Candace S Johnson

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Antiproliferative effects of 1alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells
    Ronald J Bernardi
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 143:2508-14. 2002
  2. ncbi request reprint Vitamin D receptor: a potential target for intervention
    Candace S Johnson
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Urology 60:123-30; discussion 130-1. 2002
  3. ncbi request reprint Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
    Sanjay K Srivastava
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Carcinogenesis 24:1665-70. 2003
  4. ncbi request reprint Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    J Biol Chem 280:19911-24. 2005
  5. ncbi request reprint Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 3:567-75. 2004
  6. ncbi request reprint Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression
    Pamela A Hershberger
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 1:821-9. 2002
  7. ncbi request reprint Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    Kristin K Deeb
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Nat Rev Cancer 7:684-700. 2007
  8. ncbi request reprint Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses
    Josephia R Muindi
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Oncology 66:62-6. 2004
  9. ncbi request reprint Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
    Dong Xiao
    Department of Pharmacology and Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 23:5594-606. 2004
  10. ncbi request reprint Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel
    Josephia R Muindi
    Center for Clinical Pharmacology and Cancer Institute, University of Pittsburgh, PA 15213, USA
    Clin Pharmacol Ther 72:648-59. 2002

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Antiproliferative effects of 1alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells
    Ronald J Bernardi
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 143:2508-14. 2002
    ..Thus, our work supports the hypothesis that angiogenesis inhibition plays a role in the antitumor effects of 1,25-(OH)(2)D(3)...
  2. ncbi request reprint Vitamin D receptor: a potential target for intervention
    Candace S Johnson
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Urology 60:123-30; discussion 130-1. 2002
    ..Studies continue to define the MTD of calcitriol on this intermittent schedule, either alone or with other agents, and to evaluate the mechanisms of calcitriol effects in prostate cancer models...
  3. ncbi request reprint Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
    Sanjay K Srivastava
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Carcinogenesis 24:1665-70. 2003
    ..In conclusion, the results of the present study indicate that AITC administration inhibits growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity...
  4. ncbi request reprint Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    J Biol Chem 280:19911-24. 2005
    ....
  5. ncbi request reprint Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 3:567-75. 2004
    ..Furthermore, the results of the present study point toward involvement of both caspase-8- and caspase-9-mediated pathways in apoptosis induction by PEITC...
  6. ncbi request reprint Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression
    Pamela A Hershberger
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 1:821-9. 2002
    ..We propose that the increased cytotoxicity for 1,25D3/cisplatin results from cisplatin enhancement of 1,25D3-induced apoptotic signaling through MEKK-1...
  7. ncbi request reprint Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    Kristin K Deeb
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Nat Rev Cancer 7:684-700. 2007
    ..Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents...
  8. ncbi request reprint Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses
    Josephia R Muindi
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Oncology 66:62-6. 2004
    ..The objective of this study was to determine plasma calcitriol PK in normal mice at doses of calcitriol which are active in suppressing tumor growth...
  9. ncbi request reprint Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
    Dong Xiao
    Department of Pharmacology and Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 23:5594-606. 2004
    ..In conclusion, our data point towards important roles for Bcl-2, JNK and ERK in DATS-induced apoptosis in human prostate cancer cells...
  10. ncbi request reprint Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel
    Josephia R Muindi
    Center for Clinical Pharmacology and Cancer Institute, University of Pittsburgh, PA 15213, USA
    Clin Pharmacol Ther 72:648-59. 2002
    ..An additional goal was to evaluate the relationship between calcitriol dose and hypercalcemia...
  11. ncbi request reprint Calcitriol (1,25-dihydroxycholecalciferol) potentiates activity of mitoxantrone/dexamethasone in an androgen independent prostate cancer model
    Sharmila Ahmed
    Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    J Urol 168:756-61. 2002
    ..Therefore, we investigated the effect of calcitriol on the antitumor efficacy of mitoxantrone and dexamethasone or mitoxantrone/dexamethasone in the PC-3 androgen independent prostate cancer model...
  12. ncbi request reprint A limited sampling method for the estimation of serum calcitriol area under the curve in cancer patients
    Josephia R Muindi
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Pharmacol 43:894-900. 2003
    ..90, p = 0.0001). These results show that serum calcitriol AUC0-12 h after s.c. and p.o. calcitriol administration is accurately estimated using pretreatment and 2- and 6-hour blood samples...
  13. ncbi request reprint Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review
    Marwan Fakih
    Department ofMedicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Urology 60:553-61. 2002
  14. ncbi request reprint Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis
    Dong Xiao
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, PA 15213, USA
    Carcinogenesis 24:891-7. 2003
    ..In conclusion, it seems reasonable to hypothesize that AITC, and possibly other ITCs, may find use in the treatment of human prostate cancers...
  15. ncbi request reprint C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells
    Masatoshi Eto
    Department of Surgery Division of Biological Therapeutics, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15219, USA
    Prostate 57:66-79. 2003
    ....
  16. ncbi request reprint Phase I and pharmacokinetic study of vinblastine and high-dose megestrol acetate
    Khalid Matin
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Chemother Pharmacol 50:179-85. 2002
    ..Based on these data, we performed a phase I study of high-dose oral megestrol acetate and vinblastine to evaluate the safety of this regimen...
  17. ncbi request reprint CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines
    Josephia R Muindi
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlson Streets, Buffalo, NY 14263, USA
    J Steroid Biochem Mol Biol 103:334-7. 2007
    ..These results demonstrate that calcitriol treatment modulates CYP24 splicing, and suggests that differences in CYP24 splicing are associated with different patterns of CYP24 activity...
