Candace M Kammerer

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Two quantitative trait loci affect ACE activities in Mexican-Americans
    Candace M Kammerer
    Graduate School of Public Health, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hypertension 43:466-70. 2004
  2. ncbi request reprint Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6
    Candace M Kammerer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 22:1720-5. 2002
  3. ncbi request reprint Two loci affect angiotensin I-converting enzyme activity in baboons
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Hypertension 41:854-9. 2003
  4. ncbi request reprint Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 18:2245-52. 2003
  5. pmc Association analysis of WNT10B with bone mass and structure among individuals of African ancestry
    Joseph M Zmuda
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:437-47. 2009
  6. pmc Evidence for a genetic link between bone and vascular measures in African ancestry families
    Allison L Kuipers
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 28:1804-10. 2013
  7. pmc Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults
    John R Shaffer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, A300 Crabtree Hall, GSPH, Pittsburgh, PA 15213, USA
    Calcif Tissue Int 84:75-84. 2009
  8. pmc Fat infiltration in muscle: new evidence for familial clustering and associations with diabetes
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:1854-60. 2008
  9. pmc Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
    Sudeshna Dasgupta
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Med Genet 12:7. 2011
  10. ncbi request reprint APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003

Detail Information

Publications46

  1. ncbi request reprint Two quantitative trait loci affect ACE activities in Mexican-Americans
    Candace M Kammerer
    Graduate School of Public Health, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hypertension 43:466-70. 2004
    ..We also have evidence that an additional QTL affects ACE activity. Identification of this additional QTL might lead to alternate means of prophylaxis...
  2. ncbi request reprint Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6
    Candace M Kammerer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 22:1720-5. 2002
    ..We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map...
  3. ncbi request reprint Two loci affect angiotensin I-converting enzyme activity in baboons
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Hypertension 41:854-9. 2003
    ..The existence of at least 2 genes that affect ACE activity, one of which is diet-responsive, may help explain the lack of consistency among studies of the relationship between ACE and CVD...
  4. ncbi request reprint Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 18:2245-52. 2003
    ..We obtained evidence for QTL on chromosome 4p, affecting forearm BMD overall, and on chromosomes 2p and 13q, affecting hip BMD in men...
  5. pmc Association analysis of WNT10B with bone mass and structure among individuals of African ancestry
    Joseph M Zmuda
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:437-47. 2009
    ..This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry...
  6. pmc Evidence for a genetic link between bone and vascular measures in African ancestry families
    Allison L Kuipers
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 28:1804-10. 2013
    ....
  7. pmc Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults
    John R Shaffer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, A300 Crabtree Hall, GSPH, Pittsburgh, PA 15213, USA
    Calcif Tissue Int 84:75-84. 2009
    ..Linkage to chromosome 1q23 suggests that this region may harbor one or more genes involved in regulating early BMD change of the femoral neck...
  8. pmc Fat infiltration in muscle: new evidence for familial clustering and associations with diabetes
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:1854-60. 2008
    ..Therefore, our aim is to determine genetic and environmental contributions to measures of skeletal muscle composition, and describe their associations with type 2 diabetes in multigenerational families of African ancestry...
  9. pmc Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
    Sudeshna Dasgupta
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Med Genet 12:7. 2011
    ....
  10. ncbi request reprint APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003
    ..These data support the hypothesis that the APOE*4 allele is an independent risk factor not only for the presence of CAD and hyperlipidemia, but also for the angiographic severity of CAD in white women with a family history of disease...
  11. pmc Sex and genetic effects on upper and lower body fat and associations with diabetes in multigenerational families of African heritage
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Metabolism 57:819-23. 2008
    ..Our findings also suggest that, in this population, leg fat is associated with diabetes independent of overall adiposity...
  12. pmc Correlates of trabecular and cortical volumetric BMD in men of African ancestry
    Yahtyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsuburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:1960-8. 2009
    ..Longitudinal studies are needed to gain a better understanding of the mechanisms underlying these differential associations that may show new insight into the etiology of trabecular and cortical bone loss in men...
  13. pmc Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men
    Laura M Yerges
    Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 25:330-8. 2010
    ..These findings identify novel genetic variants for cortical and trabecular vBMD and raise the possibility that some genetic loci may be unique for each bone compartment...
  14. ncbi request reprint Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study
    Xiaojing Wang
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Bone Miner Res 22:527-36. 2007
    ..Heritabilities of areal and volumetric BMD were moderate in our large families of African descent but differed for trabecular and cortical BMD...
