Jonathan J Juliano

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina Doctor of Medicine Doctor of Philosophy Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Department of Parasitology, School of Public Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania Institut Pasteur de Madagascar, Antananarivo, Madagascar Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo National Institute of Immunology NII, Department of Biotechnology, Aruna Asif Ali Marg, New Delhi, India Department of Medicine, Sriram Chandra Bhanj S C B Medical College, Odisha, India University of North Carolina Project, Lilongwe, Malawi Malaria Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden International Maternal and Child Health Unit, Uppsala University
    Am J Trop Med Hyg 94:143-6. 2016
  2. pmc Detection of the dihydrofolate reductase-164L mutation in Plasmodium falciparum infections from Malawi by heteroduplex tracking assay
    Jonathan J Juliano
    Division of Infectious Diseases, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7300, USA
    Am J Trop Med Hyg 78:892-4. 2008
  3. pmc Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar
    Jonathan J Juliano
    University of North Carolina, Chapel Hill, USA
    Malar J 8:47. 2009
  4. pmc Novel dhps and pfcrt polymorphisms in Plasmodium falciparum detected by heteroduplex tracking assay
    Jonathan J Juliano
    Division of Infectious Diseases, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7300, USA
    Am J Trop Med Hyg 80:734-6. 2009
  5. pmc Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
    Proc Natl Acad Sci U S A 107:20138-43. 2010
  6. ncbi request reprint Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi
    Jonathan J Juliano
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Emerg Infect Dis 13:872-7. 2007
  7. pmc Epidemiology of Plasmodium falciparum gametocytemia in India: prevalence, age structure, risk factors and the role of a predictive score for detection
    Naman K Shah
    School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Trop Med Int Health 18:800-9. 2013
  8. pmc Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 (pvmdr1) polymorphisms
    Jessica T Lin
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Am J Trop Med Hyg 88:1116-23. 2013
  9. pmc Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA
    Sci Rep 3:1165. 2013
  10. pmc Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Infect Dis 200:624-8. 2009

