Affiliation: University of California
- Multiple pathologies are common and related to dementia in the oldest-old: The 90+ StudyClaudia H Kawas
From the Departments of Neurology C H K, S S B, M M C, Neurobiology and Behavior C H K, and Epidemiology C H K, M M C, Institute for Memory Impairments and Neurological Disorders C H K, M M C, and School of Biological Sciences T T, University of California, Irvine Department of Pathology R K, University of California, Irvine Medical Center, Orange, CA Department of Pathology J S, Huntsman Cancer Institute, University of Utah, Salt Lake City
Neurology 85:535-42. 2015..The purpose of this study was to examine the role of multiple pathologies in the expression of dementia in the oldest-old...
- Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ StudyClaudia H Kawas
Department of Neurology, University of California, Irvine, Irvine, CA, USA
Alzheimers Dement 9:199-203. 2013..The goal of this study was to examine cross-sectional and longitudinal associations between cognitive performance and beta amyloid (Aβ) load determined by florbetapir F18 positron emission tomography (PET) in nondemented oldest-old...
- Visual memory predicts Alzheimer's disease more than a decade before diagnosisC H Kawas
Alzheimer s Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 60:1089-93. 2003....
- Alzheimer's and dementia in the oldest-old: a century of challengesClaudia H Kawas
Department of Neurology, University of California, Irvine, CA 92697 4540, USA
Curr Alzheimer Res 3:411-9. 2006....
- Clinical practice. Early Alzheimer's diseaseClaudia H Kawas
Institute for Brain Aging and Dementia and the Departments of Neurology and Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
N Engl J Med 349:1056-63. 2003
- Medications and diet: protective factors for AD?Claudia H Kawas
Department of Neurology, Institute for Brain Aging and Dementia, University of California Irvine, 1121 Gillespie, Irvine, CA 92627 4540, USA
Alzheimer Dis Assoc Disord 20:S89-96. 2006..At present, there is insufficient evidence to make public health recommendations, but these studies can provide potentially important clues and new avenues for clinical and laboratory research...
- Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's diseaseEllen Grober
Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
J Int Neuropsychol Soc 14:266-78. 2008..It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD...
- High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ StudyB Adar Kravitz
Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California, USA
J Am Geriatr Soc 57:641-6. 2009..To evaluate whether high levels of C-reactive protein (CRP) in serum are associated with greater risk of all-cause dementia or mortality in the oldest-old...
- Neuropsychological data in nondemented oldest old: the 90+ StudyChristina Whittle
Institute of Brain Aging and Dementia, University of California, Irvine, CA, USA
J Clin Exp Neuropsychol 29:290-9. 2007..Cognitive performance declined with age for two-thirds of the tests. Performance on some tests was also affected by gender, education, and depression scores...
- Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotypeDaniel J Berlau
Institute of Brain Aging and Dementia, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697 1400, USA
Arch Neurol 64:1193-6. 2007..The apolipoprotein E (APOE) epsilon2 allele has been suggested as having a protective effect and delaying the age at onset of Alzheimer disease...
- The prevalence of disability in the oldest-old is high and continues to increase with age: findings from The 90+ StudyDaniel J Berlau
Institute for Brain Aging and Dementia, University of California, Irvine, USA
Int J Geriatr Psychiatry 24:1217-25. 2009..To examine the prevalence and type of disability in the oldest-old (90+), the fastest growing age group in the United States...
- Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairmentRuth A Mulnard
Departments of Neurology, and Neurobiology and Behavior, University of California Irvine, Gillespie NRF, Room 1113, Irvine, CA 92697 4540, USA
Curr Neurol Neurosci Rep 4:368-73. 2004..Additional basic and clinical investigations are necessary to examine different forms and dosages of estrogens, other populations, and the relevance of timing and duration of exposure...
- Synaptic proteins, neuropathology and cognitive status in the oldest-oldElizabeth Head
Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
Neurobiol Aging 30:1125-34. 2009..Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition...
- Sensitivity and specificity of the mini-mental state examination for identifying dementia in the oldest-old: the 90+ studyKristin Kahle-Wrobleski
Institute of Brain Aging and Dementia, University of California at Irvine, Irvine, California 92697, USA
J Am Geriatr Soc 55:284-9. 2007..To evaluate the sensitivity and specificity of the Mini-Mental State Examination (MMSE) in identifying dementia in the oldest-old when stratified by age and education...
- Neuronal localization of C1q in preclinical Alzheimer's diseaseMaria I Fonseca
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Neurobiol Dis 15:40-6. 2004..Thus, it is possible that this neuronal-associated C1q reflects an early, but transient, response to injury that may modulate the progression of neurological dysfunction in AD...
- APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest oldDaniel J Berlau
Institute of Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 1400, USA
Neurology 72:829-34. 2009..This would predict, even with advanced age, that APOE2 carriers would be less likely to have dementia and less likely to meet pathologic criteria for AD...
- Association of body mass index and weight change with all-cause mortality in the elderlyMaria M Corrada
Department of Neurology, School of Medicine, University of California, Irvine, 92697 1400, USA
Am J Epidemiol 163:938-49. 2006..This study highlights the influence on older-age mortality risk of being overweight or obese in young adulthood and underweight or obese in later life...
