George Kaysen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Serum albumin concentration in dialysis patients: why does it remain resistant to therapy?
    George A Kaysen
    Department of Medicine, Division of Nephrology, University of California Davis, Davis, Califonia 95616, USA
    Kidney Int Suppl . 2003
  2. ncbi request reprint Factors that affect albumin concentration in dialysis patients and their relationship to vascular disease
    George A Kaysen
    Department of Veterans Affairs Northern California Health Care System, Mather, CA, USA
    Kidney Int Suppl . 2003
  3. pmc Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis
    George A Kaysen
    Department of Medicine, University of California, Davis, Davis, California Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis California Electronic address
    J Ren Nutr 25:351-6. 2015
  4. doi request reprint Dietary protein restriction and preservation of kidney function in chronic kidney disease
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, Davis, CA 95616, USA
    Blood Purif 35:22-5. 2013
  5. pmc The effect of frequent hemodialysis on nutrition and body composition: frequent Hemodialysis Network Trial
    George A Kaysen
    Department of Medicine, Division of Nephrology, University of California, Davis School of Medicine, Davis, California 95616, USA
    Kidney Int 82:90-9. 2012
  6. ncbi request reprint Metabolic syndrome and renal failure: similarities and differences
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, CA 95616, USA
    Panminerva Med 48:151-64. 2006
  7. doi request reprint New insights into lipid metabolism in chronic kidney disease
    George A Kaysen
    Departments of Biochemistry and Molecular Medicine and Internal Medicine Division of Nephrology, School of Medicine, University of California Davis, One Shields Ave, 451 Health Sciences Drive, Davis, CA 95616, USA
    J Ren Nutr 21:120-3. 2011
  8. ncbi request reprint Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients
    George A Kaysen
    Department of Medicine, and Department of Statistics, University of California, Davis, California 95616, USA
    Kidney Int 63:315-22. 2003
  9. pmc Baseline physical performance, health, and functioning of participants in the Frequent Hemodialysis Network (FHN) trial
    George A Kaysen
    University of California Davis School of Medicine, Davis, 95616, USA
    Am J Kidney Dis 57:101-12. 2011
  10. doi request reprint Biochemistry and biomarkers of inflamed patients: why look, what to assess
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, CA 95616, USA
    Clin J Am Soc Nephrol 4:S56-63. 2009

Research Grants

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Serum albumin concentration in dialysis patients: why does it remain resistant to therapy?
    George A Kaysen
    Department of Medicine, Division of Nephrology, University of California Davis, Davis, Califonia 95616, USA
    Kidney Int Suppl . 2003
    ....
  2. ncbi request reprint Factors that affect albumin concentration in dialysis patients and their relationship to vascular disease
    George A Kaysen
    Department of Veterans Affairs Northern California Health Care System, Mather, CA, USA
    Kidney Int Suppl . 2003
    ..Fibrinogen levels are an independent risk factor for cardiovascular disease (CVD) in HD patients, and fibrinogen levels are increased in HD patients. Plasma volume expansion is also an independent risk factor for CVD...
  3. pmc Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis
    George A Kaysen
    Department of Medicine, University of California, Davis, Davis, California Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis California Electronic address
    J Ren Nutr 25:351-6. 2015
    ..We examined correlates of serum TMAO and the relations among serum TMAO concentrations, all-cause mortality, and cardiovascular mortality and hospitalizations in a nationally derived cohort of patients new to hemodialysis (HD)...
  4. doi request reprint Dietary protein restriction and preservation of kidney function in chronic kidney disease
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, Davis, CA 95616, USA
    Blood Purif 35:22-5. 2013
    ....
  5. pmc The effect of frequent hemodialysis on nutrition and body composition: frequent Hemodialysis Network Trial
    George A Kaysen
    Department of Medicine, Division of Nephrology, University of California, Davis School of Medicine, Davis, California 95616, USA
    Kidney Int 82:90-9. 2012
    ..Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition...
