Andrew R Judge

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70
    Sarah M Senf
    Department of Physical Therapy, 101 S Newell Dr, PO Box 100154, Univ of Florida, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 298:C38-45. 2010
  2. pmc Diaphragm and ventilatory dysfunction during cancer cachexia
    Brandon M Roberts
    Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA
    FASEB J 27:2600-10. 2013
  3. pmc Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy
    Stephen L Dodd
    Department of Applied Physiology and Kinesiology, 25 Stadium Rd, University of Florida, Gainesville, FL 32611, USA
    FASEB J 23:3415-23. 2009
  4. pmc Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy
    Sarah A Reed
    Department of Physical Therapy, 101 S Newell Dr, University of Florida, Gainesville, FL 32611, USA
    FASEB J 26:987-1000. 2012
  5. pmc Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
  6. pmc HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy
    Adam W Beharry
    Department of Physical Therapy, University of Florida, Gainesville, FL 32610 0154, USA
    J Cell Sci 127:1441-53. 2014
  7. doi request reprint IκBα degradation is necessary for skeletal muscle atrophy associated with contractile claudication
    Brian A Hain
    Department of Applied Physiology, Univ of Florida, Gainesville, 32611, USA
    Am J Physiol Regul Integr Comp Physiol 300:R595-604. 2011
  8. pmc Oxidative stress and disuse muscle atrophy: cause or consequence?
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Curr Opin Clin Nutr Metab Care 15:240-5. 2012
  9. doi request reprint Determination of gene promoter activity in skeletal muscles in vivo
    Sarah M Senf
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 798:461-72. 2012
  10. pmc Ros-mediated activation of NF-kappaB and Foxo during muscle disuse
    Stephen L Dodd
    Department of Applied Physiology and Kinesiology, University of Florida, P O Box 118205, Gainesville, Florida 32611, USA
    Muscle Nerve 41:110-3. 2010