  15. pmc Genetic epidemiology and genome-wide linkage analysis of carotid artery ultrasound traits in multigenerational African ancestry families
    Allison L Kuipers
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, A521 Crabtree Hall, Pittsburgh, PA 15261, USA Electronic address
    Atherosclerosis 231:120-3. 2013
    ..Therefore, we estimated heritability and performed genome-wide linkage analysis of carotid ultrasound traits in 7 multigenerational families of African ancestry...
  16. ncbi request reprint Lipoprotein subclass and particle size differences in Afro-Caribbeans, African Americans, and white Americans: associations with hepatic lipase gene variation
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Metabolism 55:96-102. 2006
    ..Our findings indicate that the higher frequency of the LIPC -514T allele found in men of African origin living in different environments significantly contributes to the more favorable distribution of HDL subclasses compared with whites...
  17. pmc Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus
    F Yesim K Demirci
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Rheumatol 38:652-7. 2011
    ....
  18. pmc Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?
    Laura M Yerges
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:87-96. 2009
    ..This study indicates that a cis-regulatory polymorphism in the FZD1 promoter region may have a functional role in determining bone structural geometry...
  19. pmc The association between renal function biomarkers and subclinical cardiovascular measures in African Caribbean families
    Hu Li
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Ethn Dis 23:492-8. 2013
    ....
  20. ncbi request reprint Pleiotropy and heterogeneity in the expression of bone strength-related phenotypes in extended pedigrees
    Xiaojing Wang
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 22:1766-72. 2007
    ..The majority of the phenotypic variation in bone size and volumetric BMD also seems to be strongly influenced by distinct genes for each trait...
  21. pmc Natural history and correlates of hip BMD loss with aging in men of African ancestry: the Tobago Bone Health Study
    Yahtyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:1290-8. 2009
    ..Additional studies are needed to better define the natural history and factors underlying bone loss with aging in men of African ancestry...
  22. pmc Genetic determination of adiponectin and its relationship with body fat topography in multigenerational families of African heritage
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Metabolism 56:234-8. 2007
    ..Adiponectin may serve as a promising quantitative intermediate trait in studies designed to map the genes underlying diabetes and obesity in this population...
  23. pmc Rate of bone loss is greater in young Mexican American men than women: the San Antonio Family Osteoporosis Study
    John R Shaffer
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Bone 47:49-54. 2010
    ....
  24. pmc Markers of inflammation are heritable and associated with subcutaneous and ectopic skeletal muscle adiposity in African ancestry families
    Iva Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Metab Syndr Relat Disord 9:319-26. 2011
    ..Inflammation is one mechanism that may link myosteatosis with increased T2DM risk, but studies examining the relationship between inflammation and myosteatosis are lacking...
  25. pmc Heritability and genetics of serum dickkopf 1 levels in African ancestry families
    Allison L Kuipers
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, A543 Crabtree Hall, Pittsburgh, PA, 15261, USA
    Calcif Tissue Int 96:155-9. 2015
    ..036). Serum DKK1 levels are highly heritable in the African ancestry families. Two SNPs within the DKK1 region accounted for nearly 5% of the variation in serum DKK1...
  26. pmc Functional and genetic characterization of the promoter region of apolipoprotein H (beta2-glycoprotein I)
    Sangita Suresh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    FEBS J 277:951-63. 2010
    ..In conclusion, we have characterized the functional promoter of APOH and identified functional variants that affect the transcriptional activity of the APOH promoter...
  27. pmc Apolipoprotein H promoter polymorphisms in relation to lupus and lupus-related phenotypes
    Sangita Suresh
    Department of Human Genetics, Graduate School of Public Health, A300 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Rheumatol 36:315-22. 2009
    ..We tested the hypothesis that common promoter variation in the APOH gene (encoding for ss(2)-glycoprotein I) is associated with systemic lupus erythematosus (SLE) risk and SLE-related clinical phenotypes in a Caucasian cohort...
  28. pmc Association of SLC34A2 variation and sodium-lithium countertransport activity in humans and baboons
    Xiaojing Zheng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 22:288-93. 2009
    ..The specific aim of this study was to identify genetic variants of the SLC34A2 gene in both baboon and human, and to examine the relationship of these polymorphisms with SLC activity and blood pressure...