  6. ncbi request reprint Metabolic syndrome and renal failure: similarities and differences
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, CA 95616, USA
    Panminerva Med 48:151-64. 2006
    ..Whether treatment of elements of MS, with the exception of hypertension, will avoid the onset and progression of renal failure is unknown...
  7. doi request reprint New insights into lipid metabolism in chronic kidney disease
    George A Kaysen
    Departments of Biochemistry and Molecular Medicine and Internal Medicine Division of Nephrology, School of Medicine, University of California Davis, One Shields Ave, 451 Health Sciences Drive, Davis, CA 95616, USA
    J Ren Nutr 21:120-3. 2011
    ....
  8. ncbi request reprint Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients
    George A Kaysen
    Department of Medicine, and Department of Statistics, University of California, Davis, California 95616, USA
    Kidney Int 63:315-22. 2003
    ..The relationships among albumin synthesis, the acute phase response and plasma fibrinogen levels in hemodialysis patients are unknown...
  9. pmc Baseline physical performance, health, and functioning of participants in the Frequent Hemodialysis Network (FHN) trial
    George A Kaysen
    University of California Davis School of Medicine, Davis, 95616, USA
    Am J Kidney Dis 57:101-12. 2011
    ..Self-reported physical health and functioning and direct measures of physical performance are decreased in hemodialysis patients and are associated with mortality and hospitalization...
  10. doi request reprint Biochemistry and biomarkers of inflamed patients: why look, what to assess
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, CA 95616, USA
    Clin J Am Soc Nephrol 4:S56-63. 2009
    ..Inflammation is multifactorial in dialysis patients. Some sources are recognizable and correctable, such as vascular access type, clinical infection, and water quality, and some are not. Inflammation is strongly associated with outcome...
  11. ncbi request reprint Association between inflammation and malnutrition as risk factors of cardiovascular disease
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, CA 95616, USA
    Blood Purif 24:51-5. 2006
    ....
  12. ncbi request reprint The role of oxidative stress-altered lipoprotein structure and function and microinflammation on cardiovascular risk in patients with minor renal dysfunction
    George A Kaysen
    Division of Nephrology, Department of Medicine University of California Davis, Davis, CA 95616, USA
    J Am Soc Nephrol 15:538-48. 2004
    ..The changes in lipoprotein composition and structure as well as AngII-mediated alterations in endothelial function amplify the effect of subsequent inflammatory events...
  13. doi request reprint Potential restoration of HDL function with apolipoprotein A-I mimetic peptide in end-stage renal disease
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, Davis, California 95616, USA
    Kidney Int 76:359-61. 2009
    ....
  14. pmc Relationship between adiposity and cardiovascular risk factors in prevalent hemodialysis patients
    George A Kaysen
    Renal Research Institute, New York, New York, USA
    J Ren Nutr 19:357-64. 2009
    ..Renal failure is associated with dyslipidemia and inflammation in normal-weight patients. We hypothesized that the effects of obesity may be obscured by renal failure in HD...
  15. doi request reprint New insights into lipid metabolism in chronic kidney disease: what are the practical implications?
    George A Kaysen
    Division of Nephrology, Department of Medicine and of Biochemistry and Molecular Medicine, UC Davis, Davis, Calif 95616, USA
    Blood Purif 27:86-91. 2009
    ..Bariatric surgery reduces hyperlipidemia in patients with chronic kidney disease, but has also been associated with subsequent rapid decline in renal function secondary to oxalate deposition...
  16. ncbi request reprint Challenging the validity of the EPO index
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Department of Veterans Affairs, Medical Northern California Health Care System, CA, USA
    Am J Kidney Dis 47:166. 2006
    ..We hypothesized that the EPO dose-hematocrit (EPO/Hct) ratio, also known as the EPO index, may be a surrogate for inflammation and that greater EPO/Hct ratios would be associated with decreased survival...
  17. ncbi request reprint Characteristics and effects of inflammation in end-stage renal disease
    George A Kaysen
    Department of Internal Medicine, Division of Nephrology, University of California Davis, Davis, California 95616, USA
    Semin Dial 16:438-46. 2003
    ..Treatment should be focused on identifying potential causes of inflammation, if obvious, and reduction of other risk factor for cardiovascular disease...
