John A Kellum

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Controversies in acute kidney injury: the 2011 Brussels Roundtable
    John A Kellum
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:155. 2011
  2. ncbi request reprint Recovery After Acute Kidney Injury
    John A Kellum
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    Am J Respir Crit Care Med . 2016
  3. pmc Diagnostic Criteria for Acute Kidney Injury: Present and Future
    John A Kellum
    Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA Electronic address
    Crit Care Clin 31:621-32. 2015
  4. pmc Classifying AKI by Urine Output versus Serum Creatinine Level
    John A Kellum
    Center for Critical Care Nephrology and Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    J Am Soc Nephrol 26:2231-8. 2015
  5. pmc Understanding genetics of sepsis: will new technology help?
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:141. 2009
  6. ncbi request reprint Acid-base disorders and strong ion gap
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15216, USA
    Contrib Nephrol 156:158-66. 2007
  7. ncbi request reprint Disorders of acid-base balance
    John A Kellum
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2630-6. 2007
  8. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
  9. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
  10. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. pmc Controversies in acute kidney injury: the 2011 Brussels Roundtable
    John A Kellum
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:155. 2011
    ..Progress in this area will require new ideas and thinking outside the conventional box. By confronting some of the most significant controversies in the field of AKI we seek to develop new concepts that will ultimately yield new results...
  2. ncbi request reprint Recovery After Acute Kidney Injury
    John A Kellum
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    Am J Respir Crit Care Med . 2016
    ..Little is known about how acute kidney injury (AKI) resolves and whether patterns of reversal of renal dysfunction differ among patients with respect to ultimate recovery...
  3. pmc Diagnostic Criteria for Acute Kidney Injury: Present and Future
    John A Kellum
    Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA Electronic address
    Crit Care Clin 31:621-32. 2015
    ..Short- and long-term outcomes are worse when patients have some stage of AKI by both criteria. New biomarkers for AKI may substantially aid in the risk assessment and evaluation of patients at risk for AKI. ..
  4. pmc Classifying AKI by Urine Output versus Serum Creatinine Level
    John A Kellum
    Center for Critical Care Nephrology and Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    J Am Soc Nephrol 26:2231-8. 2015
    ..We conclude that short- and long-term risk of death or RRT is greatest when patients meet both the serum creatinine level and urine output criteria for AKI and when these abnormalities persist. ..
  5. pmc Understanding genetics of sepsis: will new technology help?
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:141. 2009
    ..Careful attention should be paid to different aspects of study design and analyses as large, multicenter cohorts are assembled for genome-wide association studies...
  6. ncbi request reprint Acid-base disorders and strong ion gap
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15216, USA
    Contrib Nephrol 156:158-66. 2007
    ..Attempts to identify the exact chemical nature of ions identified by the strong ion gap have only been of limited success and further study is needed...
  7. ncbi request reprint Disorders of acid-base balance
    John A Kellum
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2630-6. 2007
    ..Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology...
  8. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
    ..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals...
  9. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  10. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
    ..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice...
  11. doi request reprint Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
    ..We test the hypothesis that increased inflammatory response is associated with fewer organs transplanted and decreased recipient survival...
  12. pmc Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis
    Zhi Yong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:538-43. 2012
    ..To explore the relationships among bactericidal antimicrobial treatment of sepsis, inflammatory response, severity of acute kidney injury, and outcomes...
  13. pmc Preload responsiveness is associated with increased interleukin-6 and lower organ yield from brain-dead donors
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care Med 37:2387-93. 2009
    ..Using functional hemodynamic monitoring in brain-dead organ donors, we test the hypothesis that donor preload (fluid) responsiveness is associated with increased inflammatory response and lower organ yield for transplantation...
  14. pmc Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis*
    Feihu Zhou
    1The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 2Department of Critical Care Medicine, Chinese People s Liberation Army General Hospital, Beijing, China 3The Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 4Department of Cardiac Surgery, National University of Heart Center, Singapore 5Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA
    Crit Care Med 42:e270-8. 2014
    ..To compare the acute effects of 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis...
  15. pmc Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:363-9. 2012
    ..These results may have important implications for the design and conduct of future trials in sepsis including defining alternative targets for extracorporeal blood purification and other therapies...
  16. doi request reprint Blood purification in sepsis: a new paradigm
    Zhiyong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:322-8. 2010
    ..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis...
  17. pmc Understanding the potential role of statins in pneumonia and sepsis
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 39:1871-8. 2011
    ..To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis...
  18. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
    ..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response...
  19. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  20. pmc The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    Sachin Kale
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13852. 2010
    ..To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly...
  21. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
    ..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear...
