MELISSA JURICA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Searching for a wrench to throw into the splicing machine
    Melissa S Jurica
    Center for Molecular Biology of RNA and the Department of Cell, Developmental and Molecular Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA
    Nat Chem Biol 4:3-6. 2008
  2. pmc Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
    Gabriel A Roybal
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA, USA
    Nucleic Acids Res 38:6664-72. 2010
  3. pmc Spliceosome database: a tool for tracking components of the spliceosome
    Ivan Cvitkovic
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    Nucleic Acids Res 41:D132-41. 2013
  4. pmc Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate
    Patricia Coltri
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS ONE 6:e19061. 2011
  5. ncbi request reprint Three-dimensional structure of C complex spliceosomes by electron microscopy
    Melissa S Jurica
    Howard Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Struct Mol Biol 11:265-9. 2004
  6. pmc Detailed close-ups and the big picture of spliceosomes
    Melissa S Jurica
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, CA 95064, United States
    Curr Opin Struct Biol 18:315-20. 2008
  7. pmc The role of exon sequences in C complex spliceosome structure
    Janine Ilagan
    Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    J Mol Biol 394:363-75. 2009
  8. doi request reprint Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3
    John T Little
    Department of Molecular, Cell, and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA 95064, USA
    J Biol Chem 283:8145-52. 2008
  9. pmc A protein-based EM label for RNA identifies the location of exons in spliceosomes
    Eric A Alcid
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, California 95064, USA
    Nat Struct Mol Biol 15:213-5. 2008
  10. pmc Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
    Thomas Ø Tange
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA
    RNA 11:1869-83. 2005

Collaborators

  • N Grigorieff
  • Melissa J Moore
  • Ivan Cvitkovic
  • Patricia Coltri
  • Gabriel A Roybal
  • A L Burlingame
  • Robert J Chalkley
  • Janine Ilagan
  • Eric A Alcid
  • John T Little
  • Thomas Ø Tange
  • Vienna L Reichert
  • Kerstin Effenberger
  • Patrick Yuh
  • Toshiharu Shibuya
  • Hervé Le Hir

Detail Information

Publications14

  1. ncbi request reprint Searching for a wrench to throw into the splicing machine
    Melissa S Jurica
    Center for Molecular Biology of RNA and the Department of Cell, Developmental and Molecular Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA
    Nat Chem Biol 4:3-6. 2008
  2. pmc Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
    Gabriel A Roybal
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA, USA
    Nucleic Acids Res 38:6664-72. 2010
    ..This work establishes SSA as a powerful tool for dissecting the dynamics of spliceosomes in cells. In addition our data will inform the design of synthetic splicing modulator compounds for targeted anti-tumor treatment...
  3. pmc Spliceosome database: a tool for tracking components of the spliceosome
    Ivan Cvitkovic
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    Nucleic Acids Res 41:D132-41. 2013
    ..Together, the information in the database provides an easy reference for spliceosome components and will support future modeling of spliceosome structure and dynamics...
  4. pmc Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate
    Patricia Coltri
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS ONE 6:e19061. 2011
    ..The results also suggest a set of candidate proteins that hold the lariat-intron intermediate together in C complex. This information is critical for further interpreting the complex architecture of the mammalian spliceosome...
  5. ncbi request reprint Three-dimensional structure of C complex spliceosomes by electron microscopy
    Melissa S Jurica
    Howard Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Struct Mol Biol 11:265-9. 2004
    ..The structure reveals a particle of dimensions 27 x 22 x 24 nm with a relatively open arrangement of three primary domains...
  6. pmc Detailed close-ups and the big picture of spliceosomes
    Melissa S Jurica
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, CA 95064, United States
    Curr Opin Struct Biol 18:315-20. 2008
    ....
  7. pmc The role of exon sequences in C complex spliceosome structure
    Janine Ilagan
    Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    J Mol Biol 394:363-75. 2009
    ..Trimming the 3' exon does, however, alter the distribution of particles that appear to be missing some density, suggesting that the exon plays a role in stabilizing C complex...
  8. doi request reprint Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3
    John T Little
    Department of Molecular, Cell, and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, CA 95064, USA
    J Biol Chem 283:8145-52. 2008
    ..Finally, we note that SPF30 and its partner-interacting domains are not conserved in yeast, suggesting this interaction network may play an important role in the complex splicing observed in higher eukaryotes...
  9. pmc A protein-based EM label for RNA identifies the location of exons in spliceosomes
    Eric A Alcid
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, 1156 High Street, Santa Cruz, California 95064, USA
    Nat Struct Mol Biol 15:213-5. 2008
    ..This labeling strategy will serve as a general tool for analyzing the structures of RNA-containing macromolecular complexes...
  10. pmc Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
    Thomas Ø Tange
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA
    RNA 11:1869-83. 2005
    ..Using the same methodology, we further identified what appears to be the minimal stable EJC core, a heterotetrameric complex consisting of eIF4AIII, Magoh, Y14, and MLN51...
  11. ncbi request reprint Pre-mRNA splicing: awash in a sea of proteins
    Melissa S Jurica
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Mol Cell 12:5-14. 2003
    ..Another recurring theme regards the dynamic nature of spliceosomal complexes, which may be even more intricate than previously thought...
  12. ncbi request reprint Capturing splicing complexes to study structure and mechanism
    Melissa S Jurica
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Methods 28:336-45. 2002
    ..In this paper, we describe the purification in detail and discuss additional methods for trapping and analyzing other splicing complexes...
  13. pmc 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
    Vienna L Reichert
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Massachusetts 02454, USA
    Genes Dev 16:2778-91. 2002
    ..Upon exon ligation, association of RNPS1, UAP56, and SRm160 is destabilized. In contrast, REF/Aly, Y14, and Magoh remain stably bound to spliced mRNA, indicating that these three proteins are components of the EJC core...
  14. pmc Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis
    Melissa S Jurica
    Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA
    RNA 8:426-39. 2002
    ..These images represent an important first step toward attaining a comprehensive three-dimensional understanding of pre-mRNA splicing...