S B Joseph
Affiliation: University of North Carolina
- HIV-1 target cells in the CNSSarah B Joseph
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
J Neurovirol 21:276-89. 2015..Prior to the evolution of macrophage-tropic variants, the viruses that are predominately infecting T cells (R5 T cell-tropic) may infect macrophages at a low level and inefficiently, but this could contribute to the reservoir. ..
- Effects of the [PSI+] prion on rates of adaptation in yeastS B Joseph
Section of Integrative Biology, University of Texas, Austin, TX, USA
J Evol Biol 21:773-80. 2008..A major factor affecting the rate of adaptation was initial fitness in the new environment: lines with low initial fitness evolved faster than lines with high initial fitness...
- Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expectedSarah B Joseph
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
Genetics 168:1817-25. 2004..The mutation rate was estimated as 6.3 x 10(-5) mutations per haploid genome per generation and the average heterozygous fitness effect of a mutation as 0.061. These estimates are compatible with previous estimates in yeast...
- Spontaneous mutations in diploid Saccharomyces cerevisiae: another thousand cell generationsDavid W Hall
Department of Biological Sciences, University of Texas, Austin, TX 78712, USA
Genet Res (Camb) 90:229-41. 2008..We also estimate the genome-wide mutation rate to be 13.7x10-5 mutations per haploid genome per cell generation and the absolute value of the average heterozygous effect of a mutation to be 7.3%...
- The Causes and Consequences of Complementation and Selfishness in VirusesSarah Joseph; Fiscal Year: 2008..As a result, understanding these interactions in bacteriophage may provide insights into the evolution and pathogenesis of viral pathogens of humans. [unreadable] [unreadable] [unreadable]..