  22. ncbi request reprint Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 286:R686-92. 2004
    ..7 cells. HCl is essentially proinflammatory as assessed by NO release, IL-6-to-IL-10 ratios, and NF-kappa B DNA binding. By contrast, lactic acidosis is anti-inflammatory...
  23. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  24. pmc Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia
    David T Huang
    Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 136:823-31. 2009
    ..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection...
  25. pmc Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  26. pmc Prevalence and significance of coagulation abnormalities in community-acquired pneumonia
    Eric B Milbrandt
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Med 15:438-45. 2009
    ..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials...
  27. pmc Development of venovenous extracorporeal blood purification circuits in rodents for sepsis
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Electronic address
    J Surg Res 185:790-6. 2013
    ..We developed a venovenous (VV) purification model in the rat as an adjunct for the treatment of sepsis...
  28. pmc Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia
    Raghavan Murugan
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:895-905. 2012
    ..This study examined whether statin use was associated with a lower risk for pneumonia-induced AKI and 1-year and cause-specific mortality in patients with AKI...
  29. doi request reprint Recovery from acute kidney injury: determinants and predictors
    Nattachai Srisawat
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:284-91. 2010
    ..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery...
  30. pmc The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia
    Michael C Reade
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 10:15. 2010
    ..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals...
  31. pmc Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 80:545-52. 2011
    ..Thus, in this cohort of patients with pneumonia-induced severe acute kidney injury, plasma NGAL appears to be a useful biomarker for predicting renal recovery...
  32. ncbi request reprint Hyperchloremic acidosis increases circulating inflammatory molecules in experimental sepsis
    John A Kellum
    University of Pittsburgh, School of Medicine, Department of Critical Care Medicine, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 130:962-7. 2006
    ..7 cells. However, evidence that hyperchloremic acidosis leads to increased inflammation in vivo has been limited to nitric oxide...
  33. ncbi request reprint Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats
    Jose L Gómez
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Chest 131:1295-300. 2007
    ..To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals...
  34. ncbi request reprint Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia
    John A Kellum
    Mechanisms and Novel Therapies for Resuscitation and Acute Illness MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:801-5. 2004
    ..Because adsorptive capacity of hollow-fiber dialyzers is limited, we sought to determine whether hemoadsorption using high surface area beads would result in greater mediator removal and improved survival in experimental sepsis...
  35. pmc Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies
    Rami A Namas
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States of America
    Mol Med 18:1366-74. 2012
    ..Hemoadsorption (HA) is an emerging approach to modulate sepsis-induced inflammation. We sought to define the effects of HA on inflammatory compartmentalization in Escherichia coli-induced fibrin peritonitis in rats...
  36. doi request reprint Is there a difference between strong ion gap in healthy volunteers and intensive care unit patients?
    Kyle J Gunnerson
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Crit Care 25:520-4. 2010
    ..Thus, we conducted this pilot study to examine differences in quantitative acid-base variables between healthy adult volunteers and stable ICU patients with no suspected acid-base abnormalities...
  37. doi request reprint A comparison of three methods to estimate baseline creatinine for RIFLE classification
    Jakub Zavada
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, USA
    Nephrol Dial Transplant 25:3911-8. 2010
    ..Estimation of baseline creatinine by solving the Modification of Diet in Renal Disease (MDRD) equation assuming a glomerular filtration rate of 75 ml/min/1.73 m(2) has been widely used but never validated...
  38. ncbi request reprint Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis
    John A Kellum
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Chest 125:243-8. 2004
    ..To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat...
  39. ncbi request reprint The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells
    Meaghan E Killeen
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 615 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 316:1070-9. 2006
    ..7 cells. These data suggest that phase 2 inducers may exert anti-inflammatory effects by inhibiting secretion of the cytokine-like nuclear protein HMGB1...
  40. pmc Associations between Intensity of RRT, Inflammatory Mediators, and Outcomes
    Raghavan Murugan
    Center for Critical Care Nephrology and Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Clin J Am Soc Nephrol 10:926-33. 2015
    ..Whether intensive dosing of RRT is associated with changes in specific mediators is unknown...
  41. pmc Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan
    Francis Pike
    Department of Biostatistics, Pitt Public Health, University of Pittsburgh, Pittsburgh, PA, United States
    Crit Care Resusc 15:301-10. 2013
    ..The Protocolized Care for Early Septic Shock study is a randomised, multicentre, prospective, three-arm, parallel-group trial of alternative resuscitation strategies for early septic shock...