  18. ncbi request reprint Longitudinal and cross-sectional effects of C-reactive protein, equilibrated normalized protein catabolic rate, and serum bicarbonate on creatinine and albumin levels in dialysis patients
    George A Kaysen
    Veterans Affairs Northern California Health Care System, Mather, USA
    Am J Kidney Dis 42:1200-11. 2003
    ..Loss of muscle mass and hypoalbuminemia each may result in part from either malnutrition, inflammation, or a combination of both. Short-term acidosis increases muscle protein catabolism and inhibits albumin synthesis...
  19. ncbi request reprint Hyperlipidemia in chronic kidney disease
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, California 95616, USA
    Int J Artif Organs 30:987-92. 2007
    ..Lp (a) levels are also associated with cardiovascular outcome among dialysis patients...
  20. ncbi request reprint Dialysis removes apolipoprotein C-I, improving very low-density lipoprotein clearance
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California, Davis, California 95616, USA
    Kidney Int 72:779-81. 2007
    ..VLDL from dialysis patients is structurally abnormal and is not metabolized at a normal rate by lipoprotein lipase (LPL)...
  21. ncbi request reprint Evidence that C-reactive protein or IL-6 are not surrogates for all inflammatory cardiovascular risk factors in hemodialysis patients
    George A Kaysen
    Department of Internal Medicine, Division of Nephrology, University of California, and Department of Biochemistry and Molecular Medicine, Davis, CA, USA
    Blood Purif 24:508-16. 2006
    ..That the prevalence of atherosclerosis and markers of inflammation are increased in renal failure patients suggests that inflammation causes accelerated vascular disease...
  22. ncbi request reprint Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, California 95616, USA
    Kidney Int 65:1408-15. 2004
    ..3 g/dL was accompanied by a change in albumin synthesis and if so whether these changes were associated with increased levels of acute phase proteins and/or with a decrease in equilibrated normalized protein catabolic rate (enPCR)...
  23. ncbi request reprint Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy
    George A Kaysen
    Renal Research Institute, New York, NY, USA
    Am J Clin Nutr 82:988-95. 2005
    ..Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive...
  24. ncbi request reprint Relationships among inflammation nutrition and physiologic mechanisms establishing albumin levels in hemodialysis patients
    George A Kaysen
    Division of Nephrology Department of Medicine, University of California Davis, 95616, USA
    Kidney Int 61:2240-9. 2002
    ....
  25. ncbi request reprint High-protein diets augment albuminuria in rats with Heymann nephritis by angiotensin II-dependent and -independent mechanisms
    G A Kaysen
    Department of Medicine, University of California Davis School of Medicine, 95616, USA
    Miner Electrolyte Metab 24:238-45. 1998
    ..2%), suggesting that under these conditions ACEI reduces U(alb)V by a mechanism that is independent of inhibition of Ang-II and that high protein diets augment U(alb)V by both Ang-II-independent and Ang-II-dependent mechanisms...
  26. ncbi request reprint New insights into lipid metabolism in the nephrotic syndrome
    G A Kaysen
    Department of Medicine, UC, Davis, USA
    Kidney Int Suppl 71:S18-21. 1999
    ..HDL concentration is normal but maturation is impaired leading to a shift from the larger HDL2 to the smaller HDL3, a variant that is less effective as a transporter of the LPL cofactor apolipoprotein C II...
  27. ncbi request reprint Effects of inflammation on plasma composition and endothelial structure and function
    George A Kaysen
    Department of Medicine, Division of Nephrology, University of California Davis, Davis, USA
    J Ren Nutr 15:94-8. 2005
    ..The link between inflammation and apparent malnutrition explains the relationship between low levels of albumin, prealbumin, and transferrin with subsequent cardiovascular risk...
  28. ncbi request reprint The acute-phase response varies with time and predicts serum albumin levels in hemodialysis patients. The HEMO Study Group
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, 95616, USA
    Kidney Int 58:346-52. 2000
    ..The longitudinal relationship among laboratory measurements and how they vary over time in a population of patients are unknown...
