Asaf Keller

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Neonatal whisker clipping alters intracortical, but not thalamocortical projections, in rat barrel cortex
    A Keller
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 412:83-94. 1999
  2. pmc The whisking rhythm generator: a novel mammalian network for the generation of movement
    Nathan P Cramer
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, Rm S251, Baltimore, MD 21201, USA
    J Neurophysiol 97:2148-58. 2007
  3. pmc Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain
    Jessica L Whitt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 33:3915-26. 2013
  4. pmc Superior colliculus control of vibrissa movements
    Marie E Hemelt
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 100:1245-54. 2008
  5. pmc Encoding of stimulus frequency and sensor motion in the posterior medial thalamic nucleus
    Radi Masri
    Program in Neuroscience, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 100:681-9. 2008
  6. pmc Laterodorsal nucleus of the thalamus: A processor of somatosensory inputs
    Tatiana Bezdudnaya
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 507:1979-89. 2008
  7. pmc Whisker primary afferents encode temporal frequency of moving gratings
    Lauren M Jones
    Program in Neuroscience and the Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Somatosens Mot Res 23:45-54. 2006
  8. pmc Conditioned place preference reveals tonic pain in an animal model of central pain
    Leyla Davoody
    Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore College of Dental Surgery, 650 West Baltimore Street, Baltimore, MD, USA
    J Pain 12:868-74. 2011
  9. pmc Consistency of angular tuning in the rat vibrissa system
    Marie E Hemelt
    Dept of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 104:3105-12. 2010
  10. pmc Zona incerta: a role in central pain
    Radi Masri
    Department of Anatomy, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 102:181-91. 2009

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Neonatal whisker clipping alters intracortical, but not thalamocortical projections, in rat barrel cortex
    A Keller
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 412:83-94. 1999
    ..e., corresponding to the injected cortical barrel) thalamic barreloid. These findings indicate that manipulations of sensory experience alter patterns of intracortical, but not thalamocortical, connections...
  2. pmc The whisking rhythm generator: a novel mammalian network for the generation of movement
    Nathan P Cramer
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, Rm S251, Baltimore, MD 21201, USA
    J Neurophysiol 97:2148-58. 2007
    ....
  3. pmc Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain
    Jessica L Whitt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 33:3915-26. 2013
    ..These data support our hypothesis that SCI pain results, at least in part, from a loss of inhibition to thalamic nuclei associated with both the sensory-discriminative and emotional-affective components of pain...
  4. pmc Superior colliculus control of vibrissa movements
    Marie E Hemelt
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 100:1245-54. 2008
    ..With the motor cortex controlling the whisking frequency, the superior colliculus control of set point and amplitude would account for the main parameters of voluntary whisking...
  5. pmc Encoding of stimulus frequency and sensor motion in the posterior medial thalamic nucleus
    Radi Masri
    Program in Neuroscience, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 100:681-9. 2008
    ..These observations suggest that POm neurons might not faithfully encode vibrissae inputs to provide reliable information on vibrissae movements or contacts...
  6. pmc Laterodorsal nucleus of the thalamus: A processor of somatosensory inputs
    Tatiana Bezdudnaya
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 507:1979-89. 2008
    ..These findings suggest that LD is part of a novel processing stream involved in spatial orientation and learning related to somatosensory cues...
  7. pmc Whisker primary afferents encode temporal frequency of moving gratings
    Lauren M Jones
    Program in Neuroscience and the Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Somatosens Mot Res 23:45-54. 2006
    ..This suggests that, during naturally occurring whisking, individual primary afferents faithfully encode temporal frequency evoked by whisker contacts...
  8. pmc Conditioned place preference reveals tonic pain in an animal model of central pain
    Leyla Davoody
    Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore College of Dental Surgery, 650 West Baltimore Street, Baltimore, MD, USA
    J Pain 12:868-74. 2011
    ..These findings are consistent with the conclusion that animals with spinal cord injury suffer from tonic pain...
  9. pmc Consistency of angular tuning in the rat vibrissa system
    Marie E Hemelt
    Dept of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 104:3105-12. 2010
    ..We discuss the relevance of these findings for the transformation of inputs along the vibrissa trigeminal pathway and for the detection of sensory cues by whisking animals...
