Kelly L Jordan-Sciutto

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Expression of Nrf2 in neurodegenerative diseases
    Chenere P Ramsey
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:75-85. 2007
  2. pmc Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis
    Kelly L Jordan-Sciutto
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:2185-95. 2002
  3. ncbi request reprint Expression patterns of retinoblastoma protein in Parkinson disease
    Kelly L Jordan-Sciutto
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neuropathol Exp Neurol 62:68-74. 2003
  4. pmc Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania, 4010 Locust Street, Philadelphia, Pennsylvania 19104 6030, USA
    Biochemistry 43:12113-22. 2004
  5. ncbi request reprint Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania, 240 S 40th St, Room 312 Levy Bldg, Philadelphia, PA 19104 6030, USA
    Exp Neurol 193:455-68. 2005
  6. ncbi request reprint The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust St, Rm 312 Levy Research, Philadelphia 19104 6002, USA
    J Cell Biochem 88:557-68. 2003
  7. pmc Altered distribution of cell cycle transcriptional regulators during Alzheimer disease
    Kelly L Jordan-Sciutto
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Neuropathol Exp Neurol 61:358-67. 2002
  8. pmc Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration
    Michael G White
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Res 70:220-9. 2011
  9. pmc Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection
    Stephanie A Cross
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 187:5015-25. 2011
  10. ncbi request reprint Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis
    Elizabeth M Chalovich
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Neuropathology 25:315-25. 2005