  18. ncbi request reprint Altered VDR-mediated transcriptional activity in prostate cancer stroma
    Alejandro A Hidalgo
    Department of Urologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Steroid Biochem Mol Biol 103:731-6. 2007
    ..These results indicate that VDR structure/function and coregulator recruitment to 1alpha,25(OH)(2)D(3) regulated genes is altered in the CaP stroma microenvironment...
  19. ncbi request reprint Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
    Ivy Chung
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:8704-14. 2007
    ....
  20. ncbi request reprint Antitumor effects of two less-calcemic vitamin D analogs (Paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells
    Adebusola A Alagbala
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, N Y, USA
    Oncology 70:483-92. 2006
    ..These less-calcemic vitamin D analogs are as effective as calcitriol in vitro and are promising for prevention and treatment of cancer and other diseases...
  21. ncbi request reprint Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis
    Geraldine Flynn
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, N Y, USA
    Oncology 70:447-57. 2006
    ..Thus calcitriol exerts differential effects on TDEC compared to normal cells...
  22. ncbi request reprint Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carcinoma
    Yingyu Ma
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14201, USA
    Cancer Res 66:8131-8. 2006
    ..1,25D3 induces the activation of phosphatidylinositol 3-kinase/Akt, which suppresses 1,25D3-mediated apoptosis and prolongs the survival of SCC cells...
  23. ncbi request reprint The antitumor efficacy of calcitriol: preclinical studies
    Candace S Johnson
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 26:2543-9. 2006
    ..These studies demonstrated that calcitriol has significant antiproliferative activity in a number of pre-clinical model systems and form the groundwork for on-going clinical studies investigating calcitriol as an anticancer agent...
  24. pmc 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model
    Yingyu Ma
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 7:3047-55. 2008
    ..The combination treatment may provide a more effective therapeutic regimen in cancer treatment...
  25. ncbi request reprint Anti-tumor activity of calcitriol: pre-clinical and clinical studies
    Donald L Trump
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Steroid Biochem Mol Biol 89:519-26. 2004
    ..These results demonstrate that high intermittent doses of calcitriol can be administered to patients without toxicity, that the MTD is yet to be determined and that calcitriol has potential as an anti-cancer agent...
  26. ncbi request reprint Pharmacokinetics of liquid calcitriol formulation in advanced solid tumor patients: comparison with caplet formulation
    Josephia R Muindi
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Chemother Pharmacol 56:492-6. 2005
    ..83). We conclude that the commercially available liquid 1,25-D(3) formulation offers no PK advantage over caplet formulation...
  27. ncbi request reprint Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer
    Donald L Trump
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 106:2136-42. 2006
    ..The combination of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) plus dexamethasone was studied based on evidence that dexamethasone potentiates the antitumor effects of calcitriol and ameliorates hypercalcemia...
  28. ncbi request reprint Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients
    Josephia R Muindi
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Chemother Pharmacol 59:97-104. 2007
    ....
  29. ncbi request reprint Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway
    Soo Ok Lee
    Department of Medicine and Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 60:178-86. 2004
    ..Previous studies demonstrated that IL-6 promotes androgen-independent growth of prostate cancer cells. In this study, the effect of IL-6 on apoptosis induced by androgen deprivation was investigated...
  30. ncbi request reprint Overview consensus statement. Newer approaches to androgen deprivation therapy in prostate cancer
    Peter R Carroll
    Department of Urology, University of California School of Medicine, San Francisco, San Francisco, California, USA
    Urology 60:1-6. 2002
  31. pmc Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue
    Ravi J Menezes
    Department of Cancer Prevention and Control Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:1104-10. 2008
    ..This is the first comprehensive survey of VDR expression in a series of human lung tissues, including normal and premalignant central airway biopsies and lung tumors...
  32. ncbi request reprint Anti-proliferative effects of calcitriol on endothelial cells derived from two different microenvironments
    Ivy Chung
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Steroid Biochem Mol Biol 103:768-70. 2007
    ....
  33. ncbi request reprint Vitamin D-related therapies in prostate cancer
    Candace S Johnson
    Cancer Metastasis Rev 21:147-58. 2002
    ..Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer...
  34. ncbi request reprint A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors
    Marwan G Fakih
    Department of Medicine, Roswell Park Cancer Institute and The University at Buffalo, NY 14263, USA
    Clin Cancer Res 13:1216-23. 2007
    ..Therefore, we conducted a phase I study of calcitriol and gefitinib to determine the maximum tolerated dose (MTD) of this combination...
  35. pmc Characterization of Vitamin D insensitive prostate cancer cells
    Adebusola A Alagbala
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Steroid Biochem Mol Biol 103:712-6. 2007
    ..In summary, VDI cells are less responsive to the antiproliferative effects of calcitriol. Understanding Vitamin D insensitivity will further clinical development of Vitamin D compounds for prevention and treatment of CaP...
  36. ncbi request reprint Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer
    Tomasz M Beer
    Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Science University, Mail Code CR 145, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Cancer Chemother Pharmacol 59:581-7. 2007
    ..DN-101 is a new, high-dose, oral formulation of calcitriol under investigation for the treatment of cancer. We sought to evaluate the tolerability and pharmacokinetics (PK) of weekly doses of DN-101 in patients with advanced cancer...
  37. ncbi request reprint Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells
    Ivy Chung
    Department of Molecular Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Res 66:8565-73. 2006
    ..These results show that TDEC were more sensitive than MDEC to the antiproliferative effects of calcitriol despite apparently normal VDR content and structure of signaling axis in both cell types...
  38. ncbi request reprint Vitamin D compounds: clinical development as cancer therapy and prevention agents
    Donald L Trump
    Departments of Medicine and Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 26:2551-6. 2006
    ....