelial function...
  24. pmc TNF-α gene polymorphisms and excessive daytime sleepiness in pediatric obstructive sleep apnea
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    J Pediatr 158:77-82. 2011
    ..To assess sleepiness, TNF-α plasma levels, and genomic variance in the TNF-α gene in children with obstructive sleep apnea (OSA)...
  25. pmc Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling
    Fahed Hakim
    Authors Affiliations Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, Illinois and Department of Microbiology and Immunology, The University of Louisville, Louisville, Kentucky
    Cancer Res 74:1329-37. 2014
    ..Our findings offer mechanistic insights into how sleep perturbations can accelerate tumor growth and invasiveness through TAM recruitment and TLR4 signaling pathways...
  26. doi request reprint Catecholamine alterations in pediatric obstructive sleep apnea: effect of obesity
    Ayelet B Snow
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Pediatr Pulmonol 44:559-67. 2009
    ..Moreover, urinary catecholamine excretion is altered in obese patients. We hypothesized that morning urine catecholamine levels would be correlated with the severity of obstructive sleep apnea and degree of obesity in children...
  27. pmc Sleep fragmentation in mice induces nicotinamide adenine dinucleotide phosphate oxidase 2-dependent mobilization, proliferation, and differentiation of adipocyte progenitors in visceral white adipose tissue
    Abdelnaby Khalyfa
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL
    Sleep 37:999-1009. 2014
    ....