  42. pmc N-acetylcysteine is effective for prevention but not for treatment of folic acid-induced acute kidney injury in mice
    Hong zhi Wang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 39:2487-94. 2011
    ..There is controversy regarding the benefits of N-acetylcysteine in acute kidney injury. This study was to compare three commonly used regimens and explore which regimen is best for the protection of acute kidney injury...
  43. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  44. pmc Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22847. 2011
    ....
  45. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  46. pmc Biomarker Enhanced Risk Prediction for Adverse Outcomes in Critically Ill Patients Receiving RRT
    Francis Pike
    The Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennyslvania The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
    Clin J Am Soc Nephrol 10:1332-9. 2015
    ....
  47. doi request reprint Sex differences in deceased donor organ transplantation rates in the United States
    Raghavan Murugan
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Transplantation 92:1278-84. 2011
    ..Understanding sex differences in transplantation will help to design interventions to mitigate disparities in transplantation...
  48. ncbi request reprint Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:1061-7. 2007
    ....
  49. ncbi request reprint Blood purification in non-renal critical illness
    John A Kellum
    University of Pittsburgh School of Medicine, Department of Critical Care Medicine, PA 15213, USA
    Blood Purif 21:6-13. 2003
    ..However, extracorporeal therapies are being used or investigated in the management of many other disease processes including systemic inflammation, liver disease, cardiac disease and thrombotic diseases...
  50. pmc Science review: extracellular acidosis and the immune response: clinical and physiologic implications
    John A Kellum
    Critical Care Medicine and Medicine, The Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 8:331-6. 2004
    ..Finally, we discuss potential clinical implications...
  51. doi request reprint Intensive care unit renal support therapy volume is not associated with patient outcome
    Yên Lan Nguyen
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 39:2470-7. 2011
    ..Our objective was to determine whether there is a volume-outcome relationship among intensive care unit patients receiving renal support therapy in two different healthcare systems (France and the United States)...
  52. pmc Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy
    Raghavan Murugan
    The Center for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nephrol Dial Transplant 29:1854-64. 2014
    ..Survivors of critical illness complicated by acute kidney injury requiring renal replacement therapy (RRT) are at an increased risk of dialysis dependence and death but the mechanisms are unknown...
  53. pmc Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) trial methodology
    Ali Al-Khafaji
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Resusc 15:234-40. 2013
    ..We describe the study design and discuss unique aspects of doing research in this population...
  54. doi request reprint The anti-oxidant effects are not the main mechanism for glutamine's protective effects on acute kidney injury in mice
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Pharmacol 705:11-9. 2013
    ..Regulating neutrophil infiltration might be a potential therapeutic target for AKI...
  55. doi request reprint AKI in the ICU: definition, epidemiology, risk stratification, and outcomes
    Kai Singbartl
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:819-25. 2012
    ..Experimental and small observational studies provide evidence that AKI impairs (innate) immunity and is associated with higher infection rates...
  56. pmc Duration and magnitude of hypotension and monocyte deactivation in patients with community-acquired pneumonia
    Peter M Simon
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Shock 36:553-9. 2011
    ..These results suggest that persistent hypotension might contribute to immunosuppression following septic shock...
  57. ncbi request reprint Comparison of inflammatory response during on-pump and off-pump coronary artery bypass surgery
    Thomas Rimmelé
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 1526, USA
    Int J Artif Organs 33:131-8. 2010
    ..However with the development of polymer-coated biocompatible extracorporeal circuits, we wanted to see if cardiopulmonary bypass still played an important role in triggering this inflammatory response...
  58. ncbi request reprint Consensus development in acute renal failure: The Acute Dialysis Quality Initiative
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 11:527-32. 2005
    ..The general lack of consensus with regard to definitions, prevention, and treatment of acute renal failure has limited progress in this field...
  59. pmc What blood temperature for an ex vivo extracorporeal circuit?
    Thomas Rimmelé
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Artif Organs 35:593-601. 2011
    ..Investigators in this field must be aware of the fact that blood temperature is a crucial confounding parameter and the type of "background noise" they will face depending on the strategy adopted...
  60. ncbi request reprint Cytokine removal with a novel adsorbent polymer
    Mingchen Song
    The MANTRA Laboratories, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:428-34. 2004
    ..We sought to characterize a novel adsorbent polymer in terms of cytokine removal...