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Expression of Nrf2 in neurodegenerative diseases
    Chenere P Ramsey
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:75-85. 2007
    ..In PD, nuclear localization of Nrf2 is strongly induced, but this response may be insufficient to protect neurons from degeneration...
  2. pmc Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis
    Kelly L Jordan-Sciutto
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:2185-95. 2002
    ....
  3. ncbi request reprint Expression patterns of retinoblastoma protein in Parkinson disease
    Kelly L Jordan-Sciutto
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neuropathol Exp Neurol 62:68-74. 2003
    ..These results indicate that there are changes in pRb and its inactive phospho-isoform in neurons responding to neurodegenerative stimuli associated with PD...
  4. pmc Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania, 4010 Locust Street, Philadelphia, Pennsylvania 19104 6030, USA
    Biochemistry 43:12113-22. 2004
    ..Furthermore, the observed competition between FAC1 and Nrf2 for binding hKeap1 indicates that the interplay between these three proteins has important implications for neuronal response to oxidative stress...
  5. ncbi request reprint Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania, 240 S 40th St, Room 312 Levy Bldg, Philadelphia, PA 19104 6030, USA
    Exp Neurol 193:455-68. 2005
    ..These findings demonstrate that alterations in ppRb distribution and E2F1 antigen availability by NTF and chemokines occur by distinct mechanisms suggesting that E2F1 function may be independent of pRb regulation in post-mitotic neurons...
  6. ncbi request reprint The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust St, Rm 312 Levy Research, Philadelphia 19104 6002, USA
    J Cell Biochem 88:557-68. 2003
    ..These data indicate that the MDMX protein is capable of associating with E2F-1 and negatively regulating its DNA binding ability...
  7. pmc Altered distribution of cell cycle transcriptional regulators during Alzheimer disease
    Kelly L Jordan-Sciutto
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Neuropathol Exp Neurol 61:358-67. 2002
    ..Although neither of these proteins significantly co-localized with NFTs, both ppRb and E2F1 were found in cells surrounding a subset of Abeta-containing plaques. These results support a role for G1 to S phase cell cycle regulators in AD...
  8. pmc Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration
    Michael G White
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Res 70:220-9. 2011
    ....
  9. pmc Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection
    Stephanie A Cross
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 187:5015-25. 2011
    ..We propose that dysregulation of the antioxidant response during HIV infection drives macrophage-mediated neurotoxicity and that DMF could serve as an adjunctive neuroprotectant and HIV disease modifier in ART-treated individuals...
  10. ncbi request reprint Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis
    Elizabeth M Chalovich
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Neuropathology 25:315-25. 2005
    ..These findings suggest that p107 and p130 are differentially expressed in CNS macrophage populations which may have multiple derivations and/or roles in lentiviral encephalitis...
  11. pmc NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury
    Denise R Cook
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 118:1113-23. 2011
    ..Defining apelin-mediated neuroprotection advances our understanding of neuroprotective pathways and will potentially improve our ability to develop therapeutics for excitotoxicity-associated neurodegenerative disorders...
  12. pmc E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    Neurosci Lett 479:97-101. 2010
    ..We propose that the predominantly cytoplasmic localization of E2F1 in neurons may account for the lack of E2F1 target transactivation in neurons responding to HIV-induced neurotoxicity...
  13. pmc Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical cultures
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6030, USA
    Neuroreport 23:1052-8. 2012
    ..The findings presented here show that neuronal cell death mechanisms vary with culture age and highlight the necessity of considering culture age when interpreting neural cell culture data...
  14. ncbi request reprint Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells
    James Rhodes
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuroreport 14:449-52. 2003
    ..These findings suggest that FAC1 expression and subcellular localization are regulated by NGF signaling pathways during neurite outgrowth...
  15. ncbi request reprint Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes
    Lauren A O'Donnell
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:981-90. 2006
    ..Antagonists of NR2A and NR2B subunits as well as inhibitors of calpain activation offer attractive neuroprotective approaches against HIV in both developing and mature brain...
  16. pmc Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits
    Jenhao H Ting
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 129:850-63. 2014
    ..Coincident with these behavioral changes, we also found age-matched synaptic disruption and persisting reduction in adult neurogenesis. Our study demonstrates that E2F1 contributes to physiologic brain structure and function. ..
  17. pmc E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity
    Jacob W Zyskind
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 132:742-55. 2015
    ..Calpain-cleaved E2F1 may contribute to calpain-mediated neuronal damage observed in NMDA receptor-mediated neurotoxicity (6). ..
  18. ncbi request reprint Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 103:439-55. 2007
    ..Taken together, our data suggest calpain activation of CDK5, a pathway activated in HIV-infected individuals, can mediate neuronal damage and death in a model of HIV-induced neurotoxicity...
  19. ncbi request reprint Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death
    Gordon D Strachan
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    Biochem Biophys Res Commun 336:490-5. 2005
    ..Disruption of the Keap1:Nrf2 interaction enhances FAC1 induction of apoptosis. These findings suggest a role for FAC1 in apoptosis following release of Nrf2 from Keap1 in response to oxidative stress...
  20. pmc HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities
    Kathryn A Lindl
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 S 40th St, Room 312 Levy Building, Philadelphia, PA 19104 6030, USA
    J Neuroimmune Pharmacol 5:294-309. 2010
    ..By considering the specific mechanisms and consequences of HIV neuropathogenesis, unified approaches for neuroprotection will likely emerge using a tailored, combined, and non-invasive approach...
  21. ncbi request reprint E2F4 expression patterns in SIV encephalitis
    Kathleen L Morgan
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, 240 S 40th St, Rm 312 Levy Bldg, Philadelphia, PA 19104 6030, USA
    Neurosci Lett 382:259-64. 2005
    ..When E2F4 is normalized to MAP2, we found an increase in E2F4 fluorescence intensity per MAP2 in SIVE mid-frontal cortex. These findings suggest changes in E2F4 may be contributing to altered neuronal morphology or survival in SIVE...
  22. ncbi request reprint E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis
    Gordon D Strachan
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6030, USA
    J Cell Biochem 96:728-40. 2005
    ..Together these experiments support a new function for E2F1 in the activation of calpain proteases and suggest a role for this pathway in SIVE...
  23. pmc Location, location, location: altered transcription factor trafficking in neurodegeneration
    Charleen T Chu
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:873-83. 2007
    ..Studying the pathophysiologic mechanisms regulating transcription factor localization should facilitate strategies to bypass deficits and restore adaptive neuroprotective transcriptional responses...
  24. pmc Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin
    Kathleen Boesze-Battaglia
    Department of Biochemistry, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
    Cell Microbiol 8:823-36. 2006
    ..Thus, lipid raft integrity is vital to the action of Cdt on host cells. The implications of our observations with respect to Cdt mode of action are discussed...
  25. pmc Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage
    Daniel J Colacurcio
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 312 Levy Building, 240 South 40th Street, Philadelphia, PA 19104, United States
    Mol Cell Neurosci 57:54-62. 2013
    ....
  26. pmc Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage
    Daniel J Colacurcio
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 S 40th Street, Levy Building, Room 323, Philadelphia, PA 19104, USA
    Neurosci Lett 609:182-8. 2015
    ....
  27. pmc Painful facet joint injury induces neuronal stress activation in the DRG: implications for cellular mechanisms of pain
    Ling Dong
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 443:90-4. 2008
    ..03) in injury compared to sham at day 7. Findings suggest neuronal stress activation is associated with painful facet joint injury, and that joint loading may directly mediate the behavior of DRG neurons in this class of injury...
  28. pmc p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 70:596-609. 2011
    ..These results provide insights into cell cycle deregulation in the pathogenesis of human MRT and may aid in the design and evaluation of potential therapies for these tumors...
  29. ncbi request reprint Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease
    Kelly L Jordan-Sciutto
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Alzheimers Dis 1:409-417. 1999
    ..In addition, cyclin G1 immunoreactivity was not evident in cells containing cytoskeletal pathology...
  30. doi request reprint Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro
    Hubert Monnerie
    Department of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurochem . 2016
    ..This suggests SREBPs activity during oligodendrocyte maturation is required for myelin formation and integrity...
  31. pmc Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue
    Kathryn A Lindl
    Robert Schattner Center, School of Dental Medicine, Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA
    Methods Mol Biol 477:229-43. 2008
    ..Immunofluorescent analysis (IFA) of Nrf2 in human tissue is a particularly powerful tool in the study of Nrf2 in disease, because it allows examination of both of these regulatory mechanisms that modulate Nrf2 activity...
  32. pmc Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
    Cagla Akay
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 S 40th St, Rm 312 Levy Bldg, Philadelphia, PA, 19104 6030, USA
    J Neurovirol 20:39-53. 2014
    ....
  33. ncbi request reprint Identification of interacting proteins using the yeast two-hybrid screen
    Kelly L Jordan-Sciutto
    Department of Pathology, School of Dental Medicine, The University of Pennsylvania, Philadelphia, USA
    Methods Mol Biol 332:211-31. 2006
    ..Here we describe a two-hybrid yeast system that has been used to successfully characterize protein interactions among signaling molecules...
  34. ncbi request reprint Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact
    E Berla Thangam
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    FASEB J 19:798-800. 2005
    ....
  35. pmc Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
    Patrice D Smith
    Neuroscience Group, Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 100:13650-5. 2003
    ..We propose that cdk5 is a key regulator in the degeneration of dopaminergic neurons in Parkinson's disease...
  36. ncbi request reprint Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist
    Ying Wang
    Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Peking University, 38 Xueyuan Rd, Beijing 100083, PR China
    Exp Neurol 202:313-23. 2006
    ....

Research Grants1

  1. Novel Pathways of HAARTmediated Neuronal Toxicity in the Central Nervous System
    Kelly L Jordan Sciutto; Fiscal Year: 2010
    ..abstract_text> ..