- Abnormal EEGs in cognitively and physically healthy oldest old: findings from the 90+ studyCarrie Brumback Peltz
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 1400, USA
J Clin Neurophysiol 27:292-5. 2010..The high rates of EEG abnormalities found in these physically and cognitively healthy participants prompt reappraisal of pathologic significance in this unique population...
- Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-oldB Adar Kravitz
Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
Alzheimers Dement 5:318-23. 2009..Using a cross-sectional design, we examined whether high levels of serum CRP are associated with increased odds of prevalent dementia in the oldest-old...
- Dementia incidence continues to increase with age in the oldest old: the 90+ studyMaria M Corrada
Department of Neurology, University of California, Irvine, CA 92697 1400, USA
Ann Neurol 67:114-21. 2010..Here, we estimate age- and sex-specific incidence rates of all-cause dementia in people aged 90 years and older, including estimates for centenarians...
- Session II: Mechanisms of age-related cognitive change and targets for intervention: neural circuits, networks, and plasticityCharles DeCarli
Department of Neurology and Center for Neuroscience, University of California, Davis, USA
J Gerontol A Biol Sci Med Sci 67:747-53. 2012..Moreover, this understanding will assist in promoting the utilization of existing interventions, such as lifestyle and therapeutic modifiers of vascular disease...
- Ginkgo biloba for preventing cognitive decline in older adults: a randomized trialBeth E Snitz
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 302:2663-70. 2009..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
- Children of persons with Alzheimer disease: what does the future hold?Lissy Jarvik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Alzheimer Dis Assoc Disord 22:6-20. 2008..We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring...
- Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementiaJohn M Ringman
Alzheimer s Disease Center, UCLA Department of Neurology, Los Angeles, CA, USA
Int Psychogeriatr 19:323-32. 2007..Persons known to be at 50% risk for young-onset AD due to presenilin-1 (PSEN1) mutations provide the opportunity to assess which measures on the Mini-mental State Examination (MMSE) are most sensitive to these early changes...
- Survival following a diagnosis of Alzheimer diseaseRon Brookmeyer
Department of Biostatistics, The Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Arch Neurol 59:1764-7. 2002..Survival following a diagnosis of Alzheimer disease (AD) is important information for health planners, caregivers, patients, and their families...
- Computerized neuropsychiatric assessment of geriatric subjects by content analysis of brief samples of their speechLouis A Gottschalk
Departments of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
Comput Inform Nurs 22:351-5. 2004..The computerized content-analysis scores obtained from this elderly cohort reveal plausible deviations from the norms for younger people...
- Immune reactive cells in senile plaques and cognitive decline in Alzheimer's diseaseAnne K Vehmas
Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205 2196, USA
Neurobiol Aging 24:321-31. 2003..Tau immunoreactivity appears as the strongest morphological correlate of dementia...
- Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)Irina Mikolaenko
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
J Neuropathol Exp Neurol 64:156-62. 2005..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar...
- The oldest old and the 90+ StudyClaudia H Kawas
Department of Neurology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
Alzheimers Dement 4:S56-9. 2008..Through our collective efforts, we will continue the scientific work that Leon so strongly supported...
- Depressive symptoms, sex, and risk for Alzheimer's diseaseGloria Dal Forno
Clinical Neurosciences, University Campus BioMedico and Associazione Fatebenefratelli per la Ricerca A Fa R, Via dei Compositori 130 132, 00128 Rome, Italy
Ann Neurol 57:381-7. 2005..We conclude that the impact of depressive symptoms on risk for dementia and AD may vary with sex. Further studies assessing separately the role of depression as a risk factor in men and women are necessary...
- Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort StudyAnnlia Paganini-Hill
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, USA
Prev Med 44:305-10. 2007..To examine the effects of non-alcoholic beverage and caffeine consumption on all-cause mortality in older adults...
- Survival following dementia onset: Alzheimer's disease and vascular dementiaAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
J Neurol Sci 229:43-9. 2005..4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive...
- Increased longevity in older users of postmenopausal estrogen therapy: the Leisure World Cohort StudyAnnlia Paganini-Hill
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, USA
Menopause 13:12-8. 2006..To examine the effect of postmenopausal estrogen therapy (ET), including duration and recency of use, on all-cause mortality in older women...
- Hippocampal neurons in pre-clinical Alzheimer's diseaseMark J West
Department of Neurobiology, Institute of Anatomy, Building 234, University Park, Aarhus 8000, Denmark
Neurobiol Aging 25:1205-12. 2004..However, we did not observe a significant loss of neurons in CA1 or any of the other subdivisions of the hippocampus in preclinical AD...
- Informed consent for Alzheimer's disease clinical trials: a survey of clinical investigatorsJason H T Karlawish
Internal Ethics Committee of the Alzheimer s Disease Cooperative Study
IRB 24:1-5. 2002
- Diet and the risk for Alzheimer's diseaseClaudia H Kawas
Ann Neurol 59:877-9. 2006