Roberta L Keller

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr . 2017
  2. pmc Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study
    Roberta L Keller
    Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA
    Pediatr Res 72:613-9. 2012
  3. pmc Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, 94143, USA
    Am J Respir Crit Care Med 182:555-61. 2010
  4. ncbi request reprint Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management
    Roberta L Keller
    University of California San Francisco, San Francisco, CA, USA
    Am J Med Genet C Semin Med Genet 145:184-200. 2007
  5. ncbi request reprint Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns
    Roberta L Keller
    Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
    Pediatr Res 58:1216-21. 2005
  6. ncbi request reprint Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    Pediatr Crit Care Med 7:589-94. 2006
  7. pmc Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide
    Roberta A Ballard
    Department of Pediatrics, UCSF Benioff Children s Hospital, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr 168:23-9.e4. 2016
  8. ncbi request reprint Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Roberta L Keller
    The Cardiovascular Research Institute and Department of Pediatrics, UCSF Box 0748, San Francisco, CA 94143, USA
    Pediatr Res 56:818-25. 2004
  9. ncbi request reprint Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks
    Soon Ha Yang
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 197:30.e1-7. 2007
  10. doi request reprint Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis?
    Erich J Grethel
    Department of Pediatric Surgery, University of California, San Francisco, CA 94143 0570, USA
    Fetal Diagn Ther 23:250-3. 2008