  10. pmc Zona incerta: a role in central pain
    Radi Masri
    Department of Anatomy, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 102:181-91. 2009
    ..Thus CPS can result from suppressed inputs from the inhibitory nucleus zona incerta to the posterior thalamus...
  11. ncbi request reprint Serotonin regulates rhythmic whisking
    Alexis Hattox
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuron 39:343-52. 2003
    ..These findings suggest that serotonin is both necessary and sufficient to generate rhythmic whisker movements and that serotonergic premotoneurons are part of a whisking CPG...
  12. pmc The role of thalamic inputs in surround receptive fields of barrel neurons
    Ernest E Kwegyir-Afful
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 25:5926-34. 2005
    ..Response magnitude decreased only for inhibitory neurons. All of these findings are consistent with the hypothesis that AW responses are determined primarily by direct thalamic inputs and not by intracortical interactions...
  13. pmc Chronic pain following spinal cord injury
    Radi Masri
    Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore College of Dental Surgery, University of Maryland Baltimore, Baltimore, Maryland, USA
    Adv Exp Med Biol 760:74-88. 2012
    ..Here we describe a novel mechanism of loss of inhibition within the thalamus that may predispose for the development of this chronic pain and discuss a potential treatment that may restore inhibition and ameliorate pain...
  14. pmc Superior sensation: superior colliculus participation in rat vibrissa system
    Marie E Hemelt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Neurosci 8:12. 2007
    ..In anesthetized rats, we characterized extracellularly recorded responses of collicular neurons to different types of vibrissa stimuli...
  15. pmc Abnormal anterior pretectal nucleus activity contributes to central pain syndrome
    Peter D Murray
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    J Neurophysiol 103:3044-53. 2010
    ..Taken together, these findings suggest that APT regulates ZI inputs to PO and that enhanced APT activity during CPS contributes to the abnormally high activity of PO neurons in CPS...
  16. pmc Cholinergic regulation of the posterior medial thalamic nucleus
    Radi Masri
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    J Neurophysiol 96:2265-73. 2006
    ..We propose the state-dependent gating hypothesis, which asserts that differing behavioral states, regulated by the brain stem cholinergic system, modulate the flow of information through POm...
  17. pmc State-dependent gating of sensory inputs by zona incerta
    Jason C Trageser
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 96:1456-63. 2006
    ....
  18. pmc Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion
    Junfang Wu
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, National Study Center for Trauma and EMS, University of Maryland, School of Medicine, Bressler Research Building, 655 W Baltimore Street, Room 6 009, Baltimore, MD 21201, USA
    Neurotherapeutics 10:520-38. 2013
    ..Moreover, cell cycle modulation may provide an effective therapeutic strategy to improve reduce both hyperpathia and motor dysfunction after SCI. ..
  19. pmc Abnormal activity of primary somatosensory cortex in central pain syndrome
    Raimi L Quiton
    Program in Neuroscience, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 104:1717-25. 2010
    ..Thus, the excruciatingly painful symptoms of CPS may result, at least in part, from abnormally increased activity in SI...
  20. pmc Cortical control of a whisking central pattern generator
    Nathan P Cramer
    Program in Neuroscience and the Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 96:209-17. 2006
    ..In addition, whisking frequency was correlated with the firing rate of these motoneurons. These findings support the hypothesis that vMCx regulates whisking through its actions on a subcortical CPG...
  21. pmc GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism
    Emilio R Garrido Sanabria
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
    J Neurophysiol 91:182-93. 2004
    ..Because GCP II inhibition is thought to increase NAAG levels, these results suggest that NAAG suppresses synaptic transmission at mossy fiber-CA3 synapses through presynaptic activation of group II mGluRs...
  22. pmc Robust temporal coding in the trigeminal system
    Lauren M Jones
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 304:1986-9. 2004
    ..These predictions are significantly improved by integrating responses from neurons with opposite angular preferences...
  23. pmc Functional independence of layer IV barrels
    Nora Laaris
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 87:1028-34. 2002
    ....
  24. pmc Response properties of whisker-related neurons in rat second somatosensory cortex
    Ernest E Kwegyir-Afful
    Dept of Anatomy and Neurobiology, Univ of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 92:2083-92. 2004
    ..Thus whisker-related inputs are processed in parallel by a lemniscal system involving SI and a paralemniscal system that processes complimentary aspects of somatosensation...