  29. pmc Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica
    Candace M Kammerer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 51:2929-39. 2010
    ..The results of this study indicate that genetic variation in ABCB4, or closely linked genes, is responsible for the dramatic differences among opossums in their V+LDL cholesterol response to an atherogenic diet...
  30. pmc High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men
    Laura M Yerges
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:2039-49. 2009
    ....
  31. ncbi request reprint Decreased bone mineral density is correlated with increased subclinical atherosclerosis in older, but not younger, Mexican American women and men: the San Antonio Family Osteoporosis Study
    John R Shaffer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Calcif Tissue Int 81:430-41. 2007
    ..In summary, our results demonstrate that decreased BMD is correlated with increased IMT in older (but not younger) Mexican American men and women, independent of serum CVD risk factors...
  32. pmc Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 205:603-9. 2012
    ..Toll-like receptors (TLRs) are involved in the innate immune response. We examined whether TLR variants are associated with Chlamydia trachomatis infection among women with pelvic inflammatory disease (PID)...
  33. pmc A comparison of principal component analysis and factor analysis strategies for uncovering pleiotropic factors
    Xiaojing Wang
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Genet Epidemiol 33:325-31. 2009
    ....
  34. doi request reprint Snipping away at osteoporosis susceptibility
    Joseph M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Lancet 371:1479-80. 2008
  35. pmc Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1435-9. 2006
    ..012). These data suggest that the ACT gene may affect AAO and disease duration of AD...
  36. ncbi request reprint Estimates of African, European and Native American ancestry in Afro-Caribbean men on the island of Tobago
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Hered 60:129-33. 2005
    ..We hypothesize that the degree of European and Native American admixture in the Tobago population is low...
  37. pmc Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Hum Genet 72:13-22. 2003
    ..26-10.68; P=.017) for PON2 codon 311 Cys/Cys. Our data indicate that the severity of CAD, in terms of the number of diseased vessels, may be affected by common genetic variation in the PON gene cluster, on chromosome 7...
  38. ncbi request reprint Type 2 diabetes is associated with increased bone mineral density in Mexican-American women
    W H Linda Kao
    Department of Epidemiology, The Johns Hopkins University, Baltimore, MD, USA
    Arch Med Res 34:399-406. 2003
    ..Our purpose was to determine whether type 2 diabetes is associated with altered bone mineral density (BMD) and whether fasting serum insulin levels are correlated with BMD...
  39. ncbi request reprint A major gene influences variation in large HDL particles and their response to diet in baboons
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 163:241-8. 2002
    ..Our results suggest this major gene in baboons plays a pivotal role in HDL metabolism, but is unlikely to code for any of the proteins previously implicated in studies of human HDL(1)...
  40. ncbi request reprint Localization of genes that control LDL size fractions in baboons
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 168:15-22. 2003
    ..15) on the baboon homologue of human chromosome 16. Thus, we have evidence for three putative QTLs that influence variation in baboon LDL size phenotypes on different diets...
  41. ncbi request reprint Genetic and environmental determinants of bone mineral density in Mexican Americans: results from the San Antonio Family Osteoporosis Study
    Braxton D Mitchell
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Bone 33:839-46. 2003
    ..Identifying the individual genes involved will shed insights into the processes that govern bone remodeling and may suggest strategies for the prevention of osteoporosis...
  42. ncbi request reprint Genetic determination of HDL variation and response to diet in baboons
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 161:335-43. 2002
    ..Therefore, dietary fat and cholesterol alter HDL levels and characteristics, but the dietary responses are not strongly mediated by additive genetic effects...
  43. pmc Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  44. pmc First-generation linkage map of the gray, short-tailed opossum, Monodelphis domestica, reveals genome-wide reduction in female recombination rates
    Paul B Samollow
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, 78245 0549, USA
    Genetics 166:307-29. 2004
    ..We discuss possible explanations for reduced female recombination in marsupials as a consequence of the metatherian characteristic of determinate paternal X chromosome inactivation...
  45. ncbi request reprint Genetic and environmental influences on thyroid hormone variation in Mexican Americans
    Paul B Samollow
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    J Clin Endocrinol Metab 89:3276-84. 2004
    ....
  46. ncbi request reprint A microsatellite-based, physically anchored linkage map for the gray, short-tailed opossum (Monodelphis domestica)
    Paul B Samollow
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Chromosome Res 15:269-81. 2007
    ..54. These results greatly extend earlier findings, and provide an improved microsatellite-based linkage map for this species...