  29. doi request reprint Estimation of adipose pools in hemodialysis patients from anthropometric measures
    George A Kaysen
    Renal Research Institute, New York, New York, USA
    J Ren Nutr 18:473-8. 2008
    ..We measured total adipose tissue, subcutaneous adipose tissue, and VAT in 48 prevalent HD patients, using magnetic resonance imaging...
  30. ncbi request reprint Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients
    G A Kaysen
    Division of Nephrology, University of California, Davis, USA
    Kidney Int 60:333-40. 2001
    ..The net effects of inflammation and dietary protein intake on nutritional markers over time are unknown...
  31. ncbi request reprint The microinflammatory state in uremia: causes and potential consequences
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, CA 95156, USA
    J Am Soc Nephrol 12:1549-57. 2001
    ....
  32. ncbi request reprint Levels of alpha1 acid glycoprotein and ceruloplasmin predict future albumin levels in hemodialysis patients
    G A Kaysen
    Division of Nephrology Department of Medicine, University of California, Davis 95616, USA
    Kidney Int 60:2360-6. 2001
    ..If inflammation causes rather than is simply associated with hypoalbuminemia, then changes in the levels of acute phase proteins should precede changes in serum albumin concentration...
  33. ncbi request reprint Disorders in high-density metabolism with insulin resistance and chronic kidney disease
    George A Kaysen
    Department of Medicine, Division of Nephrology, UC Davis, Davis, CA 95616, USA
    J Ren Nutr 17:4-8. 2007
    ..Whether insulin resistance is entirely responsible for disorders of HDL metabolism in CKD, or whether the process is a result of unrelated pathophysiology, is currently unknown...
  34. ncbi request reprint Effective diffusion volume flow rates (Qe) for urea, creatinine, and inorganic phosphorous (Qeu, Qecr, QeiP) during hemodialysis
    Frank A Gotch
    Renal Research Institute, New York, New York, USA
    Semin Dial 16:474-6. 2003
    ..Equations are derived to calculate Qe for each of these solutes from Qb and hematocrit and in vivo KoAs for each solute were calculated...
  35. ncbi request reprint Serum albumin: relationship to inflammation and nutrition
    Burl R Don
    Division of Nephrology, Department of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Semin Dial 17:432-7. 2004
    ..Thus the inference from these clinical studies suggests that the cause of hypoalbuminemia, rather than low albumin levels specifically, is responsible for morbidity and mortality...
  36. ncbi request reprint Proteinuria and plasma compositional changes contribute to defective lipoprotein catabolism in the nephrotic syndrome by separate mechanisms
    G C Shearer
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, USA
    Am J Kidney Dis 37:S119-22. 2001
    ..The former has no relationship to proteinuria while the latter occurs as a consequence of proteinuria. These effects combine to suppress VLDL clearance...
  37. ncbi request reprint Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome
    G C Shearer
    Division of Nephrology, Department of Medicine, UC Davis, Davis, CA 95616, USA
    Kidney Int 59:179-89. 2001
    ..We tested the hypotheses that impaired binding of VLDL and impaired VLDL-high density lipoprotein (HDL) interactions contribute to hyperlipidemia in NS...
  38. ncbi request reprint The role of improved water quality on inflammatory markers in patients undergoing regular dialysis
    M A Rahmati
    Division of Nephrology, Beth Israel Medical Center, New York, USA
    Int J Artif Organs 27:723-7. 2004
    ....
  39. ncbi request reprint Measurement of intraperitoneal volume by segmental bioimpedance analysis during peritoneal dialysis
    Fansan Zhu
    Renal Research Institute, Beth Israel Medical Center, New York, NY, USA
    Am J Kidney Dis 42:167-72. 2003
    ..A new technique based on segmental bioimpedance analysis (SBIA) has been developed to accurately measure intraperitoneal volume continuously during peritoneal dialysis...