Collaborators

Detail Information

Publications33

  1. pmc Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina Doctor of Medicine Doctor of Philosophy Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina Department of Parasitology, School of Public Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania Institut Pasteur de Madagascar, Antananarivo, Madagascar Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo National Institute of Immunology NII, Department of Biotechnology, Aruna Asif Ali Marg, New Delhi, India Department of Medicine, Sriram Chandra Bhanj S C B Medical College, Odisha, India University of North Carolina Project, Lilongwe, Malawi Malaria Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden International Maternal and Child Health Unit, Uppsala University
    Am J Trop Med Hyg 94:143-6. 2016
    ..Pooled deep sequencing provides a scalable and cost-effective approach for the targeted study of allele frequencies of P. falciparum candidate vaccine antigens. ..
  2. pmc Detection of the dihydrofolate reductase-164L mutation in Plasmodium falciparum infections from Malawi by heteroduplex tracking assay
    Jonathan J Juliano
    Division of Infectious Diseases, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7300, USA
    Am J Trop Med Hyg 78:892-4. 2008
    ..Using this assay, we confirmed the presence of the mutation in P. falciparum infections in Malawi...
  3. pmc Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar
    Jonathan J Juliano
    University of North Carolina, Chapel Hill, USA
    Malar J 8:47. 2009
    ..falciparum minority variants in individual patients that were undetectable by conventional PCR. However, as this assay required a radiolabeled probe, it could not be used in many resource-limited settings...
  4. pmc Novel dhps and pfcrt polymorphisms in Plasmodium falciparum detected by heteroduplex tracking assay
    Jonathan J Juliano
    Division of Infectious Diseases, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7300, USA
    Am J Trop Med Hyg 80:734-6. 2009
    ..In Peru, we found no drug-resistant minority variants and a synonymous mutation in dhps. Thus, even in regions of low malaria transmission, HTA assays are more informative than PCR with agarose gel electrophoresis...
  5. pmc Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC 27514, USA
    Proc Natl Acad Sci U S A 107:20138-43. 2010
    ..The combination of ecological statistics and massively parallel pyrosequencing provides a powerful tool for studying the evolution of drug resistance and the in-host ecology of malaria infections...
  6. ncbi request reprint Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi
    Jonathan J Juliano
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Emerg Infect Dis 13:872-7. 2007
    ..Surveillance for minority-variant drug resistant mutations may be useful in making antimalarial drug policy...
  7. pmc Epidemiology of Plasmodium falciparum gametocytemia in India: prevalence, age structure, risk factors and the role of a predictive score for detection
    Naman K Shah
    School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Trop Med Int Health 18:800-9. 2013
    ..To characterise the epidemiology of Plasmodium falciparum gametocytemia and determine the prevalence, age structure and the viability of a predictive model for detection...
  8. pmc Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 (pvmdr1) polymorphisms
    Jessica T Lin
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Am J Trop Med Hyg 88:1116-23. 2013
    ..Finally, genotyping of paired isolates from individuals suspected of suffering relapse supports a complex scheme of relapse whereby recurrence of multiple identical variants is sometimes accompanied by the appearance of novel variants...
  9. pmc Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA
    Sci Rep 3:1165. 2013
    ..Given the importance of central Africa as a corridor for the spread of antimalarial resistance, the identification of the mechanisms of this transit can inform future policies to contain drug-resistant parasite strains...
  10. pmc Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia
    Jonathan J Juliano
    Division of Infectious Diseases, School of Medicine, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Infect Dis 200:624-8. 2009
    ..Misclassification in this manner overestimates the efficacy of antimalarials and delays the recognition of decreasing therapeutic efficacy, thus delaying potential changes in policy...
  11. pmc Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi
    Natalie M Bowman
    University of North Carolina Chapel Hill, Department of Medicine, Division of Infectious Diseases, Chapel Hill, NC, USA
    Sci Rep 3:1990. 2013
    ..We show that P. falciparum is very diverse with respect to NANP repeat length even on a local level and that diversity appears higher in children...
  12. pmc Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse
    Jessica T Lin
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Clin Microbiol 50:1449-51. 2012
    ..Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described...
  13. pmc A Prolonged Outbreak of KPC-3-Producing Enterobacter cloacae and Klebsiella pneumoniae Driven by Multiple Mechanisms of Resistance Transmission at a Large Academic Burn Center
    Hajime Kanamori
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 61:. 2017
    ....
  14. pmc Longitudinal Pooled Deep Sequencing of the Plasmodium vivax K12 Kelch Gene in Cambodia Reveals a Lack of Selection by Artemisinin
    Nicholas F Brazeau
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina
    Am J Trop Med Hyg 95:1409-1412. 2016
    ..These results suggest a lack of selection in the P. vivax population in Cambodia due to artemisinin drug pressure...
  15. pmc Development of a capillary electrophoresis-based heteroduplex tracking assay to measure in-host genetic diversity of initial and recurrent Plasmodium vivax infections in Cambodia
    Matthew B Givens
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Clin Microbiol 52:298-301. 2014
    ..vivax infections in Cambodia. More than half of the recurrent parasitemias sampled displayed identical or highly related genotypes compared to the initial genotype, suggesting that they represented relapses. ..
  16. pmc Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse
    Jessica T Lin
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill
    J Infect Dis 212:999-1008. 2015
    ..In areas of high P. vivax diversity, targeted deep sequencing can help detect genetic signatures of relapse, key to evaluating antivivax interventions and achieving a better understanding of relapse-reinfection epidemiology. ..