Collaborators

Detail Information

Publications37

  1. pmc The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr . 2017
    ....
  2. pmc Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study
    Roberta L Keller
    Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA
    Pediatr Res 72:613-9. 2012
    ....
  3. pmc Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, 94143, USA
    Am J Respir Crit Care Med 182:555-61. 2010
    ..Endothelin-1 (ET1) is dysregulated in pulmonary hypertension (PH). It may be important in the pathobiology of congenital diaphragmatic hernia (CDH)...
  4. ncbi request reprint Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management
    Roberta L Keller
    University of California San Francisco, San Francisco, CA, USA
    Am J Med Genet C Semin Med Genet 145:184-200. 2007
    ..However, any of these interventions will require careful selection of those infants at risk for poor outcome and thorough follow up, since long-term morbidity is significant in children with diaphragmatic hernia...
  5. ncbi request reprint Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns
    Roberta L Keller
    Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
    Pediatr Res 58:1216-21. 2005
    ..However, the combined administration of L-NMMA and indomethacin was limited by acute side effects in this treatment protocol...
  6. ncbi request reprint Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy
    Roberta L Keller
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    Pediatr Crit Care Med 7:589-94. 2006
    ..We further report cardiac catheterization measures after chronic pulmonary vasodilator therapy with sildenafil alone or a combination of sildenafil and inhaled nitric oxide (three patients)...
  7. pmc Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide
    Roberta A Ballard
    Department of Pediatrics, UCSF Benioff Children s Hospital, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr 168:23-9.e4. 2016
    ....
  8. ncbi request reprint Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Roberta L Keller
    The Cardiovascular Research Institute and Department of Pediatrics, UCSF Box 0748, San Francisco, CA 94143, USA
    Pediatr Res 56:818-25. 2004
    ..We conclude that fetal TO for severe CDH results in modest improvements in neonatal pulmonary function that are of questionable clinical significance...
  9. ncbi request reprint Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks
    Soon Ha Yang
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 197:30.e1-7. 2007
    ....
  10. doi request reprint Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis?
    Erich J Grethel
    Department of Pediatric Surgery, University of California, San Francisco, CA 94143 0570, USA
    Fetal Diagn Ther 23:250-3. 2008
    ..We reviewed our experience to evaluate if prognosis was better in the CDH infants with associated bronchopulmonary sequestration...
  11. doi request reprint Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection
    Jong Hau Hsu
    Department of Pediatrics, University of California, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 135:746-53. 2008
    ....
  12. pmc Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension
    Emily Morell Balkin
    Department of Pediatrics, UCSF Benioff Children s Hospital, University of California San Francisco, San Francisco, CA, USA
    Pediatr Cardiol 37:756-64. 2016
    ..Multicenter prospective studies are necessary to further validate these findings...
  13. doi request reprint B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion
    Rambod Amirnovin
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    J Thorac Cardiovasc Surg 145:1279-87. 2013
    ..Our objective was to determine the alterations in perioperative B-type natriuretic peptide levels and their predictive value on postoperative outcomes, in infants undergoing congenital heart surgery...
  14. pmc Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns
    Katherine C Wai
    School of Medicine, University of California San Francisco, San Francisco, CA
    J Pediatr 177:97-102.e2. 2016
    ..To assess the prognostic accuracy of early cumulative supplemental oxygen (CSO) exposure for prediction of bronchopulmonary dysplasia (BPD) or death, and to evaluate the independent association of CSO with BPD or death...
  15. pmc Inhaled nitric oxide increases urinary nitric oxide metabolites and cyclic guanosine monophosphate in premature infants: relationship to pulmonary outcome
    Philip L Ballard
    Department of Pediatrics, University of California, San Francisco, California
    Am J Perinatol 32:225-32. 2015
    ..We hypothesized that levels of NO metabolites (NOx) and cGMP in urine, as a noninvasive source for biospecimen collection, would reflect the dose of iNO and relate to pulmonary outcome...
  16. ncbi request reprint Survival of severe congenital diaphragmatic hernia has morbid consequences
    Raul A Cortes
    Department of Surgery and Fetal Treatment Center, University of California in San Francisco Medical Center and Children s Hospital, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 40:36-45; discussion 45-6. 2005
    ....
  17. pmc Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis
    Aida Field-Ridley
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Pediatr Cardiol 34:291-5. 2013
    ..A decrease in endostatin may promote angiogenesis. The mechanism whereby the pulmonary circulation processes endostatin and its potential role in the pathogenesis of PAVMs warrant further study...
  18. doi request reprint Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution
    Tim Jancelewicz
    Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Pediatr Surg 45:155-60; discussion 160. 2010
    ..Surgical complications are common in survivors of congenital diaphragmatic hernia (CDH), but little is known about long-term incidence patterns and associated predictors...
  19. ncbi request reprint Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex
    Erich J Grethel
    Division of Pediatric Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Pediatr Surg 41:29-33; discussion 29-33. 2006
    ..A recent trend has been toward the use of bioactive prosthetic materials. We reviewed different patch closure techniques used for CDH repair at our institution and their association with these sequelae...
  20. pmc Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan)
    Monique Radman
    Department of Pediatrics, University of California, San Francisco, Calif Cardiovascular Research Institute, University of California, San Francisco, Calif
    J Thorac Cardiovasc Surg 148:212-9. 2014
    ..Although outcomes have improved, there remains an unpredictable risk of early total cavopulmonary connection takedown. The prediction of adverse postoperative outcomes is imprecise, despite an extensive preoperative evaluation...
  21. doi request reprint Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia
    Sarkis Christopher Derderian
    Fetal Treatment Center, University of California, San Francisco, San Francisco, Calif, USA
    Fetal Diagn Ther 39:117-24. 2016
    ..These results suggest a multifactorial origin for PH in CDH and support the idea of using prenatal medical therapies to promote vascular remodeling in these patients. ..