  40. ncbi request reprint Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion
    G C Shearer
    Department of Veterans Affairs Northern California Health Care System, Mather, California 95616, USA
    Kidney Int 70:647-53. 2006
    ..The finding that NS serum alters LpL binding to RAEC suggests LpL depletion results from decreased binding rather than defective delivery. This in turn is a consequence of reduced serum albumin or pi but does not require proteinuria...
  41. ncbi request reprint Factors influencing serum albumin in dialysis patients
    J Y Yeun
    Department of Medicine, University of California Davis, USA
    Am J Kidney Dis 32:S118-25. 1998
    ..Future studies should focus on elucidating the inflammatory stimuli and the complex interaction between the acute-phase response and nutritional status...
  42. ncbi request reprint Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients
    J Y Yeun
    Department of Medicine, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 30:923-7. 1997
    ..CRP and SAA significantly correlated with one another, but neither correlated with transperitoneal albumin losses. Hypoalbuminemia in PD patients is a consequence of transperitoneal albumin losses and of the acute phase response...
  43. ncbi request reprint Hyperlipidemia and renal disease: the use of animal models in understanding pathophysiology and approaches to treatment
    F T Stevenson
    Department of Medicine, University of California, Davis School of Medicine, USA
    Wien Klin Wochenschr 111:307-14. 1999
    ..Animal models are a crucial tool for the further elucidation of mechanisms of lipoprotein-mediated glomerular injury...
  44. ncbi request reprint C-reactive protein, oxidative stress, homocysteine, and troponin as inflammatory and metabolic predictors of atherosclerosis in ESRD
    J Y Yeun
    Department of Veterans Affairs Northern California Health Care System, Mather, USA
    Curr Opin Nephrol Hypertens 9:621-30. 2000
    ..Sorting out the role of each of these risk factors may be difficult since the factors may influence each other, may increase oxidative stress, and may mediate atherosclerosis through oxidative modification of lipids...
  45. ncbi request reprint Leptin is a negative acute phase protein in chronic hemodialysis patients
    B R Don
    Division of Nephrology, Department of Medicine, University of California Davis Medical Center, Sacramento, 95817, USA
    Kidney Int 59:1114-20. 2001
    ..Factored for body weight, leptin is known to be increased in hemodialysis patients, but its relationship to inflammation is unknown...
  46. ncbi request reprint C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients
    J Y Yeun
    Department of Medicine, Division of Nephrology, and the Department of Statistics, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 35:469-76. 2000
    ..The acute-phase response or the cause of the acute-phase response is largely responsible for the effect of hypoalbuminemia on mortality in HD patients...
  47. ncbi request reprint Pretransplant systemic inflammation and acute rejection after renal transplantation
    R V Perez
    University of California Davis Medical Center, Department of Surgery, Sacramento 95817, USA
    Transplantation 69:869-74. 2000
    ..We studied whether pretransplant serum levels of C-reactive protein (CRP), a marker for the presence of systemic inflammation, would predict the occurrence of acute rejection episodes after renal transplantation...
  48. ncbi request reprint Estrogen worsens incipient hypertriglyceridemic glomerular injury in the obese Zucker rat
    F T Stevenson
    Divisions of Nephrology and Endocrinology, Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
    Kidney Int 57:1927-35. 2000
    ..At this time point, rats exhibit no overt histologic glomerular disease, but are just beginning to show elevated urinary albumin excretion...
  49. ncbi request reprint Assessment of inflammation and nutrition in patients with end-stage renal disease
    B R Don
    Division of Nephrology, University of California Davis Medical Centre, Sacramento, USA
    J Nephrol 13:249-59. 2000
    ..Novel therapies will need to be developed to counter this systemic inflammation since it appears to be a major cause of mortality in patients with end-stage renal disease...
  50. ncbi request reprint A kinetic model of inorganic phosphorus mass balance in hemodialysis therapy
    Frank A Gotch
    Renal Research Institute, New York, NY, USA
    Blood Purif 21:51-7. 2003
    ..We have developed a kinetic model (iPKM) designed to monitor these three parameters of iP mass balance in individual patients and report here preliminary evaluation of the model in 23 HD patients...
