Genomes and Genes
Lee Way Jin
Affiliation: University of Washington
- Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell deathLee Way Jin
Department of Pathology, University of Washington, Seattle 98195 7470, USA
J Mol Neurosci 19:57-61. 2002..Lead compounds will now be selected for their abilities to ameliorate A beta/CTF-mediated pathology in transgenic mice. Our hope is that these compounds may eventually prove beneficial for the prevention and treatment of AD...
- Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositisL W Jin
Department of Pathology, University of Washington, Seattle 98195 6480, USA
Am J Pathol 153:1679-86. 1998..The expression of IBM-like lesions was age dependent. These transgenic mice provide a model for the study of IBM and for the peripheral expression of a key element in the pathogenesis of Alzheimer disease...
- Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalitiesLee Way Jin
Department of Pathology, University of Washington, Seattle, Washington 98104 2499, USA
Am J Pathol 164:975-85. 2004..Our results suggest that endosomal abnormalities related to abnormal lipid trafficking in NPC may contribute to abnormal APP processing and Abeta42/C99/APP-CTF deposition...
- Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicityIzumi Maezawa
Department of Pathology, University of Washington, Seattle 98195 7470, USA
Pathol Int 52:551-4. 2002..These findings suggest that PS1 mutations may, in part, contribute to the development of DAT via altered expression of chaperone proteins...
- Early intraneuronal Abeta deposition in the hippocampus of APP transgenic miceFeng Shiun Shie
Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195 7490, USA
Neuroreport 14:123-9. 2003..Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation...
- Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic miceFeng Shiun Shie
Nutritional Sciences Interdisciplinary Program and Department of Pathology, Box 353410, Raitt Hall, Room 305, University of Washington, Seattle, WA 98195, USA
Neuroreport 13:455-9. 2002..Overall, plasma lipoproteins may be an important factor in induction of AD-like plaques in mice. The lowering of plasma lipids may be therapeutic for AD patients...
- Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's diseaseSimona Vuletic
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Lipid Res 44:1113-23. 2003..Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD...
- Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicityIzumi Maezawa
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Neurochem 91:1312-21. 2004....
- Imaging linear birefringence and dichroism in cerebral amyloid pathologiesLee Way Jin
Departments of Chemistry and Pathology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:15294-8. 2003..This investigation illustrates that the latest methods for the optical analysis of heterogeneous substances are useful for in situ study of amyloid...
- Isoform-specific knockout of FE65 leads to impaired learning and memoryBaiping Wang
Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
J Neurosci Res 75:12-24. 2004..Reduced secretion of Abeta peptides was observed in primary neuronal cultures of hybrids of p97FE65(-/-)/betaPP transgenic (Tg2576) mice. These studies suggest an important and novel function of FE65 in learning and memory...
- Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamateIzumi Maezawa
Department of Pathology, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
J Neurosci 30:5346-56. 2010..Our results suggest that microglia may influence the onset and progression of RTT and that microglia glutamate synthesis or release could be a therapeutic target for RTT...
- Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleDavid G Cook
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Am J Pathol 162:313-9. 2003..These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism...
- Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tanglesBitao Bu
Department of Pathology, University of Washington, Seattle, 98195, USA
Neurobiol Dis 11:285-97. 2002..Even without NFT, cerebellar neurodegeneration may be triggered by the inappropriate activation of the cell cycle cdc2 kinase, and the npc-1 murine model provides an opportunity to test this hypothesis...
- A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexesIzumi Maezawa
MIND Institute and Department of Pathology, University of California Davis, Sacramento, California, USA
J Neurochem 98:57-67. 2006..CP2 analogs represent a new class of promising compounds for the amelioration of Abeta toxicities within both intracellular and extracellular sites...
- Congo red and thioflavin-T analogs detect Abeta oligomersIzumi Maezawa
M I N D Institute and Department of Pathology, University of California Davis, Sacramento, California 95817, USA
J Neurochem 104:457-68. 2008..We propose that by improving the binding affinity of current ligands, in vivo imaging of AbetaO is feasible by a 'signal subtraction' procedure. This approach may facilitate the identification of individuals with early AD...
- Characterization of radioiodinated ligand binding to amyloid beta plaquesMei Ping Kung
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
J Mol Neurosci 20:249-54. 2003....
- Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegenerationAndrei Tomashevski
Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195, USA
J Alzheimers Dis 3:195-207. 2001..These data suggest that Wee1 functions in normal postmitotic neurons, but is altered in AD so as to promote activation of Cdc2/cyclin B1. Thus, Wee1 is yet another mitotic regulator that participates in the AD neurodegenerative process...
- Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitroSimona Vuletic
Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
J Neurosci Res 80:406-13. 2005..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis...
- Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer diseaseErin M Ramos
Institute for Public Health Genetics, Department of Medicine, University of Washington, Seattle, WA, USA
Arch Neurol 63:1165-9. 2006..Functional polymorphisms in tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) can affect immune response, inflammation, tissue injury, and possibly the susceptibility to Alzheimer disease (AD)...
- Polarimetric imaging of amyloidWerner Kaminksy
Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, USA
Micron 37:324-38. 2006..The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures...
- Mapping the structural transition in an amyloidogenic apolipoprotein A-IJens O Lagerstedt
Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
Biochemistry 46:9693-9. 2007....
- Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detectionWenchao Qu
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Bioorg Med Chem Lett 17:3581-4. 2007..Taken together, these preliminary results strongly suggest that these novel iodinated aza-diphenylacetylenes may be potentially useful for imaging Abeta plaques in the living human brain...
- New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaquesRajesh Chandra
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Med Chem 50:2415-23. 2007..These preliminary results suggest that the novel diphenylacetylenes may be potentially useful for imaging of Abeta plaques in the brain of patients with Alzheimer's disease...
- Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patientsMichael J House
School of Physics, University of Western Australia, Perth, Australia
Magn Reson Med 57:172-80. 2007..High-field MRI may therefore be a useful research tool for assessing brain iron changes associated with AD...
- Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicityHyun Seok Hong
M I N D Institute and Department of Pathology, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
Brain Res 1130:223-34. 2007..Both assays are simple, suitable for rapid screening of a large number of medicinal libraries, and amenable for automation...
- Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson diseaseJin Xu
Department of Neurology, Harvard Medical School and Division of Neuroscience, The Children s Hospital, Boston, Massachusetts, USA
Nat Med 8:600-6. 2002..Thus, accumulation of soluble alpha-synuclein protein complexes can render endogenous dopamine toxic, suggesting a potential mechanism for the selectivity of neuronal loss in PD...
- Genetic modulation of tau phosphorylation in the mouseJochen Brich
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 23:187-92. 2003..Dab1 mutant mice provide an animal model for studying the relationships between ApoE receptors, tau hyperphosphorylation, and Alzheimer's disease...