  25. pmc Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms
    Masamichi Okubo
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    J Neurosci 33:5152-61. 2013
    ....
  26. pmc Somatosensory response properties of excitatory and inhibitory neurons in rat motor cortex
    Peter D Murray
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201, USA
    J Neurophysiol 106:1355-62. 2011
    ..These findings suggest that somatosensory inputs preferentially evoke feedforward inhibition in the motor cortex. We suggest that this provides a mechanism for dynamic selection of motor cortical modules during voluntary movements...
  27. pmc Reducing the uncertainty: gating of peripheral inputs by zona incerta
    Jason C Trageser
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 24:8911-5. 2004
    ..Because ZI innervates all higher-order nuclei, this gating mechanism may exert similar regulation of thalamic processing in other sensory systems...
  28. pmc Intercellular interactions in the mammalian olfactory nerve
    Karen J Blinder
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 466:230-9. 2003
    ..Such an arrangement would facilitate ephaptic transmission, calcium waves, current oscillations, and paracrine communication and may be important for olfactory neural code processing...
  29. pmc Use-dependent inhibition of dendritic spines
    Asaf Keller
    Dept of Anatomy and Neurobiology, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    Trends Neurosci 25:541-3; discussion 543-4. 2002
    ..These findings lend further support to the hypothesis that synapses in the mature cortex are subject to continual use-dependent plasticity...
  30. pmc Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms
    Sylvina M Raver
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St HSF II S241, Baltimore, MD 21201, USA
    Neuropharmacology 86:161-73. 2014
    ..These findings represent a novel attempt to antagonize the effects of adolescent cannabinoid exposure on neural network activity, and reveal the contribution of non-CB1R targets to the suppression of cortical oscillations. ..
  31. pmc Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice
    Sylvina M Raver
    1 Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA 2 Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 38:2338-47. 2013
    ..These data establish a link between chronic adolescent cannabinoid exposure and alterations in adult cortical network activity that underlie cognitive processes. ..
  32. pmc Functional circuitry involved in the regulation of whisker movements
    Alexis M Hattox
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Comp Neurol 442:266-76. 2002
    ....
  33. pmc The glial sling is a migratory population of developing neurons
    Tianzhi Shu
    The University of Maryland, Baltimore, School of Medicine, Department of Anatomy and Neurobiology, and the Program in Neuroscience, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Development 130:2929-37. 2003
    ..These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance...
  34. pmc Precise temporal responses in whisker trigeminal neurons
    Lauren M Jones
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 92:665-8. 2004
    ..We show that all classes of trigeminal ganglion neurons respond with highly reproducible temporal spike patterns to transient stimuli. Such a robust coding mechanism may allow rapid perception of complex tactile features...
  35. ncbi request reprint Gap junction proteins in inhibitory neurons of the adult barrel neocortex
    C A Priest
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
    Somatosens Mot Res 18:245-52. 2001
    ....
  36. ncbi request reprint Membrane bistability in olfactory bulb mitral cells
    P Heyward
    Department of Anatomy, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 21:5311-20. 2001
    ..We conclude that bistability is an intrinsic property of mitral cells that is a major determinant of their responses to ON input...
  37. ncbi request reprint Ephaptic interactions in the mammalian olfactory system
    H Bokil
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 21:RC173. 2001
    ..Our findings suggest that ephaptic interactions may be significant determinants of the olfactory code and that such interactions may occur in other, similarly organized axonal or dendritic bundles...
  38. ncbi request reprint Whisker motor cortex ablation and whisker movement patterns
    Puhong Gao
    Department of Psychology, Hunter College CUNY, New York City, NY 10021, USA
    Somatosens Mot Res 20:191-8. 2003
    ..We suggest that the observed deficits reflect an imbalance in cortical inputs to a brainstem central pattern generator...
  39. pmc Anticipatory activity of motor cortex in relation to rhythmic whisking
    Wendy A Friedman
    Department of Psychology, Hunter College, City University of New York, New York, New York, USA
    J Neurophysiol 95:1274-7. 2006
    ..These data support the hypothesis that vMCx may initiate and modulate whisking behavior through its action on a subcortical CPG...