  51. ncbi request reprint Endothelial chylomicron binding is altered by interaction with high-density lipoprotein in Heymann's nephritis
    G C Shearer
    Department of Veterans Affairs Northern California Health Care System, Mather, CA, USA
    Am J Kidney Dis 38:1385-9. 2001
    ..HDL from rats with HN alters CM binding to lipoprotein lipase by a mechanism that does not involve reducing the content of apo E already present on CMs at the time of secretion...
  52. ncbi request reprint Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states
    J Kang
    Department of Biological Chemistry, University of California, Davis 95616, USA
    Kidney Int 56:452-60. 1999
    ..This is the only known condition in which transcription of both positive and negative acute phase proteins (APPs) are increased simultaneously. The specific transcription factor(s) that might regulate this cascade is not defined...
  53. ncbi request reprint The effect of etanercept on suppression of the systemic inflammatory response in chronic hemodialysis patients
    B R Don
    Division of Nephrology, University of California Davis School of Medicine and the UC Davis Medical Center, Davis, CA, USA
    Clin Nephrol 73:431-8. 2010
    ..8 g/dl, CRP > 8.0 mg/l) prevalent hemodialysis patients...
  54. ncbi request reprint Heat accumulation with relative blood volume decrease
    Daniel Schneditz
    Renal Research Institute and the Division of Nephrology, Beth Israel Medical Center, New York, NY, USA
    Am J Kidney Dis 40:777-82. 2002
    ..In hemodialysis, hypovolemia and heat accumulation often develop simultaneously, and the question arises of whether and to what extent these perturbations are linked...
  55. ncbi request reprint Metabolic consequences of body size and body composition in hemodialysis patients
    S R Sarkar
    Renal Research Institute and Beth Israel Medical Center, New York, USA
    Kidney Int 70:1832-9. 2006
    ..The poorer survival observed in smaller dialysis patients may be related to these relative differences...
  56. ncbi request reprint Segment-specific resistivity improves body fluid volume estimates from bioimpedance spectroscopy in hemodialysis patients
    F Zhu
    Renal Research Institute, Yorkville Dialysis Center, 1555 3rd Ave 218, New York, NY 10128, USA
    J Appl Physiol (1985) 100:717-24. 2006
    ..Use of segmental resistivity values combined with adjustment for body volumes that are neglected by traditional SBIS technique significantly improves estimations of body fluid volume in hemodialysis patients...
  57. ncbi request reprint Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats
    A Swislocki
    Medical Service, Department of Veterans Affairs, Northern California System of Clinics, Martinez 94553, USA
    Am J Hypertens 8:1009-14. 1995
    ....
  58. ncbi request reprint The pharmacokinetics of etanercept in patients with end-stage renal disease on haemodialysis
    Burl R Don
    Division of Nephrology, Department of Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA
    J Pharm Pharmacol 57:1407-13. 2005
    ..The pharmacokinetics of etanercept in patients with chronic renal failure on HD are similar to patients with normal renal function. It is, therefore, feasible to administer etanercept to HD patients without adjusting the dose...
  59. pmc Higher serum creatinine concentrations in black patients with chronic kidney disease: beyond nutritional status and body composition
    Joy Hsu
    Stanford University School of Medicine, Grant Building, S 161, Stanford, CA 94305 5114, USA
    Clin J Am Soc Nephrol 3:992-7. 2008
    ..These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass...
  60. doi request reprint The effect of lipoproteins on the development and progression of renal disease
    Lorien S Dalrymple
    Department of Medicine, University of California, Davis, California 95817, USA
    Am J Nephrol 28:723-31. 2008
    ..In humans, the evidence that lipid-lowering therapy delays renal progression is limited. The purpose of this paper is to review the current literature on lipoprotein abnormalities and the development or progression of renal disease...
  61. pmc Trends and outcomes associated with serum albumin concentration among incident dialysis patients in the United States
    George A Kaysen
    Division of Nephrology, Department of Medicine and Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California, USA
    J Ren Nutr 18:323-31. 2008
    ..To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004...