  22. ncbi request reprint Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia
    Roberta L Keller
    Cardiovascular Research Institute and the Department of Pediatrics, The University of California San Francisco, San Francisco, CA, USA
    Pediatr Crit Care Med 5:184-7. 2004
    ..We describe successful discontinuation of the inhaled therapy as well as a period of stabilization and improvement with continued sildenafil administration...
  23. pmc Persistence of pulmonary hypertension by echocardiography predicts short-term outcomes in congenital diaphragmatic hernia
    Leslie A Lusk
    Division of Neonatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr 166:251-6.e1. 2015
    ..To describe the natural history of pulmonary hypertension (PH) and the risk of death and pulmonary morbidity associated with the persistence of PH through the neonatal hospitalization for these infants...
  24. pmc The many faces of hydrops
    S Christopher Derderian
    Fetal Treatment Center, The University of California, San Francisco, CA, United States Department of Surgery, The University of California, San Francisco, CA, United States
    J Pediatr Surg 50:50-4; discussion 54. 2015
    ..Fetal hydrops arises from multiple disease processes and can portend a grim prognosis. We reviewed our experience with hydropic fetuses to understand relevant antenatal anatomic and physiologic predictors of survival...
  25. ncbi request reprint Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus
    Roberta L Keller
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Pediatrics 112:583-7. 2003
    ..The objective of this study was to determine the rate of permanent ductus closure after a second course of indomethacin for a recurrent, symptomatic PDA and to identify the factors associated with permanent ductus closure...
  26. doi request reprint Outcomes of multigestational pregnancies affected by congenital diaphragmatic hernia
    Tim Jancelewicz
    Department of Surgery, Division of Pediatric Surgery, University of California, San Francisco, CA 94143, USA
    J Pediatr Surg 45:1753-8. 2010
    ..To improve the counseling of families with multiple gestation pregnancies complicated by CDH, we examined outcomes of a consecutive series of CDH cases occurring in multiple gestation pregnancy referrals...
  27. ncbi request reprint A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia
    Michael R Harrison
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    N Engl J Med 349:1916-24. 2003
    ..We performed a randomized, controlled trial comparing fetal tracheal occlusion with standard postnatal care...
  28. doi request reprint Pulmonary Hypertension and Pulmonary Vasodilators
    Roberta L Keller
    Neonatology, Department of Pediatrics, UCSF Benioff Children s Hospital, University of California San Francisco, Box 0734, 550 16th Street, 5th Floor, San Francisco, CA 94143, USA Electronic address
    Clin Perinatol 43:187-202. 2016
    ..It is not clear who should be treated without confirmation of pulmonary vascular disease by cardiac catheterization, with concurrent evaluation of any contributing cardiovascular comorbidities. ..
  29. pmc B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia
    Martina A Steurer
    Department of Pediatrics, University of California, San Francisco, San Francisco, California
    Pediatr Res 76:549-54. 2014
    ..B-type natriuretic peptide (BNP) has not been evaluated in newborns with congenital diaphragmatic hernia (CDH). We hypothesized that BNP and severity of pulmonary hypertension (PH) would predict clinical outcome in these infants...
  30. ncbi request reprint Spleen Behind the Heart Complicates Lung-to-Head Ratio Measurement in Left-Sided Congenital Diaphragmatic Hernia
    Amaya M Basta
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, Medical Center, San Francisco, California USA
    J Ultrasound Med 35:2717-2721. 2016
    ..Here we describe how herniation of the spleen behind the heart can complicate measurement of the lung-to-head ratio on sonography and lead to overestimation, with implications for perinatal prognostication and management...
  31. pmc Fetal ultrasound markers of severity predict resolution of pulmonary hypertension in congenital diaphragmatic hernia
    Leslie A Lusk
    Division of Neonatology, Department of Pediatrics, Benioff Children s Hospital, University of California, San Francisco, CA Electronic address
    Am J Obstet Gynecol 213:216.e1-8. 2015
    ..We sought to define the relationship between fetal ultrasound markers of severity in CDH and the time to resolution of neonatal PH...
  32. doi request reprint Outcomes of fetal intervention for primary hydrothorax
    S Christopher Derderian
    Fetal Treatment Center, University of California, San Francisco, CA, USA Department of Surgery, University of California, San Francisco, CA, USA
    J Pediatr Surg 49:900-3; discussion 903-4. 2014
    ..Primary hydrothorax is a rare congenital anomaly with outcomes ranging from spontaneous resolution to fetal demise. We reviewed our experience with fetuses diagnosed with primary hydrothorax to evaluate prenatal management strategies...
  33. ncbi request reprint B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery
    Jong Hau Hsu
    Department of Pediatrics, University of California, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 134:939-45. 2007
    ..Therefore, the objective of this study was to determine the predictive value of perioperative B-type natriuretic peptide levels for postoperative outcomes in neonates undergoing cardiac surgery...
  34. pmc Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair
    Emma Olson
    Division of Pediatric Critical Care, Department of Pediatrics, Benioff Children s Hospital, University of California San Francisco, San Francisco, CA
    J Pediatr 167:762-4. 2015
    ..Repeat cardiac catheterization showed dramatic improvement. Both infants were weaned off the drug, representing the first reports of successful short-term treprostinil use in neonates with congenital diaphragmatic hernia...
  35. pmc Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia
    Shannon Fleck
    Department of Pediatrics, University of California, San Francisco UCSF, San Francisco, CA, USA
    Pediatr Res 74:290-8. 2013
    ..We studied biomarkers at the maternal-fetal interface to understand factors associated with the persistence of PH...
  36. ncbi request reprint MR imaging of hepatic pulmonary fusion in neonates
    Roberta L Keller
    Department of Pediatrics, The University of California at San Francisco and The Cardiovascular Research Institute, San Francisco, CA 94143, USA
    AJR Am J Roentgenol 180:438-40. 2003
  37. pmc Multi-institutional practice patterns and outcomes in uncomplicated gastroschisis: a report from the University of California Fetal Consortium (UCfC)
    Leslie A Lusk
    Department of Pediatrics, Division of Neonatology, University of California, San Francisco Electronic address
    J Pediatr Surg 49:1782-6. 2014
    ..Gastroschisis is a resource-intensive birth defect without consensus regarding optimal surgical and medical management. We sought to determine best-practice guidelines by examining differences in multi-institutional practices and outcomes...