Collaborators

Detail Information

Publications24

  1. pmc FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70
    Sarah M Senf
    Department of Physical Therapy, 101 S Newell Dr, PO Box 100154, Univ of Florida, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 298:C38-45. 2010
    ..In summary, FOXO signaling is required for physiological muscle atrophy and is directly inhibited by Hsp70...
  2. pmc Diaphragm and ventilatory dysfunction during cancer cachexia
    Brandon M Roberts
    Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA
    FASEB J 27:2600-10. 2013
    ..These data demonstrate that C-26 cancer cachexia causes profound respiratory muscle atrophy and weakness and ventilatory dysfunction...
  3. pmc Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy
    Stephen L Dodd
    Department of Applied Physiology and Kinesiology, 25 Stadium Rd, University of Florida, Gainesville, FL 32611, USA
    FASEB J 23:3415-23. 2009
    ..In conclusion, Hsp27 is a negative regulator of NF-kappaB in skeletal muscle, in vivo, and is sufficient to inhibit MuRF1 and atrogin-1 and attenuate skeletal muscle disuse atrophy...
  4. pmc Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy
    Sarah A Reed
    Department of Physical Therapy, 101 S Newell Dr, University of Florida, Gainesville, FL 32611, USA
    FASEB J 26:987-1000. 2012
    ....
  5. pmc Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
    ..In conclusion, advanced age is associated with disruption of muscle iron metabolism which is further perturbed by disuse and persists over a longer time period...
  6. pmc HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy
    Adam W Beharry
    Department of Physical Therapy, University of Florida, Gainesville, FL 32610 0154, USA
    J Cell Sci 127:1441-53. 2014
    ..Together, these data solidify the importance of class I HDACs in the muscle atrophy program and indicate that class I HDAC inhibitors are feasible countermeasures to impede muscle atrophy and weakness...
  7. doi request reprint IκBα degradation is necessary for skeletal muscle atrophy associated with contractile claudication
    Brian A Hain
    Department of Applied Physiology, Univ of Florida, Gainesville, 32611, USA
    Am J Physiol Regul Integr Comp Physiol 300:R595-604. 2011
    ..These findings demonstrate that when blood flow to skeletal muscle is restricted, repeated cycles of muscle contraction can cause muscle fiber atrophy that requires NF-κB-IκBα signaling...
  8. pmc Oxidative stress and disuse muscle atrophy: cause or consequence?
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Curr Opin Clin Nutr Metab Care 15:240-5. 2012
    ..This review will discuss the evidence both for and against the concept that reactive oxygen species (ROS) play an important role in the regulation of inactivity-induced skeletal muscle atrophy...
  9. doi request reprint Determination of gene promoter activity in skeletal muscles in vivo
    Sarah M Senf
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 798:461-72. 2012
    ..Therefore, the use of such gene promoter reporters allows for an in-depth physiological assessment of the gene's transcriptional regulation...
  10. pmc Ros-mediated activation of NF-kappaB and Foxo during muscle disuse
    Stephen L Dodd
    Department of Applied Physiology and Kinesiology, University of Florida, P O Box 118205, Gainesville, Florida 32611, USA
    Muscle Nerve 41:110-3. 2010
    ..Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy...
  11. pmc Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia
    Sarah M Judge
    Department of Physical Therapy, University of Florida, 1225 Center Drive, HPNP Building 1142, Gainesville, Florida, USA
    BMC Cancer 14:997. 2014
    ..We hypothesize that FoxO is a central upstream regulator of diverse gene networks in skeletal muscle during cancer that may act coordinately to promote the wasting phenotype...
  12. pmc Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration
    Sarah M Senf
    Department of Physical Therapy, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e62687. 2013
    ....
  13. pmc Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension
    Bumsoo Ahn
    Department of Applied Physiology and Kinesiology University of Florida, Gainesville, Florida, USA
    PLoS ONE 8:e62702. 2013
    ..Overall, the murine model of PH elicited by MCT mimics loss of body weight and diaphragm muscle weakness reported in PH patients...
  14. doi request reprint Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy
    Sarah M Senf
    Department of Applied Physiology and Kinesiology, 25 Stadium Rd, University of Florida, Gainesville, FL 32611, USA
    FASEB J 22:3836-45. 2008
    ..We conclude that overexpression of Hsp70 is sufficient to inhibit key atrophy signaling pathways and prevent skeletal muscle atrophy...
  15. pmc Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy
    Daniel J Ryder
    Department of Physical Therapy, University of Florida, Gainesville, FL, United States of America
    PLoS ONE 10:e0136247. 2015
    ....
  16. doi request reprint Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle
    Fan Ye
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL, United States Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States Electronic address
    Steroids 87:59-66. 2014
    ..In addition, testosterone increased WISP-2 protein levels. Together, these findings identify specific mechanisms by which testosterone and trenbolone may regulate skeletal muscle maintenance and growth. ..
  17. doi request reprint Skeletal muscle interleukin-6 regulation in hyperthermia
    Steven S Welc
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 305:C406-13. 2013
    ....
  18. pmc Differential expression of HDAC and HAT genes in atrophying skeletal muscle
    Adam W Beharry
    Department of Physical Therapy, 101 S Newell Drive, P O Box 100154, University of Florida, Gainesville, Florida, USA, 32610
    Muscle Nerve 52:1098-101. 2015
    ..Despite this, it remains unknown whether a common or unique transcriptional profile of HDAC and HAT genes exist during the progression of muscle atrophy...
  19. pmc Forelimb muscle plasticity following unilateral cervical spinal cord injury
    Elisa J Gonzalez-Rothi
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P O Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA
    Muscle Nerve 53:475-8. 2016
    ..Motor dysfunction and muscle atrophy are well documented in the lower extremity after spinal cord injury. However, the extent and time course of myoplastic changes in forelimb musculature is not clear...
  20. pmc p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle
    Sarah M Senf
    Dept of Physical Therapy, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 300:C1490-501. 2011
    ....
  21. pmc Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy
    Thomas W Buford
    Institute on Aging, University of Florida, Gainesville, FL 32611, United States
    Ageing Res Rev 9:369-83. 2010
    ..Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia...
  22. ncbi request reprint Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats
    Joshua T Selsby
    Muscle Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, P O Box 118205, Gainesville, FL 32611, USA
    Exp Gerontol 40:37-42. 2005
    ..The large increase in HSP 90 is intriguing and further studies are required to elucidate its role in maintaining 20S proteasome function...