  61. pmc TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients
    Kyle J Gunnerson
    From the Departments of Emergency Medicine, Anesthesiology, and Internal Medicine K J G, Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, Michigan Department of Anesthesia A D S, Vanderbilt University Medical Center, Nashville, Tennessee Department of Medicine L S C, Division of Intensive Care Medicine and Division of Nephrology, Veterans Affairs Medical Center, Washington, District of Columbia Department of Anesthesiology A B, University of Florida, Gainesville, Florida Center for Critical Care Nephrology A A K, J A K, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania Division of Pulmonary and Critical Care Medicine K K, Mayo Clinic, Rochester, Minnesota Department of Surgery M L, University of Maryland School of Maryland, Baltimore, Maryland and Statistical Consultant J S, M G W, Carlsbad, California
    J Trauma Acute Care Surg 80:243-9. 2016
    ....
  62. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  63. doi request reprint Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology
    Paul M Palevsky
    Renal Section, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Clin J Am Soc Nephrol 7:844-50. 2012
    ..Companion articles outline the discussions of workgroups for model trials related to prevention or treatment of established AKI in different clinical settings, such as in patients with sepsis...
  64. pmc Blood purification and mortality in sepsis: a meta-analysis of randomized trials
    Feihu Zhou
    Department of Critical Care Medicine, The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 41:2209-20. 2013
    ..We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans with sepsis...
  65. doi request reprint N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation
    Ibtesam A Hilmi
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 25:2328-33. 2010
    ..N-acetylcysteine (NAC) replenishes GSH stores. The aims of this study were to evaluate the efficacy of NAC in improving liver graft performance and reducing the incidence of post-operative acute kidney injury (AKI)...
  66. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  67. ncbi request reprint The concept of acute kidney injury and the RIFLE criteria
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Contrib Nephrol 156:10-6. 2007
    ..The term acute kidney injury has subsequently been proposed to distinguish this new concept from the older terminology of failure...
  68. ncbi request reprint Prevention of acute renal failure
    Ramesh Venkataraman
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 131:300-8. 2007
    ..Increasing insight into mechanisms leading to ARF and the importance of facilitating renal recovery has prompted investigators to evaluate the role of newer therapeutic agents in the prevention of ARF...
  69. doi request reprint Heat shock factor 1 inhibits nuclear factor-kappaB nuclear binding activity during endotoxin tolerance and heat shock
    Mingchen Song
    The Mechanisms and Novel Therapies for Resuscitation and Acute Illness Laboratories, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Crit Care 23:406-15. 2008
    ..We hypothesize that HS factor 1 (HSF-1) induces competitive inhibition of nuclear factor-kappaB (NF-kappaB)-induced signal transduction in both endotoxin tolerance and HS...
  70. ncbi request reprint Feasibility study of cytokine removal by hemoadsorption in brain-dead humans
    John A Kellum
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:268-72. 2008
    ..Inflammatory cytokines occur in the circulation and in the tissues after brain death and have been associated with dysfunction of donor organs before and after transplantation...
  71. doi request reprint In vitro catheter and sorbent-based method for clearance of radiocontrast material during cerebral interventions
    George O Angheloiu
    Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Cardiovasc Revasc Med 14:207-12. 2013
    ..Contrast-induced acute kidney injury is a severe condition resulting from the use of radiology contrast in patients with predisposing factors...
  72. doi request reprint Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials
    George O Angheloiu
    Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Blood Purif 34:34-9. 2012
    ..Sorbents have been shown to adsorb iodinated radiocontrast media...
  73. pmc One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice
    Xiaoyan Wen
    The Clinical Research, Investigation and Systems Modeling of Acute illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 27:3100-9. 2012
    ..It does, however, carry a significant risk of nephrotoxicity, especially with chronic use. By contrast, a single dose of CsA may be protective while limiting the risk of nephrotoxicity...
  74. doi request reprint Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte
    Andrew D Shaw
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27705, USA
    Ann Surg 255:821-9. 2012
    ..To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource use after abdominal surgery...
  75. doi request reprint Cardio-renal syndrome type 3: epidemiology, pathophysiology, and treatment
    Anan Chuasuwan
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Semin Nephrol 32:31-9. 2012
    ..Novel biomarkers and therapeutic interventions for primary and secondary disorders are being developed and tested. The hope is that improved outcomes will follow...
  76. pmc Ensemble models of neutrophil trafficking in severe sepsis
    Sang Ok Song
    CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Comput Biol 8:e1002422. 2012
    ....
  77. doi request reprint Acute kidney injury
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:S141-5. 2008
    ..The RIFLE criteria provide a uniform definition of acute kidney injury and have now been validated in numerous studies...
  78. ncbi request reprint Hemoadsorption to improve organ recovery from brain-dead organ donors: a novel therapy for a novel indication?
    Ramesh Venkataraman
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:143-9. 2004
    ..As a 'proof of concept' we tested the ability of a novel hemoadsorbent to remove S100B in vitro using two human glioblastoma cell lines. Our results indicate a >80% reduction in S100B after 2 h of circulation with the sorbent...