  62. ncbi request reprint Impact of dialysis dose and membrane on infection-related hospitalization and death: results of the HEMO Study
    Michael Allon
    Division of Nephrology, University of Alabama at Birmingham, Paula Building Room 226, 728 Richard Arrington Boulevard, Birmingham, AL 35233, USA
    J Am Soc Nephrol 14:1863-70. 2003
    ..However, the frequency of access-related, infection-related hospitalizations was disproportionately higher among patients with catheters compared with grafts or fistulas...
  63. ncbi request reprint Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure
    Berthil H C M T Prinsen
    Department of Vascular Medicine and Metabolism, University Medical Center Utrecht, Utrecht, The Netherlands
    Kidney Int 64:1495-504. 2003
    ..The mechanisms responsible for hypoalbuminemia and hyperfibrinogenemia in CRF are unknown...
  64. ncbi request reprint Breath ethane in dialysis patients and control subjects
    Garry J Handelman
    Health and Clinical Sciences, University of Massachusetts, 3 Solomont Way, Suite 4, Lowell, MA 01854 5125, USA
    Free Radic Biol Med 35:17-23. 2003
    ..Measurement of breath ethane may provide insight into severity of oxidant stress and metabolic disturbances, and provide guidance for optimal therapy and prevention of pathology in patients on long-term hemodialysis...
  65. ncbi request reprint Inflammation in ESRD: causes and potential consequences
    George A Kaysen
    Division of Nephrology, Department of Medicine, UC Davis, Davis, CA 95616, USA
    J Ren Nutr 13:158-60. 2003
    ..Whereas improvements in nutrition can increase serum albumin and creatinine levels, identification and removal of the underlying cause of inflammation should be one treatment goal...
  66. ncbi request reprint Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients
    Kirsten L Johansen
    Division of Nephrology, San Francisco Veterans Affairs Medical Center, CA 94121, USA
    Am J Clin Nutr 77:842-6. 2003
    ..Cross-sectional studies have shown an association between the duration (y) of dialysis and nutritional status, providing evidence of wasting...
  67. ncbi request reprint Serum markers of periodontal disease status and inflammation in hemodialysis patients
    Margaret A Rahmati
    Division of Nephrology, Beth Israel Medical Center, New York, NY, USA
    Am J Kidney Dis 40:983-9. 2002
    ..Because destructive periodontal diseases have been associated with elevated CRP levels, we questioned whether destructive periodontal diseases could contribute to elevated CRP values in HD populations...
  68. ncbi request reprint Association of serum albumin and atherosclerosis in chronic hemodialysis patients
    Srinivasan Beddhu
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
    Am J Kidney Dis 40:721-7. 2002
    ..Because cardiovascular disease is the leading cause of death and hypoalbuminemia predicts mortality, hypoalbuminemia may be associated with atherosclerosis...
  69. ncbi request reprint Why measure serum albumin levels?
    George A Kaysen
    J Ren Nutr 12:148-50. 2002
  70. ncbi request reprint Role of inflammation and its treatment in ESRD patients
    George A Kaysen
    Renal Research Institute, New York, NY 10128, USA
    Blood Purif 20:70-80. 2002
    ..It is speculated that use of these agents or directly suppressing inflammation may have use in treating the inflammatory-malnutrition syndrome in dialysis patients...
  71. ncbi request reprint Reverse epidemiology: a confusing, confounding, and inaccurate term
    Nathan W Levin
    Renal Research Institute, New York, New York, USA
    Semin Dial 20:586-92. 2007
    ....
  72. ncbi request reprint Prealbumin, mortality, and cause-specific hospitalization in hemodialysis patients
    Glenn M Chertow
    Division of Nephrology, Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94118 1211, USA
    Kidney Int 68:2794-800. 2005
    ..Prior studies have suggested that the serum prealbumin concentration is independently associated with mortality in hemodialysis patients, even with adjustment for serum albumin and other nutritional parameters...
  73. ncbi request reprint Cerebrovascular disease in maintenance hemodialysis patients: results of the HEMO Study
    James A Delmez
    Washington University, St Louis, MO, USA
    Am J Kidney Dis 47:131-8. 2006
    ....