  17. pmc Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of Plasmodium falciparum gametocytes
    Naman K Shah
    School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 57:2948-54. 2013
    ..falciparum gametocytes. Primaquine was well tolerated and could be administered along with an artemisinin combination therapy as the first-line therapy...
  18. pmc Mefloquine exposure induces cell cycle delay and reveals stage-specific expression of the pfmdr1 gene
    Elaine B Bohórquez
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 57:833-9. 2013
    ..These results suggest that MFQ-induced increases in pfmdr1 expression are the direct result of the maturation delay at the ring stage but that this change in expression does not affect the antimalarial activity of artemisinin...
  19. pmc Molecular malaria epidemiology: mapping and burden estimates for the Democratic Republic of the Congo, 2007
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e16420. 2011
    ..We employed new high-throughput molecular testing to characterize the state of malaria control in the DRC and estimate childhood mortality attributable to excess malaria transmission...
  20. pmc The perils of PCR: can we accurately 'correct' antimalarial trials?
    Jonathan J Juliano
    Division of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Trends Parasitol 26:119-24. 2010
    ..This article considers these limitations and proposes a framework for reporting, interpreting and improving PCR correction of antimalarial trials...
  21. doi request reprint Does this patient have malaria?
    Steve M Taylor
    Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
    JAMA 304:2048-56. 2010
    ..Malaria commonly infects residents of and travelers to tropical regions. The clinical features of infection are notoriously nonspecific but have not been comprehensively evaluated...
  22. pmc Longevity of Genotype-Specific Immune Responses to Plasmodium falciparum Merozoite Surface Protein 1 in Kenyan Children from Regions of Different Malaria Transmission Intensity
    Natalie M Bowman
    Division of Infectious Diseases, University of North Carolina, School of Medicine, Chapel Hill, North Carolina
    Am J Trop Med Hyg 95:580-7. 2016
    ....
  23. doi request reprint Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study
    Michele D Spring
    Armed Forces Research Institute of Medical Sciences, Department of Immunology and Medicine, Bangkok, Thailand
    Lancet Infect Dis 15:683-91. 2015
    ..We aimed to assess the efficacy of standard 3 day dihydroartemisinin-piperaquine treatment of uncomplicated P falciparum malaria, with and without the addition of primaquine, focusing on the factors involved in drug resistance...
  24. pmc Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens
    Christian M Parobek
    School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Negl Trop Dis 8:e2796. 2014
    ..Better understanding the geographic distribution of genetic variability in vaccine candidate antigens will be key to designing and implementing efficacious vaccines...
  25. pmc Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions
    Nagesh R Aragam
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e62427. 2013
    ....
  26. pmc High-throughput pooling and real-time PCR-based strategy for malaria detection
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Microbiol 48:512-9. 2010
    ..Our study highlights both substantial discordance between malaria diagnostics and the utility and parsimony of employing a sample pooling strategy for molecular diagnostics in clinical and epidemiologic malaria studies...
  27. pmc Estimation of Plasmodium falciparum Transmission Intensity in Lilongwe, Malawi, by Microscopy, Rapid Diagnostic Testing, and Nucleic Acid Detection
    Jonathan B Parr
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina
    Am J Trop Med Hyg 95:373-7. 2016
    ..Molecular methods should be considered for use in future transmission studies as a supplement to RDT or microscopy. ..
  28. pmc Multilocus microsatellite genotyping array for investigation of genetic epidemiology of Pneumocystis jirovecii
    Christian M Parobek
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Clin Microbiol 52:1391-9. 2014
    ..These features suggest that this novel microsatellite typing approach will be an effective tool for molecular-epidemiological investigations into P. jirovecii population structure, transmission, and drug resistance. ..
  29. pmc Next-Generation Sequencing and Comparative Analysis of Sequential Outbreaks Caused by Multidrug-Resistant Acinetobacter baumannii at a Large Academic Burn Center
    Hajime Kanamori
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA Hospital Epidemiology, University of North Carolina Health Care, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 60:1249-57. 2015
    ..NGS-based analysis demonstrated the superior resolution of outbreak transmission networks for MDRAB and provided insight into the mechanisms of strain diversification between sequential outbreaks through recombination. ..
  30. pmc Efficacy of two versus three-day regimens of dihydroartemisinin-piperaquine for uncomplicated malaria in military personnel in northern Cambodia: an open-label randomized trial
    Chanthap Lon
    US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Department of Immunology and Medicine, Bangkok, Thailand US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Phnom Penh, Cambodia
    PLoS ONE 9:e93138. 2014
    ..We compared two regimens of dihydroartemisinin-piperaquine in military and civilians on the Thai-Cambodian border to evaluate national treatment policy...
  31. pmc Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study
    Steve M Taylor
    Division of Infectious Diseases, Department of Medicine Duke Global Health Institute, Duke University Medical Center, Durham Department of Epidemiology, Gillings School of Global Public Health
    J Infect Dis 211:680-8. 2015
    ..Rapid, scalable molecular surveillance offers a useful adjunct in tracking and containing artemisinin resistance. ..
  32. pmc Can pharmacogenomics improve malaria drug policy?
    Mary W Roederer
    Institute of Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina, 120 Mason Farm Road, Chapel Hill, NC 27599 7361, United States of America
    Bull World Health Organ 89:838-45. 2011
    ..We also consider current knowledge on some component drugs of artemisinin combination therapies and ways to increase our understanding of host genetics, with the goal of guiding policy decisions for drug selection...
  33. pmc Drug-Resistant Malaria: The Era of ACT
    Jessica T Lin
    Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, 27514, USA
    Curr Infect Dis Rep 12:165-73. 2010
    ....