  79. doi request reprint Pathophysiology of acute kidney injury: a new perspective
    Xiaoyan Wen
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 165:39-45. 2010
    ..We review the pathophysiology of AKI in light of new information regarding renal injury and repair...
  80. doi request reprint Pathogenesis of acute kidney injury: effects of remote tissue damage on the kidney
    Xiaoyan Wen
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 174:129-37. 2011
    ..In this chapter, we will discuss the pathogenesis of AKI in light of new information concerning injury and repair, and focus on the controversies arising from emerging evidence...
  81. ncbi request reprint Adequacy of dialysis in acute renal failure
    Ramesh Venkataraman
    Department of Critical Care Medicine, CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Semin Nephrol 25:120-4. 2005
    ..The heterogeneity of patient population, variation in RRT practices, and differences in outcomes studied have made it difficult to define or study adequate dialysis in ARF or its impact on clinical outcomes...
  82. ncbi request reprint Interleukin-6
    Mingchen Song
    MANTRA Mechanisms and Novel Therapies for Resuscitation and Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:S463-5. 2005
  83. ncbi request reprint Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells
    Mingchen Song
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh Pennsylvania, USA
    J Pharmacol Exp Ther 308:307-16. 2004
    ..Moreover, the findings presented here suggest that an unusual combination of biochemical effects (inhibition of lipid peroxidation and GSH depletion) might account for the anti-inflammatory effects of EP...
  84. pmc Clinical review: extracorporeal blood purification in severe sepsis
    Ramesh Venkataraman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:139-45. 2003
    ..Here, we discuss the various modalities of extracorporeal blood purification, the existing evidence, and future prospects...
  85. pmc A simple mathematical model of cytokine capture using a hemoadsorption device
    Morgan V DiLeo
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA
    Ann Biomed Eng 37:222-9. 2009
    ..The model of the CAD and the values of Gamma( i ) will be applied in mathematical models of the inflammatory process and treatment of patients with sepsis...
  86. doi request reprint Use of loop diuretics in the critically ill
    Thomas Rimmelé
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:219-25. 2010
    ..We will briefly review the available evidence for and against the use of diuretics in the critically ill, including cardiorenal syndromes...
  87. doi request reprint Modern classification of acute kidney injury
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 29:300-7. 2010
    ..The RIFLE criteria have been extensively validated in more than 550,000 patients worldwide...
  88. pmc IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy
    Jeremy D Kimmel
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Biomed Mater Res B Appl Biomater 92:390-6. 2010
    ..Development of smaller beads may accelerate cytokine adsorption by maximizing available surface area per bead mass...
  89. doi request reprint Definition and classification of acute kidney injury
    John A Kellum
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Nephron Clin Pract 109:c182-7. 2008
    ..The RIFLE criteria provide a uniform definition of AKI and have now been validated in numerous studies...
  90. pmc Cost of acute renal replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Crit Care 14:R46. 2010
    ..The aim of this study was to estimate the cost difference between CRRT and IRRT in the intensive care unit (ICU)...
  91. pmc Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia
    Kai Singbartl
    Department of Critical Care Medicine, CRISMA Center, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Kidney Int 80:633-44. 2011
    ..Thus, during acute kidney and pneumonia-induced lung injury, clinically relevant kidney-lung interactions are both neutrophil and platelet dependent...
  92. pmc Isolation of Aspergillus in three 2009 H1N1 influenza patients
    Amesh A Adalja
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15212, USA
    Influenza Other Respir Viruses 5:225-9. 2011
    ..To describe the association of Aspergillus with influenza...
  93. ncbi request reprint Acute Dialysis Quality Initiative: methodology
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 8:500-1. 2002
    ..This brief report details the process of the Acute Dialysis Quality Initiative and its goals and methodology...
  94. ncbi request reprint Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  95. doi request reprint Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 3:887-94. 2008
    ..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury...
  96. pmc Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, PA, USA
    Crit Care 6:429-33. 2002
    ..We sought to distinguish clearance from adsorption as the principal mechanism responsible for reducing circulating IL-6 levels with hemofiltration...
  97. doi request reprint Acute kidney injury: epidemiology and assessment
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Scand J Clin Lab Invest Suppl 241:6-11. 2008
    ..Patients with AKI who are treated with RRT, still have a mortality of 50-60 %. Of surviving patients, 5-20 % remain dialysis-dependent at hospital discharge...
  98. pmc Closing the gap on unmeasured anions
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:219-20. 2003
  99. ncbi request reprint A drug to prevent renal failure?
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    Lancet 362:589-90. 2003