  74. ncbi request reprint Diabetes, a cause of progressive sarcopenia in dialysis patients?
    George A Kaysen
    Kidney Int 68:2396-7. 2005
  75. ncbi request reprint The spectrum of infection-related morbidity in hospitalized haemodialysis patients
    Michael Allon
    Division of Nephrology, University of Alabama at Birmingham, AL, USA
    Nephrol Dial Transplant 20:1180-6. 2005
    ..Few prospective studies have examined the clinical consequences of infection-related hospitalizations in haemodialysis patients or the risk factors predictive of clinical outcomes...
  76. ncbi request reprint Assessment of body composition in long-term hemodialysis patients: rationale and methodology
    Shubho R Sarkar
    Renal Research Institute, New York, NY 10128, USA
    J Ren Nutr 15:152-8. 2005
    ..Preliminary results based on up to 40 hemodialysis patients are reported...
  77. ncbi request reprint Inflammation: cause of vascular disease and malnutrition in dialysis patients
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, CA 95616, USA
    Semin Nephrol 24:431-6. 2004
    ..The cause(s) of inflammation must be identified and treated to resolve malnutrition and reduce cardiovascular risk...
  78. ncbi request reprint Association of body size with outcomes among patients beginning dialysis
    Kirsten L Johansen
    Division of Nephrology, University of California San Francisco, San Francisco, CA 94118 1211, USA
    Am J Clin Nutr 80:324-32. 2004
    ..These reports have generally not examined extremely high values of body mass index (BMI; in kg/m(2)), survival >1 y, or alternative measures of adiposity...
  79. ncbi request reprint The influence of patient- and facility-specific factors on nutritional status and survival in hemodialysis
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, CA 94118 1211, USA
    J Ren Nutr 14:72-81. 2004
    ..We aimed to determine whether patient and facility characteristics modify the risk profiles associated with malnutrition in hemodialysis patients...
  80. ncbi request reprint Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat
    John W Newman
    Western Human Nutrition Research Center, United States Department of Agriculture, USA
    J Lipid Res 48:1792-800. 2007
    ..These proteinuria-induced changes may be associated with the cardiovascular risk of lipoprotein oxidation...
  81. ncbi request reprint GFR, body mass index, and low high-density lipoprotein concentration in adults with and without CKD
    Joan C Lo
    Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Am J Kidney Dis 50:552-8. 2007
    ..Low high-density lipoprotein (HDL) cholesterol level is common in patients with chronic kidney disease, but associations between severity of chronic kidney disease, obesity, and HDL level have not been well defined...
  82. pmc Inflammation and inverse associations of body mass index and serum creatinine with mortality in hemodialysis patients
    Srinivasan Beddhu
    Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah 84112, USA
    J Ren Nutr 17:372-80. 2007
    ..Protein-energy wasting and inflammation are common and associated with an increased risk of mortality in hemodialysis (HD) patients. We examined the extent to which they mediate the associations of each other with death in this population...
  83. ncbi request reprint On-line clearance: a useful tool for monitoring the effectiveness of the reuse procedure
    Margaret A Rahmati
    Division of Nephrology, Beth Israel Medical Center, New York, New York, USA
    ASAIO J 49:543-6. 2003
    ..It is concluded that on-line clearance measurements provide a simple noninvasive method to monitor dialyzer performance over each use and between uses...
  84. ncbi request reprint Idiopathic hypoalbuminemia explained by reduced synthesis rate and an increased catabolic rate
    Berthil H C M T Prinsen
    Department of Vascular Medicine and Metabolism, University Medical Center, Utrecht, The Netherlands
    Clin Biochem 35:545-53. 2002
    ..To determine the contribution of albumin synthetic and catabolic rates to steady state levels in a patient with idiopathic hypoalbuminemia...
  85. ncbi request reprint Why measure serum albumin levels?
    George A Kaysen
    Adv Ren Replace Ther 10:228-31. 2003

Research Grants1

  1. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..